Must be able to understand and complete study-related forms and adequately communicate in English. Participant must have the ability to understand and communicate with the investigator Able to communicate in the English language Able to communicate sensations during the ExAblate MRGFUS procedure. Able to communicate sensations during the ExAblate MRgFUS treatment Patients unable to communicate with the investigator and staff. Able to communicate sensations during the ExAblate MRGFUS procedure. Able to communicate sensations during the ExAblate treatment Patients unable to communicate with the investigator and staff. Able to communicate in English or Spanish. (Patient participation) Ability to read and communicate in English (Caregiver participation) is able to read and communicate in English Be able to communicate in English; and be competent to consent Able to communicate in English or Spanish In the judgment of the consenting professional able to communicate, comprehend, and complete questionnaires in English Inability to communicate in English With sufficient ability to communicate in English in order to provide informed consent and complete study procedures and materials Able to communicate in English or Spanish CAREGIVERS: Cannot read/communicate in English CARE-RECIPIENTS: Cannot read/communicate in English Ability to understand and communicate in English Must be able to understand and communicate proficiently in English Ability to communicate in English Inability to read and/or communicate in English Are able to communicate in English Participants are able to communicate in English Participants are eligible if they are able to communicate in English Are eligible if they are able to communicate in English Patients and family caregivers able to communicate in English or Spanish Participants must be able to communicate in English Able to communicate in English Able to communicate dietary and physical activity data via telephone Subjects who cannot adhere to the experimental protocols for any reason, or have an inability to communicate with the researcher Not able to communicate meaningfully with the Investigator and site staff. AIM : Able to read and communicate in English Able to communicate in English (RCT) Subjects who cannot adhere to the experimental protocols for any reason, or have an inability to communicate with the researcher