Hemoglobin (Hgb) greater than . g/dL (may have packed red blood cell [PRBC] transfusion) Hemoglobin > g/dL (prior red blood cell [RBC] transfusion allowed); patients may be transfused to achieve this value Inability to receive HCT due to alloimmunization, defined as the inability to receive packed red blood cell (pRBC) transfusion therapy. Hemoglobin < g/dL (< . mmol/L; previous red blood cell [RBC] transfusion is permitted). Have a hemoglobin ?. g/dL without red blood cell transfusion for ? month. Hemoglobin >= g/dL (with or without packed red blood cell [PRBC] transfusion) and documented within days prior to registration and within days prior to the start of treatment Hemoglobin >. mg/dL without red blood cell transfusion ? days prior to CD Hemoglobin >= . g/dL (with or without red blood cell [RBC] transfusion) Hemoglobin < g/dL (< . mmol/L; previous red blood cell transfusion is permitted) Subjects should not have packed red blood cells (PRBC) or platelet transfusion within days of the screening Hemoglobin: >= . gm/dl (may transfuse peripheral red blood cells [PRBCs]) Hemoglobin < g/dL (< . mmol/L; previous red blood cell [RBC] transfusion is permitted) Hemoglobin ?. g/dL (must be > weeks post-red blood cell transfusion) Within days prior to administration of study treatment: Hemoglobin >= g/dL with no pack red blood cell transfusion in the past days Within two weeks prior to enrollment: Hemoglobin >= gm/dL and > days since last red blood cell transfusion Hemoglobin >= . g/dL (may receive packed red blood cell [prbc] transfusion) Within days before the first dose of study drug: hemoglobin > g/dL (prior red blood cell [RBC] transfusion allowed); patients may be transfused to achieve this value; elevated indirect bilirubin due to post-transfusion hemolysis is allowed Hemoglobin ? g/dL (red blood cell [RBC] transfusion is allowed) Hemoglobin (Hgb) >= g/dL with or without packed red blood cells (pRBC) transfusion Patients may be transfused with packed red blood cells (PRBCs) up to days prior to when enrollment labs are drawn to achieve Hgb >= . mg/dL Platelet transfusion and packed red blood cell transfusion can also be given prior to the start of treatment and treatment to achieve a target plt >= ,/uL and hemoglobin of >= . g/dl, provided that patients have not received growth factors for at least days prior to entering trial Hemoglobin >= . g/dL\r\n* Patients may have a transfusion of red blood cells to meet the hemoglobin requirement PART GROUP INCLUSION CRITERIA: Hemoglobin (Hgb) >= g/dL (may receive red blood cell [RBC] transfusion) UROTHELIAL CARCINOMA EXPANSION COHORT: Hemoglobin >= g/dL in the absence of packed red blood cells transfusion days prior to dosing OR > g/dL, if the value is constant across readings within weeks in the absence of packed red blood cells transfusion days prior to dosing Patients must have hemoglobin >= . g/dl; platelet transfusion and packed red blood cell transfusion can also be given prior to the start of treatment and during treatment to achieve a target hemoglobin of >= ./ul provided that patients have not received growth factors for at least days prior to entering trial Hemoglobin >= . mg/dL without red blood cell transfusion =< days prior to CD PHASE I STUDY ELIGIBILITY CRITERIA:\r\nHemoglobin (Hgb) >= g/dL in the absence of packed red blood cell transfusion days prior to dosing OR Hgb -. g/dL and the value is constant across readings within weeks, in the absence of packed red blood cell transfusion days prior to dosing PHASE II COLORECTAL CANCER COHORT (MEDI+C ONLY):\r\nHemoglobin (Hgb) >= g/dL in the absence of packed red blood cell transfusion days prior to dosing Hemoglobin >= g/dL (packed red blood cell [pRBC] transfusion +/- erythropoiesis-stimulating agents [ESA] are allowed) (must be within days of MLA) Hemoglobin >= g/dL (packed red blood cell [PRBC] transfusions permitted) Hemoglobin (Hgb) greater than . g/dL (may have packed