Creatinine =< . x upper normal institutional limits (UNL) OR creatinine clearance >= mL/min based either on Cockcroft-Gault estimate or based on urine collection ( or hour) Calculated (Calc.) creatinine clearance >= mL/min; calculated utilizing the Cockcroft-Gault formula or -hour urine collection RE-REGISTRATION ELIGIBILITY CRITERIA (STEP ): Calc. creatinine clearance >= mL/min\r\n* Calculated utilizing the Cockcroft-Gault formula or -hour urine collection Serum creatinine =< . mg/dl or calculated creatinine clearance (CC) >= ml/min determined by -hour urine collection or estimated by Cockcroft-Gault formula, within days prior to registration Estimated creatinine clearance >= mL/min according to the Cockcroft-Gault formula or by -hour urine collection for creatinine clearance or according to local institutional standard Creatinine clearance >= mL/min per hour urine collection or the Cockcroft-Gault formula Participants must have creatinine clearance greater than or equal to mL/min as measured by -hour urine or estimated by the Cockcroft-Gault formula. Creatinine clearance >= mL/min based either on Cockcroft-Gault estimate or based on urine collection ( or hour) Creatinine clearance of ? mL/min as estimated by the Cockcroft-Gault equation or by hour urine collection. Serum creatinine clearance > mL/min by the Cockcroft-Gault formula (Cockcroft and Gault ) or by -hour urine collection for determination of creatinine clearance Renal status: Creatinine clearance ? mL/min based on Cockcroft-Gault estimate or based on urine collection ( or hour); Glomerular filtration rate > ml/min/.m^ as estimated by the Cockcroft-Gault formula or creatinine clearance > ml/min as determined by -hour urine collection Creatinine clearance >= mL/min calculated by Cockcroft-Gault or hour collection Estimated creatinine clearance greater than mL/min determined by -hour urine sampling or by the Cockcroft- Gault formula Adequate renal function defined by an estimated creatinine clearance > mL/min according to the Cockcroft-Gault formula or be measure for creatinine clearance from hour urine collection. Should be performed within days of treatment initiation: serum creatinine clearance (CL) > mL/min by the Cockcroft-Gault formula (Cockcroft and Gault ) or by -hour urine collection for determination of creatinine clearance Subject must have adequate renal function as demonstrated by a calculated creatinine clearance ? mL/min; determined via urine collection for -hour creatinine clearance or by the Cockcroft Gault formula An estimated creatinine clearance > mL/min according to the Cockcroft-Gault formula or be measure for creatinine clearance from -hour urine collection. Creatinine clearance >= mL/min based either on Cockcroft-Gault estimate or based on urine collection ( or hour). Creatinine clearance >= ml/min as determined by -hour collection or estimated by the Cockcroft-Gault formula (measured within days of registration) Renal function, as follows: Dose Escalation, NSCLC, Ovarian, and CPI Treated Expansion Cohorts: creatinine clearance of ? mL/min by the Cockcroft-Gault equation or as measured by hour urine collection. For the Renal Insufficiency Expansion Cohort: creatinine clearance estimate ? ml/min and < ml/min by Cockcroft-Gault equation or as measured by hour urine collection. Obtained within days prior to registration: serum creatinine < . mg/dl or creatinine clearance (CC) >= ml/min determined by -hour collection or estimated by Cockcroft-Gault formula Serum creatinine clearance (CL) =< . x ULN or creatinine clearance > mL/min by the Cockcroft-Gault formula (Cockcroft and Gault ) or by -hour urine collection for determination of creatinine clearance Adequate renal function defined by an estimated creatinine clearance > mL/min according to the Cockcroft-Gault formula or by measure of creatinine clearance from hour urine collection Creatinine =< . x ULN and requires creatinine clearance (CrCl) >= ml/min (per -hour urine collection or calculated according to the Cockcroft-Gault formula) Serum creatinine clearance (CL) > mL/min by the Cockcroft-Gault formula (Cockcroft and Gault ) or by -hour urine collection for determination of creatinine clearance Creatinine clearance (CL) > mL/min by the Cockcroft-Gault formula (Cockcroft and Gault ) or by -hour urine collection for determination of creatinine clearance Serum creatinine =< mg/dl or creatinine clearance (CC) >= ml/min determined by hour collection or estimated by Cockcroft-Gault formula Serum creatinine clearance (CL) > mL/min by the Cockcroft-Gault formula or by -hour urine collection for determination of creatinine clearance Serum creatinine clearance (CL) > mL/min by the Cockcroft-Gault formula (Cockcroft and Gault ) or by -hour urine collection for determination of creatinine clearance. Creatinine clearance (CrCl) >= mL/min., as measured by a -hour urine collection, or estimated by the Cockcroft and Gault formula No more than days prior to registration: Serum creatinine clearance > mL/min by the Cockcroft-Gault formula or by -hour urine collection for determination of creatinine clearance Serum creatinine clearance (CL) > mL/min by the Cockcroft-Gault formula (Cockcroft and Gault ) or by -hour urine collection for determination of creatinine clearance Serum creatinine clearance (CL) > mL/min by the Cockcroft-Gault formula or by -hour urine collection for determination of creatinine clearance Creatinine clearance (CL) > mL/min by the Cockcroft-Gault formula (Cockcroft and Gault ) or by -hour urine collection for determination of creatinine clearance Serum creatinine clearance (CL) > mL/min by the Cockcroft-Gault formula (Cockcroft and Gault ) or by -hour urine collection for determination of creatinine clearance Serum creatinine clearance (CL) > mL/min by the Cockcroft-Gault formula (Cockcroft and Gault ) or by -hour urine collection for determination of creatinine clearance Serum creatinine clearance (CL) > mL/min by the Cockcroft-Gault formula or by -hour urine collection for determination of creatinine clearance. Serum creatinine level =< . x ULN and clearance (CL) > mL/min by the Cockcroft-Gault formula (Cockcroft and Gault ) or by -hour urine collection for determination of creatinine clearance within days prior to study registration Creatinine clearance >= mL/min based either on Cockroft-Gault estimate or based on urine collection ( or hour) To be performed within business days prior to day : Creatinine clearance of >= mL/min per the Cockcroft-Gault formula and/or hour (hr) urine analysis as needed Serum creatinine clearance (CL) > mL/min by the Cockcroft-Gault formula or by -hour urine collection for determination of creatinine clearance Creatinine clearance >= mL/min based either on Cockcroft-Gault estimate or based on urine collection ( or hour) Serum creatinine clearance (CL) > mL/min by the Cockcroft-Gault formula or by -hour urine collection for determination of creatinine clearance Serum creatinine clearance (CL) > mL/min by the Cockcroft-Gault formula or by -hour urine collection for determination of creatinine clearance Serum creatinine clearance (CL) > mL/min by the Cockcroft-Gault formula or by -hour urine collection for determination of creatinine clearance Creatinine > . x ULN, or a creatinine clearance of < ml/min as calculated by Cockcroft-Gault or by -hour urine collection Within days prior to registration: Serum creatinine clearance (CL) > mL/min by the Cockcroft-Gault formula (Cockcroft and Gault ) or by -hour urine collection for determination of creatinine clearance Creatinine clearance >= mL/min based either on Cockroft-Gault estimate or based on urine collection ( or hour) Serum creatinine clearance (CL) > mL/min by the Cockcroft-Gault formula or by -hour urine collection for determination of creatinine Renal: creatinine < . X ULN or creatinine clearance >= mL/min based either on Cockcroft-Gault estimate or based on urine collection ( or hour) Serum creatinine clearance (CL) > mL/min by the Cockcroft-Gault formula or by -hour urine collection for determination of creatinine clearance Creatinine clearance >= mL/min based either on Cockcroft-Gault estimate from serum creatinine or based on urine collection ( or hour) Serum creatinine clearance (CL) > mL/min by the Cockcroft-Gault formula (Cockcroft and Gault ) or by -hour urine collection for determination of creatinine clearance Serum creatinine within the institutional normal limits, OR if the creatinine is elevated: creatinine clearance (CrCl) >= mL/min., as measured by a -hour urine collection, or estimated by the Cockcroft and Gault formula Serum creatinine clearance < ml/min on the basis of either -hour urine collection or the glomerate filtration rate estimated by Cockraft-Gault equation Within days of first dose of study drug administration: Serum creatinine: creatinine clearance (CL) > mL/min by the Cockcroft-Gault formula or by -hour urine collection for determination of creatinine clearance Calculated creatinine clearance (CrCl) >= mL/min per hour urine collection or the Cockcroft-Gault formula Calculated creatinine clearance (CrCl) >= mL/min per -hour urine collection or the Cockcroft-Gault formula Either an estimated creatinine clearance value of >= mL/min as determined by the Cockcroft-Gault formula or a creatinine clearance value of >= mL/min based on a hour urine collection Adequate renal function, as defined by creatinine clearance of ? ml/min (as estimated by the Cockcroft-Gault equation or as measured by nuclear medicine scan or hour urine collection). Creatinine clearance (CC) >= ml/min within weeks prior to registration determined by -hour collection or estimated by Cockcroft-Gault formula Obtained =< days prior to randomization:\r\nCreatinine =< . mg/dL OR calculated creatinine clearance of >= ml/min by either the Cockcroft-Gault formula or -hours urine collection analysis Creatinine within normal institutional limits OR creatinine clearance > mL/min by the Cockcroft-Gault formula or by -hour urine collection for determination of creatinine clearance Adequate renal function within weeks of study entry, defined as serum creatinine less than or equal to . x ULN for the lab. (If creatinine is .-. x ULN, the creatinine clearance should be greater than mL/min per Cockcroft-Gault formula (Cockcroft-Gault ), or by -hour urine collection for determination of creatinine clearance.) To be performed within days prior to day of protocol therapy: creatinine clearance of >= mL/min per hour urine or the Cockcroft-Gault formula Measured creatinine clearance (CL) >= mL/min or calculated creatinine CL ? mL/min by the Cockcroft-Gault formula (Cockcroft and Gault ) or by -hour urine collection for determination of creatinine clearance Serum creatinine clearance (CL) > mL/min by the Cockcroft-Gault formula (Cockcroft and Gault ) or by -hour urine collection for determination of creatinine clearance within weeks prior to initial treatment Within days prior to day of protocol therapy unless otherwise stated: Creatinine clearance of >= mL/min per hour urine test or the Cockcroft-Gault formula Serum creatinine clearance (CL) > mL/min by the Cockcroft-Gault formula or by -hour urine collection for determination of creatinine clearance. Serum creatinine clearance (CL) > mL/min by the Cockcroft-Gault formula or by -hour urine collection for determination of creatinine clearance Creatinine clearance >= mL/min (calculated by the Cockcroft-Gault or via -hour urine collection) Within days prior to step registration: Measured creatinine clearance (CL) > mL/min or calculated creatinine CL > mL/min by the Cockcroft-Gault formula (Cockcroft and Gault ) or by -hour urine collection for determination of creatinine clearance Creatinine clearance (CrCl) >= ml/min within days prior to registration as determined by -hour collection or estimated by Cockcroft-Gault formula Serum creatinine institutional ULN within days prior to registration or; creatinine clearance (CC) >= ml/min within days prior to registration determined by -hour collection or estimated by Cockcroft-Gault formula Obtained within days (or as stipulated) prior to study drug (treatment) administration: creatinine clearance ? ml/min (calculated by the Cockcroft-Gault Equation or per -hour urine collection) Creatinine clearance > mL/min/. m^ by either Cockcroft-Gault formula or -hour urine collection analysis Serum creatinine clearance (CL) > mL/min by the Cockcroft-Gault formula or by -hour urine collection for determination of creatinine clearance Serum creatinine < x institutional ULN or creatinine clearance > ml/min as determined by hour collection or estimated by Cockcroft-Gault formula Creatinine clearance of >= mL/min per hour urine collection or the Cockcroft-Gault formula Serum creatinine =< . mg/dl or creatinine clearance (CC) >= ml/min determined by -hour collection or estimated by Cockcroft-Gault formula, within days prior to registration Creatinine clearance >= mL/min by either Cockcroft-Gault formulate or hour (hr) urine collection analysis Creatinine clearance >= ml/min within weeks prior to registration as determined by -hour collection or estimated by Cockcroft-Gault formula Creatinine < . mg/dL or within normal institutional limits within days prior to registration; Note: if neither criteria is met, the creatinine clearance must be > mL/min/. m^ per either the Cockcroft-Gault equation, Jeliffe method, or - or -hour urine collection Serum creatinine < x institutional ULN or; creatinine clearance (CC) >= mL/min determined by -hour collection or estimated by Cockcroft-Gault formula Creatinine clearance (CrCL) >= mL/min, measured by a -hour urine collection or estimated by the Cockcroft and Gault formula within days prior to registration Creatinine clearance >= mL/min/. m^ by the Cockcroft-Gault formula or by -hour urine collection for determination of creatinine clearance Creatinine clearance (estimated) >= cc/min by Cockcroft Gault or hour urine Patients must have a calculated serum creatinine clearance > mL/min using Cockcroft-Gault calculation or based on -hour urine collection performed within days prior to treatment Serum creatinine clearance (CL) > mL/min by the Cockcroft-Gault formula or by -hour urine collection for determination of creatinine clearance, obtained within days prior to first treatment Serum creatinine . ULN or calculated creatinine clearance (per the Cockcroft-Gault formula or equivalent and/or -hour urine collection) milliliters/minute (mL/min). Creatinine clearance >= ml/min as determined by -hour collection or estimated by the Cockcroft-Gault formula Serum creatinine =< . mg/dl or creatinine clearance (CC) >= ml/min determined by -hour collection or estimated by Cockcroft-Gault formula within days prior to registration Creatinine =< . mg/dL OR creatinine clearance >= mL/min as determined by the Cockcroft-Gault equation or a hour urine collection Creatinine within normal institutional limits OR creatinine clearance > mL/min per hour (h) urine collection or calculated according to the Cockcroft-Gault formula Calculated creatinine clearance > mL/min by the Cockcroft-Gault formula (Cockcroft and Gault ) or by -hour urine collection for determination of creatinine clearance Serum creatinine clearance (CL) > mL/min by the Cockcroft-Gault formula (Cockcroft and Gault ) or by -hour urine collection for determination of creatinine clearance Serum creatinine clearance > mL/min by the Cockcroft-Gault formula or by -hour urine collection for determination of creatinine clearance Serum creatinine clearance (CL) >= mL/min by the Cockcroft-Gault formula or by -hour urine collection for determination of creatinine clearance Calculated by Cockcroft-Gault or measured by hour urine creatinine clearance >= mL/minn Renal function: A calculated creatinine clearance value of ? mL/min as determined by the Cockcroft Gault formula or a creatinine clearance value of ? mL/min based on a -hour urine collection; Cr Cl ? mL/min (as determined by the Cockcroft-Gault equation or by -hour urine collection) Creatinine =< . x institutional upper limits of normal or creatinine clearance of > mL/min per hour (h) urine collection or calculated according to the Cockcroft-Gault formula Creatinine clearance of > mL/min per hour urine collection of the Cockcroft-Gault formula Serum creatinine clearance (CL) > mL/min by the Cockcroft-Gault formula or by -hour urine collection for determination of creatinine clearance Creatinine clearance =< mL/min based either on Cockroft-Gault estimate or based on urine collection ( or hour) Calculated creatinine clearance > mL/min by the Cockcroft-Gault formula (Cockcroft and Gault ) or by -hour urine collection for determination of creatinine clearance Creatinine clearance ? mL/min based on Cockcroft-Gault estimate or based on a - or -hour urine collection.