Prior radiotherapy to the abdomen or pelvis Prior radiotherapy to the upper abdomen Prior radiation therapy to the abdomen that would overlap with treatment field Prior radiation treatment to the upper abdomen History of prior radiation therapy to the upper abdomen Previous radiation therapy to the lungs and/or to the upper abdomen Prior radiotherapy to the upper abdomen or radioembolization of the liver Prior radiotherapy to the pelvis (or abdomen if para-aortic nodes are involved) No prior radiotherapy to the upper abdomen Prior radiation therapy to the upper abdomen or liver Any prior radiotherapy to the pelvis or abdomen Prior radiation therapy to the abdomen or pelvis Prior radiation to the pelvis or abdomen in the metastatic or locally advanced setting. Metastatic disease outside the confines of the abdomen and pelvis (such as lung, bone, brain) Prior radiotherapy to the pelvis or abdomen Received or will receive radiation therapy to the abdomen or pelvis in the week prior to study drug administration and/or during the course of the study Previous radiotherapy delivered to the upper abdomen. Any history of metastatic TCC; subjects with suspected malignant lymphadenopathy in the abdomen or pelvis are not allowed Receipt of radiation to the abdomen for any reason during the planned -day treatment time Acute abdomen Ongoing radiation induced diarrhea or constipation or planned radiotherapy to the abdomen or pelvis while on study Prior radiotherapy to the upper abdomen/liver Has received or will receive total body irradiation of radiation therapy to the abdomen or pelvis in the week prior to Treatment Day and/or during the diary reporting period ( hours following initiation of chemotherapy) Patient must not have undergone major surgery or radiotherapy to the pelvis or abdomen within previous weeks Radiotherapy to the abdomen or pelvis within months of the screening visit Any and all primary disease sites in the abdomen and pelvis will be allowed Patients must have no previous radiation to the abdomen