Evidence of bleeding diathesis or clinically significant coagulopathy Patients with uncontrolled coagulopathy or bleeding disorder are not eligible Known bleeding diathesis or coagulopathy Evidence or history of bleeding diathesis or coagulopathy Participants with active bleeding disorder/coagulopathy Evidence or history of bleeding diathesis or coagulopathy History of bleeding diathesis or coagulopathy Evidence of bleeding diathesis or clinically significant coagulopathy. Bleeding disorder/coagulopathy Evidence or history of bleeding diathesis or coagulopathy Evidence or history of bleeding diathesis or coagulopathy Evidence or history of bleeding diathesis or coagulopathy History of tumor-related or other serious hemorrhage, bleeding diathesis, or underlying coagulopathy No coagulopathy or bleeding diathesis Evidence of bleeding diathesis or coagulopathy Evidence of bleeding diathesis or coagulopathy Uncontrolled coagulopathy or bleeding disorder Clinical evidence of bleeding diathesis or coagulopathy Patients with uncontrolled coagulopathy or bleeding disorder Evidence of bleeding diathesis or coagulopathy Patients who have clinical history of coagulopathy, bleeding diathesis or thrombosis within the past year Evidence or history of bleeding diathesis or coagulopathy Evidence or history of bleeding diathesis or coagulopathy Inherited bleeding diathesis or coagulopathy with the risk of bleeding Patients with uncontrolled coagulopathy or bleeding disorder REGORAFENIB EXCLUSION CRITERIA: Evidence or history of bleeding diathesis or coagulopathy History of or genetic predisposition to a bleeding diathesis or coagulopathy Evidence of bleeding diathesis or coagulopathy Evidence of bleeding diathesis or coagulopathy Patients who have clinical history of coagulopathy, bleeding diathesis or thrombosis within the past year Evidence of clinically significant bleeding diathesis or underlying coagulopathy, non-healing wound The subject has inherited bleeding diathesis or coagulopathy with the risk of bleeding Evidence of bleeding diathesis, coagulopathy as documented by an elevated PT, PTT or bleeding time Clinical evidence of bleeding diathesis or coagulopathy History or evidence of inherited bleeding diathesis or coagulopathy with a risk of bleeding Evidence or history of bleeding diathesis or coagulopathy Evidence of bleeding diathesis or coagulopathy (including clinically significant hemoptysis) Evidence of active bleeding diathesis or coagulopathy\r\n* For the NSCLC expanded cohort only: history of blood tinged sputum allowed Patients with uncontrolled coagulopathy or bleeding disorder History of abnormal bleeding and coagulopathy Bleeding or evidence or history of clinically significant bleeding diathesis or coagulopathy within the last months Clinically significant bleeding diathesis or coagulopathy History or evidence of inherited bleeding diathesis or coagulopathy with a risk of bleeding Evidence or history of bleeding diathesis or coagulopathy Patients with a known coagulopathy or bleeding diathesis or require the use of systemic anticoagulant medication are not eligible Evidence of bleeding diathesis or coagulopathy Evidence or history of bleeding diathesis or coagulopathy Evidence of bleeding diathesis or coagulopathy Patient has a coagulopathy or bleeding disorder Evidence or history of bleeding diathesis or coagulopathy Patients must not have a known bleeding diathesis or coagulopathy Evidence of bleeding diathesis or coagulopathy Evidence or history of bleeding diathesis or coagulopathy Evidence or history of bleeding diathesis or coagulopathy No significant bleeding within the past months; no bleeding diathesis or coagulopathy Evidence of bleeding diathesis or coagulopathy. Evidence of bleeding diathesis or coagulopathy Patients are excluded if they have evidence of bleeding diathesis or coagulopathy Evidence of bleeding diathesis or coagulopathy Known bleeding disorder or coagulopathy Evidence or history of bleeding diathesis or coagulopathy Evidence or history of bleeding diathesis or coagulopathy History or evidence of inherited bleeding diathesis or coagulopathy with the risk of bleeding Evidence or history of bleeding diathesis or coagulopathy. Evidence