Patients requiring any daily supplemental oxygen
Subject requires continuous supplemental oxygen for any reason. Additional Exclusion Criteria for Arm B
Requirement for daily supplemental oxygen
Clinically significant pulmonary compromise, including a requirement for supplemental oxygen use to maintain adequate oxygenation.
Clinically significant pulmonary compromise, including a requirement for supplemental oxygen use to maintain adequate oxygenation.
Participant has a need for supplemental oxygen with the exception of using previously existing non-invasive continuous positive airway pressure (CPAP) at night.
Subjects with a history of interstitial lung disease; patients requiring continuous supplemental oxygen are excluded to avoid possible complications from pneumonitis
ARM  - A: Pulmonary: patients with a requirement for supplemental oxygen or evidence of moderate-severe COPD by PFTs are permitted to enroll
Patients with baseline respiratory insufficiency severe enough to require supplemental oxygen.
Patients requiring ventilator support or oxygen supplementation exceeding % fraction of inspired oxygen (FiO) within  days of enrollment.
Research participant requires supplemental oxygen to keep saturation greater than % and the situation is not expected to resolve within  weeks
Research participant does not require supplemental oxygen to keep saturation greater than % and/or does not have presence of any radiographic abnormalities on chest x-ray that are progressive
Clinically-significant pulmonary compromise, including a requirement for supplemental oxygen use to maintain adequate oxygenation
Oxyhemoglobin saturation at rest >= % (off supplemental oxygen)
Pulmonary dysfunction defined as:\r\n* Severe pulmonary dysfunction with () a hemoglobin corrected DLCO < % of predicted at the Baseline Screening visit, or () FVC < % of predicted Baseline Screening visit, or\r\n* Partial pressure (pO) <  mmHg or pCO >=  mmHg without supplemental oxygen, or \r\n* O saturation < % at rest without supplemental oxygen as measured by forehead pulse oximeter
Patients requiring oxygen therapy
Patients requiring oxygen therapy
Patients requiring continuous supplemental oxygen are excluded to avoid possible complications from pneumonitis
Need for supplemental oxygen
No supplemental oxygen requirement
Patient is on supplemental home oxygen
ADDITIONAL CRITERIA FOR STUDY CONTINUATION: Patient is on supplemental home oxygen
Research participant does not require supplemental oxygen to keep saturation greater than % and/or does not have presence of any radiographic abnormalities on chest x-ray that are progressive
Research participant requires supplemental oxygen to keep saturation greater than % and the situation is not expected to resolve within  weeks
Within  days of study registration: No oxygen requirement on room air or requiring =< L supplemental oxygen (O)
Current use of supplemental oxygen
Clinically-significant pulmonary compromise, including a requirement for supplemental oxygen use to maintain adequate oxygenation.
Any patient requiring supplemental oxygen therapy
Respiratory insufficiency with oxygen requirement >  L nasal cannula
Patients must not require daily supplemental oxygen
No history of severe chronic obstructive pulmonary disease (COPD) or emphysema or interstitial lung disease currently on home supplemental oxygen; patients with NSCLC with stable COPD or emphysema not requiring supplemental oxygen are eligible
No requirement for supplemental oxygen therapy
Severe hypoxemia with room air pulmonary arterial oxygen tension (PaO) < , supplemental oxygen dependence, or DLCO < % predicted
Patients requiring supplemental oxygen
Participants requiring any daily supplemental oxygen
Patients requiring supplemental oxygen therapy
Patient is on supplemental home oxygen
Patients on supplemental home oxygen
May not be on supplemental oxygen
Patient must not have a requirement for supplemental oxygen
Requirement of supplemental oxygen.
History of interstitial pneumonitis and/or require supplemental oxygen therapy
Requiring supplemental oxygen at more than  L/min
Dyspnea of any cause requiring supplemental oxygen therapy;
Participants requiring any daily supplemental oxygen
Patients with history of lung disease currently requiring any pharmacologic or supplemental oxygen treatment
Adequate pulmonary function defined as:\r\n* No dyspnea at rest\r\n* No known requirement for supplemental oxygen\r\n* No known active pneumonitis
Clinically significant pulmonary hypertension, as defined by the requirement for ongoing pharmacologic treatment or the consistent or intermittent use of supplemental home oxygen.
Patient currently requiring supplemental oxygen for his/her daily life
Requirement for supplemental oxygen to carry out activities of daily living
Patients with active infection defined as:\r\n* Positive blood culture within  hours of study registration\r\n* Need for supplemental oxygen or vasopressors within  hours of study entry
Oxygen saturation <% on room air by trans-cutaneous method or need for any supplemental oxygenation or ventilatory support, or increase in oxygen supplementation requirement of ? litres for subjects with chronic oxygen dependency. For those subjects with a history of chronic hypoxia (without supplemental oxygen), an oxygen saturation of at least % below the patient's historical baseline oxygen saturation will satisfy this criterion.
Oxygen saturation < % despite supplemental oxygen >  L/minute.
Daily supplemental oxygen
Subjects currently on supplemental oxygen support
Patients with history of lung disease currently requiring any pharmacologic or supplemental oxygen treatment
Chronic supplemental oxygen requirement or hypoxemia < % blood oxygen saturation (SpO)
Any patients requiring oxygen at baseline
Currently requiring high flow oxygen for oxygenation
Supplemental oxygen dependency
Supplemental oxygen requirement >  L per minute
Patients requiring oxygen more than  liters
No requirement for supplemental oxygen (O)
Patients with history of lung disease currently requiring any supplemental oxygen treatment
Clinically significant pulmonary compromise (e.g. require supplemental oxygen)
Adequate pulmonary function as assessed by oxygen saturation >= % when ambulating and not requiring supplemental oxygen
Respiratory disease requiring continuous supplemental oxygen
Supplemental oxygen requirement >  L per minute
Supplemental oxygen requirement >  L per minute
Oxygen saturation < % despite supplemental oxygen >  L/min
Severe hypoxemia with room air partial pressure of oxygen (PaO) < , supplemental oxygen dependence, or DLCO < % predicted
Hypoxemia (less than % saturation with supplemental oxygen)
Current use of supplemental oxygen
Significant valvular disease, or significant pulmonary disease requiring supplemental oxygen therapy
Patients that require supplemental oxygen are excluded
Patients requiring continuous supplemental oxygen due to the requirement of spirometry during all imaging studies
Patients with history of lung disease currently requiring any pharmacologic or supplemental oxygen treatment
Requires daily supplemental oxygen.
Patients that require supplemental oxygen are excluded
Oxygen saturation >= % when ambulating and not requiring supplemental oxygen