Serum creatinine level =< IULN within days prior to registration Within days prior to registration: Serum creatinine =< . x IULN Patients must have adequate renal function with serum creatinine level =< IULN within days prior to registration Serum creatinine =< . x IULN within days prior to registration Patients must have creatinine clearance =< . x IULN Patients must have serum creatinine =< x institutional upper limits of normal (IULN) within days prior to registration Serum creatinine =< . x the IULN Creatinine =< . x IULN OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels > . x IULN (that is, if serum creatinine is > . x IULN, a -hour urine collection to calculate creatinine clearance must be performed) Serum creatinine =< . x institutional upper limit of normal (IULN) OR creatinine clearance by Cockcroft-Gault >= mL/min for patients with serum creatinine > . x IULN Serum creatinine =< . x IULN OR creatinine clearance by Cockcroft-Gault >= mL/min/. m^ for patients with creatinine levels > . x IULN Adequate renal and hepatic function (creatinine ? . x IULN, bilirubin ? . IULN, AST and ALT ? . x IULN or x IULN if known liver metastases). Serum creatinine =< . x IULN OR creatinine clearance by Cockcroft-Gault >= mL/min/. m^ for patients with creatinine levels > . x IULN Serum creatinine =< . x IULN OR creatinine clearance by Cockcroft-Gault >= mL/min/. m^ for patients with creatinine levels > . x IULN Serum creatinine < x IULN Adequate renal and hepatic function (creatinine ? . x IULN, bilirubin ? IULN, AST and ALT ? . x IULN or x IULN if know liver metastases). Creatinine =< . x IULN OR measured or calculated creatinine clearance >= mL/min for patients with creatinine levels > . x IULN Adequate renal and hepatic function (creatinine ? . x IULN, bilirubin within normal limits, AST and ALT ? . x IULN or x IULN if know liver metastases) Creatinine =< . x IULN Within days of subject registration: Serum creatinine =< . X IULN Baseline BNP > x IULN Serum creatinine =< . x IULN Serum creatinine =< x institutional upper limit of normal (IULN), unless due to lymphoma, within day prior to registration Performed within days of patient registration: Serum creatinine =< . x IULN Serum creatinine =< IULN within days prior to registration Serum creatinine =< . x IULN within days prior to Step Randomization OR Serum creatinine =< . x IULN within days prior to Step registration OR Patients must have adequate organ and bone marrow function prior to registration, as defined below: \r\n* Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) < x institutional upper limit of normal (IULN)\r\n* Total bilirubin < . x IULN (unless Gilbert syndrome has been diagnosed); if leukemia infiltration of the liver is suspected to be causing liver function abnormalities the patient will still be eligible with principal investigator (PI) approval\r\n* Creatinine < x IULN\r\n* Creatinine clearance > mL/min (measured by Cockroft-Gault) Baseline troponin I or T > IULN and b-type natriuretic peptide > IULN Serum creatinine level =< IULN Serum creatinine =< . x IULN (assessed within days prior to study day ) Serum creatinine =< . x IULN OR creatinine clearance by Cockcroft-Gault >= mL/min/. m^ for patients with creatinine levels > . x IULN Serum creatinine < . x IULN within days prior to registration Serum creatinine =< . x IULN Serum creatinine =< . x IULN obtained within days prior to registration Adequate baseline hematological and organ function, assessed by laboratory values prior to study treatment as follows: absolute neutrophil count (ANC) > . x /L; hemoglobin > g/dL; serum creatinine < x institutional upper limit of normal (IULN); aspartate transaminase (AST) < . x IULN; alanine transaminase (ALT) < . x IULN; (if liver metastases are present, ALT and AST < x IULN); total bilirubin < . x IULN.