Patients with CNS involvement, including leptomeningeal carcinomatosis, which is either asymptomatic or previously-treated and controlled, are allowed
History of leptomeningeal carcinomatosis
Meningeal carcinomatosis
Patients must be diagnosed with leptomeningeal carcinomatosis.
History of leptomeningeal carcinomatosis
History of leptomeningeal carcinomatosis.
Leptomeningeal carcinomatosis or other central nervous system (CNS) metastases
Clinical signs of or documented leptomeningeal carcinomatosis. Features such as headache, nuchal rigidity, and photophobia may indicate meningeal involvement.
History of leptomeningeal carcinomatosis
History of leptomeningeal carcinomatosis
History of leptomeningeal carcinomatosis
Uncontrolled metastases to the central nervous system (CNS) or cytological/radiographic evidence of leptomeningeal carcinomatosis. Participants with brain metastases (other than leptomeningeal carcinomatosis) are eligible provided they do not require ongoing steroids and have shown clinical and radiographic stability for at least days after definitive therapy. Primary glioblastoma is allowed.
History of leptomeningeal carcinomatosis
History of leptomeningeal carcinomatosis.
History of leptomeningeal carcinomatosis
History of leptomeningeal carcinomatosis
History of leptomeningeal carcinomatosis
History of leptomeningeal carcinomatosis
Leptomeningeal carcinomatosis or cord compression
History of leptomeningeal carcinomatosis or brain metastasis.
History of leptomeningeal carcinomatosis
History of leptomeningeal carcinomatosis
Leptomeningeal carcinomatosis, diagnosed on cytology or appropriate imaging
History of leptomeningeal carcinomatosis
History of leptomeningeal carcinomatosis
History of leptomeningeal carcinomatosis
History of leptomeningeal carcinomatosis
History of leptomeningeal carcinomatosis
History of leptomeningeal carcinomatosis
Symptomatic and uncontrolled metastasis in the central nervous system or leptomeningeal or lymphangitic carcinomatosis
Leptomeningeal carcinomatosis
History of leptomeningeal carcinomatosis
Central nervous system (CNS) metastases including a history of leptomeningeal carcinomatosis
History of leptomeningeal carcinomatosis or uncontrolled seizures
History of leptomeningeal carcinomatosis or brain metastasis
History of leptomeningeal carcinomatosis
Leptomeningeal carcinomatosis as only site of CNS disease
Subjects with leptomeningeal carcinomatosis are not permitted
Subject has peritoneal carcinomatosis.
Lymphangitic carcinomatosis.
History of carcinomatosis meningitis
Diagnosis of leptomeningeal carcinomatosis
Presence of meningeal carcinomatosis
Meningeal carcinomatosis
Brain metastases or history of leptomeningeal carcinomatosis
History of leptomeningeal carcinomatosis
History of leptomeningeal carcinomatosis
Unstable CNS metastases or leptomeningeal carcinomatosis not considered radiographically stable
Leptomeningeal carcinomatosis as the only site of CNS involvement
Meningeal carcinomatosis.
History of leptomeningeal carcinomatosis
History of leptomeningeal carcinomatosis
Meningeal carcinomatosis.
History of leptomeningeal carcinomatosis
History of leptomeningeal carcinomatosis
Diagnosed with meningeal carcinomatosis.
