The patient must have recovered from surgery with the incision completely healed and no signs of infection Must have adequate recovery from prior surgery (e.g., healed scar, resumption of diet, etc.) Recovery from surgery with the incision completely healed and no signs of infection At least weeks from completion of major surgery and a healed surgical incision Major surgery must be completed greater than days prior to registration for protocol therapy and healed surgical incision is required Major surgery within prior weeks of treatment initiation (the surgical incision should be fully healed prior to all neoadjuvant treatment initiation) Major surgery within weeks of enrollment, or a wound that has not fully healed Major surgery or a wound that has not fully healed within weeks of enrollment Major surgery =< weeks prior to registration (the surgical incision should be fully healed prior to drug administration or radiation therapy) No known non-healed dental/oral surgery, including tooth extraction Major surgery or a wound that has not fully healed within weeks of enrollment Major surgery or a wound that has not fully healed within weeks of enrollment Major surgery within weeks of study entry, or wound that is not healed from prior surgery or\r\ntrauma Patients must be a minimum of weeks from thoracotomy (if performed) and well-healed before starting treatment Major surgery or a wound that has not fully healed within weeks of initiation of therapy Non-healed infected skin ulcers Resected patients should begin treatment within weeks of surgery, once adequately healed as determined by the treating physicians Major surgery or wound that has not fully healed within weeks or vaccination with live attenuated vaccines within weeks of the first dose of study drugs. Non-healed dental/oral surgery, including tooth extraction Major surgery within prior weeks (the surgical incision should be fully healed prior to drug administration) Patients with wounds that have not fully healed are not eligible Patient has had major surgery or a wound that has not fully healed within weeks of starting study drugs Incompletely healed surgical incision prior to enrollment No defined washout period from major or minor surgery is required but incisions must be fully healed Participants must be at least weeks from prior surgical procedures and surgical incisions must be healed Surgical or other wounds must be adequately healed prior to enrollment. Patients have non healed dental/oral surgery, including tooth extraction Major surgery within weeks of enrollment; any and all surgical incisions must be fully healed prior to study enrollment; Note: recent port placement for chemotherapy administration is not considered an exclusionary surgical incision Craniotomy wound that has not sufficiently healed Incompletely healed wound Non-healed dental or oral surgery Major surgery or a wound that has not fully healed within weeks of enrollment Non-healed wound; Non-healed dental/oral surgery Major surgery within weeks prior to entry into the study, or a surgical incision that is not fully healed Major surgery with incompletely healed surgical incision before starting study therapy Non-healed dental/oral surgery Major surgery or a wound that has not fully healed =< weeks prior to registration Major surgery or a wound that has not fully healed within weeks of treatment Any non-cranial surgery within weeks of study registration; must be recovered and fully healed from any prior surgery Postsurgical open wound that has not healed at the time of enrollment. Major surgery or a wound that has not fully healed within weeks of starting ibrutinib Major injuries or surgery (e.g., craniotomy) < days from the start of nintedanib/placebo administration; wound should be healed prior to starting therapy Post-surgical open wound that has not been healed at the time of enrollment Non-healed dental/oral surgery, including tooth extraction Has incompletely healed sites of dental extractions Residual grade > skin toxicity, cellulitis, or incompletely healed wound(s) at intended site of study drug application at the time of the start of radiation therapy (RT) Major surgery within weeks or incompletely healed surgical incision before starting study therapy