Patients must not have any incidence of or uncontrolled medical illness (e.g. active cardiac symptoms, active systemic infection, etc.) that would limit the patients ability to participate in the protocol Active, uncontrolled infection, or active systemic illness that requires ongoing vasopressor support or mechanical ventilation Uncontrolled illness including ongoing or active infection Patients must not have any incidence of or uncontrolled medical illness (e.g. active cardiac symptoms, active systemic infection, etc.) that would limit the patients ability to participate in the protocol Significant co-morbid illness such as uncontrolled diabetes or active infection that would preclude treatment on this regimen Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic Patients should not have any uncontrolled illness including ongoing or active or poorly controlled infection Patients should not have any uncontrolled illness including ongoing or active infection Serious concurrent illness, including clinically relevant active infection Patients should not have any uncontrolled illness including ongoing or active infection Patients should not have any uncontrolled illness including ongoing or active infection Patients should not have any uncontrolled illness including ongoing or active infection; patients with an ongoing prednisone requirement of > mg/kg/day (or equivalent) will be excluded Patients should not have any uncontrolled illnesses including ongoing or active infection Patients should not have any uncontrolled illness including ongoing or active infection Patients should not have any uncontrolled illness including ongoing or active infection requiring therapy Uncontrolled illness including ongoing or active infection Severe/uncontrolled concurrent illness/infection Serious concurrent illness, including clinically relevant active infection Current serious illness or medical conditions including, but not limited to uncontrolled active infection, clinically significant pulmonary, metabolic or psychiatric disorders. Serious concomitant medical illness, such as active infection, uncontrolled congestive heart failure, or uncontrolled diabetes or other metabolic disorder, or psychiatric illness; Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection Any uncontrolled concurrent illness that, in the judgment of the investigators or treating physician, may put the patient at undo risk including but not limited to active infection, symptomatic cardiac or pulmonary disease, ventricular arrhythmia, or psychiatric illness Uncontrolled systemic illness, including but not limited to ongoing or active infection Patients should not have any uncontrolled illness including ongoing or active infection Patients should not have any uncontrolled illness including ongoing or active infection other than HIV Patient has an uncontrolled illness including ongoing or active infection Patients must not have any incidence of or uncontrolled medical illness (e.g. active cardiac symptoms, active systemic infection, etc.) that would limit the patients ability to participate in the protocol have a serious illness or medical condition including, but not limited to, the following: active or uncontrolled clinically serious infection, including chronic viral hepatitis Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection Patients should not have any uncontrolled illness including ongoing or active infection Patients must NOT have active or uncontrolled infection or serious medical or psychiatric illness The subject has uncontrolled, significant intercurrent or recent illness, including, but not limited to, an active or history of autoimmune disease or immune deficiency; idiopathic pulmonary fibrosis, organizing pneumonia, pneumonitis; active infection requiring systemic treatment, infection with human immunodeficiency virus (HIV), AIDS-related illness, acute or chronic hepatitis B or C infection, positive test for tuberculosis, moderate to severe hepatic impairment (Child-Pugh B or C). Uncontrolled active infection or illness Other ongoing, uncontrolled illnesses (including HIV infection and active hepatitis A, B, or C), psychiatric disorder, or social situation that would prevent good care on this study History of serious co-morbidity or uncontrolled illness that would preclude study therapy, such as active tuberculosis or any other active infection. Uncontrolled concurrent illness including: other hematologic or non-hematologic malignancy, active infection, or uncontrolled diabetes Any clinically significant uncontrolled illness including ongoing active infection Patient with serious uncontrolled concurrent medical illness including but not limited to ongoing or active infection, and \currently active\ second malignancies other than non-melanoma skin cancers Uncontrolled intercurrent illness including, but not limited to, ongoing or active Clostridium difficile infection or history of Clostridium difficile infection Patients should not have any uncontrolled illness including ongoing or active infection Patients should not have any uncontrolled illness including ongoing or active infection Patients should not have any uncontrolled illness including ongoing or active infection