Autologous blood transfusion within last days or plan to donate autologous blood prior to surgery Appropriate antibiotics, blood products, anti-emetics, fluids, electrolytes and general supportive care are to be used as necessary Acceptable blood work Agreement not to donate blood or blood products during the study and for months after discontinuation of vismodegib Refusal to potentially receive blood products and/or have a hypersensitivity to blood products Abnormal blood results Study subjects with known chronic infection with HIV, hepatitis B or C, since these infections may interfere with the evaluation of vaccine-induced immune responses. Infectious disease testing will be performed whenever a study subject exhibits clinical signs of infection or to confirm a history of infection. Testing will also be performed for all study subjects undergoing leukapheresis, as required by the blood bank for autologous blood products (standard donor transmissible disease testing) Patients who have eligible blood counts within weeks from enrollment will not be considered ineligible if subsequent blood counts prior to enrollment fluctuate and become ineligible up until the time of enrollment Difficulty providing blood samples. Patients who are receiving licensed cord blood products (only) Patients who are receiving unlicensed cord blood products from other banks (only) Patients who are receiving cord blood products that will be \manipulated\ post-thaw (e.g., ex vivo expansion, incubation in vitro, etc.) To be performed within days prior to day of protocol therapy: platelets >= ,/mm^\r\n* NOTE: transfusion of blood products are not allowed to normalize baseline blood parameters, however subsequent transfusions are allowed per standard supportive care guidelines To be performed within days prior to day of protocol therapy: hemoglobin (HgB) >= . g/dL\r\n* NOTE: transfusion of blood products are not allowed to normalize baseline blood parameters, however subsequent transfusions are allowed per standard supportive care guidelines Patients who refuse to potentially receive blood products and/or have a hypersensitivity to blood products Blood counts are not required to be normal prior to enrollment on trial Received blood products within days to first dosing Patients with known sensitivities to albumin, blood, or blood products Blood transfusion (including blood products) within week of screening. Patients who decline possible transfusion of blood products will be excluded Patients must be willing to receive transfusions of blood products Agreement not to donate blood or blood products during the study and for months after discontinuation of vismodegib ELIGIBILITY CRITERIA AT THE TIME OF APHERESIS: Patients must NOT have an active severe infection defined as:\r\n* A positive blood culture within hours of blood draw OR\r\n* A fever above . C AND clinical signs of infection within hours of blood draw Relapsed/refractory MCL: Patients must be willing to receive transfusions of blood products Newly diagnosed MCL: Patients must be willing to receive transfusions of blood products Blood counts no restrictions Appropriate antibiotics, blood products, antiemetics, fluids, electrolytes and general supportive care are to be used as necessary DONOR: Has not donated blood products to recipient Patients who have eligible blood counts within weeks from enrollment will not be considered ineligible if subsequent blood counts prior to enrollment fluctuate and become ineligible up until the time of enrollment Donation of blood or blood products in excess of mL within days of screening Has received transfusion of blood products (including platelets or red blood cells) or administration of colony stimulating factors within weeks prior to study Day . Agreement to provide blood samples for pharmacodynamic studies utilizing Peripheral Blood Mononuclear Cells (PMBCs) as outlined in the protocol Difficulty providing blood samples. A recognized single pathogen cultured from or more blood cultures; OR Unwillingness to receive infusion of blood products. DONOR: Donor must meet all Robert Wood Johnson (RWJ) Blood Services requirements for hematopoietic stem cell donation including:\r\n* Age >= years old;\r\n* Normal hemogram (white blood cells [WBC] .-. x ^/mm^; platelet count , to ,/mm^ ; hemoglobin/hematocrit; .