Patients should have no contraindications to having a contrast enhanced MRI scan; these contraindications will be assessed at the time of enrollment using the guidelines set up and in clinical use by the Institutional Standard Practice Increased intracranial pressure or other contraindications to internal or external jugular venous compression. Known contraindications to radiotherapy including but not limited to radiation sensitivity syndromes such as xeroderma pigmentosum and ataxia telangiectasia mutated Lack of contraindications to systemic immunotherapy (see list of exclusions below) Patients with anticipated contraindications to interval tumor reductive surgery Is ineligible for an operation based on medical or oncologic contraindications to surgery Any contraindications to MRI (eg, participants with pacemakers, claustrophobia, excessive weight, etc). Medical contraindications to thoracic irradiation No contraindications to the study medications or uncontrolled medical illness No contraindications for leukapheresis No contraindications for leukapheresis PHASE II: No contraindications to MRI Contraindications to MRI, including claustrophobia, metallic implants, and pacemakers Contraindications for transdermal nicotine patch therapy (TNP) Medical oncology examination to evaluate medical contraindications prior to start chemotherapy Any known contraindications to cyclophosphamide, fludarabine, etoposide, bendamustine, cetuximab or tocilizumab Any known contraindications to cyclophosphamide, fludarabine, etoposide, cetuximab or tocilizumab Have contraindications to receiving doxorubicin hydrochloride (HCl). No contraindications for leukapheresis Subjects who have contraindications to carboplatin, melphalan, etoposide phosphate, or sodium thiosulfate Subjects who have contraindications to carboplatin, cyclophosphamide, etoposide phosphate, or sodium thiosulfate No contraindications to protocol chemotherapy. Any contraindications for ipilimumab (Yervoy) or nivolumab (Opdivo) as per the package inserts. Contraindications to MRI such as non-MRI-compatible implanted devices mCRC currently not amenable to surgical intervention due to either medical contraindications or non-resectability of the tumor. Subjects who have contraindications to carboplatin, melphalan, or STS No contraindications to breast MRI Medical contraindications to esophagectomy Any contraindications to pegylated or non-pegylated interferon Any contraindications to pegylated interferon or hydroxyurea Patients undergoing breast conservation therapy (i.e. lumpectomy) must not have any contraindications to radiation therapy Contraindications to angiography and selective visceral catheterization such as bleeding diathesis or coagulopathy that is not correctable by usual therapy of hemostatic agents Allergy or contraindications to administration of the GI anti-spasmodic drug: Contraindications to angiography and selective visceral catheterization Contraindications for doxorubicin administration MRI contraindications. Contraindications to angiography and selective visceral arterial catheterization Patients undergoing breast conservation therapy (i.e. lumpectomy) must not have any contraindications to radiation therapy No contraindications for leukapheresis Contraindications to administration of bortezomib E . Contraindications to the use of corticosteroid treatment. Any contraindications to irradiation Contraindications for doxorubicin administration. Contraindications to angiography or selective visceral catheterization Any medical contraindications for chemotherapy Contraindications to the use of corticosteroid treatment. Patients with a malignancy that is currently not amenable to surgical intervention due to either medical contraindications or non-resectability of the tumor. Contraindications to steroid use Locally advanced basal cell carcinoma lesion that is considered to be inoperable or to have medical contraindications to surgery Patients with a malignancy that is currently not amenable to surgical intervention, due to either medical contraindications or non-resectability of the tumor. Contraindications to exercise Major contraindications to anamorelin e.g. hypersensitivity In the opinion of the surgeon, the subject has no medical contraindications to pancreatectomy In the opinion of the surgeon, the subject has medical contraindications to pancreatectomy Standard general contraindications to ERCP or PTBD (e.g. hemodynamic instability, uncorrected coagulopathy). Absolute contraindications by pulmonary function testing In the opinion of the surgeon, the subject has no medical contraindications to distal pancreatectomy In the opinion of the surgeon, the subject has medical contraindications to distal pancreatectomy No contraindications to undergo MRI Contraindications to MRI Patients should have no contraindications to having a contrast enhanced MRI scan; these contraindications will be assessed at the time of enrollment using the guidelines set up and in clinical use by the Radiology Department Medical contraindications to undergoing endoscopy or obstruction of the gastrointestinal (GI) tract that precludes passage of the endoscope Patients with contraindications to MRI will not be enrolled Medical contraindications to blood draw (e.g., hemophilia) Patients with contraindications to CEUS Patients with contraindications to both CT and MRI Has known contraindications to MRI Subjects with contraindications to MRI With contraindications to MRI examinations as per standard screening guidelines used in the Department of Radiology (i.e., ferromagnetic material or implants, pacemakers or defibrillators, stents, claustrophobia) Patients with standard contraindications to MRI, including claustrophobia and metallic implants incompatible with MRI Subjects with contraindications to the use of [F] FAZA including confirmed allergy. Patients with contraindications for MRI due to embedded foreign metallic objects. Bullets, shrapnel, metalwork fragments, or other metallic material adds unnecessary risk to the patient Contraindications for MRI or GBCA (standard of care) Subjects with contraindications for receiving HIDA scans and MRI scans will not be eligible to participate in this study No contraindications to getting contrast enhanced MRI examinations Patients with contraindications for MRI due to embedded foreign metallic objects; bullets, shrapnel, metalwork fragments, or other metallic material adds unnecessary risk to the patient Contraindications to undergo MRI Patient has no contraindications to the MRI Contraindications for MRI (e.g. cardiac pacemaker) Contraindications for MRS (e.g. history of abdomino-perineal resection of rectum) Patients with contraindications for MRI Medical contraindications to esophagectomy No obvious contraindications for primary chemotherapy Contraindications to TRUS prostrate biopsy Participant must not have any contraindications to MRI scanning Patient must not have any medical contraindications to MRI (e.g., unsafe foreign metallic implants, incompatible pacemaker, inability to lie still for long periods, severe to end-stage kidney disease or on hemodialysis) Contraindications for MRI Patients should have no contraindications to having a contrast enhanced MRI scan; these contraindications will be assessed at the time of enrollment using the guidelines set up and in clinical use by the Radiology Department Contraindications for MRI Subjects with contraindications to MRI Contraindications to fMRI, including severe claustrophobia, presence of tissue expanders for breast reconstruction, and presence of a port-a-cath that is incompatible with MRI Participants with standard contraindications to non-contrast MRI will be excluded, including claustrophobia and metallic implants incompatible with MRI Patients with contraindications to having a contrast enhanced MRI scan