Patients on supraphysiologic doses of steroids or use of such within the previous six weeks
Are not using steroids for at least days prior to trial treatment
Patients who have any prior chemoimmunotherapy are not eligible; NOTE: the use of steroids to control the disease is permitted and does not have a washout period
Previous treatment for ALL, except for prior steroids and/or hydroxyurea
>= weeks from protocol tissue procurement since resolution of all immune related toxicities and off systemic steroids >= weeks; prophylactic use of steroids in preparation for radiologic exams are acceptable
Patients with endocrine deficiencies are allowed to receive physiologic or stress doses of steroids if necessary
Subjects receiving prednisone or steroids must continue on the same dose they were receiving at the time of screening
other lymphotoxic chemotherapy (including steroids except as below) within weeks of enrollment
Is on chronic systemic steroids.
Patient may not have received prior systemic chemotherapy for LCH or other malignant disorder; systemic steroids equivalent to prednisone mg/kg/day cannot have been given for more than days in the day period prior to study enrollment; however, patients who have only received surgical or radiation therapy, intralesional injection of steroids, or topical steroids may be enrolled
For cohort only (glioblastoma), patients must either not be receiving steroids, or be on a stable dose of steroids for at least five days prior to registration
Patients may take steroids for disease control up to hours prior to study enrollment; topical steroids are allowed for CTCL patients as described in inclusion criteria above
There is no need for steroids and patients have not had steroids at least weeks
Has a diagnosis of immunodeficiency and is not on continuous daily immunosuppressive therapy within days prior to the first dose of trial treatment; (subjects may receive steroids before or after SRS to prevent or manage cerebral edema; inhalational steroids are permitted)
other lymphotoxic chemotherapy (including steroids except as below) within weeks of enrollment
Patients on systemic steroids (except if solely for adrenal replacement) within two weeks of collection
There is no need for steroids and patients have not had steroids at least weeks
Subject using chronic systemic steroids greater than the equivalent of mg of prednisone/prednisolone per day in the weeks preceding study entry; replacement doses of steroids, topical, inhalational, nasal and ophthalmic steroids are permitted
Steroids: patients with endocrine deficiencies are allowed to receive physiologic or stress doses of steroids if necessary
Any form of immunosuppressive therapy within days prior to the first dose of trial treatment excluding steroids; attempts should be made to have patient on lowest possible dose of steroids; these medical entities can be exacerbated by PD- blockade
Use of chronic corticosteroids, hydroxyurea, or immunomodulating agents (e.g., interleukin , interferon alpha or gamma, granulocyte colony stimulating factors, etc.) within days prior to study entry\r\n* NOTE: recent or current use of inhaled steroids is not exclusionary; if subjects are prescribed a brief course of oral corticosteroids, the use should be limited to less than days; isolated use of steroids as premedication for medical procedures to minimize allergic reaction e.g. CT scan dye are allowed
Patients may take steroids for disease control up to hours prior to study enrollment
Immunosuppressed state (e.g. HIV, use of chronic steroids)
Patients may be on steroids prior to initiation of treatment, provided that, by cycle day , steroids use was tapered down to less than or equal to mg of prednisone
If patients are taking systemic therapy for cGVHD at the time of enrollment, they must be receiving stable or tapering doses within the previous weeks; patients are not required to have completed a course of steroids prior to enrollment
If patient is on steroids, patient must be on a stable or decreasing dose of steroids for days, no more than mg dexamethasone (or equivalent) total per day at the time of screening and consent; if on steroids at the time of screening, the dose will need to be tapered and discontinued at least days prior to CMV T cell infusion
Concurrent use of systemic steroids or chronic use of immunosuppressant medications; recent or current use of inhaled steroids is not exclusionary
Concurrent use of systemic steroids or immunosuppressant medications; recent or current use of inhaled steroids or physiologic replacement with hydrocortisone is not exclusionary
Concurrent use of systemic steroids or immunosuppressant medications; recent or current use of inhaled steroids or physiologic replacement with hydrocortisone is not exclusionary
Is in an immunosuppressed state (e.g. HIV +, use of chronic steroids [> month])
Patients must be at least days post systemic steroids prior to enrollment
Patient may be on steroids or anti-epileptics
Concurrent use of systemic steroids or immunosuppressant medications
Concurrent use of systemic steroids; recent or current use of inhaled steroids is not exclusionary
Patients must be on stable dose of steroids for at least days prior to baseline imaging
Known immunosuppressed conditions or active immunosuppressive therapy such as organ transplantation (including bone marrow transplant), high dose steroids, or human immunodeficiency virus (HIV); although a documented negative HIV test is not mandatory for enrollment, patients felt to have a high clinical suspicion for HIV will need to test negative prior to enrollment; use of topicals or eye drops containing steroids is acceptable; inhaled steroids are excluded
Patients must either not be receiving steroids, or be on a stable dose of steroids for at least five days prior to registration
Chronic treatment with systemic steroids or another immunosuppressive agent with the following exceptions:\r\n* Intermittent steroids may be used on an as-needed basis (e.g. treatment for chemotherapy-related nausea)\r\n* Patients on physiologic replacement doses of steroids due to adrenal insufficiency for any reason may remain on these medications
Concurrent use of systemic steroids with the exception of chronically administered steroids equivalent to ? mg/day prednisone if patient has been on this therapy for ?month
No steroids for at least weeks prior to enrollment, and patient must not be expected to require steroids during the study period
Patients on supraphysiologic doses of steroids or use of such =< weeks prior to registration
Patients may not be receiving any steroids or other anti-immune therapy at the time of registration
Patients requiring chronic systemic treatment with steroids
Chronic treatment with steroids or any other immunosuppressant drugs
Neurologic symptoms or imaging findings that necessitate the use of steroids on the day of enrollment or in the prior days
Concurrent radiation, with or without steroids, or steroids alone for emergency conditions secondary to lymphoma (i.e. cord compression, etc.) will be permitted
Steroids for physiological replacement are allowed.
