Intrinsic lung disease resulting in dyspnea Symptomatic intrinsic lung disease or extensive tumor involvement of the lungs, resulting in dyspnea at rest Symptomatic intrinsic lung disease or extensive tumor involvement of the lungs resulting in dyspnea at rest EXCLUSION CRITERIA FOR REGISTRATION: Symptomatic intrinsic lung disease or extensive tumor involvement of the lungs resulting in dyspnea at rest Intrinsic lung disease resulting in moderate to severe dyspnea Symptomatic intrinsic lung disease or extensive tumor involvement of the lungs resulting in dyspnea at rest Symptomatic intrinsic lung disease or extensive tumor involvement of the lungs, resulting in dyspnea at rest Intrinsic lung disease resulting in dyspnea Symptomatic intrinsic lung disease or lung involvement Symptomatic intrinsic lung disease or extensive tumor involvement of the lungs, resulting in grade or higher dyspnea at rest Symptomatic intrinsic lung disease or extensive tumor involvement of the lungs, resulting in dyspnea at rest REGISTRATION EXCLUSION CRITERIA: Symptomatic intrinsic lung disease or extensive tumor involvement of the lungs resulting in dyspnea at rest Symptomatic intrinsic lung disease or extensive tumor involvement in the lungs resulting in dyspnea at rest Symptomatic intrinsic lung disease or extensive tumor involvement of the lungs, resulting in dyspnea at rest