History of interstitial lung disease. History of interstitial lung disease Has a history of interstitial lung disease. History of interstitial lung disease Patients with history of interstitial lung disease. Patient has a known history of chronic interstitial lung disease Has a history of interstitial lung disease related to prior EGFR inhibitor therapy. Has a history of interstitial lung disease History of interstitial lung disease. Has a history of interstitial lung disease Past medical history of interstitial lung disease, drug-induced interstitial lung disease, radiation pneumonitis which required steroid treatment, or any evidence of clinically active interstitial lung disease Subjects with a history of interstitial lung disease Has a history of interstitial lung disease Subjects with a history of interstitial lung disease Past medical history of interstitial lung disease, drug-induced interstitial lung disease, radiation pneumonitis which required steroid treatment, or any evidence of clinically active interstitial lung disease. History of interstitial lung disease Patients with evidence of interstitial lung disease (bilateral, diffuse, parenchymal lung disease) Clinically significant interstitial lung disease Patient has interstitial lung disease Symptomatic interstitial lung disease Evidence of interstitial lung disease Has a known history of interstitial lung disease History or any evidence of interstitial lung disease; Past medical history of interstitial lung disease, drug-induced interstitial lung disease, radiation pneumonitis which required steroid treatment, or any evidence of clinically active interstitial lung disease Participants must not have evidence of interstitial lung disease Past medical history of interstitial lung disease, drug-induced interstitial lung disease, radiation pneumonitis requiring steroid treatment, or any evidence of clinically active interstitial lung disease Evidence of interstitial lung disease Subjects with a history of interstitial lung disease. Has a history of interstitial lung disease Has evidence of interstitial lung disease Has evidence of interstitial lung disease Has a history of interstitial lung disease. History or active interstitial lung disease Known interstitial lung disease Patient has a known history of chronic interstitial lung disease Interstitial lung disease Evidence of interstitial lung disease Interstitial lung disease Has evidence of interstitial lung disease Clinically significant interstitial pulmonary disease or known diagnosis of interstitial lung disease (ILD) Evidence of interstitial lung disease History of, or evidence of clinically active, interstitial lung disease Patients have history of diagnosed interstitial lung disease Has evidence or a history of interstitial lung disease Has evidence of interstitial lung disease Patients with interstitial lung disease. Has evidence of interstitial lung disease Has evidence of interstitial lung disease History of interstitial lung disease Past medical history of interstitial lung disease, drug-induced interstitial disease, radiation pneumonitis which required steroid treatment or any evidence of clinically active interstitial lung disease Has evidence of interstitial lung disease Subjects with a history of symptomatic interstitial lung disease Patient has evidence of interstitial lung disease Evidence of interstitial lung disease Past medical history of interstitial lung disease, drug-induced interstitial lung disease, radiation pneumonitis which required steroid treatment, or any evidence of clinically active interstitial lung disease Evidence of interstitial lung disease Has a history of interstitial lung disease. Interstitial lung disease Active or prior documented interstitial lung disease Evidence of interstitial lung disease Evidence of interstitial lung disease Patients with known and confirmed diagnosis of interstitial lung disease (IDL) Evidence of interstitial lung disease Patients with clinically significant interstitial lung disease or history of cardiac disease Patients with active interstitial lung disease Patients must not have any known clinically active interstitial lung disease Past medical history of interstitial lung disease, drug-induced interstitial lung disease, radiation pneumonitis requiring steroid treatment, or any evidence of clinically active interstitial lung disease History of interstitial lung disease History of interstitial lung disease Has a history of interstitial lung disease. History of symptomatic or p previously established interstitial lung disease SUB-PROTOCOL AIM A: Patients with a history of interstitial lung disease and/or pneumonia Past medical history of interstitial lung disease, drug-induced interstitial lung disease, radiation pneumonitis which required steroid treatment, or any evidence of clinically active interstitial lung disease. History of or active interstitial lung disease Subjects with a history of interstitial lung disease History of interstitial lung disease Any evidence of clinically active interstitial lung disease (patients with chronic stable radiographic changes who are asymptomatic need not be excluded) Evidence of interstitial lung disease Subjects with a history of interstitial lung disease Has evidence of interstitial lung disease History of or current interstitial lung disease Subjects with clinically significant interstitial lung disease, or obstructive disease without sufficient reserve History of interstitial lung disease Other clinically severe or uncontrolled systemic illness or any concurrent condition that in the view of the principal investigator could compromise the participants ability to tolerate vandetanib or could compromise study procedures or endpoints, including interstitial lung disease, drug-induced interstitial disease, radiation pneumonitis which required steroid treatment or any evidence of clinically active interstitial lung disease Any evidence of clinically active interstitial lung disease Patients with evidence of interstitial lung disease Past medical history of interstitial lung disease, drug-induced interstitial lung disease, radiation pneumonitis which required steroid treatment, or any evidence of clinically active interstitial lung disease. History or concurrent condition of interstitial lung disease Has a known history of interstitial lung disease Has a history of interstitial lung disease Known history of, or any evidence of, interstitial lung disease Any evidence of clinically significant interstitial lung disease Known interstitial lung disease History of interstitial lung disease. Subject has history of drug-induced interstitial lung disease or any evidence of active interstitial lung disease. Has a history of interstitial lung disease. Patients with a history of interstitial Non-malignant interstitial lung disease; Radiographically evident interstitial lung disease , concurrent infection, or a history of any of these conditions History of interstitial lung disease Evidence of interstitial lung disease. Any evidence of clinically active interstitial lung disease (patients with chronic,stable, radiographic changes who are asymptomatic need not be excluded). Known or suspected history of interstitial lung disease. History of interstitial lung disease History of interstitial lung disease Any serious intercurrent or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol including but not limited to: \r\n* Uncontrolled diabetes mellitus (fasting plasma glucose > mg/dL or . mmol/L)\r\n* Past medical history of interstitial lung disease, drug-induced interstitial lung disease, radiation pneumonitis which required steroid treatment, or any evidence of clinically active interstitial lung disease\r\n* Active infections \r\n* Gastrointestinal disease limiting the ability to swallow oral medications or absorb oral medications including refractory nausea and vomiting, chronic gastrointestinal diseases, inflammatory bowel disease; malabsorption syndromes\r\n* Patients with enteric stomata or significant bowel resection\r\n* Prior history of corneal ulceration\r\n* Patients with any evidence of severe or uncontrolled systemic liver disease including those with known hepatitis B and hepatitis C (excluding treated hepatitis C that has been cured)\r\n* Active bleeding diatheses Active interstitial lung disease; asthma requiring more than as needed bronchodilators for management; or other autoimmune lung disease Has interstitial lung disease Has history of interstitial lung disease. Has active, or a history of, interstitial lung disease. Known interstitial lung disease. History of interstitial lung disease (Parts D and E only).