Significant bleeding disorder; Active bleeding disorder in the past months. History of a bleeding disorder History of significant bleeding disorder unrelated to cancer history of bleeding disorder History of significant bleeding disorder unrelated to chronic myelogenous leukemia (CML), including:\r\n* Diagnosed congenital bleeding disorders (e.g. von Willebrands disease) \r\n* Diagnosed acquired bleeding disorder within one year (e.g. acquired anti-factor VII antibodies) History of significant bleeding disorder unrelated to cancer, including:\r\n* Diagnosed congenital bleeding disorders (e.g., von Willebrands disease)\r\n* Diagnosed acquired bleeding disorder within one year (e.g., acquired anti-factor VIII antibodies)\r\n* Ongoing or recent (=< months) significant gastrointestinal bleeding Evidence of active bleeding or bleeding disorder History of significant bleeding disorder unrelated to cancer, including: \r\n* Diagnosed congenital bleeding disorders (e.g., von Willebrands disease) \r\n* Diagnosed acquired bleeding disorder within one year (e.g., acquired anti-factor VIII antibodies) \r\n* History of gastrointestinal (GI) bleeding within one year History of significant bleeding disorder unrelated to cancer, including: ) diagnosed congenital bleeding disorders (e.g., von Willebrands disease); ) diagnosed acquired bleeding disorder within one year (e.g., acquired anti-factor VIII antibodies) of screening visit; ) history of gastrointestinal (GI) bleeding within months of screening visit requiring >= units packed red blood cells. History of significant bleeding disorder unrelated to cancer, including: diagnosed congenital bleeding disorders (e.g., von Willebrands disease); diagnosed acquired bleeding disorder within one year (e.g., acquired anti-factor VIII antibodies). Evidence or history of bleeding disorder. History of significant bleeding disorder unrelated to cancer, including: diagnosed congenital bleeding disorders (e.g., von Willebrands disease, diagnosed acquired bleeding disorder within one year (e.g., acquired anti-factor VIII antibodies, or ongoing or recent (=< months) significant gastrointestinal bleeding History of significant bleeding disorder unrelated to cancer, including: Diagnosed congenital bleeding disorders (e.g., von Willebrands disease); and diagnosed acquired bleeding disorder within one year (e.g., acquired anti-factor VIII antibodies). Has a bleeding disorder or a screening platelet count < /L. History of clinically significant bleeding or known platelet or coagulation disorder Anti-coagulant therapy, bleeding or clotting disorder History of significant congenital or acquired bleeding disorder unrelated to cancer Documented or known bleeding disorder. Have a significant bleeding disorder or vasculitis or had a Grade ? bleeding episode within weeks prior to enrollment. Any history of significant bleeding disorder unrelated to cancer, including any congenital bleeding disorder or any acquired bleeding disorder within one year of start of study Patients meeting the following criteria are not eligible unless cleared by cardiology: \r\n* Uncontrolled angina within months\r\n* Diagnosed or suspected congenital long QT syndrome\r\n* Any history of clinically significant ventricular arrhythmias (such as ventricular tachycardia, ventricular fibrillation, or Torsades de pointes)\r\n* Prolonged corrected QT (QTc) interval on pre-entry electrocardiogram (> msec) \r\n* History of significant bleeding disorder unrelated to cancer, including: \r\n** Diagnosed congenital bleeding disorders (e.g., von Willebrands disease) \r\n** Diagnosed acquired bleeding disorder within one year (e.g., acquired anti-factor VIII antibodies) Documented or known bleeding disorder. Patients with history of clinically significant bleeding disorder Documented or known bleeding disorder. History of significant bleeding disorder unrelated to cancer, including:\r\n* Diagnosed congenital bleeding disorders (e.g., von Willebrands disease)\r\n* Diagnosed acquired bleeding disorder within one year (e.g., acquired anti-factor VIII antibodies) History of significant bleeding disorder unrelated to cancer History of significant bleeding disorder unrelated to cancer, including:\r\n* Diagnosed congenital bleeding disorders (e.g., von Willebrands disease)\r\n* Diagnosed acquired bleeding disorder within one year (e.g., acquired anti-factor VIII antibodies)\r\n* Ongoing or recent (=< months) significant gastrointestinal bleeding History of significant bleeding disorder unrelated to cancer, including diagnosed congenital bleeding disorders (e.g., von Willebrands disease), or diagnosed acquired bleeding disorders within one year (e.g., acquired anti-factor VIII antibodies) Patients with history of bleeding disorder or with history of spontaneous haemorrhage tumour History of significant bleeding disorder unrelated to cancer, including:\r\n* Diagnosed congenital bleeding disorders (e.g., von Willebrand's disease)\r\n* Diagnosed acquired bleeding disorder within one year (e.g., acquired anti-factor VIII antibodies) History of significant bleeding disorder or uncontrolled seizures Subject has an underlying bleeding disorder Have active uncontrolled bleeding or a known bleeding disorder History or evidence of bleeding disorder or active clinically significant bleeding requiring medical intervention. History of significant congenital or acquired bleeding disorder unrelated to cancer Active bleeding disorder or other history of significant bleeding episodes within days before study entry History of significant bleeding disorder unrelated to cancer, including diagnosed congenital bleeding disorders (e.g., von Willebrands disease) The participant has a significant bleeding disorder or vasculitis. Has active bleeding disorder or other history of significant bleeding episodes within days of randomization. History of significant bleeding disorder unrelated to cancer, including:\r\n* Diagnosed congenital bleeding disorders (e.g., von Willebrands disease)\r\n* Diagnosed acquired bleeding disorder within one year (e.g., acquired anti-factor VIII antibodies) Patients with an uncontrolled bleeding disorder History of significant congenital or acquired bleeding disorder History of significant congenital or acquired bleeding disorder unrelated to cancer Patient has a bleeding disorder or a screening platelet count