No use of medications, herbals, or foods that are known potent cytochrome P, subfamily A, polypeptide  (CYPA) inhibitors or inducers, included but not limited to those outlined
Patients must not have taken within  days prior to registration, be taking, nor plan to take while on protocol treatment, strong cytochrome P, family , subfamily A, polypeptide  (CYPA) inhibitors and/or CYPA inducers
Participants are to discontinue the use of the following classes of inhibitors of cytochrome P, family , subfamily A, polypeptide  (CYPA); patients who are on these drugs are eligible if a washout period of a minimum of  days occurs before start of olaparib and temozolomide:\r\n* Azole antifungals\r\n* Macrolide antibiotics\r\n* Protease inhibitors
Patients who have taken medications that are known strong inducers or inhibitors of cytochrome P, family , subfamily A, polypeptide  (CYPA) within  days prior to registration are NOT eligible for participation
Of the five major cytochrome P (CYP) isoforms, A (BFC) may be involved in Phase I metabolism of PLX, with possibly cytochrome P, family , subfamily A, polypeptide  (CYPA) playing a minor role; until information regarding exposure toxicity and exposure-response relationships are available with PLX, concomitant strong cytochrome P, family , subfamily A, polypeptide  (CYPA) inhibitors and inducers are not permitted in the event they alter the systemic exposure to PLX; these include anticonvulsants, mycin antimicrobials, and antiretrovirals; some common examples include inhibitors such as erythromycin, fluoxetine, gemfibrozil, and inducers such as rifampicin, carbamazepine, phenytoin, efavirenz, and nevirapine; concomitant treatment is permitted if the medication is not expected to interfere with the evaluation of safety or efficacy of the study drug; during the study, if the use of any concomitant treatment becomes necessary (e.g., for treatment of an adverse event), the treatment must be recorded on the electronic case report form (eCRF), including the reason for treatment, generic name of the drug, dosage, route, and start and stop dates of administration; sirolimus undergoes extensive hepatic and intestinal metabolism via CYPA and cytochrome P, family , subfamily A, polypeptide  (CYPA), as well as excretion by permeability (P)-glycoprotein; strong CYPA inhibitors such as ketoconazole or grapefruit juice are not permitted; patients should be monitored for supratherapeutic toxic levels of sirolimus and PLX; as bone marrow suppression including anemia, neutropenia, and thrombocytopenia have been reported in patients receiving sirolimus monotherapy, these adverse effects may be exacerbated in combination with PLX for which patients will be closely monitored
Concurrent or planned treatment with strong inhibitors or strong inducers of cytochrome P family , subfamily A, polypeptide / (A/); (a one-week wash-out period is necessary for patients who are already on these treatments)
Concomitant use of cytochrome P, family , subfamily A, polypeptide  (CYPA) inhibitors or inducers unless able to stop medication(s) prior to starting study treatment
EXCLUSION CRITERIA FOR REGISTRATION: Currently taking medications and herbal or dietary supplements that are strong cytochrome P (CYP) family , subfamily A, polypeptide  (A) inducers or inhibitors; a washout period of at least  days is required and must have been completed prior to the start of neratinib if the patient was taking any of these agents; if unavoidable, patients taking CYPA inhibitors should be monitored closely
Is chronically taking a strong cytochrome P, family , subfamily A, polypeptide  (CYPA) inhibitor or inducer and cannot be switched to an alternative agent at least  days prior to idelalisib or ibrutinib initiation that in the opinion of investigator/treating physicians precludes utilization of either Ibrutinib or Idelalisib; caution is recommended for patients taking moderate inhibitors of CYPA
Patients who are taking medications that are strong inhibitors of cytochrome P, family , subfamily A, polypeptide  (CYPA) or phosphoglycolate phosphatase (PgP) and need to remain on these medications
As ibrutinib is extensively metabolized by cytochrome P, family , subfamily A, polypeptide / (CYPA/), and patients must not require continued therapy with a strong inhibitor or inducer of CYPA/
Patients who are receiving drugs that are strong inducers or inhibitors of cytochrome P, family , subfamily A, polypeptide  (CYPA)
Concomitant use of cytochrome P, family , subfamily A, polypeptide  (CYPA) inhibitors or inducers unless able to stop medication(s) prior to starting study therapies
Current use or anticipated need for food or drugs that are known moderate/strong cytochrome P, family , subfamily A, polypeptide  (CYPA) inducers, with the exception of azole antifungals, which are permitted
