Sexually active males unless they use a condom during intercourse while taking the drug and for days after stopping treatment and should not father a child in this period; a condom is required to be used by vasectomized men in order to prevent delivery of the drug via seminal fluid Sexually active males unless they use a condom during intercourse while taking drug and for months after stopping midostaurin medication; they should not father a child in this period; a condom is required to be used also by vasectomized men in order to prevent delivery of the drug via seminal fluid Female patients must agree not to breastfeed their infants while on study; patients of child fathering potential (defined as > Tanner stage ) must use a condom during intercourse while taking the drug during treatment, for weeks after stopping treatment and should not father a child in this period; a condom is required to be used also by vasectomized men during intercourse with a male or female partner in order to prevent delivery of the study drug via semen Sexually active males must be willing to use a condom during intercourse while taking the study drug and for days after stopping the study drug and should not father a child in this period; a condom is required to be used by vasectomized men in order to prevent delivery of the drug via seminal fluid Sexually active males unless they use a condom during intercourse while taking the drug and for days after stopping treatment and should not father a child in this period; Note: A condom is required to be used also by vasectomized men in order to prevent delivery of the drug via seminal fluid Sexually active males unless they use a condom during intercourse while taking the drug and for months after stopping treatment and should not father a child in this period; a condom is required to be used also by vasectomized men in order to prevent delivery of the drug via seminal fluid Sexually active males, unless they use a condom during intercourse while taking the drug, and for days after stopping treatment of LEE -- should not father a child in this period; a condom is required to be used also by vasectomized male in order to prevent delivery of the drug via seminal fluid Sexually active males must use a condom during intercourse while taking the drug and for days after stopping treatment and should not father a child in this period; a condom is required to be used also by vasectomized men in order to prevent delivery of the drug via seminal fluid; fertile males must use a condom with spermicide (double barrier method) Male Contraception\r\n* During the course of the clinical trial, sexually active males must use a condom during intercourse while taking the drug and should not father a child in this period and for up to weeks after stopping treatment\r\n* A condom is required to be used also by vasectomized men in order to prevent delivery of the drug via seminal fluid\r\n* Female partners of male patients must also be advised to use one of the following contraception methods: use of () oral, injected, implanted or other hormonal methods of contraception, or () intrauterine device (IUD) or intrauterine system (IUS), or () prior male/female sterilization Sexually active males unless they use a condom during intercourse while taking the drug and for days after stopping treatment and should not father a child in this period; a condom is required to be used also by vasectomized men in order to prevent delivery of the drug via seminal fluid Sexually active males unless they use a condom during intercourse while taking drug and for days after stopping treatment and should not father a child in this period; a condom is required to be used also by vasectomized men in order to prevent delivery of the drug via seminal fluid; for males with female partners of childbearing potential, couples must use highly effective means of contraception while taking the study drug Sexually active males must use a condom during intercourse while taking the drug and for months after stopping study drug and should not father a child in this period; a condom is required to be used also by vasectomized men in order to prevent delivery of the drug via seminal fluid Sexually active males unless they use a condom during intercourse while taking drug and for months after the last dose of study treatment; male patients for months should not father a child in this period; a condom is required to be used also by vasectomized men in order to prevent delivery of the drug via seminal fluid Men treated or enrolled on this protocol must also agree to use adequate contraception prior to the study, for the duration of study participation, and days after completion of study medication; this includes condom use: a condom is required to be used also by vasectomized men in order to prevent delivery of the drug via seminal fluid Sexually active males must agree to use a condom during intercourse while receiving and for months after the last dose of study treatment; male patients should not father a child for months after the last dose of study treatment; a condom is required to be used also by vasectomized men in order to prevent delivery of the drug via seminal fluid Sexually active males unless they use a condom during intercourse while taking drug and for months after the last dose of the study drug and should not father a child in this period; a condom is required to be used also by vasectomized men in order to prevent delivery of the drug via seminal fluid CAPMATINIB EXCLUSION CRITERIA: Sexually active males unless:\r\n* A condom is used during intercourse while taking drug and days after the last dose of entrectinib; male patients should not father a child in the days after the last dose of the study treatment\r\n* Male sterilization has taken place, with appropriate postvasectomy documentation of the absence of sperm in the ejaculate; condom use is also required in vasectomized men in order to prevent delivery of the drug via seminal fluid CERITINIB EXCLUSION CRITERIA: Sexually active males unless:\r\n* A condom is used during intercourse while taking drug and days after the last dose of entrectinib; male patients should not father a child in