Positive human immunodeficiency virus (HIV) or human T-cell lymphotrophic virus (HTLV)- serology Subject has an active infection with human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), or human T-lymphotropic virus (HTLV) as defined below: Positive for HIV, hepatitis B, hepatitis C, syphilis or human T Cell leukemia virus (HTLV). Negative human T-lymphotropic virus (HTLV)- and antibodies. EXCLUSION - PROCUREMENT: Active infection with human immunodeficiency virus (HIV) or human T-lymphotropic virus (HTLV) EXCLUSION - PROCUREMENT: Active infection with human immunodeficiency virus (HIV), human T-lymphotropic virus (HTLV), hepatitis B virus (HBV), hepatitis C virus (HCV) (can be pending at this time) PROCUREMENT EXCLUSION: Active infection with human immunodeficiency virus (HIV) or human T-cell leukemia virus (HTLV) (can be pending at this time) Positive for HIV, hepatitis B, hepatitis C, syphilis or human T cell leukemia virus (HTLV). No known history of human immunodeficiency virus (HIV) and , human T-cell lymphotropic virus (HTLV)-I/II, and hepatitis B and C Donors who are HIV-, HIV-, human T-lymphotropic virus (HTLV)-, HTLV- seropositive or with active hepatitis B or hepatitis C virus infection PART I: Negative serology for anti-human immunodeficiency virus (HIV)-/ and anti-human T-lymphotropic virus (HTLV) / Patients must have serum antibodies directed to human T-cell lymphotropic virus (HTLV)- Known infection with human immunodeficiency virus (HIV) or human T-cell leukemia virus (HTLV-) Seropositivity for human T-lymphotropic virus type (HTLV-). Known infection with human immunodeficiency virus (HIV) or human T-cell leukemia virus (HTLV-) Donors who are human immunodeficiency virus (HIV)-, HIV-, human T-lymphotropic virus (HTLV)-, HTLV- seropositive or with active hepatitis B or hepatitis C virus infection Known infection with human immunodeficiency virus (HIV) or human T-cell leukemia virus (HTLV-) seropositive status Known infection with Human Immunodeficiency Virus (HIV) or Human T-lymphotropic Virus (HTLV-). Known infection with human immunodeficiency virus (HIV) or human T-cell leukemia virus (HTLV-) seropositive status DONOR: Active hepatitis, positive for human T-cell lymphotropic virus (HTLV), or HIV on donor viral screen Seronegative for human T-cell lymphotropic virus type (HTLV-) Positive results for the human T-lymphotrophic virus (HTLV-) Patients with human immunodeficiency virus (HIV) or human T-cell leukemia virus (HTLV-) are not eligible DONOR: Chronic viral infection including active hepatitis B, hepatitis C, HIV, or human T-lymphotropic virus (HTLV)-/ DONOR: Positive for hepatitis, human T-lymphotropic virus (HTLV), or HIV on donor viral screen Any positive history for human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS), human T-cell lymphotropic virus (HTLV), hepatitis B or hepatitis C virus indicating acute or chronic infection No known history of human immunodeficiency virus (HIV) and , human T-lymphotropic virus (HTLV)-, or active hepatitis B or hepatitis C Human immunodeficiency virus (HIV), human T-cell lymphotropic virus type (HTLV-), hepatitis B virus (HBV), and hepatitis C virus (HCV) negative Subject has positive test result at the screening visit for one or more of the following:\r\n* Human T-cell lymphotropic virus (HTLV-/)\r\n* Anti-human immunodeficiency virus (HIV) antibody (alpha-HIV-) EXCLUSION CRITERIA FOR ENROLLMENT: Human immunodeficiency virus (HIV)-/ or human T-cell lymphotropic virus (HTLV)-/ positivity Human immunodeficiency virus (HIV) or human T-cell leukemia virus type (HTLV)/HTLV (seropositivity and/or polymerase chain reaction [PCR] positivity) Active symptomatic fungal, bacterial and/or viral infection including evidence of infection with human immunodeficiency virus (HIV), human T-cell leukemia virus (HTLV-) seropositive status Subject has positive test result at the screening visit for one or more of the following: human T-lymphotropic virus (HTLV)-/ and/or anti-human immunodeficiency virus (HIV) antibody (alpha-HIV-) Known history of infection with human immunodeficiency virus (HIV) or human T cell leukemia virus (HTLV-) Positive for human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), human