Concomitant use of cytochrome P, family , subfamily A, polypeptide  (CYPA) inducers are not permitted
Patients who are currently receiving treatment with agents that are known strong inducers or inhibitors of cytochrome P family , subfamily A, polypeptide  (CYPA) are prohibited
Concomitant use of cytochrome P, family , subfamily A, polypeptide  (CYPA) inhibitors
Patients who would be required to concurrently take ruxolitinib in conjunction with a strong cytochrome p, family , subfamily A, polypeptide  (CYPA) inhibitors and have a platelet count less than , are ineligible for the study
Nonclinical studies indicate that DS-b is metabolized by cytochrome P, family , subfamily A, polypeptide  (CYPA)/; drugs that are strong inhibitors or inducers of these enzymes may alter the PK of DS-b and should therefore be avoided; St. Johns wort (hypericin) will not be permitted for  days before and during participation in the study; foods or beverages containing grapefruit should not be taken within  hours before initial dose of study drug and throughout the duration of the study
PHASE I: Concomitant use of known potent cytochrome P, family , subfamily A, polypeptide  (CYPA) inhibitors
Need for concurrent treatment with medications that strongly interact with everolimus (cytochrome P family  subfamily A member  [CYPA] inducers or inhibitors)
Concomitant use of cytochrome P, family , subfamily A, polypeptide  (CYPA) inhibitors where the interaction is thought too great to proceed with romidepsin
Any concomitant potent inducers of cytochrome P, family , subfamily A, polypeptide  (CYPA)
Subject takes cytochrome P, family , subfamily A (CYPA) inhibitors/inducers within  days prior to the study drug administration
Patients requiring strong cytochrome P, family , subfamily A, polypeptide  (CYPA) inhibitors
Inducers and Inhibitors of cytochrome P family , subfamily A, polypeptide  (CYPA): patients required to be on any CYPA/ inhibitors or inducers will be excluded (with the exception of dexamethasone, but all efforts should be made to reduce the dose of dexamethasone); patients must discontinue drug at least  days prior to starting dasatinib
Planned ongoing administration of STRONG cytochrome P, family , subfamily A, polypeptide  (CYPA) inducers
Concomitant use of strong cytochrome P, family , subfamily A, polypeptide  (CYPA) inducers
Patients taking medications or herbal supplements that are known to be strong cytochrome P, family , subfamily A, polypeptide  (CYPA) inhibitors within at least  days prior to registration are excluded
Use of a strong cytochrome P, family , subfamily A, polypeptide  (CYPA) inhibitor less than  days prior to initiation of study treatment
Patients who are receiving treatment with medications known to be strong inhibitors or inducers of cytochrome P, family , subfamily A, polypeptide  (CYPA)/ or drugs metabolized by cytochrome P, family , subfamily B, polypeptide  (CYPB) or cytochrome P, family , subfamily C, polypeptide  (CYPC) that have narrow therapeutic index, and that cannot be discontinued before starting study treatment with sonidegib\r\n* Note: if patients can stop receiving these medications, strong CYPA/ inhibitors should be discontinued at least  days prior to starting study treatment with sonidegib and strong CYPA/ inducers should be discontinued at least  weeks prior to starting study treatment with sonidegib
Exclude persons who require ongoing administration of STRONG cytochrome P, family , subfamily A, polypeptide  (CYPA) inhibitors and/or STRONG CYPA inducers and/or STRONG cytochrome P, family , subfamily C, polypeptide  (CYPC) inhibitors
Unable to discontinue use of potent cytochrome P, family , subfamily A, polypeptide  (CYPA) inhibitors/inducers
Patients that are taking cytochrome P family , subfamily A, polypeptide  (CYPA) inducers and/or inhibitors; if a patient has a history of taking CYPA inducers and/or inhibitors prior to enrollment on the protocol, it is strongly recommended that the patient stops the drug and waits at least  half-lives of said drug before initiating therapy on protocol
Use of St. Johns wort, orrifampin (rifampicin), or other strong cytochrome P, family , subfamily A, polypeptide  (CYPA) inducers; dexamethasone is okay as long as the dose is  mg /day or less\r\n* Note: patients who are on the above referenced medications may be considered eligible with a washout period of  days; contact the coordinating center to discuss patients with the above aforementioned agents before patient registration
Taking any medications or herbal supplements that are known to be strong inhibitors of cytochrome P, family , subfamily A, polypeptide  (CYPA) within at least  days before the first dose of ponatinib