the days after the last dose of the study treatment\r\n* Male sterilization has taken place, with appropriate postvasectomy documentation of the absence of sperm in the ejaculate; condom use is also required in vasectomized men in order to prevent delivery of the drug via seminal fluid REGORAFENIB EXCLUSION CRITERIA: Sexually active males unless:\r\n* A condom is used during intercourse while taking drug and for months after the last dose of entrectinib; male patients should not father a child in the months after the last dose of the study treatment\r\n* Male sterilization has taken place, with appropriate post-vasectomy documentation of the absence of sperm in the ejaculate; condom use is also required in vasectomized men in order to prevent delivery of the drug via seminal fluid Sexually active males unless they agree to use a condom during intercourse while taking drug and agree to continue for months after the last dose of study treatment; male patients for months should not father a child in this period; a condom is required to be used also by vasectomized men in order to prevent delivery of the drug via seminal fluid Sexually active males unless they use a condom during intercourse while taking drug and for months after the last dose of study treatment; male patients for months should not father a child in this period; a condom is required to be used also by vasectomized men in order to prevent delivery of the drug via seminal fluid; also male patients whose sexual partner(s) are WOCBP who are not willing to use adequate contraception during the study and for months after the end of enrollment Sexually active males unless they agree to use a condom during intercourse while taking drug and agree to continue for months after the last dose of study treatment; male patients for months should not father a child in this period; a condom is required to be used also by vasectomized men in order to prevent delivery of the drug via seminal fluid Sexually active males must use a condom during intercourse while taking the drug and for months after stopping study drug and should not father a child in this period; a condom is required to be used also by vasectomized men in order to prevent delivery of the drug via seminal fluid Sexually active males unless they use a condom during intercourse while taking the drug and for days after stopping treatment and should not father a child in this period; a condom is required to be used also by vasectomized men in order to prevent delivery of the drug via seminal fluid Sexually active men must use a condom during intercourse while taking study drug and for days after study drug discontinuation; a condom is required for vasectomized men to prevent delivery of study drug via seminal fluid Sexually active males should use a condom during intercourse while taking drug and for weeks after the final dose of study treatment and should not father a child in this period; a condom is required to be used also by vasectomized men in order to prevent delivery of the drug via seminal fluid Sexually active males must use a condom during intercourse while taking the drug and for months after stopping study drug and should not father a child in this period; a condom is required to be used also by vasectomized men in order to prevent delivery of the drug via seminal fluid Sexually active males unless they use a condom during intercourse while taking the drug and for days after stopping treatment and should not father a child in this period; a condom is required to be used also by vasectomized men in order to prevent delivery of the drug via seminal fluid Sexually active males unless they use a condom during intercourse while taking drug and for months after stopping midostaurin medication; they should not father a child in this period; a condom is required to be used also by vasectomized men in order to prevent delivery of the drug via seminal fluid Sexually active males unwilling to use a condom during intercourse while taking drug and for days after stopping investigational medication. A condom is required to be used also by vasectomized men in order to prevent delivery of the drug via seminal fluid. Male patients should not father a child in this period. Sexually active males unless they use a condom during intercourse while taking the drug and for days after stopping treatment and should not father a child in this period; a condom is required to be used also by vasectomized men in order to prevent delivery of the drug via seminal fluid A male subject of fathering potential must use an adequate method of contraception to avoid conception throughout the study (and for up to weeks after the last dose of study drug) to minimize the risk of pregnancy; if the partner is pregnant or breastfeeding, the subject must use a condom; a condom is required to be used also by vasectomized men in order to prevent delivery of the drug via seminal fluid Sexually active males must use a condom during intercourse while taking the drug for months after stopping treatment and should not father a child in this period; a condom is required to be use also by vasectomized men in order to prevent delivery of the drug via seminal fluid Sexually active males must use a condom during intercourse while taking the drug and for days after stopping treatment and should not father a child in this period; a condom is required to be used also by vasectomized men in order to prevent delivery of the drug via seminal fluid Sexually active males unless they use a condom during intercourse during and for months after the last dose of the study treatment and should not father a child in this period; a condom is required to be used also by vasectomized men in order to prevent delivery of the drug via seminal fluid Male patient must use highly effective (double barrier) methods of contraception (e.g., spermicidal gel plus condom) for the entire duration of the study, and continue using contraception and refrain from fathering a child for months following the study drug; a condom is required to be used also by vasectomized men as well as during intercourse with a male partner in order to prevent delivery of the study treatment via seminal fluid