Patients must not have baseline peripheral neuropathy that exceeds grade =< grade peripheral neuropathy; patients with grade peripheral neuropathy with pain will be excluded Patients with a baseline peripheral neuropathy >= grade will not be eligible Patients with preexisting grade II peripheral neuropathy Patients must not have peripheral neuropathy ? grade Patients with greater than or equal to grade peripheral neuropathy or active herpes infection Patients with > grade peripheral neuropathy Patients with a peripheral neuropathy > grade Patients with greater than or equal to grade peripheral neuropathy at baseline Patients with a peripheral neuropathy > grade Patients with peripheral neuropathy of > grade Patients with preexisting peripheral neuropathy >= grade are ineligible Patients with grade >= peripheral neuropathy For the bortezomib arm of the study, patients with grade >= peripheral neuropathy Patients with peripheral neuropathy greater than grade II Patients with grade or greater peripheral neuropathy. Preexisting peripheral neuropathy is not allowed from any cause Patients with existing grade or peripheral neuropathy Patients with grade / peripheral neuropathy Patients who have baseline peripheral neuropathy >= grade are not eligible Patients with >= grade peripheral neuropathy Patients must not have peripheral neuropathy >= grade Patients with peripheral neuropathy > grade regardless of etiology Patients must not have peripheral neuropathy > grade Patients must not have grade or greater peripheral neuropathy Patients with grade peripheral neuropathy or greater are excluded Patients with existing peripheral neuropathy grade > Patients with grade II or greater peripheral neuropathy will be excluded from study COHORT II: Patients must not have >= grade peripheral neuropathy Patients with greater than or equal to grade peripheral neuropathy at baseline Peripheral neuropathy of grade >=. Patients with painful grade neuropathy are also excluded Patients with peripheral neuropathy of grade >= ; patients with painful grade neuropathy are also excluded Patients with peripheral neuropathy > Patients with grade >= peripheral neuropathy will not be permitted on study Patients with preexisting peripheral neuropathy grade >= will not be eligible Patients with > grade neuropathy according to the Modified (Balis) Pediatric Scale of Peripheral Neuropathies will be excluded except in cases in which neuropathy is secondary to prior surgery Subjects with preexisting Grade or neuropathy. Any peripheral neuropathy must recover to Grade less than or equal to before enrollment Patients with peripheral neuropathy >= grade Patients with greater than screening peripheral neuropathy Patients who have grade >= peripheral neuropathy Preexisting grade >= peripheral neuropathy Patients with peripheral neuropathy >= grade are not permitted unless discussed with the principal investigator and only in unique circumstances (i.e. unilateral neuropathy due to trauma) Part only: Patients with >= grade peripheral neuropathy. Patients with a >= grade peripheral neuropathy Patients with peripheral neuropathy >= grade Patients with peripheral neuropathy > grade will be excluded from study participation Patients with symptomatic peripheral neuropathy> Grade . Patients must not have a history of peripheral neuropathy (regardless of cause) Patients with known, previously diagnosed peripheral neuropathy from causes other than chemotherapy Patients with known, previously diagnosed peripheral neuropathy from causes other than chemotherapy.