VX- is primarily metabolized by cytochrome P, family , subfamily A, polypeptide  (CYPA); therefore, concomitant administration with strong inhibitors or inducers of CYPA should be avoided
Current use of a prohibited medication; patients receiving any medications or substances that are strong inhibitors or inducers of cytochrome P, family , subfamily A (CYPA) or cytochrome P, family , subfamily C, polypeptide  (CYPC) are ineligible; current use of, or intended ongoing treatment with: herbal remedies (e.g., St. Johns wort), or strong inhibitors or inducers of P-glycoprotein (Pgp) or breast cancer resistance protein  (Bcrp) should also be excluded
Requiring potent cytochrome P family , subfamily A, polypeptide  (CYPA) inducers or inhibitors
Patients on cytochrome P, family , subfamily A, polypeptide  (CYPA) inhibitors or inducers
Subjects taking strong cytochrome P, family , subfamily A, polypeptide  (CYPA) and cytochrome P, family , subfamily C, polypeptide  (CYPC) inhibitors and/or inducers should be considered with caution; alternative treatments that are less likely to affect MLN metabolism, if available, should be considered; if a subject requires treatment with  or more of the strong CYPA and CYPC inhibitors and/or inducers, the principal investigator should be consulted
Patients who are on concomitant medications that are STRONG inducers or inhibitors of the cytochrome P family , subfamily A, polypeptide  (CYPA) enzyme should stop  weeks prior to first dose of dasatinib, if all other eligibility has been confirmed
Current use of a prohibited medication; patients receiving any medications or substances that are strong inhibitors or inducers of cytochrome P, family , subfamily A (CYPA) or cytochrome P, family , subfamily C, polypeptide  (CYPC) are ineligible; current use of, or intended ongoing treatment with: herbal remedies (e.g., St. Johns wort), or strong inhibitors or inducers of P-glycoprotein (Pgp) or breast cancer resistance protein  (Bcrp) should also be excluded
Patients who are taking concomitant medications that in the investigators opinion are strong inducers of the cytochrome P, family , subfamily A, polypeptide  (CYPA) enzymes and therefore likely to interact with the study agents, will not be eligible
Patient currently receiving any drugs considered to be strong cytochrome P, family , subfamily A, polypeptide  (CYPA) inducers or inhibitors which cannot be discontinued or changed to an alternative drug prior to enrolling on the trial
Patients on potent cytochrome P, family , subfamily A, polypeptide  (CYPA) inducers and inhibitors
Co-administration with strong inhibitors of cytochrome P, family , sub family A, polypeptide  (CYPA) (e.g., ketoconazole, itraconazole, ritonavir) or P-glycoprotein (PgP)
Subjects who require therapy with a strong cytochrome P, family , subfamily A, polypeptide  (CYPA) inhibitor prior to enrollment to this study
Concomitant administration with strong inhibitors or inducers of cytochrome P, family , subfamily A, polypeptide  (CYPA) should be avoided; because the lists of these agents are constantly changing, it is important to regularly consult a frequently-updated medical reference for a list of drugs to avoid or minimize use of; ongoing phenytoin should be either discontinued if clinically safe or transitioned to non-enzyme-inducing antiepileptics like levetiracetam with a -day washout period (half-life - hours, time to steady-state - days) prior to first dose of VX- (-days prior to WBRT)
Potent cytochrome P family , subfamily A, polypeptide  (CYPA) inhibitors, such as ketoconazole and erythromycin, should be avoided during the study treatment period with T-DM
Use of a strong cytochrome P, family , subfamily A, polypeptide  (CYPA) inhibitor less than  days prior to initiation of study treatment
Chronic concomitant treatment of strong cytochrome P family , subfamily A, polypeptide  (CYPA) inducers or CYPA inhibitors
Concomitant use with strong or moderate cytochrome P, family , subfamily A, polypeptide  (CYPA)/P-glycoprotein (PgP) inhibitors and CYPA/PgP inducers
SUB-PROTOCOL AIM A: Receiving any concomitant antitumor therapy or inhibitors of cytochrome P, family , subfamily A, polypeptide  (CYPA)
Requirement for chronic use of medications known to be strong inhibitors or inducers of cytochrome P, family , subfamily A, polypeptide  (CYPA) iso-enzymes; Note: if patients can stop receiving these medications, CYPA inhibitors should be discontinued at least  days prior to starting treatment with G-
Concurrent use of drugs that are known to be moderate or strong cytochrome P, family , subfamily A (CYPA) inhibitors or inducers or drugs that are known to prolong the QT interval
