For subjects planned to potentially receive bevacizumab, they have no evidence of uncontrolled hypertension (defined as a blood pressure of ? mm Hg systolic and/or ? mm Hg diastolic on medication) or active GI perforation Systolic blood pressure (BP) =< mg HG Uncontrolled hypertension (diastolic blood pressure > mm Hg; systolic > mm Hg); patients with hypertension should be under treatment on study entry to effect blood pressure control Uncontrolled hypertension (i.e., systolic blood pressure > mm Hg, diastolic blood pressure > mm Hg). Use of antihypertensive agents to control hypertension before week , day is allowed. No uncontrolled hypertension (systolic blood pressure greater than mm Hg or diastolic blood pressure greater than mm Hg) The patient has uncontrolled hypertension defined as a blood pressure measurement greater than mm Hg systolic or mm Hg diastolic with medication Blood pressure less than / mm Hg with or without anti-hypertensive therapy\r\n* Patients may be rescreened after initial ineligibility if due to elevated blood pressure, if adequately medically managed within approximately days Has inadequately controlled hypertension (defined as systolic blood pressure greater than mm Hg or diastolic blood pressure greater than mm Hg); the use of antihypertensive medications to control blood pressure is permitted; retesting is permitted Uncontrolled hypertension (that is, either systolic blood pressure > millimeter of mercury [mm Hg] or diastolic blood pressure > mm Hg). Systolic blood pressure >mm Hg or diastolic blood pressure > mm Hg No evidence of preexisting uncontrolled hypertension as documented by baseline blood pressure readings taken at least minutes apart; the baseline systolic blood pressure readings must be =< mm Hg, and the baseline diastolic blood pressure readings must be =< mm Hg; patients whose hypertension is controlled by antihypertensive therapies are eligible Systolic blood pressure =< mg Hg or diastolic pressure =< mg Hg within days prior to study registration Poorly controlled arterial hypertension (systolic > mm Hg and/or diastolic > mm Hg), with or without antihypertensive medication; patients presenting with high blood pressure are eligible if the dose or adjustment of anti-hypertensive lowers blood pressure to meet the inclusion criteria of the study Uncontrolled hypertension (systolic blood pressure > mm Hg and diastolic blood pressure of > mm Hg which cannot be controlled by anti-hypertensive therapy), congestive heart failure (CHF), or other major medical illness Clinically significant, uncontrolled intercurrent illness including, but not limited to:\r\n* Symptomatic or active infection\r\n* Uncontrolled hypertension (diastolic blood pressure > mm Hg; systolic > mm Hg); patients with hypertension should be under treatment on study entry to effect blood pressure control\r\n* Psychiatric illness/social situations that would limit compliance with study requirements Systolic blood pressure =< mg Hg or diastolic pressure =< mg Hg within days prior to registration Hypotension as indicated by systolic blood pressure < millimeters of mercury (mm Hg) at screening Uncontrolled high blood pressure (ie, systolic blood pressure > mm Hg, diastolic blood pressure > mm Hg) Uncontrolled hypertension defined as an average systolic blood pressure of >= mm Hg or an average diastolic pressure >= mm Hg Have diastolic blood pressure of > mm Hg resting at baseline despite medication. Systolic blood pressure =< mm Hg at baseline, diastolic =< mm Hg at baseline within weeks prior to start of any therapy Treatment refractory hypertension defined as a blood pressure of systolic > mmHg and/or diastolic > mm Hg which cannot be controlled by anti-hypertensive therapy Baseline blood pressure must be adequately controlled with or without antihypertensive medications prior to enrollment (systolic =< mm Hg, diastolic =< mm Hg) Uncontrolled hypertension, defined as systolic blood pressure > mm Hg or diastolic blood pressure > mm Hg, despite optimal medical management Has poorly controlled hypertension defined as systolic blood pressure (SBP) ? mm Hg and/or diastolic blood pressure (DBP) ? mm Hg. Uncontrolled hypertension (ie, either systolic blood pressure greater than [>] millimeter of mercury [mm Hg]; diastolic blood pressure > mm Hg). Use of anti-hypertensive agents to control hypertension before Cycle Day is allowed; Have an uncontrolled arterial hypertension with systolic blood pressure ? or diastolic blood pressure ? millimeters of mercury (mm Hg) despite standard medical management. Patients who are ? years of age must have a systolic blood pressure that is > or diastolic < mm of Hg at the time of enrollment Treatment refractory hypertension systolic blood pressure (SBP) > mm Hg and/or diastolic blood pressure (DBP) > mm Hg Clinically significant cardiac disease such as history of ventricular arrhythmia requiring therapy, currently uncontrolled hypertension (defined as persistent systolic blood pressure > mm Hg and/or diastolic blood pressure > mm Hg on antihypertensive medications), or any history of symptomatic CHF Has inadequately controlled hypertension (defined as systolic blood pressure greater than mm Hg or diastolic blood pressure greater than mm Hg); the use of antihypertensive medications to control blood pressure is permitted Clinically uncontrolled hypertension (diastolic blood pressure > mm mercury [Hg]; systolic > mm Hg); Note: patients with hypertension should be undergoing treatment at study entry for blood pressure control Uncontrolled hypertension (defined as blood pressure > / mm Hg not controlled with anti-hypertensives) Uncontrolled high blood pressure (i.e., systolic blood pressure > mm Hg, diastolic blood pressure > mm Hg) Patients must not have uncontrolled hypertension (defined as systolic blood pressure > mm Hg and/or diastolic blood pressure > mm Hg which cannot be controlled by anti-hypertensive therapy) Systolic blood pressure > mm/Hg Patients with a history of hypertension must have blood pressure that is adequately controlled on