Steroids: Therapeutic systemic doses of steroids must be stopped > hours prior to CTL infusion. However, the following physiological replacement doses of steroids are allowed: < mg/m/day hydrocortisone or equivalent
Steroids: Therapeutic doses of steroids must be stopped > hours prior to CTL infusion. However, the following physiological replacement doses of steroids are allowed: < - mg/m/day hydrocortisone or equivalent
Is on chronic systemic steroids.
Steroids: Therapeutic doses of steroids must be stopped > hours prior to CTL infusion. However, the following physiological replacement doses of steroids are allowed: < mg/m/day hydrocortisone or equivalent
Concurrent systemic therapy with steroids or other immunosuppressive agents, or use of any investigational drug within days before the start of trial treatment. Short-term administration of systemic steroids (that is, for allergic reactions or the management of immune-related adverse events [irAE]) while on study is allowed. Also, subjects requiring hormone replacement with corticosteroids for adrenal insufficiency are eligible if the steroids are administered only for the purpose of hormonal replacement and at doses <= mg or equivalent prednisone per day. Note: Subjects receiving bisphosphonate or denosumab are eligible.
Concurrent use of systemic steroids, through hours post the last RNA CART infusion; recent or current use of inhaled steroids or physiologic replacement with hydrocortisone is not exclusionary\r\n* Therapeutic doses of steroids must be stopped > hours prior to CTL infusion; however, the following physiological replacement doses of steroids are allowed: < - mg/m^/day hydrocortisone or equivalent
Current treatment with steroids
Long-term use of systemic corticosteroids; patients with replacement steroids and not immunosuppressive steroids may enroll in the study
Current use of steroids
Prior treatment with systemic steroids within weeks prior to lymphodepletion (except for physiologic replacement doses for adrenal insufficiency, premedication for contrast allergies for scans, and for drug fever related to targeted therapy)
Patients must have been off pharmacologic doses of systemic steroids for at least days prior to enrollment; patients who require or are likely to require pharmacologic doses of systemic corticosteroids while receiving treatment on this study are ineligible; the only exception is for patients known to require mg/kg or less of hydrocortisone (or an equivalent dose of an alternative corticosteroid) as premedication for blood product administration in order to avoid allergic transfusion reactions; the use of conventional doses of inhaled steroids for the treatment of asthma is permitted, as is the use of physiologic doses of steroids for patients with known adrenal insufficiency
Receipt of glucocorticoids (with the exception of inhaled glucocorticoid steroids for the use of allergic rhinitis or pulmonary disease) within weeks of registration
Has a known diagnosis of immunodeficiency (human immunodeficiency virus [HIV] / antibodies) or any other form of immunosuppressive therapy within days prior to the first dose of trial treatment excluding steroids; attempts should be made to have patient on lowest possible dose of steroids
History of contact dermatitis to clobetasol propionate or similarly fluorinated steroids or other steroids with the propionate ester
Have used any systemic steroids within days of study treatment
Steroids: subjects with endocrine deficiencies are allowed to receive physiologic or stress doses of steroids if necessary
Chronic treatment with systemic steroids or another immunosuppressive agent; subjects with endocrine deficiencies are allowed to receive physiologic or stress doses of steroids if necessary
Patients who are on chronic steroids for unrelated conditions (i.e. rheumatologic conditions) are not eligible if their total daily dose of steroids is >= mg prednisone
Patients must not be on steroids other than for physiologic replacement
Steroids for the treatment of hypersensitivity or transfusion reactions.