T-lymphotropic virus (HTLV) and/or HTLV Seroreactivity for human immunodeficiency virus (HIV), human T-lymphotropic virus type I (HTLV I) or II, hepatitis B virus (HBV), hepatitis C virus (HCV) Uncontrolled infection, including human immunodeficiency virus (HIV), human T-lymphotropic virus (HTLV)-, hepatitis B or hepatitis C viremia History of human immunodeficiency virus (HIV), hepatitis B, hepatitis C and human t-lymphotropic virus (HTLV) Active infection with human immunodeficiency virus (HIV) or human T-cell lymphotropic virus (HTLV) History of positive serology tests for human immunodeficiency virus (HIV) and , human T cell lymphotropic virus (HTLV)-, hepatitis B and C DONOR: Must be free from risk factors for, and no clinical evidence of, infection due to relevant communicable disease agents and diseases including: human immunodeficiency virus; hepatitis B virus; hepatitis C virus; human transmissible spongiform encephalopathy, including Creutzfeldt-Jakob disease; treponema pallidum and human T-cell lymphotropic virus (HTLV) and Known infection with human immunodeficiency virus (HIV), human T-cell lymphotropic virus (HTLV)-I, hepatitis B, or hepatitis C DONOR: HIV or human T-lymphotropic virus (HTLV) seropositive Patient seropositive for human immunodeficiency virus (HIV)-I/II; human T-cell lymphotropic virus (HTLV)-I/II Active infection with human immunodeficiency virus (HIV), human T-cell lymphotropic virus (HTLV), hepatitis B virus (HBV), hepatitis C virus (HCV) (can be pending at this time) DONOR: Human T-lymphotropic virus (HTLV)/HIV(+) or hepatitis B or C antigen(+) donors Active infection with human immunodeficiency virus (HIV), human T-cell lymphotropic virus (HTLV), human T-cell lymphotropic virus (HBV), hepatitis C virus (HCV) (can be pending at this time) Patient seropositive for human immunodeficiency virus (HIV)-I/II; human t-lymphotrophic virus (HTLV) -I/II Seropositivity for human T-lymphotropic virus type (HTLV-) Immunocompromised patients (other than that related to the use of corticosteroids) including patients known to be human immunodeficiency virus (HIV), human T-cell lymphotropic virus (HTLV), hepatitis B (HepB), or hepatitis C (HepC) positive Human immunodeficiency virus (HIV)-/HIV- or human T-lymphotropic virus (HTLV)-/HTLV- seropositivity Patients with evidence of human immunodeficiency virus (HIV) seropositivity and/or positive polymerase chain reaction (PCR) assay, human T-cell leukemia virus type (HTLV)/HTLV seropositivity DONOR: Positive or reactive test results for Food and Drug Administration (FDA)-mandated relevant communicable diseases (HIV, hepatitis B [hep B], hepatitis C, human T-cell lymphotropic virus [HTLV], Syphilis, Trypanosoma [T.] cruzi) Human immunodeficiency virus (HIV), hepatitis C virus (HCV), hepatitis B virus (HBV) or human T-lymphotropic virus (HTLV) I/II infections Active infection with human immunodeficiency virus (HIV), human T-lymphotropic virus (HTLV), hepatitis B virus (HBV), hepatitis C virus (HCV) (can be pending at this time) Known human immunodeficiency virus (HIV) or human T-cell lymphotropic virus (HTLV) infection Exclusions for the leukapheresis procedure (this can be performed at a later time of symptoms resolve): \r\n* Infection, with or without antibiotic treatment\r\n* Recent hepatitis exposure (hepatitis B or C antigenemia)\r\n* Pregnancy or nursing\r\n* HIV or human T-lymphotropic virus (HTLV) infection\r\n* Positive result on standard test for syphilis (STS) Participants with known infection with human immunodeficiency virus (HIV) or human T-cell leukemia virus (HTLV-) Participants with known infection with human immunodeficiency virus (HIV) or human T-cell leukemia virus- (HTLV-) Patient is positive for human immunodeficiency virus (HIV) or human T-cell lymphotropic virus- (HTLV-) Immunocompromised patients (other than that related to the use of corticosteroids) including patients known to be human immunodeficiency virus (HIV), human T-cell lymphotropic virus (HTLV), hepatitis B (HepB), or hepatitis C (HepC) positive DONOR: Donors who are HIV-, HIV-, human T-lymphotropic virus (HTLV)-, HTLV- seropositive or with active hepatitis B or hepatitis C virus infection Seroreactivity for human immunodeficiency