Severe active co-morbidity as determined by the investigator or principal investigator Severe, active co-morbidity, defined as follows: Severe, active co-morbidity, defined as follows: Severe, active co-morbidity Severe, active co-morbidity defined as follows:\r\n* Life expectancy < months Severe or uncontrolled concurrent disease, infection or co-morbidity. Patients with severe, active co-morbidity, defined as follows: Severe, active co-morbidity Severe, active co-morbidity, defined as follows: Sorrors co-morbidity factors with total score > Sorror co-morbidity index > Sorrors co-morbidity factors with total score > Sorrors co-morbidity factors with total score >= \r\n* Important modification to co-morbidity index calculation: DLCO adjusted will not be included in assessment of pulmonary risk, except those patients with DLCO adjusted < % who are excluded from the trial Severe, active co-morbidity, defined as follows: