The investigators belief that the subject is medically unfit to receive pembrolizumab and or unsuitable for any other reason Medically significant (symptomatic) bradycardia The investigators belief that the subject is medically unfit to receive nivolumab, and/or ipilimumab or unsuitable for any other reason Patients must be medically or surgically inoperable as determined by a physician OR unwilling to undergo surgical resection Is considered medically unfit for the study by the investigator as a result of the medical interview, physical exam, or screening investigations Medically indicated use of known radiosensitizing drugs (such as protease inhibitors) Be medically stable Patients must be willing to and medically capable of undergoing the surgical operation Has unresectable disease or is medically inoperable Medically significant (symptomatic) bradycardia. Must be deemed medically fit for SBRT by the treating physician Medically fit and willing to undergo resection of disease Medically fit to undergo cystectomy Patient desires and is medically fit to undergo prostatectomy Deemed medically inoperable per urology evaluation Medically significant cardiac event or unstable cardiovascular function defined as: Must be considered medically fit for operation as determined by multidisciplinary evaluation Patients must be considered unresectable or medically-inoperable Patients must be medically fit enough to undergo surgery as determined by the surgical oncology team SUITABLE DONOR Medically cleared to donate Patient is medically fit to receive cisplatin Patient deemed medically unfit to undergo surgical resection of brain metastasis Participant must be evaluated by surgical oncologist and felt to have potentially resectable tumor and be medically fit for proposed surgery DONOR: Meets institutional selection criteria and medically fit to donate Medically fit to undergo radical surgery as per treating surgeon's discretion In the opinion of the investigator, patient must be medically fit to undergo surgical procedure Medically unfit for anesthesia Patients must have unresectable disease, be medically inoperable, or unwilling to undergo surgical management Medically eligible to receive MEC Medically eligible to receive \+\ cytarabine/idarubicin Medically operable Medically significant (symptomatic) bradycardia; Clinical status of either subject or tumor such that administration of day neoadjuvant IRX- Regimen or before surgery would be medically inappropriate Medically fit to and willing to donate Deemed medically fit for stereotactic body radiation therapy by the treating physician Patients must be medically fit enough to undergo surgery as determined by the treating medical and surgical oncology team Willingness to use medically acceptable contraception Patients must have resectable adenocarcinoma of the esophagus or GE-junction and are medically fit to undergo surgery; patients must have no evidence of distant metastasis based on imaging studies Unresectable disease or medically inoperable Patient has either metastatic disease (M; stage IVB), is medically unable to receive brachytherapy, or refuses brachytherapy Patients must be considered unresectable or medically inoperable; patients who decline surgery are also eligible Pts who are medically unfit to tolerate surgery Patients are unwilling, or who are determined to be medically unfit for or resistant to standard intensive induction chemotherapy; patients who are medically unfit will be determined by the treating primary hematologist and the principal investigator (including but not limited to evaluation of co-morbidities, and response and complications to previous AML treatment strategy) The investigator's belief that the participant is medically unfit to receive eribulin mesylate and pembrolizumab or unsuitable for any other reason. Surgically or medically castrated, with testosterone levels of < nanograms/deciliter. B: Neurofibromatosis Type - associated plexiform neurofibromas (NF- with PN) that are unresectable and medically significant. Medically or technically inoperable as per thoracic surgeon or patient's preference not to undergo surgical resection The participants NSCLC must be considered medically inoperable for a standard lobectomy and mediastinal lymph node dissection/sampling procedure; the participant may have underlying physiological medical problems that would prohibit a surgery due to a low probability of tolerating general anesthesia, the operation, the postoperative recovery period, or the removal of adjacent functioning lung; these types of patients with severe underlying health problems are generally deemed medically inoperable;\ standard justification for deeming a patient medically inoperable based on pulmonary function for surgical resection of NSCLC may include baseline forced expiratory volume in one second (FEV) < % predicted, postoperative FEV < % predicted, severely reduced diffusion capacity, baseline hypoxemia and/or hypercapnia, severe pulmonary hypertension, severe cerebral, cardiac, or peripheral vascular disease; if the participant has medically operable disease but declines surgery after consulting with a thoracic surgeon, he/she will be considered eligible DONOR: Medically fit to and willing to donate Eligible patients should be deemed as likely to be medically fit to undergo surgical cytoreduction after cycles of neoadjuvant chemotherapy by a surgical gynecologic oncologist Patient must be considered medically inoperable as determined by the principal investigator No medically documented preexisting auditory damage. Is considered medically unfit for the study by the investigator as a result of the medical interview, physical exam, or baseline investigations. Subjects deemed unsuitable candidates and not medically optimized for RARC Subjects deemed unsuitable candidates and not medically optimized for partial nephrectomy Medically unable to undergo desensitization Patient is considered medically unstable Subjects who are not medically well enough to receive study therapy as determined by the investigator Has been told by a doctor to have a heart condition and recommended only medically supervised activity DONOR: medically fit to and willing to donate Presence or recent history of other concurrent cancers, with the following exceptions: \r\n* Participants with completely treated basal or squamous skin cancers can be included in the study if their physicians deem that they are medically stable\r\n* Participants with completely treated in situ carcinoma of the breast or cervix may be included in the study if they have not had chemotherapy within the past month and their physicians deem that they are medically stable\r\n* Participants with pre-cancerous lesions in the colon can be included in the study if they have not had chemotherapy within the past month and their physicians deem that they are medically stable Patients for whom an MRI of the spine is medically contraindicated Women who are already participating in a formal or medically prescribed weight management program Patients with ovarian cancer not medically fit for diagnostic laparoscopy prior to initiation of therapy Patients who are medically fit for surgery defined as the following Completed medically indicated physical therapy Medically ineligible as a result of screening questions Medically eligible to receive varenicline Medically at risk in the judgment of the study physician Patients who are medically unfit to undergo surgical resection Medically stable as judged by patients physician Patients who are medically unstable, terminally ill, or whose clinical course is unpredictable Patients who are medically unstable, terminally ill, or whose clinical course is unpredictable Medically stable as judged by patients physician SUB-STUDY I: Patients considered as candidates for and medically fit to undergo prostatectomy Medically stable as judged by patients physician. PATIENT: Be medically stable Patients considered as candidates for and medically fit to undergo radiation and ADT Be medically stable. Patients who are medically unstable, patients who are seriously or terminally ill, and patients whose clinical course is unpredictable. Be medically stable Patients who are medically unstable Medically unstable Be medically stable Patients who are medically unstable, patients who are seriously or terminally ill, and patients whose clinical course is unpredictable Be medically stable