Must be obtained within days prior to registration for protocol therapy: Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Direct bilirubin ? . ULN (may be assumed if total bilirubin is below ULN) Bilirubin =< . x ULN OR direct bilirubin of =< ULN for subjects with total bilirubin levels of > . x ULN obtained within days prior to registration Total bilirubin =< . x ULN OR, for subjected with total bilirubin levels > . x ULN, a direct bilirubin =< ULN must be met within days of CD Serum total bilirubin =< . x ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN SAFETY RUN-IN: Within days of registration: Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN RANDOMIZED PHASE II CLINICAL TRIAL: Within days of registration: Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Total bilirubin and direct bilirubin =< ULN Total bilirubin ? . x ULN or direct bilirubin ? ULN for subjects with total bilirubin > . x ULN Total bilirubin =< . x ULN OR direct bilirubin =< x ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for patients with total bilirubin levels > . ULN. Within days of treatment registration: Serum total bilirubin =< . x ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . x ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Total bilirubin ? . ULN or direct bilirubin ? ULN. At time of registration and within weeks prior to initiating on-protocol treatment: Total bilirubin =< . x ULN, OR direct bilirubin =< ULN for participants with total bilirubin levels >. x ULN Within days prior to the start of study treatment: Total bilirubin =< . X ULN OR direct bilirubin =< ULN for participants with total bilirubin levels > . x ULN STRATUM A: Total bilirubin =< ULN or if > ULN then direct bilirubin =< . x ULN STRATUM B: Total bilirubin =< ULN; or if > ULN then direct bilirubin =< . x ULN STRATUM C: Total bilirubin =< ULN; or if > ULN then direct bilirubin =< . x ULN Serum total bilirubin =< . times upper limit of normal (ULN) OR direct bilirubin =< ULN for subjects with total bilirubin >= . x ULN Within days of cycle day : Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Within days prior to the start of study treatment: Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN. Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Total bilirubin =< . x ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . x ULN Serum total bilirubin =< . x ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN. Within days of registration: Total bilirubin =< . x ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . x ULN Obtained =< days prior to registration: Serum total bilirubin =< . X upper limit of normal (ULN) or direct bilirubin =< (ULN) for subjects with total bilirubin levels > . ULN Within days prior to enrollment: Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin >= . ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for patients with total bilirubin levels > . ULN Total bilirubin ? . upper limit of normal (ULN) OR direct bilirubin ? ULN for subjects with total bilirubin levels > . x ULN Serum total bilirubin ? . X ULN OR direct bilirubin ? ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . x ULN or direct bilirubin =< ULN for subjects with total bilirubin levels > . x ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . X upper limit of normal (ULN) OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Obtained =< days prior to registration: Total bilirubin =< . x ULN OR direct bilirubin =< ULN for patients with total bilirubin levels > . x ULN Total bilirubin ?. times the ULN, or direct bilirubin .xULN; Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . x ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin >= . x ULN OR direct bilirubin >= ULN for patients with total bilirubin levels > . x ULN Serum total bilirubin =< . x upper limit of normal (ULN) OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Within days prior to registration for protocol therapy: Serum total bilirubin => . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN; unless due to Gilberts disease or hemolysis Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . x ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . x ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . x ULN OR direct bilirubin =< ULN for patients with total bilirubin levels > . ULN Serum total bilirubin =< . x ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN, during screening and on cycle , day Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . x ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin: =< . X ULN OR direct bilirubin =< ULN for participants with total bilirubin levels > . ULN Total serum bilirubin =< . x upper limit of normal (ULN) OR direct bilirubin =< ULN if total bilirubin levels > . x ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN within days prior to registration Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . X ULN or direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . X ULN (except for subjects with Gilbert Syndrome, who may have total bilirubin < . mg/dl) or direct bilirubin =< ULN for subjects with total bilirubin levels > . X ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Performed days prior to study registration up to the first dose of study drug: serum total bilirubin =< . X ULN (except for subjects with Gilbert syndrome, who may have total bilirubin < . mg/dl) or direct bilirubin =< ULN for subjects with total bilirubin levels > . x ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . x ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . x ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Total bilirubin levels =< . x ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Total bilirubin ? . x ULN for age, direct bilirubin ? ULN for age Serum total bilirubin =< . x ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . X ULN (patients who do not meet this criteria must have a direct\r\nbilirubin =< . X ULN) Direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Direct bilirubin ? ULN for subjects with total bilirubin levels > . x ULN Performed within days prior to study registration up to the first dose of study drug: Serum total bilirubin =< . X ULN or direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . x ULN OR direct bilirubin =< ULN for patients with total bilirubin level . ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . x ULN OR direct bilirubin =< ULN for patients with total bilirubin levels > . x ULN Serum total bilirubin =< . x ULN OR direct bilirubin =< ULN for patients with total bilirubin levels > . x ULN Serum total bilirubin ? . X ULN OR direct bilirubin ? ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin ? . x ULN OR o Direct bilirubin ? ULN for subjects with total bilirubin >. x ULN Total bilirubin (<=) * ULN or direct bilirubin level (<=) .* ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . X upper limit of normal (ULN) or direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin ? . X ULN OR direct bilirubin ? ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN REGISTRATION TO TREATMENT (STEP ): Serum total bilirubin =< . X ULN OR direct bilirubin \r\n=< ULN for subjects with total bilirubin levels > . X ULN, within days prior to first dose of pembrolizumab REGISTRATION TO TREATMENT (STEP ): Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . X ULN, within days prior to first dose of pembrolizumab Total bilirubin ? . ULN OR direct bilirubin ? ULN if total bilirubin > . x ULN Serum total bilirubin ? . X ULN OR direct bilirubin ? ULN for patients with total bilirubin levels > . ULN Serum total bilirubin =< . x ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . x upper limit of normal (ULN) OR direct bilirubin =< ULN for subjects with total bilirubin levels > . x ULN obtained =< days prior to registration Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Direct bilirubin: =< ULN for patients with total bilirubin levels > . ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . X upper limit of normal (ULN) or direct bilirubin =< ULN for patients with total bilirubin levels > . ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN; patients with Gilberts syndrome must have a total bilirubin < . mg/dL Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Total bilirubin =< . x ULN OR direct bilirubin =< ULN for participants with total bilirubin levels > . x ULN, specimens must be collected within days prior to the start of study treatment Serum total bilirubin =< . x ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . x ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Total Bilirubin: ?.xULN OR Direct bilirubin ?ULN for subjects with total bilirubin levels >.xULN Total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . X ULN or direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . x upper limit of normal (ULN) OR direct bilirubin =< ULN if total bilirubin levels > . x ULN (within days prior to day of protocol therapy) Serum total bilirubin =< . x ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Within weeks of administration of study therapy: Serum total bilirubin =< . x ULN or direct bilirubin =< ULN for patients with total bilirubin levels > . ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . x ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . x ULN Serum total bilirubin =< . x ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN total bilirubin ? . upper limit of normal (ULN) OR direct bilirubin ? ULN for subjects with total bilirubin levels > . x ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN, performed within days prior to registration Performed within days of radiation therapy: Serum total bilirubin =< . x ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . x ULN (direct bilirubin =< ULN if total bilirubin [bili] > . x ULN) Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin >= . ULN Total bilirubin levels < . X ULN Serum total bilirubin =< . x ULN or direct bilirubin =< ULN for subjects with total bilirubin levels > . x ULN Total bilirubin ? . upper limit of normal (ULN) OR direct bilirubin ? ULN for subjects with total bilirubin levels > . x ULN Serum total bilirubin =< . x ULN (. mg/dL or . umol/L) OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN; except patients with Gilbert's disease (=< x ULN) Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . X ULN or direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Total bilirubin ? .x ULN for age. If the total bilirubin is elevated, patient will still be eligible if the conjugated (direct) serum bilirubin ? ULN for age. Bilirubin and total bilirubin levels =< . x ULN Total bilirubin ? . ULN OR direct bilirubin ? ULN Bilirubin levels < . x ULN Serum total bilirubin =< . x ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Total bilirubin =< . x ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Total bilirubin =< . x ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Direct serum bilirubin ? . x ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN, obtained =< days prior to registration Serum total bilirubin =< . x ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN Serum total bilirubin =< . X ULN OR direct bilirubin =< ULN for subjects with total bilirubin levels > . ULN, performed within days of protocol enrollment