History of non-pharmacologically induced prolonged QTc interval
Prolonged rate corrected QT (QTc) interval <  msec
Patients with a pre-existing diagnosis of a prolonged QT syndrome (even if corrected QT interval [QTc] is normal at the time of APL diagnosis) are excluded
QTc =<  msec; Note: Patients with grade  prolonged QTc (-  msec) at the time of study enrollment should have correctable causes of prolonged QTc addressed if possible (i.e., electrolytes, medications)
Patients must not have a history of clinically significant arrhythmia, prolonged corrected QT (QTc) interval, or unexplained syncope not thought to be vasovagal in nature within  months prior to registration
Prolonged corrected QT (QTc) interval >  msec, calculated according to Fridericia's formula
History of prolonged QTc interval.
No known history of prolonged QT syndrome
Prolonged corrected QT (QTc) interval
Prolonged baseline QTc
Patients with prolonged corrected QT (QTc) interval (>  msec) (for cohort a and b [belinostat cohorts] only, electrocardiogram [ECG] nor required for cohort )
Subjects with prolonged corrected QT (QTc) (>  msec) will be excluded from the study.
Corrected QT (QTc) interval using Fridericias formula (QTcF) >=  msec. Bundle branch block and prolonged QTc interval are permitted after discussion with the PI.
Prolonged rate corrected QT (QTc) interval ?  msec, calculated according to institutional guidelines
QTc interval using Fridericia's formula (QTcF) ? msec or other factors that increase the risk of QT interval prolongation or arrhythmic events (e.g., heart failure, hypokalemia, family history of long QT interval syndrome). Bundle branch block and prolonged QTc are permitted with approval of the study Sponsor
Prolonged rate corrected QT (QTc) interval >=  msec, calculated according to institutional guidelines
Unstable or serious concurrent medical conditions in the previous  months, eg, pancreatitis, severe/unstable angina, prolonged QT interval corrected by Fridericias formula (QTcF) >  msec (calculated as average of triplicate readings, taken no greater than  minutes apart, and no history of torsades de pointes or symptomatic corrected QT [QTc] abnormality), symptomatic congestive heart failure, myocardial infarction and/or pulmonary hypertension, ongoing maintenance therapy for life-threatening ventricular arrhythmia, stroke, and uncontrolled major seizure disorder
Prolonged rate corrected QT (QTc) interval of >  msec, calculated according to institutional guidelines
Adequate cardiac function defined as\r\n* No history of congenital QTc syndrome, New York Heart Association (NYHA) class III or IV congestive heart failure (CHF)\r\n* No clinical significant cardiac arrhythmias, stroke or myocardial infarction within  months prior to enrollment\r\n* QTc =<  msec; Note: Three electrocardiograms (ECGs) must be performed for eligibility determination; if the average of these three consecutive results for corrected QT using Fridericia's formula (QTcF) is =<  msec, the subject meets eligibility in this regard; patients with grade  prolonged QTc (- msec) at the time of study enrollment should have correctable causes of prolonged QTc addressed if possible (i.e. electrolytes, medications)
No history of prolonged QTC or cardiomyopathy unless normal QTC and ejection fraction confirmed within  month prior to study entry
Prolonged corrected QT (QTc) interval on pre-entry electrocardiogram (>=  msec)
A clinically significant ECG abnormality, including a marked baseline prolonged QT or QTc interval (eg, a repeated demonstration of a QTc interval greater than  msec).
Patients with known prolonged corrected QT (QTc) syndrome or prolonged QTc syndrome noted on baseline electrocardiography (ECG)
Prolonged rate corrected QT (QTc) interval >=  msec, calculated according to institutional guidelines
At increased risk for developing prolonged QT interval unless corrected to within normal limits prior to first dose of SNX-
At increased risk for developing prolonged QT interval unless corrected to within normal limits prior to first dose of SNX-
History of cardiac disease (arrhythmia, conduction abnormality, congenital prolonged QT syndrome, or prolonged corrected QT [QTc] rhythm noted during initial electrocardiogram [EKG] >  ms)
Documented history of prolonged QTc interval =<  months prior to registration
Clinically significant active cardiovascular disease or history of prolonged QT interval corrected for heart rate (QTc)
Corrected QT (QTc) =<  msec\r\n* Note: patients with grade  prolonged QTc (- msec) at the time of study enrollment should have correctable causes of prolonged QTc addressed if possible (i.e. electrolytes, medications)
Prolonged corrected QT interval (QTc) on pre-entry electrocardiogram (>  msec for men and >  msec for women per American Heart Association (AHA)/American College of Cardiology (ACC)  scientific statement
Patients with a history of prolonged corrected QT (QTc) syndrome
Patients with a known history of a prolonged QT interval (corrected QT interval [QTc] > ) may not be enrolled in this study
Patients may not have any clinically significant cardiovascular disease including the following:\r\n* Myocardial infarction or ventricular tachyarrhythmia within  months\r\n* Prolonged corrected QT (QTc) >  msec (Fridericia correction)\r\n* Known ejection faction less than institutional normal\r\n* Major conduction abnormality (unless a cardiac pacemaker is present)
Documentation of the patients history of corrected QT interval (QTc) prolongation, family history of prolonged QTc, and relevant cardiac disease within  days prior to registration
Prolonged corrected QT interval (QTC) on electrocardiogram (EKG)
Prolonged QTC
Has clinically active heart disease including prolonged corrected QT interval
Patients with prolonged corrected QT (QTc) interval (>  msec) determined by electrocardiogram (EKG) within  days prior to registration
Patients with a left ventricular cardiac ejection fraction < % as assessed by an echocardiogram or MUGA scan or prolonged QTc interval of Grade  or higher or history of prolonged QTc interval from other drugs.
Prolonged corrected QT (QTc) interval on pre-entry electrocardiogram (>  msec) within  days prior to study registration
Patients with a baseline QTc >  msec and patients with a family history of prolonged QT syndrome
Subjects with heart-rate corrected QT (QTc) interval ?  msec or with other factors that increase the risk of QT prolongation or arrhythmic events (e.g., heart failure, hypokalemia, family history of long QT interval syndrome). Subjects with right bundle branch block and a prolonged QTc interval should be reviewed by the Medical Monitor for potential inclusion.
Participants with a history of congenitally prolonged corrected QT interval (QTc), a first degree relative with unexplained sudden death under  years of age, or a measured QTcB (Bazetts correction) longer than  msec on electrocardiogram (ECG); ECGs should be performed after correction of electrolyte abnormalities; participants with a prolonged QTcB should have a repeat ECG twice, at least  hour apart, and the average of the  QTcBs should not exceed  msec; history of QT prolongation associated with other medications that required discontinuation of that medication
Prolonged rate corrected QT (QTc) interval >=  msec, calculated according to institutional guidelines
Prolonged QTc interval on pre-entry electrocardiogram (>/=  msec)
Prolonged corrected QT (QTc) interval (>=  msec), as calculated by Bazett's formula
History of significant cardiovascular disease, defined as:\r\n* Congestive heart failure greater than New York Heart Association (NYHA) class III according to the NYHA functional classification \r\n* Unstable angina or myocardial infarction within  months of enrollment\r\n* Serious cardiac arrhythmia\r\n* A prolonged QT/corrected QT (QTc) interval (QTc >  ms) demonstrated on electrocardiogram (ECG) at screening or baseline; a history of risk factors for torsade de pointes (e.g., heart failure, hypokalemia, family history of long QT syndrome) or the use of concomitant medications that prolonged the QT/QTc interval
Prolonged QTc interval on pre-entry electrocardiogram (>  msec)
Patients must not have any clinically significant cardiovascular disease including the following: myocardial infarction or ventricular tachyarrhythmia within  months, prolonged corrected QT interval (QTc) >  msec (Fridericia correction), ejection fraction less than institutional normal, major conduction abnormality (unless a cardiac pacemaker is present); patients with any cardiopulmonary symptoms of unknown cause (e.g. shortness of breath, chest pain, etc.) are to be evaluated by a baseline echocardiogram with or without stress test as needed in addition to electrocardiogram (EKG) to rule out QTc prolongation; the patient may be referred to a cardiologist at the discretion of the principal investigator; patients with underlying cardiopulmonary dysfunction are excluded from the study
Heart-rate corrected QT (QTc) interval > msec or with other factors that increase the risk of QT prolongation or arrhythmic events (e.g., heart failure, hypokalemia, family history of long QT interval syndrome). Subjects with right bundle branch block and a prolonged QTc interval should be reviewed by the Medical Monitor for potential inclusion
Clinically active heart disease including prolonged QTc or prolonged PR interval, or history of arrhythmias
Prolonged rate corrected QT interval (QTc) >= millisecond (msec), calculated according to institutional guidelines.
Prolonged QTcF
Mean corrected QT (QTc) interval >=  (triplicate electrocardiograms [ECGs]) or history congenital prolonged QT interval
Patients must not have prolonged corrected QT (QTc) interval (>  msec) determined by electrocardiogram (EKG) within  days prior to registration
Patients may not have any clinically significant cardiovascular disease including the following:\r\n* Myocardial infarction or ventricular tachyarrhythmia within  months\r\n* Prolonged corrected QT interval (QTc) >  msec\r\n* Ejection fraction less than %\r\n* Major conduction abnormality (unless a cardiac pacemaker is present)
At increased risk for developing prolonged QT interval, including hypokalemia or hypomagnesemia, unless corrected to within normal limits prior to first dose of SNX- Chronic diarrhea.
Patient with prolonged QT/QTc (defined as QTc interval >  msec) are not eligible.
Documented history of prolonged QTc interval =<  months prior to registration
Prolonged QTc interval on pre-entry electrocardiogram (>  msec) on the Bazetts correction
Medical disorder that would endanger subjects well-being (e.g., uncorrected hypothyroidism, cardiac arrhythmia, hypertension requiring treatment, sick sinus syndrome, prolonged corrected QT [QTc])
Diagnosis of narcolepsy, sick sinus syndrome, arrhythmia, or prolonged corrected QT interval (QTc)
Subjects having an electrocardiogram with a prolonged corrected QT (QTc) interval by manual reading: QTc greater than  msec
Prolonged QTc interval > msec
Subjects with prolonged QT interval.