Serum creatinine below the upper limit of the institutional normal range (ULN) or creatinine clearance ? mL/min/. m for patients with serum creatinine levels above institutional ULN. Creatinine < . x institutional upper limit of normal or creatinine clearance >= mL/min/. m^ for subjects with creatinine levels above institutional normal Creatinine =< institutional upper limit or creatinine clearance >= mL/min/. m^ for subjects with creatinine levels above institutional normal Creatinine =< . x institutional upper limit of normal OR creatinine clearance >= mL/min/. m^ for participants with creatinine levels above . x upper limit of normal Creatinine =< institutional upper limit of normal OR creatinine clearance >= ml/min/.m^ for patients with creatinine levels above institutional normal INCLUSION CRITERIA FOR SECOND-LINE THERAPY: Serum creatinine =< . X upper normal limit of institution's normal range OR creatinine clearance >= mL/min/. m^ for subjects with creatinine levels above institutional normal INCLUSION CRITERIA FOR THIRD-LINE THERAPY: Serum creatinine =< . X upper normal limit of institution's normal range OR creatinine clearance >= mL/min/. m^ for subjects with creatinine levels above institutional normal Creatinine =< . x the upper limit of normal or creatinine clearance >= mL/min/. m^ for patients with creatinine levels > . x the upper limit of normal Creatinine =< . x institutional upper limit of normal OR creatinine clearance >= mL/min/. m^ for participants with creatinine levels above institutional normal Creatinine =< . times the normal upper institutional limit OR creatinine clearance >= mL/min/. m^ in participants with creatinine levels > . times the normal upper institutional limit Creatinine within upper normal institutional limit OR creatinine clearance >= mL/min/. m^ for participants with creatinine levels above institutional normal Within weeks prior to initiation of study treatment: Creatinine =< upper limit of institutional normal OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine =< institutional upper limit of normal OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal COHORT I: Creatinine < x upper limit of normal (ULN) or creatinine clearance >= mL/min/. m^ for subjects with creatinine levels above institutional normal Creatinine =< . x institutional upper limit of normal OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above . x institutional normal Creatinine =< . x upper limit of normal (ULN) OR creatinine clearance >= mL/min for subject with creatinine levels > . x institutional ULN (obtained =< days prior to registration) Creatinine < x institution upper limit of normal OR creatinine clearance > mL/min/. m^, for patients with creatinine levels above institutional normal Creatinine =< . X institutional upper limit of normal OR measured creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Serum creatinine < x institutional upper limit of normal OR creatinine clearance >= mL/min/for patients with creatinine levels above institutional normal Creatinine =< . x institutional upper limit of normal OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine =< . x upper limit of normal (ULN) OR creatinine clearance > mL/min/. m for patients with creatinine levels =< . x upper limit above institutional normal Creatinine < institutional upper limit of normal (ULN) OR creatinine clearance >= mL/min for patients with creatinine levels greater than ULN Creatinine =< institutional upper limit of normal OR creatinine clearance >= ml/min/. m^ for patients with creatinine levels above institutional normal Creatinine =< upper limit of normal (ULN) OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above normal within days of treatment initiation Obtained =< days prior to registration: Creatinine =< . X upper limit of normal (ULN)\r\n* NOTE: measured or calculated (per institutional standard) creatinine clearance is acceptable >= mL/min for subject with creatinine levels > . X institutional ULN Obtained with days of registration: creatinine =< x institutional upper limit of normal OR creatinine clearance > mL/min for patients with creatinine levels greater than institutional upper limit of normal Serum creatinine =< . x upper limit of normal (ULN) or >= mL/minute for subjects with creatinine levels > . x the institutional ULN Creatinine < . X institution upper limit of normal OR creatinine clearance >= mL/min/. m^, for patients with creatinine levels above institutional normal Creatinine =< . x institutional upper limit of normal OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels >= . x upper limit of normal (after the HDT/ASCT) Creatinine < . X institution upper limit of normal OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Serum creatinine below institutional upper limit of normal or creatinine clearance >= mL/min/. m^ for patients with serum creatinine levels above institutional ULN OR creatinine clearance >= mL/min for patients with creatinine levels above . X institutional upper limit of normal Serum creatinine =< . x upper normal limit of institution's normal range or creatinine clearance >= mL/min/. m^ for subjects with creatinine levels above institutional normal Creatinine < . x institution upper limit of normal OR creatinine clearance >= mL/min/. m^, for patients with creatinine levels above institutional normal Creatinine =< institutional upper limit of normal OR creatinine clearance > mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine =< the institutional upper limit of normal (ULN) OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine =< institutional upper limit of normal OR creatinine clearance >= mL/min/. m^ for patients with creatinine above institutional upper limit of normal (IULN) obtained no more than days prior to the start of neoadjuvant endocrine therapy Creatinine =< . x institutional upper limit of normal OR creatinine clearance >= mL/min for patients with creatinine levels above institutional normal Creatinine < . x institutional upper limit of normal (ULN), OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels greater than . x ULN Serum creatinine =< . x upper limit of normal or creatinine clearance >= ml/min for patients with creatinine levels above institutional normal Creatinine =< . x institutional upper limit of normal or creatinine clearance >= mL/min/. m^ Creatinine =< institutional upper limit of normal OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal (within weeks prior to radiotherapy) Serum creatinine =< . upper normal limit of institution's normal range OR creatinine clearance >= mL/min/. m^ for subjects with creatinine levels above institutional normal Within weeks of preregistration: Creatinine =< institutional upper limit of normal (ULN) OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine > x normal Creatinine level within normal institutional limit, or creatinine clearance >= mL/min/. m^ for patients with creatinine level above institutional normal Creatinine < . x institutional upper limit of normal (ULN) OR creatinine clearance (CrCl) >= mL/min/. m^ for subjects with creatinine levels greater than . x ULN Creatinine or measured/calculated creatinine clearance (as calculated by institutional standard) =< . X institutional upper limit of normal (ULN) OR >= mL/min for subjects with creatinine levels > . x institutional ULN Creatinine levels =< upper limit of institutional normal; or creatinine clearance >= mL/min/. m^ for participants with creatinine levels above institutional normal Creatinine =< the institutional upper limit of normal OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine =< . x institutional upper limit of normal OR creatinine clearance >= mL/min/. m^ for subjects with creatinine levels above institutional normal TUMOR BIOPSY SEQUENCING: Creatinine < . x institutional upper limit of normal OR creatinine clearance >= mL/min for patients with creatinine levels >= . x institutional upper limit of normal TREATMENT: Creatinine < . x institutional upper limit of normal OR creatinine clearance >= mL/min for patients with creatinine levels >= . x institutional upper limit of normal Creatinine =< . x institutional upper limit of normal OR creatinine clearance >= mL/min/. m^ for participants with creatinine levels above institutional normal Creatinine < . x institutional upper limit of normal OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine =< institutional upper limit of normal OR creatinine clearance >= ml/min/. m^ for patients with creatinine levels above institutional normal Serum creatinine =< . upper normal limit of institution's normal range OR creatinine clearance >= mL/min/. m^ for subjects with creatinine levels above institutional normal Creatinine clearance >= mL/min/. m^ for patients with creatinine levels above . X institutional upper limit of normal Creatinine < . x institutional upper limit of normal OR creatinine clearance > ml/min OR > mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine =< . x institutional upper limit of normal OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine =< . institutional upper limit of normal OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above . x institutional limit of normal Creatinine ? . ULN or, for patients with creatinine levels above institutional upper limit of normal, creatinine clearance must be > mL/min/. m^. Creatinine clearance >= mL/min for subject with creatinine levels > . X institutional upper limit of normal (ULN) Creatinine ? . ULN or, for patients with creatinine levels above institutional upper limit of normal, creatinine clearance must be > mL/min/. m^. Creatinine =< . x institutional upper limit of normal OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine =< . x University of Iowa Hospitals and Clinics (UIHC) upper limit of normal or creatinine clearance of at least ml/min/. m^ for patients with creatinine levels above institutional normal Creatinine less than or equal to the institutional upper limit of normal or creatinine clearance >= mL/min/. m^ for participants with creatinine levels above institutional normal Creatinine below institutional upper limit of normal OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine =< institutional upper limit of normal or creatinine clearance >= mL/min/. m^ for subjects with creatinine levels above institutional normal Creatinine < . X institutional upper limit of normal OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine < . X institutional upper limit of normal OR calculated creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine < . X institutional upper limit of normal OR creatinine clearance >= mL/min for patients with creatinine levels above . X institutional upper limit of normal Creatinine within . x upper limit of normal, OR creatinine clearance > mL/min for patients with creatinine levels above institutional normal Creatinine < . x institution upper limit of normal OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Serum creatinine =< upper limit of normal (ULN) or creatinine clearance (either estimated or calculated) >= mL/min/. m for patients with creatinine levels above institutional normal Serum creatinine =< the