Male subject must not donate sperm starting at screening and throughout the study period and for days after the final study drug administration. Male participants must not donate sperm throughout the study drug treatment period and for days after the final study drug administration. Male subject who is of childbearing potential must not donate sperm starting at screening and throughout the study and, for days after the final study drug administration. Male subject must not donate sperm starting at Screening and throughout the study period and, for months after the final study drug administration Note: *Highly effective forms of birth control include: Must not donate sperm starting at screening throughout the study period and for days after the final study drug administration. Agree to use a male condom starting at screening and continue throughout study treatment and for months after the final study drug administration. Male subject must not donate sperm starting at Screening and throughout the study period and for months after the final study drug administration. Male subject with a pregnant or breastfeeding partner(s) must agree to remain abstinent or use a condom for the duration of the pregnancy or for the time partner is breastfeeding throughout the study period and for months after the final study drug administration. Male subject must not donate sperm starting at Screening and throughout the study period and days after the final study drug administration. In a man whose sexual partner is a woman of childbearing potential, unwillingness or inability of the man or woman to use a highly effective contraceptive method for the entire study treatment period for at least months after study completion. Male subjects must not freeze or donate sperm starting at Screening and throughout the study period, and days after the final study drug administration. Male subject must not donate sperm starting at Screening and throughout the study period and, for days after the final study drug administration. Male subject must not donate sperm starting at screening and throughout the study period and for days after the final study drug administration. Female subject must not be breastfeeding at Screening or during the study period and for months after final study drug administration. Male subject must not donate sperm starting at Screening and throughout the study period and for at least months after final drug administration. Female subject must not be breastfeeding at Screening or during the study period, and for days after the final study drug administration. Male subject must not donate sperm starting at Screening and throughout the study period and for days after the final study drug administration. Female subject must not be breastfeeding at Screening or during the study period, and for days after the final study drug administration. Male subject must not donate sperm starting at Screening and throughout the study period and for days after the final study drug administration. Male subject with a pregnant or breastfeeding partner(s) must agree to remain abstinent or use a condom for the duration of the pregnancy or time partner is breastfeeding throughout the study period and for days after the final study drug administration Male subject must not donate sperm starting at screening and throughout the study period, and for days after the final study drug administration. Must not donate sperm from screening through months after final study drug administration. Female subject must not be breastfeeding at screening or during the study period, and for days after the final study drug administration. Male subject must not donate sperm starting at screening and throughout the study period and for days after final study drug administration. Female subject must not be breastfeeding at screening or during the study period, and for days after the final study drug administration. Male subject must not donate sperm starting at screening and throughout the study period and for days after the final study drug administration. *Acceptable forms of birth control include: Subject agrees to avoid sperm donation during the study and for at least months after final enzalutamide administration. Male subject must not donate sperm starting at screening and throughout the study period and for months and week after the final study drug administration.