Liver disease including history of viral hepatitis B or C, evidence of cirrhosis, chronic active or persistent hepatitis Liver disease such as cirrhosis, chronic active hepatitis or chronic persistent hepatitis Active or symptomatic viral hepatitis or chronic liver disease Active or symptomatic viral hepatitis or chronic liver disease Active or symptomatic viral hepatitis or chronic liver disease. Active liver disease such as cirrhosis, chronic active hepatitis or chronic persistent hepatitis Active or symptomatic viral hepatitis or chronic liver disease. Any known active chronic liver disease Any known active chronic liver disease Known active viral hepatitis, HIV or chronic liver disease. Active or symptomatic viral hepatitis or chronic liver disease Known active or symptomatic viral hepatitis or chronic liver disease Active or symptomatic viral hepatitis or chronic liver disease Active or symptomatic viral hepatitis or chronic liver disease No evidence of chronic active hepatitis or cirrhosis Evidence of acute or chronic active hepatitis or cirrhosis No evidence of chronic active hepatitis or cirrhosis Active symptomatic viral hepatitis or chronic liver disease Active liver disease such as cirrhosis, chronic active hepatitis or chronic persistent hepatitis Liver disease such as cirrhosis, chronic active hepatitis or chronic persistent hepatitis Patients with liver disease such as cirrhosis, chronic active hepatitis, or chronic persistent hepatitis History of liver disease, such as cirrhosis or chronic active hepatitis B and C Patient has known chronic liver disease, e.g. diagnosis of chronic active hepatitis or cirrhosis Active systemic hepatitis infection requiring treatment (carriers of hepatitis virus are permitted to enter the study), of any type or known acute or chronic liver disease including cirrhosis Patients must not have liver disease such a cirrhosis, chronic active hepatitis or chronic persistent hepatitis known active or symptomatic viral hepatitis, chronic liver disease or liver cirrhosis; Any chronic or concurrent acute liver disease, including viral hepatitis Patients with liver disease such as cirrhosis, chronic active hepatitis, or chronic persistent hepatitis, or patients with defined elevated ALT/ AST/ Bilirubin. Liver disease such as cirrhosis, chronic active hepatitis or chronic persistent hepatitis Active or symptomatic viral hepatitis or chronic liver disease Known active liver disease (cirrhosis, chronic viral hepatitis, autoimmune liver disease or other known clinically significant active liver disease) Active or symptomatic viral hepatitis or chronic liver disease Active or symptomatic viral hepatitis or chronic liver disease Active or severe liver disease (acute or chronic hepatitis, cirrhosis) Active chronic liver disease No evidence of chronic active hepatitis or cirrhosis Active liver disease such as cirrhosis, chronic active hepatitis or chronic persistent hepatitis Any severe and/or uncontrolled medical conditions or other conditions that, in the treating physicians opinion, could adversely impact their ability to participate in the study; NOTE: patients on chronic oxygen therapy, those with liver disease such as cirrhosis, chronic hepatitis or chronic persistent hepatitis, or uncontrolled infections will be excluded Liver disease such as chronic cirrhosis, active hepatitis or chronic persistent hepatitis EXPANSION COHORT ONLY: Liver disease such as chronic cirrhosis, active hepatitis or chronic persistent hepatitis Active or chronic hepatitis B or hepatitis C as demonstrated by hepatitis B surface antigen positivity and/or anti- hepatitis C virus positivity, respectively. Patients with clinically active or chronic liver disease, including liver cirrhosis of Child-Pugh class C, are also excluded. Patient with known chronic liver disease (i.e., chronic active hepatitis, and cirrhosis) Serious concurrent medical conditions including: serious heart disease, heart conduction abnormalities, persistent infection, uncontrolled psychiatric illness, liver cirrhosis, chronic liver disease, active or symptomatic viral hepatitis, any other condition that may place the subject at an increased risk or confound the results of the study. Active or symptomatic viral hepatitis or chronic liver disease Active or symptomatic viral hepatitis or chronic liver disease Active or symptomatic viral hepatitis or chronic liver disease, including Child-Pugh class B and C liver disease Active or symptomatic viral hepatitis or chronic liver disease Cirrhosis or chronic active/persistent hepatitis Active or symptomatic viral hepatitis or chronic liver disease History of liver disease, such as cirrhosis or chronic active hepatitis B and C No liver disease such as cirrhosis, chronic active hepatitis or chronic persistent hepatitis. Evidence of acute or chronic active hepatitis or cirrhosis Liver disease such as cirrhosis, chronic active hepatitis or chronic persistent hepatitis Chronic active hepatitis or cirrhosis No evidence of chronic active hepatitis or cirrhosis Active or symptomatic viral hepatitis or chronic liver disease Active or symptomatic viral hepatitis or chronic liver disease Known chronic active hepatitis or cirrhosis