or history of bleeding diathesis or coagulopathy Evidence of bleeding diathesis or coagulopathy Evidence of bleeding diathesis or coagulopathy within the past months Evidence of bleeding diathesis or coagulopathy within months Patients with a history of hemoptysis, bleeding diathesis, known platelet disorder, or coagulopathy are not eligible Evidence of bleeding diathesis or clinically significant coagulopathy Evidence of prior or current coagulopathy or bleeding diathesis Clinically-significant evidence of bleeding diathesis or coagulopathy as so judged by the treating physician Evidence or history of bleeding diathesis or coagulopathy Evidence or history of bleeding diathesis or coagulopathy Pre-existing bleeding diathesis, coagulopathy or hemorrhage The subject has inherited bleeding diathesis or coagulopathy with the risk of bleeding Patients must have no known bleeding diathesis or coagulopathy that would make intratumoral injection or biopsy unsafe. Evidence or history of bleeding diathesis or coagulopathy Evidence or history of bleeding diathesis or coagulopathy Evidence or history of bleeding diathesis or coagulopathy Evidence or history of bleeding diathesis or coagulopathy Evidence of bleeding diathesis or clinically significant coagulopathy Evidence of bleeding diathesis or a clinically significant coagulopathy Patients with an active, bleeding diathesis or significant coagulopathy History of bleeding diathesis or coagulopathy. (Patients on stable anticoagulant therapy are eligible.) Patient has a coagulopathy or bleeding disorder which is uncontrolled. Evidence of bleeding diathesis or significant coagulopathy Patients with uncontrolled coagulopathy or bleeding disorder Evidence or history of bleeding diathesis or uncontrolled coagulopathy Evidence or history of a bleeding diathesis or coagulopathy, including therapy-induced coagulopathy Evidence or history of bleeding diathesis or coagulopathy Concurrent use of anti-coagulant drugs (not including prophylactic doses), history of coagulopathy, or evidence of bleeding diathesis or coagulopathy Presence of bleeding diathesis or coagulopathy No known bleeding diathesis or coagulopathy History of bleeding diathesis or coagulopathy Coagulopathy or bleeding diathesis Evidence of bleeding diathesis or coagulopathy Evidence or history of bleeding diathesis or coagulopathy Evidence or history of bleeding diathesis or coagulopathy. Evidence or history of bleeding diathesis or coagulopathy Evidence or history of bleeding diathesis or coagulopathy Evidence of clinically significant bleeding diathesis or coagulopathy Active GI bleeding and any bleeding diathesis or coagulopathy that is not correctable by usual therapy or hemostatic agents Known bleeding disorder or coagulopathy Evidence of clinically significant bleeding diathesis or underlying coagulopathy (e.g. INR > . without vitamin K antagonist therapy), non-healing wound Patients must not have a bleeding diathesis, hereditary of acquired bleeding disorder or coagulopathy History of bleeding diathesis or coagulopathy other than that due to anticoagulation therapy Evidence or history of bleeding diathesis or coagulopathy Evidence or history of bleeding diathesis or coagulopathy at the time of enrollment History or evidence of inherited bleeding diathesis or coagulopathy with a risk of bleeding and active gastrointestinal bleeding Evidence or history of bleeding diathesis or coagulopathy History of tumor-related or other serious hemorrhage, bleeding diathesis, or underlying coagulopathy Evidence or history of bleeding diathesis or coagulopathy Any evidence of bleeding diathesis or coagulopathy Evidence or history of bleeding diathesis or coagulopathy Clinically significant bleeding diathesis or coagulopathy, including known platelet function disorders Evidence or history of bleeding diathesis or coagulopathy Known bleeding diathesis or coagulopathy Evidence or history of bleeding diathesis or coagulopathy Known bleeding diathesis or coagulopathy History of coagulopathy or bleeding disorders Known inherited bleeding disorder or coagulopathy Severe coagulopathy or bleeding disorder Patient must not have a known bleeding diathesis or coagulopathy