Presence of a non-healing wound, or non-healing ulcer, (that is not tumor related) or bone fracture
Presence of any non-healing wound, fracture, or ulcer within  days prior to study registration.
Presence of non-healing wound, non-healing ulcer, or bone fracture
Presence of a non-healing wound, non-healing ulcer, or bone fracture
Presence of a non-healing wound, non-healing ulcer, or bone fracture
Non-healing wound(s) or ulcer(s) except for ulcerative lesions caused by the underlying neoplasm;
Serious non-healing or dehiscing wound, active ulcer, or untreated or non-healing bone fracture
FOR ALL PHASES (Ib AND II): Non-healing wound or ulcer
Presence of a non-healing wound, non-healing ulcer, or bone fracture
Presence of a non-healing wound, non-healing ulcer or bone fracture
Serious, non-healing or dehiscing wound or active ulcer
Presence of a non-healing wound, non-healing ulcer, or bone fracture
Serious, non-healing or dehiscing wound
REGORAFENIB EXCLUSION CRITERIA: Presence of a non-healing wound, non-healing ulcer, or bone fracture
Presence of a non-healing wound, non-healing ulcer, or benign bone fracture (patients with stress insufficiency fractures e.g. from osteoporosis or pathological fracture from tumor are eligible for study)
Presence of any non-healing wound, fracture, or ulcer
Serious non-healing wound, non-healing ulcer, or bone fracture
Non-healing wound(s) or ulcer(s) except for ulcerative lesions caused by the underlying neoplasm;
Presence of a non-healing wound, non-healing ulcer, or bone fracture
Presence of a non-healing wound, non-healing ulcer, or bone fracture
Prior major surgery within the previous  days of study registration and/or presence of any non-healing wound, fracture, or ulcer
Presence of a non-healing wound, non-healing ulcer, or bone fracture
Presence of any non-healing wound, fracture, or ulcer, or presence of symptomatic peripheral vascular disease
Patients are excluded if they have a non-healing wound or ulcer
Presence of non-healing wound, non-healing ulcer, or bone fracture.
Presence of a non-healing wound, non-healing ulcer, or bone fracture
Presence of a non-healing wound, non-healing ulcer, or bone fracture.
Presence of a non-healing wound or non-healing ulcer that is not tumor related
Presence of any non-healing wound, fracture, or ulcer within  days prior to the first dose of study drug.
Presence of a non-healing wound, non-healing ulcer, or bone fracture
Presence of any non-healing wound, fracture, or ulcer within  days prior to study registration.
Presence of a non-healing wound, non-healing ulcer, or bone fracture
Presence of a non-healing wound or non-healing ulcer that is not tumor related
Presence of a non-healing wound, non-healing ulcer, or bone fracture
Presence of a non-healing wound, non-healing ulcer, or bone fracture
Presence of a non-healing wound, non-healing ulcer, or bone fracture
Serious, non-healing wound
Serious non-healing wound or ulcer on scalp
Severe acute infection; serious non-healing wound or ulcer on scalp
Presence of a non-healing wound, non-healing ulcer, or bone fracture
Presence of a non-healing wound, non-healing skin ulcer, or bone fracture
Presence of a non-healing wound or bone fracture
Patients must not have a non-healing wound or fracture
Presence of any non-healing wound, fracture, or ulcer
Presence of a non-healing wound, non-healing ulcer, or bone fracture
No history of serious non-healing wound, ulcer, or bone fractures
Serious, non-healing or dehiscing wound or active ulcer
Presence of a non-healing wound, non-healing ulcer, or bone fracture
Serious, non-healing or dehiscing wound or active ulcer