Evidence of clinically significant cardiovascular and respiratory conditions Clinically significant cardiovascular disease Subjects with clinically significant cardiovascular disease, including: Clinically significant cardiovascular disease Clinically significant cardiovascular disease or condition Patients with clinically significant cardiovascular disease, thromboembolic disease, or significant risk of bleeding. Clinically significant cardiovascular or pulmonary disease History of clinically significant cardiovascular disease Clinically significant cardiovascular disease. Clinically significant cardiovascular disease or condition History of clinically significant cardiovascular disease; Clinically significant cardiovascular disease. Clinically significant cardiovascular disease Clinically significant cardiovascular disease. Have clinically significant, uncontrolled, or active cardiovascular disease, specifically including, but not restricted to: Clinically significant cardiovascular disease Clinically significant cardiovascular disease including: Clinically significant cardiovascular disease or condition Subjects who developed cardiovascular disease within weeks prior to study entry, which is deemed to be clinically significant by the Investigator. Known clinically significant cardiovascular disease or condition. Impaired cardiovascular function or clinically significant cardiovascular disease including any of the following: symptomatic congestive heart failure, clinically significant cardiac arrhythmias and/or conduction abnormalities < months prior to screening except for atrial fibrillation and paroxysmal supraventricular tachycardia Clinically significant, uncontrolled, cardiovascular disease. History of clinically-significant cardiovascular disease. Clinically significant cardiovascular disease Clinically significant cardiovascular risk. Clinically significant (i.e., active) cardiovascular disease Clinically significant cardiovascular disease Subject has clinically significant cardiovascular disease. Clinically significant cardiovascular disease; Clinically symptomatic and uncontrolled cardiovascular disease Patients with clinically significant cardiovascular disease. Patients with clinically significant, uncontrolled cardiovascular disease Subjects with clinically significant cardiovascular disease. Subject has clinically significant cardiovascular disease including: Subjects with clinically significant cardiovascular disease. This includes: Clinically significant cardiovascular disease; Clinically significant cardiovascular disease Clinically significant cardiovascular disease Clinically significant (that is, active) cardiovascular disease Impaired cardiovascular function or clinically significant cardiovascular diseases Impaired cardiovascular function or clinically significant cardiovascular diseases. Impaired cardiovascular function or clinically significant cardiovascular diseases History of clinically significant cardiovascular disease including. Clinically significant cardiovascular disease; History of clinically significant cardiovascular disease including: Clinically significant cardiovascular disease at screening including: Clinically significant cardiovascular disease. Clinically significant cardiovascular impairment Impaired cardiovascular function or clinically significant cardiovascular diseases, including any of the following: symptomatic chronic heart failure; evidence of clinically significant cardiac arrhythmias and/or conduction abnormalities < months prior to screening except atrial fibrillation and paroxysmal supraventricular tachycardia Clinically significant cardiovascular risk Clinically significant cardiovascular disease Clinically significant cardiovascular disease including: Uncontrolled hypertension or clinically significant cardiovascular disease Impaired cardiovascular function or clinically significant cardiovascular diseases History of clinically-significant cardiovascular disease History of clinically significant cardiovascular disease, gastrointestinal disorder, or significant pulmonary compromise. History of clinically significant cardiovascular disease Clinically severe cardiovascular disease or clinically significant electrocardiogram (ECG) abnormality. Clinically significant cardiac/cardiovascular disease, or pulmonary compromise Clinically significant cardiovascular disease including: