Documented progression on and/or intolerance/hypersensitivity to both paclitaxel and irinotecan (Part B only)
Known hypersensitivity or intolerance to metformin
Known hypersensitivity/intolerance to capecitabine, infusional -flurouracil, or bevacizumab
Known or suspected intolerance or hypersensitivity to IT- or any of the stated ingredients.
Known hypersensitivity or intolerance to metformin
Known hypersensitivity or intolerance to any of the agents under investigation
Known hypersensitivity or intolerance to any of the agents under investigation
History of intolerance or hypersensitivity to study drug
Intolerance or hypersensitivity to octreotide
Have a history of hypersensitivity to any study drugs or their excipients, or intolerance to hydration due to preexisting pulmonary or cardiac impairment, or intolerance to opioid pain medications, or a history of severe hypersensitivity to any other antigen.
Known hypersensitivity or intolerance to dexamethasone
Patients with known hypersensitivity or intolerance to melphalan
Known hypersensitivity or intolerance to metformin
Known intolerance of or hypersensitivity to fosbretabulin
History of hypersensitivity or severe intolerance to azoles
Known hypersensitivity or intolerance to metformin
No known hypersensitivity or intolerance to metformin
Known intolerance, hypersensitivity, or contraindication to glucocorticoids.
Subject has intolerance or hypersensitivity to iron or dextran compounds or to SiennaXP.
Known hypersensitivity or intolerance to itraconazole or similar class agents.