Concomitant use of strong inhibitors of the cytochrome p, family , subfamily a, polypeptide  (CYPA) isoenzyme is not permitted; must have wash-out period of  times the half-life of the compound before first dasatinib dose
Inability or unwillingness to abstain from taking any medications or herbal supplements that are moderate or strong inducers of cytochrome P family , subfamily A, polypeptide  (CYPA) at least  week prior dosing with AZD and while on study treatment
Able to stop all cytochrome P, family , subfamily A, polypeptide  (CYPA) inhibitors (voriconazole or posaconazole) at least  days before admission
Patients who are currently receiving treatment (within  days prior to starting study drug) with agents that are known strong inducers or inhibitors of cytochrome P, family , subfamily A polypeptide  (CYPA)/cytochrome P, family , subfamily A polypeptide  (), or that have a narrow therapeutic window and are predominantly metabolized through CYPA/
Taking any medications or herbal supplements that are known to be strong inhibitors of cytochrome P, family , subfamily A, polypeptide  (CYPA) =<  days prior to registration
Patients who are taking strong cytochrome P family , subfamily A, polypeptide  (CYPA) inhibitors
Patients must not have taken within  days prior to registration, be taking, nor plan to take while on protocol treatment, strong cytochrome P, family , subfamily A, polypeptide  (CYPA) inhibitors, and/or CYPA inducers
Patients who are receiving treatment with medications known to be moderate and strong inhibitors or inducers of cytochrome P family , subfamily A, polypeptide / (CYPA/) or drugs metabolized by cytochrome P family , subfamily B, polypeptide  (CYPB) or cytochrome P family , subfamily C, polypeptide  (CYPC) that have narrow therapeutic index, and that cannot be discontinued before starting treatment with LDE; medications that are strong CYPA/ inhibitors should be discontinued at least  days and strong CYPA/ inducers for at least  weeks prior to starting treatment with LDE
Patients who are receiving treatment with medications known to be moderate and strong inhibitors or inducers of cytochrome P, family , subfamily A, polypeptide  (CYPA)/cytochrome P, family , subfamily A, polypeptide  () or drugs metabolized by cytochrome P, family , subfamily B, polypeptide  (CYPB) or cytochrome P, family , subfamily C, polypeptide  (CYPC) that have narrow therapeutic index, and that cannot be discontinued before starting treatment with LDE; medications that are strong CYPA/ inhibitors should be discontinued at least  days and strong CYPA/ inducers for at least  weeks prior to starting treatment with LDE; NOTE: patients who are already on or require initiation of azoles other than fluconazole will be excluded from the phase I dose escalation portion of the study
Women currently taking drugs which are strong inhibitors or inducers of cytochrome P, family , subfamily A, polypeptide  (CYPA) are not eligible
Use of strong cytochrome P, family , subfamily A, polypeptide  (CYPA) inducers
Concurrent use with strong cytochrome P family , subfamily A, polypeptide  (CYPA) inhibitors/inducers is prohibited; moderate CYPA inhibitors/inducers should be used with caution
Concomitant use of cytochrome P, family , subfamily A, polypeptide  (CYPA) inhibitors
Concomitant use of cytochrome P family , subfamily A, polypeptide  (CYPA) inhibitors at time of screening; if use of CYPA inhibitors becomes medically necessary during study, they must be used with caution
Required, chronic, use of drugs that are strong inhibitors or inducers of cytochrome p, family , subfamily A, polypeptide  (CYPA)
PART B: Ponatinib is a substrate for cytochrome P, family , subfamily A, polypeptide / (CYPA/), concurrent use with potent CYPA/ inhibitors or inducers should be undertaken with caution
Unable or unwilling to discontinue use of inducers and inhibitors of cytochrome P (CYP) and breast cancer resistance protein (BCRP) and permeability glycoprotein (PgP) inducers and inhibitors listed in the protocol for at least  days or five half-lives of a drug (whichever is longer) prior to the first dose of study drug and for the duration of the study; cytochrome P, family , subfamily A, polypeptide  (CYPA) substrates can be administered, but investigators will need to be aware of possible increased or decreased effectiveness of the non-study drug and this should be recorded in concomitant medications; dexamethasone is acceptable although listed as a CYPA inducers/inhibitors as long as the dose is  mg/day or lesser