institutional upper limit of normal or creatinine clearance >= mL/min/. m^ for participants with creatinine levels above institutional normal Creatinine < . x institutional upper limit of normal or creatinine clearance >= mL/min/. m^ Creatinine =< . x upper limit of normal OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels > . x upper limit of normal Serum creatinine levels =< . x upper limit of normal (ULN) OR creatinine clearance >= mL/min/. m^ for subjects with creatinine levels above institutional normal Creatinine less than the institutional upper limit of normal or creatinine clearance >= mL/min/. m^ for subjects with creatinine levels above institutional normal Serum creatinine =< . upper normal limit of institution's normal range OR creatinine clearance >= mL/min/. m^ for subjects with creatinine levels above institutional normal Creatinine less than institutional upper limit of normal or creatinine clearance >= mL/min/. m^ for subjects with creatinine levels above the institutional normal Creatinine < . x upper limit of normal OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels >= . x upper limit of normal Serum creatinine clearance =< . x ULN or >= mL/minute for subjects with creatinine levels > . x the institutional upper limit of normal (ULN) Creatinine =< the institutional upper limit of normal or creatinine clearance >= mL/min/. m^ for subjects with creatinine levels above institutional normal Creatinine clearance >= mL/min for patients with creatinine levels above . x institutional upper limit of normal Creatinine < . x upper limit of normal OR measured creatinine clearance > mL/min/. m^ for patients with creatinine levels > . x upper limit of normal Serum creatinine =< . x upper normal limit of institution's normal range OR creatinine clearance >= mL/min/. m^ for subjects with creatinine levels above institutional normal Creatinine =< . x institutional upper limit of normal OR creatinine clearance > mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine =< . x institutional upper limit of normal OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within . x upper limit of normal OR creatinine clearance > mL/min for patients with creatinine levels above institutional normal Creatinine =< institutional upper limit of normal OR creatinine clearance >= ml/min/. m^ for patients with creatinine levels above institutional normal Creatinine =< institutional upper limit of normal OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Serum creatinine =< . X upper normal limit of institution's normal range OR creatinine clearance >= mL/min/. m^ for subjects with creatinine levels above institutional normal Creatinine < institutional upper limit of normal (ULN) OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels greater than ULN Creatinine =< . x institutional upper limit of normal OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Serum creatinine =< . x upper limit of normal or creatinine clearance >= ml/min for patients with creatinine levels above institutional normal Creatinine < . X institution upper limit of normal OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine less than the institutional upper limit of normal OR creatinine clearance >= mL/min/. m^ Creatinine < . x institutional upper limit or normal OR creatinine clearance >= mL/min for patients with creatinine levels above . x institutional upper limit of normal Creatinine =< institution upper limit of normal OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine =< . x institutional upper limit of normal OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine =< institutional upper limit of normal OR creatinine clearance >= ml/min/. m^ for patients with creatinine levels above institutional normal Serum creatinine =< institutional upper limit of normal or creatinine clearance (either estimated or calculated) >= mL/min/. m for patients with creatinine levels above institutional normal Creatinine below . X upper limit of normal or creatinine clearance >= mL/min/. m^ for subjects with creatinine levels about institutional normal Creatinine =< institutional upper limit of normal OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine < . X institutional upper limit of normal OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine < . X institutional upper limit of normal OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within . x institutional upper limit of normal OR creatinine clearance >= mL/min/. m^ for patients with creatinine level above institutional normal Creatinine =< . X institutional upper limit of normal or creatinine clearance less than ml/min Creatinine < . x upper limit of normal (ULN) or creatinine clearance >= mL/min/. m^ for subjects with creatinine levels above institutional normal Creatinine =< institutional upper limit of normal OR creatinine clearance >= mL/min/. m^ for participants with creatinine levels above institutional normal Creatinine =< institutional upper limit of normal OR creatinine clearance >= ml/min/. m^ for patients with creatinine levels above institutional normal Creatinine clearance >= mL/min for subject with creatinine levels > . x institutional upper limit of normal (ULN) Creatinine =< . times institutional upper limit of normal or creatinine clearance >= mL/min/. m^ Creatinine below upper limit of normal OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within . x upper limit of normal (ULN) OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine =< . X institutional upper limit of normal or creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal