Patients with a history of allergic reaction to irinotecan, cephalosporins or a severe penicillin allergy are not eligible Prior allergic reaction to the hormones involved in this protocol Prior allergic reaction to the study drug(s) involved in this protocol Patients with a history of intolerance to trastuzumab (i.e. a grade or infusion reaction) are excluded; Note: patients with a history of mild infusion reaction to trastuzumab who have previously been successfully re-challenged after an infusion reaction with or without prophylactic medication are allowed Previous allergic reaction to an immunomodulatory drug (IMiD) Use of steroids for non-tumor indications (for example: asthma or severe allergic reaction) is permitted Documented hypersensitivity reaction to any product with GSE History of allergic reaction/hypersensitivity to temozolomide, dacarbazine, DSF or Cu. History of allergic reaction to docetaxel Any history of allergic reaction to chemotherapies used History of allergic reaction to alpha--antitrypsin. Patients with hypersensitivity or other allergic reaction to platinum chemotherapy. Patients with hypersensitivity or other allergic reaction to taxanes. Known allergic reaction to antibiotics of the aminoglycoside group (ie, streptomycin, gentamicin) History of allergic reaction (including erythema nodosum) to lenalidomide Allergic reaction to single-agent rucaparib or irinotecan Prior allergic reaction or known intolerance to irinotecan If in Arm G, significant allergic reaction to cisplatin. Prior allergic reaction to cisplatin Patients with a history of severe allergic reaction to cisplatin or carboplatin Patient has had prior grade infusion reaction to cetuximab Documented allergic or acute hypersensitivity reaction attributed to antibody treatments Prior allergic reaction to cisplatin History of allergic reaction to interleukin- or nivolumab History of a severe allergic reaction or anaphylactic reaction to a biological agent or history of hypersensitivity to any component of the trial drug (e.g., hypersensitivity or allergy to murine products). The subject has a history of serious allergic reaction to any substance, resulting in hospitalization or requiring other emergent medical attention History of allergic reaction to DSF or Cu History of allergic reaction to natalizumab Known serious allergic reaction to vandetanib or metformin Prior allergic reaction to the study drug(s) involved in this protocol Any allergic reaction to a previously administered monoclonal antibody or other therapeutic protein Prior allergic reaction to temozolomide Previous severe or life-threatening allergic reaction with rituximab or known allergy to the compounds found in INCB Prior allergic reaction to the hormones involved in this protocol Patients with known history of allergic reaction to intravenous (IV) contrast material that is not amenable to pre-treatment by University of Alabama at Birmingham (UAB) protocol History of Grade or higher allergic reaction with prior asparaginase treatment, No prior known allergic reaction to monoclonal antibodies History of >= allergic reaction or any grade anaphylactic reaction during prior administration of tocilizumab Subject has prior severe allergic reaction or intolerance to any component of mFOLFOX. Previous allergic reaction to radioisotope bone tracers Known history of serious allergic reaction including anaphylaxis or Stevens- Johnson syndrome/ toxic epidermal necrolysis History of any hypersensitivity or allergic reaction to any beta lactam antibiotic, tazobactam, or any study therapy (IV or oral) Patients with a prior hypersensitivity reaction to sargramostim Prior allergic reaction or hypersensitivity to cetuximab or MEDI (durvalumab) or any of study drug excipients Patients with a lifetime history of dermatitis as an allergic/toxic reaction to any medication Prior allergic reaction to cetuximab History of severe allergic reaction, including erythema nodosum, to lenalidomide Prior known allergic reaction to pembrolizumab or its excipients Prior allergic reaction to cisplatin Prior allergic reaction to the study drug(s) involved in this protocol Patients with previous hypersensitivity reaction to camptothecins are excluded History of clinically significant allergic reaction attributed to any injected\n compound. Prior allergic reaction to any of the study drugs involved in this protocol Prior allergic reaction to the study drug(s) involved in this protocol Prior allergic reaction to the study drugs involved in this protocol or to a monoclonal antibody Known contraindication to dexamethasone (allergic reaction or systemic fungal infection) Known allergic reaction to any component of MEDI Prior allergic reaction to cetuximab History of significant adverse or allergic reaction to any component of G and, if enrolled in Part , anti-PD antibodies. No prior allergic reaction or hypersensitivity to sulfonamides, celecoxib or NSAIDs Patients must not have a known allergic reaction to epoetin alfa (Procrit) or human serum albumin Prior allergic reaction to the study drugs. Prior allergic reaction to the study drugs involved in this protocol Known major adverse reaction/event in connection with previously made vaccination (e.g. asthma, anaphylaxis or other serious reaction) Has prior allergic reaction to bevacizumab History of allergic reaction to parenteral administered recombinant protein product Prior allergic reaction to the study drugs (cisplatin, mitomycin, fluorouracil [FU]) involved in this protocol Prior allergic reaction to the drugs involved in this protocol Patients with history of allergic reaction to metformin Patients with history of allergic reaction to minocycline or to any of the tetracyclines Prior allergic reaction to temozolomide Prior allergic reaction to -FU or oxaliplatin Prior allergic reaction or hypersensitivity to sulfonamides (may be allowed per investigator discretion based on patient history), celecoxib or NSAIDs History of allergic reaction or intolerance to statin treatment History of an allergic reaction or intolerance to irinotecan History of allergic reaction (including erythema nodosum) to lenalidomide Prior allergic reaction or severe intolerance to either irinotecan or temozolomide History of allergic reaction to docetaxel History of allergic reaction to disulfiram Prior serious infusion reaction to cetuximab Prior allergic reaction to temozolomide. Prior allergic reaction to the study drug (bevacizumab) Known history of allergic reaction to cremophor/paclitaxel Prior allergic reaction to trastuzumab for the treatment of metastatic breast cancer Prior carboplatin or cisplatin hypersensitivity reaction Prior allergic reaction to the study drugs involved in this protocol History of allergic reaction to ATRA History of allergic reaction to dasatinib Patients who have previously been administered basiliximab or who have had an allergic reaction to basiliximab or one of its components in the past will be excluded History of serious allergic reaction, including anaphylaxis and toxic epidermal necrolysis History of allergic reaction to a structural compound or biological agent similar to TH- Prior allergic reaction to the study drug(s) involved in this protocol Patients with a prior serious infusion reaction to cetuximab History of serious allergic reaction to yeast or yeast-derived products, including known or suspected hypersensitivity reaction to sargramostim; History of severe (Grade or ) allergic or hypersensitivity reaction to therapeutic antibodies that required discontinuation of therapy History of severe (Grade or ) allergic or hypersensitivity reaction to therapeutic antibodies that required discontinuation of therapy Documented allergic or acute hypersensitivity reaction attributed to antibody treatments History of an allergic reaction to Human Serum Albumin History of severe allergic or hypersensitivity reaction to other therapeutic antibodies that required discontinuation of therapy Prior confirmed allergic reaction (including moderate rash, dyspnea, wheezing, urticaria or other symptoms) attributed to the administration of either anthracyclines or other liposomally encapsulated drugs that required discontinuation of prior therapy. Patients with known allergic reaction to lamivudine or tenofovir DF Known allergic reaction to nickel History of allergic reaction to ivabradine Patients with a history of allergic reaction to ropivacaine or other local amide anesthetics History of an allergic reaction or previous intolerance to transcutaneous electronic nerve stimulation No history of (H/O) allergic reaction to iron therapy Prior allergic reaction to memantine (memantine hydrochloride) History of an allergic reaction or previous intolerance to transcutaneous electronic nerve stimulation or to latex Patient with known allergic or hypersensitivity reaction to rHUPH or any hyaluronidase extracts Allergic reaction to carbamazepine or oxcarbazepine (major histocompatibility complex, class I, B [HLA-B]*) History of allergic or other adverse reaction to venlafaxine or SSRIs Patients with a history of a severe allergic reaction (anaphylaxis) History of severe allergic reaction to obinutuzumab Allergic reaction to omeprazole Allergic reaction to vitamin D Allergic reaction to metformin Patients with a known history of allergic reaction to ethanol, nitroglycerin, or citrate Known allergic reaction to gadopentetate dimeglumine (Gd-DTPA) History of reaction to ICG, iodides, or technetium radiocolloid Patients with renal failure or history of allergic reaction to Gadavist will be excluded Participants with multiple drug allergies, and/or subjects who have had an allergic reaction to any intravenous iron replacement product, or a known history of hypersensitivity to ferumoxytol Known allergic reaction to diethylene triamine pentaacetic acid (Gd-DTPA) Previous allergic reaction to contrast medium Known allergic reaction to gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) Subjects with multiple drug allergies and/or subjects who have had an allergic reaction to any intravenous iron replacement product or a known history of hypersensitivity to ferumoxytol Subjects with multiple drug allergies and/or subjects who have had an allergic reaction to any intravenous iron replacement product or a known history of hypersensitivity to ferumoxytol History of severe allergic/hypersensitivity reaction or significant transfusion reaction. Women with hypersensitivity to phenylmethane compounds, or a history of allergic reaction to iodides History of allergic reaction to MR contrast media