Have synchronous primary endometrial cancer Bilateral synchronous tumors with inheritable forms of RCC including von Hippel-Lindau Synchronous bilateral breast cancer at the time of diagnosis Patients with synchronous bilateral invasive disease are eligible as long as all the lesions assessed for HER on both sides are negative Synchronous bilateral breast cancer at the time of diagnosis Synchronous primaries outside of the oropharynx and larynx T tumors, known metastatic disease, recurrent disease, inflammatory breast cancer, multicentric disease, and/or synchronous bilateral breast cancer Synchronous bilateral invasive or non-invasive breast cancer Bilateral synchronous breast cancer Complete preoperative colonoscopy demonstrating no synchronous colon cancer Patients with known synchronous distant metastatic disease Patients with bilateral synchronous renal masses Synchronous bilateral invasive or non-invasive breast cancer Synchronous cancer. Synchronous colon cancer Synchronous bilateral invasive or non-invasive breast cancer Synchronous bilateral invasive breast cancer Patients with synchronous colon cancers are eligible and staging for stratification will be based on higher N stage of the more advanced primary tumor; however, patients with synchronous colon and rectal primary tumors are not eligible Operable tumor measuring >= . cm in maximal diameter\r\n* Any nodal status\r\n* Multifocal and multicentric disease is permitted\r\n* Synchronous bilateral invasive breast cancer is permitted\r\n* The tumor should be more than mm from the skin Patients may have synchronous endometrial and ovarian cancer primaries Participants with synchronous bilateral invasive disease are eligible only if both lesions are HER-positive Patients with synchronous bilateral breast cancers are eligible if at least one of the tumors is HER-positive Patients with synchronous primaries are included Patients with an obstructive synchronous colorectal tumor requiring up-front surgery or chemoradiation Participants with bilateral synchronous or metachronous disease (DCIS, LCIS, ADH, ALH) are eligible synchronous tumors Patients with synchronous bilateral breast cancers