Patients with QTc interval > milliseconds
Patients with baseline prolongation of the rate-corrected QT interval (QTc) (e.g., repeated demonstration of QTc interval > milliseconds, or history of congenital long QT syndrome, or torsades de pointes)
Corrected QT (QTc) interval =< milliseconds
Corrected QT (QTc) interval =< milliseconds
Marked baseline prolongation of QT/corrected QT (QTc) interval (e.g. demonstration of a QTc interval greater than milliseconds)
Corrected QT interval (QTc) of < milliseconds
Prolongation of QT corrected (QTc) interval to > milliseconds (ms)
Baseline QTc prolongation (e.g., repeated demonstration of QTc interval > milliseconds or history of congenital long QT syndrome or torsades de pointes)
History or presence of an abnormal ECG that, in the investigator's opinion, is clinically meaningful. Screening corrected QT (QTc) interval > msec is excluded (corrected by Fridericia). If a single QTc is > milliseconds, the subject may enroll if the average QTc for the ECGs is < milliseconds. For subjects with an intraventricular conduction delay (QRS interval > milliseconds), the JTc interval may be used in place of the QTc with sponsor approval. The JTc must be < milliseconds if JTc is used in place of the QTc. Subjects with left bundle branch block are excluded. Note: QTc prolongation due to pacemaker may enroll if the JTc is normal or with medical monitor approval.
Corrected QT interval at screening greater than (>) milliseconds (ms) (average of triplicate screening measurements)
Any known cardiac abnormalities such as:\r\n* Congenital long QT syndrome\r\n* Corrected QT(QTc) interval >= milliseconds
Baseline corrected QT (QTc) interval >= milliseconds
History or presence of an abnormal electrocardiogram (ECG) that, in the investigator's opinion, is clinically meaningful; screening corrected QT (QTc) interval > milliseconds is excluded; in the event that a single QTc is > milliseconds, the subject may enroll if the average QTc for the ECGs is < milliseconds; for subjects with an intraventricular conduction delay (QRS interval > milliseconds), the corrected JT (JTc) interval may be used in place of the QTc with sponsor approval; the JTc must be < milliseconds if JTc is used in place of the QTc; subjects with left bundle branch block are excluded\r\n* Note: QTc prolongation due to pacemaker may enroll if the JTc is normal
History or presence of an abnormal electrocardiogram (ECG) that, in the investigator's opinion, is clinically meaningful; screening corrected QT (QTc) interval >= milliseconds is excluded; in the event that a single QTc is >= milliseconds, the subject may enroll if the average QTc for the ECGs is < milliseconds; for subjects with an intraventricular conduction delay (QRS interval > milliseconds), the corrected JT (JTc) interval may be used in place of the QTc with the approval of the principal investigator; the JTc must be < milliseconds if JTc is used in place of the QTc; subjects with left bundle branch block are excluded; note: QTc prolongation due to pacemaker may enroll if the JTc is normal
Baseline prolongation of the rate-corrected QT interval (QTc) > milliseconds or history of congenital long QT syndrome or Torsades de pointes
Prolongation of corrected QT (QTc) interval to > milliseconds (msec) when electrolyte balance is normal
Marked baseline prolongation of QT/corrected QT interval (QTc) interval (e.g. demonstration of a QTc interval greater than milliseconds)
Abnormalities on -lead electrocardiogram (ECG) considered by the investigator to be clinically significant (such as acute ischemia, left bundle branch block, ventricular arrhythmias) or baseline prolongation of the rate-corrected QT interval (e.g., repeated demonstration of QTc interval > milliseconds)
Baseline prolongation of the rate-corrected QT interval (QTc) (e.g. repeated demonstration of QTc interval > milliseconds, or history of congenital long QT syndrome, or torsades de pointes)
Patients with the following cardiac diagnoses: ventricular tachycardia or fibrillation; Torsades de pointes; clinically significant bradycardia; sinus node dysfunction; heart block; prolonged corrected QT (QTc) interval (QTc > milliseconds for males, QTc > milliseconds for females); valvular, ischemic, or pulmonary heart disease; cardiomyopathy; history of heart failure
Screening corrected QT interval (QTc) interval > milliseconds
Marked baseline prolongation of QT/corrected QC (QTc) interval (e.g. demonstration of a QTc interval greater than milliseconds)
Corrected QT interval (QTc) prolongation > milliseconds (msec)
Prolongation of QTc interval to > milliseconds (ms)
History of non-pharmacologically induced prolonged QTc interval > milliseconds.
Corrected QT (QTc) interval =< milliseconds
Prolonged corrected QT interval (QTc) > milliseconds (ms) at the screening visit
Baseline electrocardiogram (EKG) shows normal corrected QT interval (QTc) interval of =< milliseconds (ms)
Prolonged QT interval (corrected QT interval [QTc] > milliseconds) on screening electrocardiogram (EKG) or congenital long QT syndrome
Corrected QT interval less than milliseconds by electrocardiogram (EKG)
Marked baseline prolongation of QT/QT corrected (QTc) interval (e.g. demonstration of a QTc interval greater than milliseconds)
Corrected QT interval (QTc) > milliseconds as corrected by the Fridericia formula
A clinically significant electrocardiogram (ECG) abnormality, including a marked Baseline prolonged QT/QTc interval (e.g., a repeated demonstration of a QTc interval > milliseconds (msec)).
History of prolonged QTc interval (e.g., repeated demonstration of a QTc interval > milliseconds).
Have a corrected QT interval > milliseconds as calculated be the Fredericia equation.
Corrected QT interval (QTc) =< milliseconds (ms)
Participants with baseline QTc greater than (>) milliseconds or symptomatic bradycardia
Concurrent use of digoxin due to cardiac disease; corrected QT (QTc) interval >= milliseconds in men and >= milliseconds in women within weeks of registration or known history of QTc prolongation or Torsades de Pointes
Abnormalities on -lead electrocardiogram (ECG) considered by the investigator to be clinically significant or baseline prolongation of the rate-corrected QT interval (e.g., repeated demonstration of QTc interval > milliseconds).
Baseline corrected QT interval (QTc) =< milliseconds (ms)
Corrected QT interval (QTc)/QT Fridericia equation (QTf) interval >= milliseconds; unless secondary to pacemaker or bundle branch block
History of congenital long QT syndrome or corrected QT interval (QTc) greater than (>) milliseconds at screening
Corrected QT (QTc) prolongation, as defined by > milliseconds on ECG
Prolongation of corrected QT interval (QTc) > milliseconds using Bazetts formula
Corrected QT interval (QTc) > milliseconds
Corrected QT interval less than milliseconds by electrocardiogram (EKG)
Prolongation of corrected QT (QTc) interval to > milliseconds (ms)
Clinically significant abnormality on electrocardiogram (ECG). The corrected QT interval (QTc, Fridericia) must be < milliseconds for men and < milliseconds for women (Must be confirmed by at least additional -lead ECGs at least minutes apart such that average manually over-read QTcF based on ECGs exceeds stated thresholds)
Patients must not have QTc prolongation defined as a QTc interval equal to or greater than milliseconds (msecs)
Baseline prolongation of the rate-corrected QT interval (QTc) > milliseconds, or history of congenital long QT syndrome, or torsades de pointes
Corrected QT (QTc) interval >= milliseconds
Prolongation of corrected QT interval (QTc) > milliseconds (msec)
Patients must not have a marked baseline prolongation of QT/corrected QT (QTc) interval (e.g., demonstration of a QTc interval > milliseconds (ms)
QTc interval < milliseconds (msec) on the baseline electrocardiogram.
Marked baseline prolongation of QT/corrected QT (QTc) interval (e.g. demonstration of a QTc interval greater than milliseconds)
Patients with baseline prolongation of the rate-corrected QT interval (QTc) (e.g., repeated demonstration of QTc interval > milliseconds, or history of congenital long QT syndrome, or torsades de pointes) are ineligible
Serious ventricular arrhythmias or high risk for arrhythmias, due to prolongation of the QT-interval (> milliseconds [msec])