antihypertensives; (< / mm Hg) Patients must have a systolic blood pressure =< mm Hg and diastolic blood pressure =< mm Hg (the use of antihypertensive medications to achieve these goals is allowed) Uncontrolled high blood pressure (systolic blood pressure > mm Hg Uncontrolled systemic vascular hypertension (systolic blood pressure > mm Hg, diastolic blood pressure > mm Hg on medication) Clinically significant cardio-vascular disease, such as ventricular arrhythmia requiring therapy, uncontrolled hypertension (defined as persistent systolic blood pressure > mm Hg and/or diastolic blood pressure > mm Hg on antihypertensive medications), or any history of symptomatic congestive heart failure (CHF) Blood pressure\r\n* Systolic blood pressure (SBP) < mm/Hg\r\n* Diastolic blood pressure (DBP) < mm/Hg Patients must not have uncontrolled hypertension as defined by systolic blood pressure >= mm Hg or diastolic blood pressure >= mm Hg; patient may be eligible once hypertension is adequately controlled with medications Hypotension as indicated by systolic blood pressure < millimeters of mercury (mm Hg) at screening; Uncontrolled hypertension defined by a systolic blood pressure (SBP) > and/or a diastolic blood pressure (DBP) > mm Hg with or without anti-hypertensive medication Uncontrolled hypertension defined by a systolic blood pressure (SBP) >= mm Hg and/or diastolic blood pressure (DBP) >= mm Hg, with or without anti-hypertensive medication Hypertension: systolic blood pressure (SBP) > or diastolic blood pressure (DBP) > mm mercury (Hg) despite antihypertensive medications Uncontrolled hypertension, defined as systolic blood pressure > mm Hg or diastolic blood pressure > mm Hg, despite medical management Uncontrolled glaucoma with intraocular pressure greater than (>) millimeters of mercury (mm Hg) Treatment refractory hypertension defined as a blood pressure of systolic > mmHg and/or diastolic > mm Hg which cannot be controlled by anti-hypertensive therapy The patient has uncontrolled hypertension despite adequate therapy (ie, systolic blood pressure higher than mm Hg or diastolic blood pressure higher than mm Hg found on separate occasions separated by week). Blood pressure > / mm/Hg on average ( separate readings taken at screening visit in a relaxed clinical environment and averaged) Supine systolic blood pressure < mm Hg, or symptomatic orthostatic hypotension, or a decrease in systolic blood pressure upon standing of > mm Hg despite medical management (e.g. midodrine, fludrocortisones) No history of uncontrolled hypertension (blood pressure > / mm Hg despite anti-hypertensive medication) Hypertension not controlled by medical therapy (systolic blood pressure greater than mm Hg or diastolic blood pressure greater than mm Hg) Intraocular pressure greater than mm Hg as measured by tonography. Treatment refractory hypertension defined as a blood pressure of systolic> mmHg and/or diastolic > mm Hg which cannot be controlled by anti-hypertensive therapy Clinically significant hypotension (systolic blood pressure [SBP] < mm HG or symptomatic) Systolic blood pressure =< mg Hg or diastolic pressure =< mg Hg within days prior to registration Patients must have a systolic blood pressure >= mm Hg within days prior to registration Patients with systolic blood pressure < mm Hg Low resting systolic blood pressure: < mm hemoglobin (Hg) Resting systolic blood pressure (SBP) > mm HG and/or diastolic blood pressure (DBP) > mm HG, or resting heart rate > beats per minute at the baseline assessment No history of hypotension (defined as resting systolic blood pressure of < mm Hg or diastolic blood pressure of < mm Hg) or orthostasis (defined as drop in systolic blood pressure of > mm Hg or increase in HR of > from supine to standing position) Uncontrolled hypertension (blood pressure > / mm Hg) Participants must not have blood pressure < mm Hg systolic Have at least one other component of metabolic syndrome reported below:\r\n* Elevated triglycerides (>= mg/dL [. mmol/L]) or on drug treatment for elevated triglycerides \r\n* Reduced high-density lipoprotein-cholesterol (HDL-C) (< mg/dL [. mmol/L]) or on drug treatment for reduced HDL-C\r\n* Elevated blood pressure (>= mm mercury [Hg] systolic blood pressure or >= mm Hg diastolic blood pressure) or on antihypertensive drug treatment in a patient with a history of hypertension\r\n* Elevated fasting glucose (>= mg/dL) Hypertension not controlled by medical therapy (systolic blood pressure greater than mm mercury [Hg] or diastolic blood pressure greater than mm Hg) Poorly controlled hypertension, defined as systolic blood pressure at study entry greater than mm Hg or diastolic blood pressure greater than mm Hg; the addition of anti-hypertensives to control blood pressure is allowed Poorly controlled hypertension, defined as systolic blood pressure at study entry greater than mm Hg or diastolic blood pressure greater than mm Hg; the addition of anti-hypertensives to control blood pressure is allowed Uncontrolled hypertension defined as persistent systolic blood pressure > mm Hg, or diastolic blood pressure > mm Hg; subjects with known HTN should be stable within these ranges while under pharmaceutical therapy. Subjects with uncontrolled hypertension defined as persistent systolic blood pressure > mm Hg, or diastolic blood pressure > mm Hg; those subjects with known HTN should be stable within these ranges while under pharmaceutical therapy The participant has uncontrolled hypertension defined as systolic blood pressure greater than or equal to millimeters of mercury (mm Hg) or diastolic blood pressure greater than or equal to mm Hg. The participant has uncontrolled hypertension defined as systolic blood pressure greater than or equal to millimeters of mercury (mm Hg) or diastolic blood pressure greater than or equal to mm Hg. Subjects with uncontrolled hypertension defined as persistent systolic blood pressure > mm Hg, or diastolic blood pressure > mm Hg; those subjects with known HTN should be under these values while under pharmaceutical therapy