Patients may not be receiving concurrent therapy with strong inhibitors of cytochrome P, family , subfamily A, polypeptide  (CYPA) or strong inhibitors or inducers of cytochrome P, family , subfamily C, polypeptide  (CYPC); please note that concurrent use of trimethoprim, a component of Bactrim, is prohibited per protocol; patients who require pneumocystis carinii pneumonia (PCP) prophylaxis will need to switch to an alternative antibiotic (e.g. Mepron)
At the time of registration, patients must not be receiving any medications or substances that are strong inhibitors or inducers of cytochrome P, family , subfamily A (CYPA) or cytochrome P, family , subfamily C, polypeptide  (CYPC); patients must not be planning to use herbal remedies (e.g., St. Johns wort), or strong inhibitors or inducers of P-glycoprotein (Pgp) or breast cancer resistance protein  (Bcrp)
Concurrent administration or received cytochrome P, family , subfamily A, polypeptide  (CYPA) inducers or inhibitors within  weeks prior to the first day of study drug treatment
Patients unwilling or unable to refrain from use of moderate or strong inhibitors or inducers of cytochrome P, family , subfamily A (CYPA)
Potent cytochrome P, family , subfamily A, polypeptide  (CYPA) inhibitors, such as ketoconazole and erythromycin, should be avoided during the study treatment period with trastuzumab emtansine
Concomitant use of any drug which is a moderate or strong cytochrome P family , subfamily A, polypeptide  (CYPA) inhibitor or strong CYPA inducer
Concurrent therapy with strong inhibitors or inducers of cytochrome P family , subfamily A, polypeptide  (CYPA) due to concerning possible drug-drug interactions with abiraterone
Concomitant use of cytochrome P, family , subfamily A, polypeptide  (CYPA) inhibitors
Patients who are receiving treatment with medications known to be moderate and strong inhibitors or inducers of cytochrome P, family , sub family A polypeptide / (CYPA/) or drugs metabolized by cytochrome P, family , subfamily B, polypeptide  (CYPB) or cytochrome P, family , subfamily C, polypeptide  (CYPC) that have narrow therapeutic index, and that cannot be discontinued before starting treatment with erismodegib; medications that are strong CYPA/ inhibitors should be discontinued at least  days and strong CYPA/ inducers for at least  weeks prior to starting treatment with erismodegib
Patients who are receiving treatment with medications known to be moderate and strong inhibitors or inducers of cytochrome P, family , subfamily A, polypeptide  (CYPA)/cytochrome P, family , subfamily A, polypeptide  (CYPA) or drugs metabolized by cytochrome P, family , subfamily B, polypeptide  (CYPB) or cytochrome P, family , subfamily C, polypeptide  (CYPC) that have narrow therapeutic index, and that cannot be discontinued before starting treatment with sonidegib; medications that are strong CYPA/ inhibitors should be discontinued at least  days and strong CYPA/ inducers for at least  weeks prior to starting treatment with sonidegib
Concomitant medications listed are prohibited; inhibitors or inducers of cytochrome P, family , subfamily, polypeptide  (CYPA) not listed can be used with caution
Concomitant use of strong or moderate cytochrome P, family , subfamily A, polypeptide  (CYPA) inhibitors
Planned use of strong cytochrome P, family , subfamily A, polypeptide  (CYPA) inhibitors or CYPA inducers while on study treatment unless deemed clinically necessary with no reasonable alternatives and with expressed permission from the principal investigator
Patients who are currently on or have used potent or moderate inhibitors or strong inducers cytochrome P, family , subfamily A, polypeptide  (CYPA) or p-glycoprotein (PgP) inhibitors in the past  weeks
Cytochrome P family , subfamily A, polypeptide  (CYPA) strong or moderate inhibitors/inducers in the past  days
Use of strong cytochrome P, family , subfamily A, polypeptide  (CYPA) inducers or inhibitors within  weeks of starting study medication
Strong inducers and inhibitors of cytochrome P, family , subfamily A, polypeptide  (CYPA), and therapeutic anticoagulation with vitamin-K antagonists (e.g., warfarin) or with heparins and heparinoids is not allowed on the study
Systemic exposure to ketoconazole or other strong cytochrome P, family , subfamily A, polypeptide  (CYPA) isoenzyme inhibitors or inducers within  days prior to the start of study treatment; systemic exposure to aminodarone is not allowed within  year prior to the start of study treatment
Patients must discontinue any medication that causes strong cytochrome P, family , subfamily A, polypeptide  (CYPA) induction  weeks prior to treatment initiation; patients who are not able to discontinue these drugs are considered ineligible
Patients taking concomitant medications (chronically or within  week of study drug administration) which are strong inhibitors of hepatic metabolism via cytochrome P (P)/cytochrome P, family , subfamily A, polypeptide  (CYPA) isoenzyme will be excluded
