Known allergy, hypersensitivity or contraindication to components of the FPA formulation including polysorbate or to platinum-containing medications, -FU, or leucovorin Allergy or hypersensitivity to components of the KO- formulation, e.g. dextrose, hydroxypropyl beta cyclodextrin, acetic acid, sodium acetate and water for injection. Known hypersensitivity to Apatinib or components of the formulation. Known allergy or hypersensitivity to the components of the atezolizumab formulation. The patient has a known allergy/history of hypersensitivity reaction to any of the treatment components, including any ingredient used in the formulation of necitumumab, or any other contraindication to one of the administered treatments The subject has a previously identified allergy or hypersensitivity to components of the study treatment formulation A previously identified allergy or hypersensitivity to components of the study treatment formulation. Allergy or hypersensitivity to components of the cobimetinib formulation Allergy or hypersensitivity to components of the vemurafenib formulation CERITINIB EXCLUSION CRITERIA: Previously identified allergy or hypersensitivity to components of ceritinib formulation ENTRECTINIB EXCLUSION CRITERIA: Previously identified allergy or hypersensitivity to components of entrectinib formulation A previously identified allergy or hypersensitivity to components of the study treatment formulation The subject has a previously identified allergy or hypersensitivity to components of the study treatment formulation The subject has a previously identified allergy or hypersensitivity to components of the study treatment formulation Previously identified allergy or hypersensitivity or intolerance to components of the study treatment formulation (cyclophosphamide, capecitabine, lapatinib [lapatinib ditosylate], trastuzumab) Known allergy or hypersensitivity to the components of the atezolizumab formulation or to any of the study drugs or excipients, (e.g., Cremophor EL) The subject has a previously-identified allergy or hypersensitivity to components of the study treatment formulation Subject with known or suspected hypersensitivity to seviteronel, or any components of the formulation Known allergy or hypersensitivity to components of the FPA formulation including polysorbate For the Combination Dose Finding and Combination Expansion cohorts only: previously identified allergy or hypersensitivity to components of the study treatment formulation or panitumumab Known hypersensitivity to any of plitidepsin's formulation components Have a known allergy / history of hypersensitivity reaction to any of the treatment components, including any ingredient used in the formulation of necitumumab, or any other contraindication to one of the administered treatments. The subject has a previously identified allergy or hypersensitivity to components of the study treatment formulation The participant has a known allergy / history of hypersensitivity reaction to any of the treatment components, including any ingredient used in the formulation of necitumumab or pembrolizumab, or any other contraindication to one of the administered treatments. The patient has a previously-identified allergy or hypersensitivity to components of the study treatment formulation The subject has a previously-identified allergy or hypersensitivity to components of the study treatment formulation The participant has a previously identified allergy or hypersensitivity to components of the study treatment formulation Subject has a known or suspected hypersensitivity to enzalutamide or any components of the formulation used. Known allergy or hypersensitivity to any of the formulation components The subject has a previously identified allergy or hypersensitivity to components of the study treatment formulation Subject has a previously-identified allergy or hypersensitivity to components of the study treatment formulation Allergy or hypersensitivity to components of either study drug formulation Allergy or hypersensitivity to components of the cobimetinib or GDC- formulation Known hypersensitivity to any involved study drug or any of its formulation components The subject has a previously identified allergy or hypersensitivity to components of the study treatment formulation The subject has a previously identified allergy or hypersensitivity to components of the study treatment formulation Allergy or hypersensitivity to components of the vemurafenib formulation Allergy or hypersensitivity to components of the emactuzumab formulation or to components of the atezolizumab formulation Allergy or hypersensitivity to components of the GDC- formulation