Shortening fraction of >= % or Cardiac ejection fraction < % (or, if unable to obtain ejection fraction, shortening fraction of < %); ejection fraction is required if the patient is > years of age, or history of cardiac disease or anthracycline exposure; patients with a shortening fraction < % may be enrolled if approved by a cardiologist Left ventricular ejection fraction >= %, or shortening fraction > % (for pediatric patients, a normal ejection fraction is required) Left ventricular ejection fraction > % (in children, shortening fraction > %) Left ventricular ejection fraction >= % or shortening fraction >= % Participants with clinically significant arrhythmias, complex congenital heart disease, or left ventricular ejection fraction (LVEF) < percent (%) or shortening fraction (SF) <=% Left ventricular ejection fraction >= % or fractional shortening >= % Cardiac: Shortening fraction >= % Patients with impaired cardiac function as evidenced by ejection fraction < % (or, if unable to obtain ejection fraction, shortening fraction of < %) or cardiac insufficiency requiring treatment or symptomatic coronary artery disease; patients with a shortening fraction < % may be enrolled if approved by a cardiologist Left ventricular ejection fraction > % or shortening fraction > % TREATMENT WITH SJCAR: Left ventricular ejection fraction > %, or shortening fraction >= % Adequate cardiac function defined as shortening fraction of ? % or ejection fraction ? % Left ventricular ejection fraction ? % or fractional shortening ? %, and no clinically significant electrocardiogram (ECG) findings Baseline left ventricular ejection fraction value <% or shortening fraction of <% Organ dysfunction\r\n* Cardiac ejection fraction < % (or, if unable to obtain ejection fraction, shortening fraction of < %); ejection fraction is required if age > years or there is a history of anthracycline exposure or history of cardiac disease; patients with a shortening fraction < % may be enrolled if approved by a cardiologist\r\n* Pulmonary: \r\n** Diffusing capacity of the lungs for carbon monoxide (DLCO) < %, total lung capacity (TLC) < %, forced expiratory volume in the first second of breath (FEV) < % and/or receiving supplementary continuous oxygen\r\n** The FHCRC PI of the study must approve of enrollment of all patients with pulmonary nodules Participants with known congestive heart failure, symptomatic or Left ventricular (LV) ejection fraction <% or shortening fraction <% and participants with congenital long QT syndrome, bradyarrhythmias, or QT interval (QTc)> milliseconds on at least separate electrocardiograms (ECG). Left ventricular ejection fraction > %, or shortening fraction >= % PART GROUP INCLUSION CRITERIA: Shortening Fraction > % PART GROUP A INCLUSION CRITERIA: Shortening Fraction > % PART GROUP INCLUSION CRITERIA: Shortening Fraction > % Shortening fraction >= % or ejection fraction (LVEF) >= %, as well as Shortening fraction >= % or ejection fraction >= %, no clinical congestive heart failure Adequate cardiac function defined as an ejection fraction > % or shortening fraction >= %. ECHO shortening fraction ? % Shortening fraction of >= % or an ejection fraction >= % Shortening fraction >= % or left ventricular ejection fraction >= % by echocardiogram within the past year prior to registration PART : Shortening fraction > % Left ventricular ejection fraction > %, or shortening fraction >= % Left ventricular ejection fraction at rest must be >= %, or shortening fraction > % Shortening fraction of >= % by echocardiogram, or ejection fraction (left ventricular ejection fraction [LVEF]) >= % by gated radionuclide study Left ventricular ejection fraction >= %, or shortening fraction > %, unless cleared by a cardiologist Left ventricular shortening fraction (LVSF) less than % Symptomatic coronary artery disease or ejection fraction < % or other cardiac failure requiring therapy (or, if unable to obtain ejection fraction, shortening fraction of < %); ejection fraction is required if the patient has a history of anthracyclines or history of cardiac disease; patients with a shortening fraction < % may be enrolled if approved by a cardiologist Adequate cardiac function defined as absence of decompensated congestive heart