Participants with clinical or radiographic evidence of pancreatitis are excluded Known history of acute or chronic pancreatitis Known history of acute or chronic pancreatitis History of acute pancreatitis within year of study treatment or a history of chronic pancreatitis Recurrent or chronic pancreatitis History of acute pancreatitis within year of study entry or history of chronic pancreatitis Patients with a prior history of documented pancreatitis are not eligible Predisposing characteristics for acute pancreatitis in the last month prior to randomization. History of chronic pancreatitis. Patients with laboratory evidence of pancreatitis are excluded. Patient has a history of pancreatitis History of recurrent pancreatitis History of acute pancreatitis within year of study or history of chronic pancreatitis. History of acute pancreatitis within year of study or history of chronic pancreatitis. Pancreatitis that is active or within the preceding months which in the judgment of the endoscopist would make tumor injection likely to trigger severe recurrent pancreatitis History of pancreatitis Known active or chronic pancreatitis History of acute pancreatitis within one year of study or history of chronic pancreatitis Acute symptomatic pancreatitis within months of study entry or a diagnosis of chronic pancreatitis at the time of randomization. History of acute pancreatitis within year of study or history of chronic pancreatitis Known acute or chronic pancreatitis History of pancreatitis History of acute pancreatitis within year of screening or past medical history of pancreatitis Known history of pancreatitis Known history of acute or chronic pancreatitis History of diverticulitis or pancreatitis within weeks of registration Current pancreatitis Subject with history of acute within one year of study entry or past medical history of chronic pancreatitis History of pancreatitis No clinical or radiographic evidence of pancreatitis History of acute pancreatitis within months prior to screening Acute or chronic pancreatitis Patient has a history of acute pancreatitis within year of screening or a past medical history of chronic pancreatitis Subject has known acute or chronic pancreatitis. History of pancreatitis or chronic pancreatitis. Known symptomatic acute or chronic pancreatitis. The patient has a history of pancreatitis. Known history of acute or chronic pancreatitis Active or chronic pancreatitis No clinical evidence of pancreatitis History of acute pancreatitis within year prior to registration, chronic pancreatitis, alcohol abuse or uncontrolled hypertriglyceridemia (triglycerides > mg/dL) History of ? Grade pancreatitis Has a history of acute or chronic pancreatitis PART B: History of acute pancreatitis within year of study or history of chronic pancreatitis Diagnosis of acute or chronic pancreatitis Acute or chronic pancreatitis History of acute pancreatitis within year prior to study entry or past medical history of chronic pancreatitis Individuals with a history of asparaginase-associated pancreatitis Patients with a prior history of documented pancreatitis Subjects with acute or chronic pancreatitis. Active or clinically symptomatic chronic pancreatitis or disease affecting pancreas Acute or chronic pancreatitis. History of acute or chronic pancreatitis History of pancreatitis of any grade History of pancreatitis History of acute or chronic pancreatitis or any risk factors that may increase the risk of pancreatitis. Known acute or chronic pancreatitis . Pregnant or lactating females Arm B only (CC- in combination with ibrutinib): History of acute pancreatitis within year of study entry Acute or chronic pancreatitis Acute or chronic pancreatitis Recent history of acute pancreatitis. Recent ( months) history of acute pancreatitis. Known gallbladder or bile duct disease, acute or chronic pancreatitis Patients with recent history of pancreatitis History of acute pancreatitis within year of study or history of chronic pancreatitis Known gallbladder or bile duct disease, symptomatic cholelithiasis, acute or chronic pancreatitis Indication for operative intervention being chronic pancreatitis Active or recent pancreatitis (within last months) At least two episodes of acute pancreatitis in the past months; acute pancreatitis is defined any of the following: () typical upper abdominal pain; () elevation in serum amylase or lipase >= times upper limit of normal; () features of acute pancreatitis on cross-sectional imaging Patients with a history of pancreatitis Known symptomatic acute or chronic pancreatitis. Acute or chronic pancreatitis Chronic or acute pancreatitis as evidenced by clinical or pathologic diagnosis History of acute pancreatitis within year of study entry or past medical history of chronic pancreatitis