Concurrent anticancer treatment or concurrent systemic therapy with steroids or other immunosuppressive agents, or use of any investigational drug within days before the start of trial treatment. Short-term administration of steroids (that is, for allergic reactions or the management of immune-related adverse events [irAE]) is allowed
Patients must be on a stable or decreased dose of steroids for at least days prior to baseline imaging
Patients treatment with systemic steroids or another immunosuppressive agent; patients with endocrine deficiencies are allowed to receive physiologic or stress doses of steroids if necessary
Concurrent use of systemic steroids; recent or current use of inhaled steroids is not exclusionary
Used any systemic steroids within days of study treatment
Use of chronic corticosteroids, hydroxyurea, or immunomodulating agents (e.g. interleukin-, interferon-alpha or gamma, granulocyte colony stimulating factors, etc.) within days prior to study entry. NOTE: Recent or current use of inhaled steroids is not exclusionary. If subjects are prescribed a brief course of oral corticosteroids, the use should be limited to less than days. Use of steroids before apheresis and immune assessment blood draws should be discouraged as it will affect white blood cell function.
Subjects who require emergent use of systemic steroids, emergent surgery and/or radiotherapy
Chronic treatment with systemic steroids or another immuno-suppressive agent
Concurrent treatment with corticosteroids. If they are already on steroids, patients will be allowed to enroll on the study but will need to taper off as soon as possible.
Is neurologically stable without the need for steroids for ? days before first dose of study treatment.
Short term (< days) concurrent systemic steroids ?. mg/kg prednisone per day (maximum . mg/day) and bronchodilators (inhaled steroids) are permitted; other steroid regimens and/or immunosuppressives are excluded while receiving vaccine. Patients requiring steroids following previous CNS radiation for metastatic disease are excluded.
Receipt of glucocorticoids (with the exception of inhaled glucocorticoid steroids for the use of allergic rhinitis or pulmonary disease) within months prior to registration
No concomitant therapy with steroids (replacement doses of steroids are allowed)
Subject should not be receiving any agent for fatigue including steroids, megace or opioids. NOTE: Subjects who have a contrast-induced allergy are allowed to receive steroids for their scans.
Subject does not require steroids or does not require escalating doses of steroids for at least weeks prior to the first dose of study drug.
Patients who have received systemic steroids within weeks prior to starting study treatment
Chronic treatment with steroids or other immunosuppressive agents for medical conditions other than cancer. Patients who require steroids for treatment of tumor-associated cerebral edema are eligible.
Received systemic steroids within days of study enrollment
If a patient had been taking steroids, at least weeks must have passed since the last dose; patients stable on physiologic replacement doses of steroids or other forms of hormone replacement therapy are eligible
Patients can be on steroids as long as the dose has been stable for >= days
Concurrent use of systemic steroids
Current treatment with steroids
Patients must have not received any prior therapy other than surgery and/or steroids
Used any systemic steroids within days of study treatment
Patients may be on steroids prior to initiation of treatment as long as by cycle day steroids use was tapered down less than or equal to mg of prednisone
Concurrent steroids are allowed if dexamethasone dose is =< mg daily; if feasible, steroids should be weaned off once sorafenib has been initiated
Systemic steroids within week before enrollment except steroids used as part of an antiemetic regimen or maintenance-dose steroids for non-cancerous disease.
Patients on concurrent steroids, other than those allowed for routine antiemetics, or inhaled steroids
Current treatment with steroids
Patients receiving chronic treatment with oral steroids or another immunosuppressive agent (excluding steroids as part of the chemotherapy pre-medication or emetic medication)
Use of systemic steroids, or other pharmacological agents such as methylphenidate for cancer-related fatigue
Patients who have not completed their initial steroids
Patients may be on steroids at study entry
Patients continuously taking systemic steroids within the last days
No concurrent use of chronic systemic steroids (defined as currently on more than week of treatment)
Patients must be scheduled for tapering doses of (or no longer treated with):\r\n* Cyclosporine;\r\n* Tacrolimus;\r\n* Sirolimus;\r\n* Steroids (patients may be on physiologic doses of steroids)
Use of oral or systemic steroids or other anti?immune therapy =< days prior to pre?registration; Note: Use of inhaled/nasal steroids is not exclusionary
Patients must be at least days post systemic steroids prior to enrollment
Patients must not have been taking steroids or are on a stable dose of steroids for at least days before enrollment
Systemic steroids at physiologic doses (equivalent to dose of oral prednisone mg) are permitted. Steroids as anti-emetics for chemotherapy are not allowed.
Patients with known immunodeficiency, known autoimmune disease, or concurrent use of immunomodulatory agents including systemic steroids within days prior to registration, are ineligible
Taking ibuprofen, naproxen, other non-steroid anti-inflammatory drugs (NSAIDs), steroids (except inhaled steroids) within days of study registration
Current treatment with steroids (must be discontinued week before starting IFN gamma)
Systemic treatment with steroids or other immunosuppressive agents within days prior to entry. Physiological replacement with hydrocortisone or equivalent is acceptable.