Unresolved toxicity (i.e., > grade or above baseline) due to previously administered agents; exception includes: subjects with =< grade neuropathy are eligible for the study Baseline neuropathy of > grade SAFETY RUN-IN: Patients with baseline grade neuropathy Neurosensory neuropathy > grade at baseline. Patient has not recovered (i.e., =< grade or baseline) from adverse events due to prior anti-cancer therapy;\r\n* Note: patients with =< grade neuropathy are eligible Patients with any baseline grade neuropathy Only for subjects enrolled in Arm - Neratinib and palbociclib: any prior neuropathy should be back to baseline or grade . Grade baseline neuropathy Diabetic neuropathy (any grade) Patient has baseline neuropathy of >= grade Grade II or greater neuropathy at baseline Baseline neuropathy > grade Patient has baseline neuropathy of > grade Neuropathy uropathy europathy Nemediastinal DLBCL. Neurosensory neuropathy ? grade at baseline. Patients with symptomatic neuropathy Previous diagnosis of diabetic neuropathy or peripheral neuropathy from any cause Neurosensory neuropathy ? grade at baseline Significant neuropathy >= grade or grade neuropathy with pain at baseline Significant neuropathy >= grade or grade neuropathy with pain at baseline Patient has baseline neuropathy of >= grade Significant neuropathy >= grade or grade neuropathy with pain at baseline Clinical evidence of neuropathy Significant neuropathy >= grade at baseline Patients with any neuropathy. Neuropathy >= grade (moderate neuropathy that limits instrumental activities of daily living) Previous diagnosis of diabetic neuropathy or peripheral neuropathy from any cause Neuropathy: no baseline neuropathy grade > History of diabetic neuropathy or neuropathy related to human immunodeficiency virus (HIV) Known diabetic neuropathy History of diabetic neuropathy or neuropathy related to human immunodeficiency virus (HIV) Diabetic neuropathy or other neurological conditions Greater than Grade neuropathy or ? Grade neuropathy with pain at baseline, regardless of whether or not the patient is currently receiving medication