Pre-existing condition that warrants long-term corticosteroid use; physiologic replacement is not permitted Have a pre-existing condition that warrants long-term corticosteroid use; inhaled steroids are allowed Have a pre-existing condition that warrants long-term corticosteroid use in excess of study dose Have a pre-existing condition that warrants long-term corticosteroid use in excess of study dose Pre-existing condition that warrants long-term corticosteroid use in excess of study dose Patients with a pre-existing condition that warrants long-term corticosteroid use in excess of study dose Pre-existing condition that warrants long-term corticosteroid use greater than the equivalent of mg prednisone daily; physiologic replacement is permitted; topical, intra-articular steroids or inhaled corticosteroids are permitted