- g/dl, to % \r\n* Not pregnant or lactating;\r\n* Not human immunodeficiency virus (HIV)-, HIV-, hepatitis C virus (HCV), hepatitis B core or human T-cell lymphotropic virus (HTLV)-I/II seropositive; hepatitis B surface antigen (HB S ag) (-); meet other infectious disease screening criteria utilized by RWJ Blood Services;\r\n* No uncontrolled infections, other medical or psychological/social conditions, or medications that might increase the likelihood of patient or donor adverse effects or poor outcomes;\r\n* Meet other blood bank criteria for blood product donation (as determined by RWJ Blood Center screening history and laboratory studies) Patients must be willing to receive transfusions of blood products. Unwillingness to receive infusion of blood products according to the protocol. Subjects who have received any anticancer therapy (including surgery, percutaneous ethanol injection, radio frequency ablation, transarterial [chemo] embolization, hepatic intra-arterial chemotherapy, biological, immunotherapy, hormonal, or radiotherapy) or any blood enhancing treatment (including blood transfusion, blood products, or agents that stimulate blood cell production, eg, granulocyte colony-stimulating factor [G-CSF]) within days prior to randomization Subject is unwilling to allow transfusion of blood or blood products. Has not donated blood products to patient Within hour (h) of initiating study treatment: Hemoglobin (Hgb) >= . g/dL; Note: transfusions of blood and blood products as well as growth factor support are prohibited within days prior to the first dose of study treatment Within h of initiating study treatment: Platelets >= ,/mm^; Note: transfusions of blood and blood products as well as growth factor support are prohibited within days prior to the first dose of study treatment Consent to potential need for transfusion of blood products Patients must be willing to receive transfusions of blood products Anticipated blood donation within the next days Transfusion of blood products are not allowed to normalize blood parameters within weeks of the first radium treatment Have a cancer of the blood Patients must be willing to receive transfusions of blood products Absence of gross blood in stool; red blood on toilet paper only acceptable. All patients should agree not to donate blood products for months after stopping sonidegib Hematopoietic growth factors, transfusions of blood or blood products within week Positive blood culture within hours of study enrollment. Hematopoietic growth factors, transfusions of blood or blood products within week DONOR: meet other blood bank criteria for blood product donation (as determined by NBAH Blood Center screening history and laboratory studies) Abnormal blood test results Patients must be willing to receive transfusions of blood products Agreement not to donate blood or blood products during the study and for months after discontinuation of vismodegib Acceptable blood test results. History of anaphylactic reaction(s) to blood or blood components. Refusal to receive allogenic transfusion of blood-derived products. Participants who refuse to potentially receive blood products and/or have a hypersensitivity to blood products Adequate availability of sickle trait negative, leukoreduced, Blood type (ABO) blood group, Rhesus factor D (Rh (D)) compatible, unexpired replacement RBC products. History of expectoration of blood within month prior to study start or blood clotting problems. Participants who refuse to potentially receive blood products and/or have a hypersensitivity to blood products History of severe (e.g. anaphylactic) reactions to blood or to any blood-derived product. DONOR: Has not donated blood products to patient Patients must be willing to receive transfusions of blood products Research blood including mL of blood in a heparinized tube for peripheral blood mononuclear cell (PBMC) collection and mL of blood for serum collection (generally in a red top tube) within days of leukapheresis collection Previous treatment with pathogen-reduced blood products History of blood clot; Must be capable of undergoing a single standard blood volume leukapheresis or donation of one unit of whole blood DONOR: has not donated blood products to patient Women with blood pressures above / or below / Estimated blood loss (EBL) > liter Difficulty providing blood samples. Patients with hemoglobin levels more than or equal to g/dl would be eligible for the study even if they are currently receiving blood products Transfusion of blood products or intravenous immune globulin within months of study entry Negative fecal occult blood test Must be willing to have about ml of blood drawn at , and months and about - ml of blood at and months Eligible for donations of human blood and blood components according to local requirements and regulations Must be willing to have about ml of blood (approximately teaspoons) drawn at and months and about - ml of blood (approximately - teaspoons) at and months Agreement not to donate blood or blood products during the study and for months after the last dose Patients with known sensitivities to albumin, blood, or blood products Peripheral Blood Samples: Abnormal blood results Patient agrees to the collection and testing of their blood and is willing and able\n to provide approximately mL blood draw(s) at: