No current peripheral neuropathy > grade  at time of randomization
Grade  or greater peripheral neuropathy
Peripheral neuropathy Grade ? 
Peripheral neuropathy of any etiology that exceeds grade 
=< grade  peripheral neuropathy
RE-REGISTRATION ELIGIBILITY CRITERIA (STEP ): =< grade  peripheral neuropathy
Peripheral neuropathy >= 
Grade >=  peripheral neuropathy
Peripheral neuropathy ? Grade .
Grade >=  peripheral neuropathy at the present time
Peripheral neuropathy of Grade  within  weeks prior to the first study therapy
Peripheral neuropathy ?grade .
Grade  or greater peripheral neuropathy
Peripheral neuropathy >= grade  at screening
Peripheral neuropathy > Grade  despite supportive therapy.
Peripheral neuropathy of severity greater than grade 
Peripheral neuropathy greater than or equal to Grade 
Participants with >= grade  peripheral neuropathy
Baseline peripheral neuropathy of severity > grade 
Presence of >= grade  peripheral neuropathy
Peripheral neuropathy >= grade 
Presence of peripheral neuropathy > grade 
Peripheral neuropathy =< grade  at the time of registration
Presence of > grade  peripheral neuropathy
Peripheral neuropathy >Grade 
Grade >=  peripheral neuropathy
Peripheral neuropathy > grade 
Clinically significant (>= grade ) peripheral neuropathy at the time of study entry
Peripheral neuropathy grade > 
Peripheral neuropathy > grade , except for grade  without limitations on instrumental daily life activities;
Has greater than Grade  peripheral sensory neuropathy or > Grade  peripheral motor neuropathy graded according to the Modified (\Balis\) Pediatric Scale of Peripheral Neuropathies.
Active >= grade  peripheral neuropathy
Peripheral neuropathy > grade 
Peripheral neuropathy grade  or less.
No peripheral neuropathy
Baseline grade II peripheral neuropathy
Current peripheral neuropathy >= grade 
Peripheral neuropathy >= grade  at screening
Peripheral neuropathy grade  or greater
Participants with baseline peripheral neuropathy greater than grade 
Peripheral neuropathy >= grade 
Baseline grade II peripheral neuropathy
ENTRECTINIB EXCLUSION CRITERIA: Peripheral neuropathy >= grade 
Grade >=  peripheral neuropathy at baseline (within  days prior to cycle  day )
No peripheral edema >= grade  at baseline
No peripheral neuropathy >= grade  at baseline
Peripheral neuropathy, if present, should be =< grade 
Peripheral neuropathy > grade  if due to brentuximab vedotin or any peripheral neuropathy > grade 
Peripheral neuropathy grade -
Peripheral neuropathy > grade 
Peripheral neuropathy >= grade 
Has > Grade  peripheral sensory neuropathy or > Grade  peripheral motor neuropathy graded according to the Modified (\Balis\) Pediatric Scale of Peripheral Neuropathies
Has history of Grade  or greater peripheral neuropathy during the  months prior to enrollment.
Patient with peripheral neuropathy Grade >
Grade >=  peripheral neuropathy
Grade >=  peripheral neuropathy
>= grade  peripheral neuropathy
Peripheral neuropathy >= grade  despite supportive therapy
Central nervous system (CNS) toxicity including peripheral neuropathy =< grade 
Peripheral neuropathy of severity greater than grade 
Greater than grade  peripheral neuropathy at baseline
Peripheral neuropathy >= grade  at baseline OR peripheral neuropathy >= grade I with neuropathic pain
Grade >  peripheral neuropathy at baseline (within  days prior to cycle  day )
Subject has >= grade  peripheral neuropathy
Peripheral neuropathy >= grade 
Patients with > grade  peripheral sensory neuropathy or > grade  peripheral motor neuropathy graded according to the Modified (Balis) Pediatric Scale of Peripheral Neuropathies are not eligible
Peripheral neuropathy >= grade 
Peripheral neuropathy >= grade 
Peripheral neuropathy =< grade 
>= grade  peripheral neuropathy
>= grade  peripheral neuropathy within  days before beginning maintenance therapy
Peripheral neuropathy grade  or greater
Has peripheral neuropathy ? Grade .
Peripheral neuropathy =< grade 
Has peripheral neuropathy ? Grade 
Subjects with baseline peripheral neuropathy that exceeds grade 
Significant symptoms (grade >= ) peripheral neuropathy
Peripheral neuropathy ? Grade  or ? Grade  with pain within  weeks prior to first dose
Peripheral neuropathy ? Grade 
Peripheral neuropathy ? Grade .
Has peripheral neuropathy ? Grade 
Current Grade > peripheral neuropathy
Grade ?  peripheral neuropathy
Equal to or greater than grade  ataxia, cranial or peripheral neuropathy
Peripheral neuropathy < grade 
Grade >=  peripheral neuropathy
Current Grade > peripheral neuropathy from any cause
Peripheral neuropathy exclusions
? Grade  peripheral neuropathy
Baseline peripheral neuropathy/paresthesia grade >= 
Patient has >= grade  peripheral neuropathy
Patient has >= grade  peripheral neuropathy
Serious peripheral neuropathy.
Peripheral neuropathy- grade  or greater
Peripheral neuropathy ? Grade .
Peripheral neuropathy grade  or greater
Participants who have more than grade  peripheral neuropathy
Peripheral neuropathy >= grade 
Peripheral neuropathy < grade 
Clinically significant peripheral neuropathy
Has baseline peripheral neuropathy/paresthesia grade ? .
Evidence of peripheral neuropathy of Grade >.
Subject has peripheral neuropathy ? grade .
Peripheral neuropathy >= grade 
Equal to or greater than grade  ataxia, cranial or peripheral neuropathy
Grade  or above peripheral neuropathy
Peripheral neuropathy: must be =< grade 
Grade >  peripheral neuropathy at baseline
Grade >=  peripheral neuropathy within  days prior to cycle  day 
Peripheral neuropathy =< grade  at the time of registration
The patient has peripheral neuropathy >= grade 
Grade >=  peripheral neuropathy within  days prior to initiation of therapy
Subject has peripheral neuropathy >= grade .
Peripheral neuropathy ? Grade  despite supportive therapy
Has baseline peripheral neuropathy/paresthesia
Peripheral neuropathy > Grade .
Patient has >= grade  peripheral neuropathy
Peripheral neuropathy greater than Grade 
Peripheral neuropathy >= grade  at baseline OR peripheral neuropathy >= grade I with neuropathic pain
No peripheral neuropathy greater than grade , due to any cause
Peripheral neuropathy: must be =< grade 
Grade  or more peripheral neuropathy
Peripheral neuropathy ? Grade 
Peripheral neuropathy >= grade 
No ? grade  peripheral neuropathy.
Peripheral neuropathy =< grade 
Peripheral neuropathy >= grade (Gr) II
Peripheral neuropathy =< grade 
Grade  peripheral neuropathy
Patient has >= grade  peripheral neuropathy
Peripheral neuropathy
Peripheral neuropathy > grade 
> grade  peripheral neuropathy at baseline
Peripheral neuropathy of grade  or greater
Presence of ? Grade  peripheral neuropathy
Peripheral neuropathy ? Grade .
Presence of clinically significant non-hematological toxicity of prior chemotherapy that has not resolved to ? Grade  as determined by CTCAE v ., with the exception of alopecia and peripheral neuropathy. Note: Peripheral neuropathy > Grade  plus pain, or Grade  or Grade  are excluded.
Presence of > Grade  peripheral neuropathy
Peripheral neuropathy ? Grade 
Peripheral edema > grade 
Baseline peripheral neuropathy ? grade .
Peripheral neuropathy ? grade .
Grade >=  peripheral neuropathy
Peripheral neuropathy greater than grade 
Evidence of peripheral neuropathy of Grade > 
Subjects with > grade  peripheral neuropathy
Peripheral neuropathy Grade >/=
Presence of peripheral neuropathy
Subjects with Grade > peripheral neuropathy
Peripheral neuropathy at study entry
Ongoing Grade  or Grade  peripheral neuropathy, or Grade  peripheral neuropathy with pain despite appropriate interventions, within  days prior to first dose of study treatment.
No grade >=  peripheral neuropathy
Patient has >= grade  peripheral neuropathy
Grade >= peripheral neuropathy
Baseline peripheral edema >= grade 
Peripheral neuropathy ?Grade .
>= grade  peripheral neuropathy
Peripheral neuropathy
Current Grade > peripheral neuropathy
History of peripheral neuropathy; (note: this does not apply to Cohort )
Grade >= peripheral neuropathy
Grade ? peripheral neuropathy at baseline (within  days prior to cycle  day ).
Grade  or greater peripheral neuropathy
Peripheral neuropathy >= grade 
Peripheral neuropathy that is greater or equal to Grade 
Has peripheral neuropathy that is greater or equal to Grade 
Patient has > Grade  painful neuropathy or peripheral neuropathy
Peripheral neuropathy ? Grade 
The participant has any Grade  (or greater) peripheral neuropathy.
No grade  or greater peripheral neuropathy.
History of peripheral neuropathy of ?grade 
Peripheral neuropathy of > grade  severity.
Peripheral neuropathy with grade =< 
Clinically significant (>= grade ) peripheral neuropathy at the time of study entry
Peripheral neuropathy >= grade 
Grade >=  peripheral neuropathy
Any peripheral neuropathy >= grade 
Grade III or IV upper extremity peripheral neuropathy
History of peripheral neuropathy prior to receiving neurotoxic chemotherapy
Pain or symptoms of peripheral neuropathy of >  month's duration attributed to chemotherapy-induced peripheral neuropathy
Peripheral neuropathy greater than or equal to grade .
No >= grade  peripheral neuropathy
Peripheral neuropathy ? grade 
Peripheral neuropathy greater than grade 
Peripheral neuropathy greater than grade