virus (HIV), human T-lymphotropic virus (HTLV) I or II, hepatitis B virus (HBV), hepatitis C virus (HCV) Patient seropositive for human immunodeficiency virus (HIV)-I/II; human T-cell lymphotropic virus (HTLV)-I/II Known or tests positive for human immunodeficiency virus (HIV), human T-cell leukemia virus (HTLV-), hepatitis B or hepatitis C. Active infections including human T-lymphotropic virus (HTLV) and , and human immunodeficiency virus (HIV) and Patient seropositive for human immunodeficiency virus (HIV)-I/II; human T-lymphotrophic virus (HTLV)-I/II Known infection with human immunodeficiency virus (HIV), human T-lymphotropic virus (HTLV-I), hepatitis B, or hepatitis C MATCHED RELATED DONOR: Donors must be human immunodeficiency virus (HIV) negative, human T-cell lymphotropic virus (HTLV) negative, hepatitis B virus surface antigen (HBsAg) negative Positive test results for human immunodeficiency virus (HIV), human T-lymphotropic virus (HTLV), hepatitis C or chronic hepatitis B Seronegativity for human immunodeficiency virus (HIV), human T-cell lymphotropic virus (HTLV), hepatitis Human T-lymphotropic virus (HTLV)-/ Patient seropositive for human immunodeficiency virus (HIV)-I/II; human T-cell lymphotropic virus (HTLV) -I/II Positive test results for human T-lymphotropic virus type I (HTLV ) virus in endemic countries DONOR: Virology testing including cytomegalovirus (CMV), human immunodeficiency virus (HIV), EpsteinBarr virus (EBV), human T-lymphotropic virus (HTLV), rapid plasma reagin (RPR), hepatitis A, B and C will be performed within days of donation DONOR: Human immunodeficiency virus (HIV) or human T-lymphotrophic virus (HTLV) infection HIV or human T-lymphotropic virus (HTLV) I/II positive, hepatitis C or chronic active hepatitis B Known human immunodeficiency virus (HIV) or human T-lymphotropic virus, type I (HTLV-I) positive status Human immunodeficiency virus (HIV) or Human T Cell Lymphotropic Virus (HTLV-) infection DONOR: not human immunodeficiency virus (HIV)-, HIV-, hepatitis C virus (HCV), hepatitis B core or human T-lymphotropic virus (HTLV)-I/II seropositive; hepatitis B surface antigen (HB S ag) (-); meet other infectious disease screening criteria utilized by NBAH Blood Center Human immunodeficiency virus (HIV) or human T-lymphotropic virus (HTLV)-I/II Active symptomatic fungal, bacterial and/or viral infection including positive serologies for human immunodeficiency virus (HIV), H\\human T-lymphotropic virus (HTLV-), , hepatitis C virus (HCV) or hepatitis B virus (HBV) (acute or chronic infection based on Center for Disease Control and Prevention [CDC] guidelines) within days of registration; (antibody, antigen and nucleic acid tests acceptable, depending on institutional standards) Human immunodeficiency virus (HIV) infection or Human T Cell Lymphotropic Virus (HTLV-) infection Has a known human T-lymphotropic virus type (HTLV) infection Known infection with human immunodeficiency virus (HIV) or human T-cell leukemia virus (HTLV-) Known infection with human immunodeficiency virus (HIV) or Human T-Cell Leukemia Virus (HTLV-) seropositive status Known history of human immunodeficiency virus (HIV) seropositive status or known infection with human T-cell leukemia virus (HTLV-) virus Uncontrolled infection, including human immunodeficiency virus (HIV), human T-cell lymphotropic virus type (HTLV-), hepatitis B or hepatitis C viremia No known history of human immunodeficiency virus (HIV) /, human T-lymphotropic virus (HTLV)-I/II DONOR: Human T-cell lymphotropic virus (HTLV)/human immunodeficiency virus (HIV)(+) or hepatitis B or C antigen(+) donors Patients seropositive for Human T-Lymphotrophic Virus (HTLV)-I or -II Positive serology for human immunodeficiency virus (HIV) or human T-cell lymphotropic virus (HTLV) at any time prior to enrollment; Positive viral test of the donor for HIV-, HIV-, hepatitis B virus (HBV), hepatitis C virus (HCV), Treponema pallidum, human T-lymphotropic virus (HTLV) (if tested), HTLV- (if tested), West Nile virus (WNV; if tested), or Zika virus (if tested) The patient has known positive human immunodeficiency virus (HIV) or known active human t-cell lymphotropic virus (HTLV) I/II disease, whether on treatment or not.