Patients with two or more active malignancies (synchronous multiple cancers, or metachronous multiple cancers with a disease-free period of ?  years, with the exception of carcinoma in situ, mucosal carcinoma, or other carcinomas that have been curatively treated with local therapy)
Assessment of HER status in patients with non-breast/non-gastric cancers may follow local institutional criteria. These criteria should be made available to the Sponsor.
Active second cancers
GU cancers with accessible metastases (e.g., bladder, renal)
Other malignancy within  years prior to entry into the study, except for those treated with surgical therapy only (e.g., localized low-grade cervical or prostate cancers).
Patients with primary salivary gland cancers are excluded
Patients with known active cancers who are on therapy for those cancers at time of screening
Prior history of other cancers (except non-melanoma skin cancers or low-grade low-stage urothelial cancers)
Must have select advanced cancers with specific genetic profiles
History of concurrent second cancers requiring active, ongoing systemic treatment.
Another previous or current invasive malignancy within the last  years, with the exception of curatively treated stage Ia cervical carcinoma, or resected stage Ia endometrial cancer, and noninvasive nonmelanoma skin cancers; patients with gBRCA/m and primary breast or ovarian cancers will be eligible for cohort 
No other active cancers
Subjects with cytologically or histologically confirmed locally advanced or metastatic HPV associated malignancies including:\r\n* Non-neuroendocrine cervical cancers\r\n* P+ oropharyngeal cancers\r\n* Anal cancers\r\n* Vulvar, vaginal, penile, squamous cell rectal and neuroendocrine cervical cancers\r\n* Other locally advanced or metastatic solid tumors (e.g. lung, esophagus) that are known HPV+
Patients with known other active cancers; skin cancers (basal or squamous) are exempted
Patients with primary nasopharynx or salivary gland cancers are excluded
Histological confirmation of advanced biliary tract cancers including cancers originating in gallbladder who have received at least one line of systemic anticancer therapy; \r\n* Note: Patients who have either progressed or intolerant to the prior therapy can be included in this study
Cancer survivors of the state of Maryland cancers of interest
Histologically confirmed cancers for which no curative therapy exists.
Prior unrelated malignancy requiring current active treatment with the exception of cervical carcinoma in situ, basal cell carcinoma of the skin, resected T-NM differentiated thyroid cancers, invasive cancers with a -year disease-free interval, Ta bladder cancers, or low and favorable intermediate risk prostate cancer.
Two or more cancers not resectable through a single lumpectomy incision
Patients with other active cancers receiving anti-cancer agents, with exceptions being hormonal therapy for breast or prostate cancer and skin cancers treated with local therapies only
Current history of neoplasm other than the entry diagnosis. Patients with previous cancers treated and cured with local therapy alone may be considered with approval of the PI
Second malignancies that require active treatment with the exception of non-melanomatous skin cancers, and/or breast or prostate cancer on endocrine therapy
CAPMATINIB EXCLUSION CRITERIA: Diagnosis of concurrent malignancy or previous malignancy within  years before study drug administration (exceptions are superficial skin cancers, or any in situ cancers deemed surgically resected, cured and not requiring systemic therapy, and indolent malignancies that currently do not require treatment)
CERITINIB EXCLUSION CRITERIA: Diagnosis of concurrent malignancy or previous malignancy within  years before study administration (exceptions are superficial skin cancers, or any in situ cancers deemed surgically resected, cured and not requiring systemic therapy)
Multicentric cancers requiring double lumpectomy
History of recent cancers (except for colorectal cancers, non-melanoma skin cancers, basal cell carcinomas, squamous cell carcinomas) in the past  years
Presence of other active invasive cancers that do not harbor CCNE amplification
Currently being treated for other cancers with medical or radiation therapy
Presence of other active invasive cancers.
All breast cancers with possibility for surgical excision will be included
No active second cancers
Other invasive cancers that are clinically active
Patients with active malignancies other than skin cancers are ineligible for this study
Patients with simultaneous primary cancers or separate bilateral primary tumor sites are excluded with the exception of patients with bilateral tonsil cancers
Bilateral breast cancers are allowed as long as both cancers are HER-positive; however, only the primary cancers status requires central review
Patients with cancers likely to be Human Papilloma Virus (HPV)-positive such as cervical cancers, oropharyngeal cancers or anal cancers must undergo additional screening to determine eligibility
Patients undergoing current treatments for other cancers
Patients with a diagnosis of two co-existing primary cancers are excluded
Human papilloma virus-associated cancers basket\r\n* None
Patients with multiple primary cancers
Patients with concomitant primaries of the bladder/urethra are allowed, as long as these sites are surgically resected and non-invasive cancers (< cTN)
Two or more breast cancers not resectable through a single lumpectomy incision
History of concurrent second cancers requiring active, ongoing systemic treatment.
Has low-grade or non-epithelial cancers, mucinous cancers, and/or borderline low-malignant potential cancers
Patients with other biliary tract cancers (extrahepatic or gallbladder cancers) with IDH or IDH mutations are allowed
No active second cancers
Subjects with simultaneous primary cancers outside of the oropharynx
Patients with BRAF WT cancers
Other malignancy within last  years other than certain limited skin, cervical, prostate, breast, or bladder cancers
Assessment of HER status in subjects with non-breast/non-gastric cancers may follow local institutional criteria. These criteria should be made available to the Sponsor.
Up to  patients with incurable Squamous cell cancers as follows:
Current history of neoplasm other than the entry diagnosis. Patients with previous cancers treated and cured with local therapy alone may be considered with approval of the Medical Monitor.
Prior diagnoses of any other type of cancer (excluding some skin cancers)
Other cancers diagnosed within the last  years (in situ and/or invasive cancers)
Show no current evidence of disease (NED) for solid-tumor cancers.
Previous diagnosis of grade  or , stage I or II endometrioid endometrial cancers (type I cancers) as confirmed during surgical intervention for treatment
Treatment for solid tumor cancers
History of multiple cancers
Prior cancers allowed if no evidence of disease
Diagnosis of pelvic malignancy (suspected/confirmed ovarian, endometrial/ uterine, cervical cancers, and vulvar cancers) undergoing surgical debulking
No active skin cancers; any skin cancers found on the screening visit after the subject has signed consent will need to be treated before the subject begins on the study drug at the baseline visit; the skin cancers found on the screening visit will not be included in the total number of skin cancers the subject had  years prior to signing the consent
History of concurrent second cancers requiring active, ongoing systemic treatment.
Patients currently on chemotherapy or with other primary cancers requiring systemic or hepatic loco-regional treatment
PATIENT: Patients with other primary cancers requiring systemic treatment
Fludeoxyglucose F  (FDG) avid cancers
Patients with other primary cancers requiring systemic treatment.
Patients with other primary cancers requiring systemic treatment
Patient with advanced skin cancers
No other active cancers
Patients with other primary cancers requiring systemic treatment
Diagnosed with advanced NSCLC, breast cancer, GBM or other cancers (such as head and neck, colorectal, pancreatic, renal cancers); patients will undergo anti-angiogenesis treatment or treatment with other drugs that may alter angiogenesis
Patients currently on chemotherapy or with other primary cancers requiring systemic treatment
Participants with second/other active cancers requiring current treatment