Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of first dose of treatment. Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment. Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device =< days prior to registration COHORT : Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment\r\n* NOTE: Subjects who were treated on a clinical study of allogeneic stem cell transplant (alloHSCT) will be eligible if they are at least months after allogeneic HCT and are at least weeks (> days) off of all immune suppression and have no evidence of active GVHD (physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency is allowed). Subjects with prior alloHSCT will not be eligible for enrollment during the safety run in phase COHORT : Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment for pre-existent myeloid disorder such as MDS or MPN Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of study drug. Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of study medication Is currently participating in or has participated in a study of an investigational agent or has used an investigational device within weeks prior to the first dose of study therapy Currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of study treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment. Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of study registration Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks or half-lives of the first dose of treatment, whichever is shorter Has participated in a study of an investigational agent and has received study therapy or has used an investigational device within days of administration of MK-. Currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of study medication Currently participating and receiving study therapy in, or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the date of allocation/randomization Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment; has a diagnosis of immunodeficiency or is receiving systemic steroid therapy or any other form of immunosuppressive therapy within days prior to the first dose of trial treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks prior to administration of pembrolizumab. Currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of study drug. Is currently participating and receiving study therapy or has participated and received study therapy in a study of an investigational agent, or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy within weeks of first dose of treatment or used an investigational device within weeks of the first dose of treatment. EXCLUSION - PARTICIPANT: Currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigation device within weeks of first dose of treatment. \r\n* Individuals in the follow-up phase of a prior investigational study may participate as long as it has been weeks since last dose of the previous investigational agent of device. Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Participants must not be currently receiving study therapy or have participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving pembrolizumab or has participated in a study of an investigational agent and received pembrolizumab or used an investigational device within weeks of the first dose of study treatment. Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within days of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment. Is currently participating in and receiving study therapy, or has participated in a study of an investigational agent and received study therapy, or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy of an investigational agent and received study therapy within weeks of the first dose of treatment; this week washout period would not apply to investigational food ingredients Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment. Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of on-study date Currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy, or herbal/complementary oral or IV medicine within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks prior to the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigation device within calendar days of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device =< days of registration Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first planned dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of study treatment. Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy with another investigational device or study drug or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of study drug Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy within weeks of the first dose of treatment Currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device =< weeks of the first dose of study drug Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of day Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy, herbal/complementary oral or IV medicine, or used an investigation device within weeks of the first dose of treatment; subjects must also have recovered from associated therapy (i.e., to grade =< or baseline) and from adverse events due to any prior therapy Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy, herbal/complementary oral or IV medicine, or used an investigation device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy, herbal/complementary oral or IV medicine, or used an investigation device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the initiation of SBRT Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational new drug and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving a study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the study drug administration Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment; an exception will be made for patients who have received CTL on experimental protocol; these patients will be eligible to enroll once progression of disease or failure to respond is documented by clinical or radiologic assessment Is currently participating in and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment. Currently receiving or has had treatment with an investigational agent or used an investigational device within weeks of study day Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study drug or using an investigation device within weeks of the first dose of treatment Currently participating or has participated in a study of an investigational agent and received study therapy or received investigational device within weeks prior to the first dose of study treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment REGISTRATION TO TREATMENT (STEP ): Patient may not be currently participating and receiving study therapy or have participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy, or has participated in a study of an investigational agent and received study therapy, or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Currently participating and receiving study therapy, or have participated in a study of an investigational agent and received study therapy, or used an investigational device =< weeks of registration Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm OR participated in a study of an investigational agent, received study therapy or used an investigational device =< weeks prior to registration Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Currently participating and receiving treatment in another study, or participated in a study of an investigational agent and received treatment, or used an investigational device within weeks of randomization Is currently participating, or has participated in a study of an investigational agent and received study drug, herbal/complementary oral or IV medicine, or used an investigational device within weeks of the first dose of study drug. Participants must also have recovered from associated therapy (i.e., to Grade ? or baseline) and from adverse events (AEs) due to any prior therapy. Is currently participating in and receiving study therapy or has participated in a study of an investigational agent and received study drug or used an investigational device within weeks of treatment allocation Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment. Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of study drug. Currently participating in and receiving study therapy or has participated in a study of an investigational agent or has used an investigational device within weeks prior to the first dose of study medication Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigation device within weeks of the first dose of study drug. Is currently participating in and receiving study therapy or has participated in a study of an investigational agent or used an investigational device within weeks of the first dose of study therapy Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks prior to administration of pembrolizumab. Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment. Currently receiving or has received an investigational treatment as part of a study of an investigational agent or has used an investigational device within weeks before randomization. Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy, herbal/complementary oral or IV medicine, or used an investigational device within weeks of the first dose of study drug. Participant must also have recovered from associated therapy (i.e., to Grade ? or baseline) and from adverse events due to any prior therapy Is currently participating in or has participated in a clinical study and received an investigational agent or used an investigational device within weeks prior to the first dose of study treatment Patients currently participating and receiving study therapy or who have participated in a study of an investigational agent and received study therapy or used and investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of study medication Participant is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks prior to administration of pembrolizumab and CC- Currently participating in another study and receiving trial treatment, participated in a study of an investigational agent and received trial treatment within weeks of the first dose of medication in this study, or used an investigational device within weeks of the first dose of medication in this study. Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study drug or using an investigation device within weeks of the first dose of treatment Currently participating and receiving study therapy, or participated in a study of an investigational agent and received study therapy or used an investigation device within weeks of the first dose of medication Currently participating and receiving study therapy, or participated in a study of an investigational agent and received study therapy or used an investigation device within weeks of the first dose of study medication Currently participating and receiving study therapy, or participated in a study of an investigational agent and received study therapy, or used an investigational device within weeks of the first dose of study medication Currently participating or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks prior to the first dose of study treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Currently participating and receiving another study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy in a study of an investigational agent or has participated and received study therapy in a study of an investigational agent or has used an investigational device within days of administration of MK- Concurrent enrollment in another therapeutic investigational clinical study or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of study drug Is currently participating and receiving study treatment or has participated in a study of an investigational agent and received study treatment or used an investigational device within weeks of the first dose of treatment for another health-related problem Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Has participated in a study of an investigational agent and received study therapy or used an investigational device within days of study start Patient is premenopausal (medical ovarian suppression is allowed); is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy for his/her advanced melanoma or has participated in a study of an investigational agent and received study therapy in the advanced melanoma setting Currently participating and receiving study therapy (except lenvatinib for patients in cohort ) or has participated in a study of an investigational agent and received study therapy within weeks prior to registration Currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigation device within weeks prior to enrollment . Is currently participating in or has participated in a study of an investigational agent and is currently receiving study therapy or has participated in a study of an investigational agent and has received study therapy or used an investigational device within weeks of the first dose of study drug. Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within weeks of the first dose of treatment