failure or uncontrolled arrhythmia AND left ventricular ejection fraction >= % OR fractional shortening > % Adequate cardiac function defined as absence of decompensated congestive heart failure, or uncontrolled arrhythmia and:\r\n* Left ventricular ejection fraction >= % or\r\n* Fractional shortening > % Has cardiac pathology: Participants with known congestive heart failure, symptomatic or left ventricular (LV) ejection fraction <% or shortening fraction <% and participants with congenital long QT syndrome, bradyarrhythmias, or QTc > msec on at least separate electrocardiograms (ECGs). Shortening fraction > % Patients with known congestive heart failure, symptomatic or left ventricular (LV) ejection fraction < % or shortening fraction < % are not eligible Left ventricular ejection fraction >= % or fractional shortening >= % With impaired cardiac function as evidenced by ejection fraction < % (or, if unable to obtain ejection fraction, shortening fraction of < %) or cardiac insufficiency requiring treatment or symptomatic coronary artery disease; patients with a shortening fraction < % may be enrolled if approved by a cardiologist Left ventricular ejection fraction < % (or, if unable to obtain ejection fraction, shortening fraction of < %); ejection fraction is required if age > years or there is a history of anthracycline exposure or history of cardiac disease; patients with a shortening fraction < % may be enrolled if approved by a cardiologist Left ventricular ejection fraction >= % or shortening fraction >= % Left ventricular ejection fraction >= % or shortening fraction > % Left ventricular fractional shortening < % Shortening fraction >= % Left ventricular ejection fraction < % or equivalent shortening fraction < % in pediatric patients Adequate cardiac function as defined as shortening fraction of > % OR ejection fraction of > % Shortening fraction > % Shortening fraction greater than or equal to % Prior left chest wall irradiation or a cumulative anthracycline dose of greater or equal to mg/m^, unless the ejection fraction or fraction shortening is within normal institutional limits, in which case the patient can be enrolled Cardiac ejection fraction < % (or, if unable to obtain ejection fraction, shortening fraction of < %); ejection fraction is required if age > years or there is a history of anthracycline exposure or history of cardiac disease; patients with a shortening fraction < % may be enrolled if approved by a cardiologist Pediatric patients: normal left ventricular function with ejection fraction > % or shortening fraction >= % Adequate cardiac function defined as shortening fraction of >= % or ejection fraction >= % Patient must have a shortening fraction ? % by Echo or an ejection fraction ? % by MUGA. Reproductive Function Cardiac: Left ventricular ejection fraction at rest must be > %, or shortening fraction > %. Left ventricular ejection fraction >= % or fractional shortening >= % Left ventricular ejection fraction >= % or shortening fraction >= % Shortening fraction greater than or equal to % Adequate cardiac function defined as shortening fraction of >= % or ejection fraction >= % Cardiac Function a. Patient must have a shortening fraction ? % or an ejection fraction ? % by ECHO/MUGA. Left ventricular ejection fraction > %, or shortening fraction >= % Cardiac function: left ventricular ejection fraction (LVEF) >= % or shortening fraction (SF) >= % Left ventricular ejection fraction greater than %, or shortening fraction greater than or equal to % Left ventricular ejection fraction >= % or shortening fraction > %, unless cleared by a cardiologist Cardiac: left ventricular ejection fraction at rest must be greater than % or shortening fraction greater than % Left ventricular ejection fraction >= % or shortening fraction > % Resting ejection fraction < % or fractional shortening < % Subjects should have a normal ejection fraction (per institutional limits), no evidence of cardiac arrhythmias requiring therapy, and a fractional shortening of > % Left ventricular ejection fraction at rest must be >= %, or shortening fraction > % Left ventricular ejection fraction < % and in children-shortening fraction < % Left ventricular ejection fraction ? % or fractional shortening ? %