Glycosylated hemoglobin measurement (HbAc) < .% Within less than or equal to days prior to registration: Glycosylated hemoglobin (HbAc) < .% Glycosylated hemoglobin (HbAC) >= .% Glycated hemoglobin (HbAc) < .%, within days of registration Glycosylated hemoglobin (HbAc) =< .% Glycosylated hemoglobin (HbAc) < .%. Have a baseline glycated hemoglobin (HbAc) ? . Glycosylated hemoglobin (HbAc) =< . % Patients with diabetes are allowed and may be on antidiabetic treatment other than metformin; the diabetes must be under control within normal range (glycosylated hemoglobin measurement [HbAC] =< .%) Glycosylated hemoglobin (HbAc) =< .% Metabolic: glycosylated hemoglobin (HbAc) < .% Glycosylated hemoglobin (HbAc) > .% or fasting plasma glucose > mg/dL at screening HbAc > .% at Screening Glycosylated hemoglobin (HbAc) < .% Metabolic - Glycated hemoglobin (HbAc) ? % Patients with HbAc > .% at Screening Glycosylated hemoglobin (HbAc) < .% Glycosylated hemoglobin (HbAc) =< % (Gedatolisib can cause hyperglycemia) Patients must have a sodium (Na), potassium (K), chlorine (Cl), calcium (Ca), magnesium (Mg), and glycosylated hemoglobin measurement (HbAc) performed within days prior to sub-study registration Patient has uncontrolled diabetes, defined as a fasting serum glucose > mg/dl or glycosylated hemoglobin (hemoglobin Ac [HbAc]) > % at screening HbAc of ? % (all subjects will have HbAc test at screening) Glycosylated hemoglobin (HbAc) >=. percent (%) History of diabetes requiring treatment, glucose > mg/dL, Glycated hemoglobin (HbAc) ?.% HbAc > %. Patients with diabetes or in risk for hyperglycemia should not be excluded from trials with MK-, but the hyperglycemia should be well controlled before the patient enters the trial (glycosylated hemoglobin [Hbac] < .) HbAc ? % Glycated hemoglobin (HbAc) =< % Glycosylated hemoglobin (HbAc) < .% Glycosylated hemoglobin measurement (HbAc) < .% within days of enrollment Fasting blood glucose level > and glycosylated hemoglobin (HbAc) > %. Glycated hemoglobin (HbAc) > % HbAc =< .%