Symptomatic congestive heart failure, unstable angina pectoris, or myocardial infarction within months of registration Patients with myocardial infarction or unstable angina < months prior to starting study drug Severe arterial thromboembolic events (myocardial infarction, unstable angina pectoris, stroke) less than months before inclusion Myocardial infarction or unstable angina pectoris within months prior to randomization. Severe/unstable angina pectoris, or myocardial infarction within months prior to study entry Acute myocardial infarction or angina pectoris. Unstable angina pectoris or myocardial infarction ? months prior to starting treatment in the study. History of angina pectoris, symptomatic pericarditis, or myocardial infarction within months prior to study entry; mCRPC EXPANSION COHORT: Any of the following within months before the first dose of study treatment:\r\n* Unstable angina pectoris\r\n* Stroke (including TIA, or other ischemic event)\r\n* Myocardial infarction Unstable angina pectoris or acute myocardial infarction =< months prior to starting study drug Unstable angina pectoris or acute myocardial infarction =< months prior to starting study drug Have active angina pectoris or recent myocardial infarction (within months). Acute myocardial infarction or unstable angina pectoris < months prior to Screening Symptomatic congestive heart failure, unstable angina pectoris, or myocardial infarction within months of enrollment Any active angina or any unstable angina pectoris or myocardial infarction within one year of study entry Symptomatic congestive heart failure, unstable angina pectoris, stroke or myocardial infarction within months Angina pectoris =< months prior to starting drug Have active angina pectoris, stroke or recent myocardial infarction (within months). Arterial thromboembolic events (myocardial infarction, unstable angina pectoris, stroke) < months prior to enrollment Acute myocardial infarction or angina pectoris ? months prior to starting study drug Unstable angina pectoris or myocardial infarction ? months prior to starting CC-. Significant cardiac dysfunction; myocardial infarction within months; unstable, poorly controlled angina pectoris. Acute myocardial infarction or unstable angina pectoris < months prior to Screening History of angina pectoris, symptomatic pericarditis, or myocardial infarction within months prior to study entry Patients with myocardial infarction or unstable angina =< months prior to starting study drug Symptomatic congestive heart failure, unstable angina pectoris, stroke or myocardial infarction within months Unstable angina pectoris or myocardial infarction less than months prior to starting either study drug Acute myocardial infarction (AMI) or unstable angina pectoris < months prior to study entry Unstable angina pectoris or myocardial infarction ? months prior to starting CC Patients with myocardial infarction or unstable angina =< months prior to starting study drug Acute myocardial infarction or angina pectoris ? months prior to starting study drug Patients with myocardial infarction or unstable angina ? months prior to starting study drug. Angina pectoris ? months prior to starting study drug Have active angina pectoris, stroke or recent myocardial infarction (within months). Subjects with any one of the following: ) Congestive heart failure, ) Myocardial infarction within months prior to starting study treatment, ) Unstable or poorly controlled angina pectoris, including Prinzmetal variant angina pectoris Angina pectoris ? months prior to dosing with study drug Acute myocardial infarction or angina pectoris ? months prior to starting study drug History of uncontrolled angina pectoris or myocardial infarction within months prior to Screening;