red blood cell [PRBC] transfusion) Hemoglobin (>=) . gram per deciliter (g/dL) ([>=] millimole per liter [mmol/L]; prior red blood cell [RBC] transfusion is permitted) Part : hemoglobin level of ? g/dL within weeks of enrollment\r\n* Packed red blood cell (PRBC) transfusions will be allowed to patients with hemoglobin < g/dl Hemoglobin < . g/dL (red blood cell transfusion and erythropoietin may be used to reach at least . g/dL, but must have been administered at least weeks prior to the first dose of study drug. Hemoglobin >= g/dL (packed red blood cells [PRBC] transfusions permitted) Hemoglobin >= g/dL, without ongoing chronic blood transfusion or colony stimulating factor support to maintain normal levels; principal investigator approval is required; (limited red blood cell [RBC] transfusion is allowed for an acute change in hemoglobin) Hemoglobin >= . g/dL or >= . mmol/L, specimens must be collected within days prior to the start of study treatment\r\n* Criteria must be met without erythropoietin dependency and without packed red blood cell (pRBC) transfusion within last weeks Hemoglobin >= g/dl (may be after transfusion of packed red blood cells or use of erythropoiesis stimulating agents) Absence of a regular red blood cell transfusion requirement Hemoglobin >= . gm/dL (may receive packed red blood cell [PRBC] transfusions) Patients must not have received a transfusion (platelets or red blood cells) within weeks of the first dose of study treatment. Platelet or packed red blood cell transfusion within days of pre-treatment evaluation Patients who have received hematopoietic growth factor support within days of day of ibrutinib; patients who are Jehovahs witnesses may be given an erythropoiesis-stimulating agent before and during the trial in lieu of red blood cell transfusions but anemia and/or red blood cell (RBC) transfusion dependence cannot be used for response assessment in these patients Hemoglobin (Hgb) >= . g/dL (no red blood cell [RBC] transfusion within past days) Hemoglobin (Hgb) >= g/dL and no red blood cell (RBC) transfusion within the past days prior to study registration Hemoglobin < g/dL (<. mmol/L; prior red blood cell [RBC] transfusion is permitted) Hemoglobin >= (packed red blood cells [pRBC] transfusion +/- erythropoiesis-stimulating agents [ESA] are allowed) (must be within days of MLA) Hematocrit =< % or hemoglobin =< g/dL (but may have red blood cell [RBC] transfusion) Hemoglobin >= g/dL (may have received packed red blood cell transfusion) Hemoglobin >= g/dl (may transfuse packed red blood cells [PRBC] to meet parameter) Hemoglobin >= g/dL; subjects may not have had a red blood cell (RBC) transfusion within days of screening assessment Hemoglobin >= . mg/dL without red blood cell transfusion =< days prior to cycle day of therapy Packed red blood cell or platelet transfusion within days of screening laboratory tests. Hemoglobin >= g/dl without packed red blood cell dependency, unless due to bone marrow involvement with lymphoma Hemoglobin ? . g/dL and not requiring > unit red blood cell transfusion per month; subjects receiving therapeutic erythropoietin preparations in accordance with the FDA product label are eligible to enroll; Hemoglobin < g/dL (< . mmol/L; previous red blood cell transfusion is permitted) Red blood cell transfusion within weeks prior to anticipated start of study treatment. Anemia, Hemoglobin (Hgb) ? . g/dL or ? units of Red Blood Cells (RBCs) within days Has received a transfusion (platelets or red blood cells) within weeks before the first dose of niraparib Has received a transfusion (platelets or red blood cells) within weeks of the first dose of niraparib Hemoglobin ? g/dL without red blood cell transfusion within hours of screening. Hemoglobin (Hgb) >= g/dL and no red blood cell (RBC) transfusion within the past days prior to study registration Hemoglobin >= . gm/dL (may receive packed red blood cell [pRBC] transfusions)