Severe liver dysfunction (Child-Pugh Class B or C) is not present; and Child-Pugh class A Patients with liver disease classified as Child Pugh class A or B, with score =< Chronic liver disease, Child-Pugh class B or C Impaired liver function Child-Pugh class B or C (score -). Child-Pugh class B and C liver failure Obtained with days of registration: Child Pugh class A (- points) or B ( points) Child Pugh class B (,) and class C are excluded. Child-Pugh class-A liver function Child-Pugh class A or B liver function Obtained =< days prior to registration: If baseline liver disease, Child Pugh score not exceeding class A Child Pugh class B or greater hepatic dysfunction Child Pugh class B & C Several hepatic impairments, define as Child-Pugh Class C or worse Child-Pugh class A or B without ascites Child Pugh class C hepatic dysfunction Child-Pugh Class A without either current encephalopathy or ascites. Child-Pugh Class A Cirrhotic status of Child-Pugh class A or B Liver function status Child-Pugh (CP) Class A. CP status should be calculated based on clinical findings and laboratory results during the screening period. Liver disease with Child-Pugh class B or C liver dysfunction HCC patients only: Child Pugh class A or B liver disease Subject is classified into Child-Pugh class C Has a Child-Pugh Class A liver score within days of first dose of study drug. Subject is classified into Child-Pugh class C Child-Pugh Class A Patients with hepatocellular carcinoma may be eligible provided they have total bilirubin ? . x ULN and are considered Child-Pugh Class A or Child-Pugh Class B (Child-Pugh Class B with a total Child-Pugh score not to exceed ). Has a Child-Pugh Class A liver score within days of first dose of study drug Preserved liver function (Child-Pugh class A or B) Subject has hepatic function status of Child Pugh Class A at Screening. Subject has status of Child-Pugh Class B or C at Screening. Child-Pugh class A Child-Pugh liver function class A Systemic disease that would prevent study treatment (uncontrolled hypertension, cardiovascular renal, hepatic (including Child-Pugh Class B and C) or metabolic disease) Child-Pugh Class A or B. Subject has Child-Pugh score of less than (ie, class A or better) with neither encephalopathy nor clinically significant ascites (ascites requiring paracentesis within months of signing the ICF is excluded). Child-Pugh status is calculated based on clinical findings and laboratory results during the screening period. Child Pugh Class A disease Child-Pugh class A with no clinically apparent ascites Child-Pugh class of A Child-Pugh Class B and C. Patients with impaired hepatic function as defined by Childs-Pugh class B or C Child Pugh Class A liver function score Must be Child-Pugh class A a. Patients with uncontrolled massive ascites or presence of hepatic encephalopathy are excluded Child Pugh class A or B liver disease Child-Pugh Class A. Child-Pugh Class A in the absence of hepatoencephalopathy or clinically evident ascites Child Pugh class A liver function or class B Child-Pugh class B and C liver failure Child-Pugh liver function Class B or C.