Patients taking moderate/strong inhibitors or inducers of cytochrome P family , subfamily A, polypeptide / (CYPA/) or drugs metabolized by cytochrome P family , subfamily B, polypeptide  (CYPB) or cytochrome P family , subfamily C, polypeptide  (CYPC) that have narrow therapeutic index, and that cannot be discontinued before starting treatment with LDE; medications that are strong CYPA/ inhibitors should be discontinued for at least  days and strong CYPA/ inducers for at least  weeks prior to starting treatment with LDE
Concomitant use of cytochrome P family , subfamily A, polypeptide  (CYPA) inhibitors
Patients currently receiving strong or moderate cytochrome P family , subfamily A, polypeptide  (CYPA) inhibitors or inducers; patients should not begin study drugs until at least  hours after the last dose (or longer) of the inhibitor or inducer
Patients who are receiving treatment with medications known to be moderate and strong inhibitors or inducers of cytochrome P family , subfamily A, polypeptide / (CYPA/) or with drugs metabolized by cytochrome , family , subfamily B, polypeptide  (CYPB) or cytochrome  family , subfamily C, polypeptide  (CYPC) that have narrow therapeutic index that cannot be discontinued before starting treatment with LDE; medications that are strong CYPA/ inhibitors should be discontinued at least  days and strong CYPA/ inducers should be discontinued for at least  days prior to starting treatment with LDE
Receiving treatment with any potent cytochrome P, family , subfamily A, polypeptide  (CYPA) inhibitors within  days of the first dose of study drug
Patients taking non-topical medication known to be a strong inhibitor of cytochrome P, family , subfamily A, polypeptide  (CYPA); however patients who either discontinue their treatment or switch to another medication at least three days prior to randomization are eligible
Concurrent administration of medications or foods that are strong inhibitors or inducers of cytochrome P, family , subfamily A (CYPA)
Patient is taking a drug known to be a moderate and strong inhibitor or inducers of the P isoenzyme cytochrome P, family , subfamily A (CYPA); participants must be off P/CYPA inhibitors and inducers for at least two weeks prior to starting the study drug
Concomitant use of cytochrome P, family , subfamily A, polypeptide  (CYPA) inhibitors
Patients who are receiving treatment with medications known to be strong inhibitors or inducers of cytochrome P, family , subfamily A, polypeptide / (CYPA/) or drugs metabolized by cytochrome P, family , subfamily B, polypeptide  (CYPB) or cytochrome P, family , subfamily C, polypeptide  (CYPC) that have a narrow therapeutic index, and that cannot be discontinued before starting treatment with LDE; medications that are strong CYPA/ inhibitors should be discontinued at least  days and strong CYPA/ inducers for at least  weeks prior to starting treatment with LDE; note that patients who require anti-fungal prophylaxis are preferred to be on fluconazole, and, patients taking voriconazole or posaconazole who must continue are excluded from the dose escalation phase of the study; once the maximum tolerated dose (MTD) is established, patients taking voriconazole or posaconazole will be allowed to enroll but at a dose adjustment to be determined before the expansion phase opens
Concurrent use of medications that are strong cytochrome P, family , subfamily A, polypeptide  (CYPA) inhibitors within  days prior to registration for protocol therapy; NOTE: concurrent use of other CYPA inhibitors may be allowed at the discretion of the treating physician or principal investigator
Concomitant use of dual strong inhibitors or inducers (cytochrome P, family , subfamily A, polypeptide  [CYPA], P-glycoprotein [P-gp])
Drugs with potent cytochrome P, family , subfamily A, polypeptide  (CYPA) inhibitors and inducers should be avoided during the course of treatment
Participants are to discontinue the use of the following classes of inhibitors of cytochrome P, family , subfamily A, polypeptide  (CYPA); patients who are on these drugs are eligible if a washout period of a minimum of  days occurs before start of olaparib and temozolomide\r\n* Azole antifungals\r\n* Macrolide antibiotics\r\n* Protease inhibitors
Patients who are taking medications that are strong inhibitors of cytochrome P, family , subfamily A, polypeptide  (CYPA) or permeability (P)-glycoprotein (PgP) and need to remain on these medications
Required administration of concomitant moderate or strong inhibitors or inducers of cytochrome P, family , subfamily A, polypeptide  (CYPA) for  days prior to the first dose of study drug; prior amiodarone for up to  months prior to day  of study treatment