Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Acceptable renal function: o Serum creatinine within normal limits, OR calculated creatinine clearance mL/min/. m for patients with creatinine levels above institutional normal. Creatinine =< . x above institutional normal or >= ml/min/. m^ for subjects with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance > mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within institutional normal limits (WNL) OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance ? mL/min/. m^ for participants with creatinine levels above institutional normal Obtained within days prior to study registration: creatinine within normal institutional limits OR creatinine clearance ? mL/min/. m^ for participants with creatinine levels above institutional normal Serum creatinine within normal institutional limits or creatinine clearance >= ml/min Creatinine =< upper limit of normal institutional limits or creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits or creatinine clearance >= mL/min/. m^ for subjects with creatinine levels about institutional normal Creatinine within normal institutional limits or creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance ? mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine =< . times normal institutional limits OR creatinine clearance >= ml/min for patients Creatinine =<. x normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above . x institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine up to . upper institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal days or fewer from registration Creatinine within normal institutional limits or creatinine clearance (estimated glomerular filtration rate [eGFR]) >= mL/min/. m^ for subjects with creatinine levels about institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine levels within normal institutional limits; or, creatinine clearance >= mL/min/. m^ for participants with creatinine levels above institutional normal; unless decreased due to renal involvement by lymphoma Serum creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Serum creatinine within normal institutional limits or creatinine clearance > mL/min/. m^ for participants with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits; OR creatinine clearance >= mL/min/. m^ for participants with creatinine levels above institutional normal Serum creatinine within normal institutional limits OR measured creatinine clearance >= mL/min/for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine . x the normal institutional limits OR creatinine clearance >= mL/min/. m^ Creatinine within normal institutional limits OR creatinine clearance >= mL/min/ per Cockroft-Gault equation\r\nfor patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine not greater than upper institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine =< . x institutional upper limits of normal OR creatinine clearance of >= ml/min/. m^ for patients with creatinine levels above institutional normal by -hour urine Creatinine within normal institutional limits OR creatinine clearance > mL/min for patients with creatinine levels above institutional normal PHASE I STUDY ELIGIBILITY CRITERIA:\r\nCreatinine =< . X within normal institutional limits OR measured creatinine clearance >= mL/min/. m^ Creatinine within normal institutional limits or creatinine clearance >= mL/min Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal, determined within days of registration Creatinine within normal institutional limits OR creatinine clearance > mL/min for patients with creatinine levels above institutional normal Creatinine within normal institutional limits (< .) OR creatinine clearance >= mL/min/.m^ (for creatinine level above normal) Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance > mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= ml/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits or creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine < .x institutional upper limits of normal (ULN) or creatinine clearance ? mL/(min . m^) for patients with elevated creatinine levels (? d of study day ) Creatinine clearance > ml/min/. m^ for patients with creatinine levels above institutional normal limits EXCLUSION CRITERIA FOR TREATMENT: Creatinine clearance > ml/min/.m^ for patients with creatinine levels above institutional normal limits Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits or creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for participants with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR calculated creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Serum creatinine within normal institutional limits or creatinine clearance must be at least ml/min Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Serum creatinine within normal institutional limits or a creatinine clearance >= mL/min for patients with creatinine levels above institutional normal Serum creatinine within normal institutional limits or a creatinine clearance >= ml/min within weeks prior to registration Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits for age OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above ULN Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits or creatinine clearance >= mL/min/. m^ for subjects with creatinine levels about institutional limits Creatinine within normal limits (creatinine clearance >= mL/min/. m^ for subjects with creatinine levels above institutional normal) Obtained within days of registration: Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits, OR creatinine clearance >= mL/min/. m^ for participants with creatinine levels above institutional normal Creatinine within normal institutional limits or creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Serum creatinine within normal institutional limits or creatinine clearance >= mL/min/. m^ for participants with creatinine levels above institutional normal Creatinine within normal institutional limits for age OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within institutional limits of normal OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal obtained =< days prior to randomization Serum creatinine within normal institutional limits or creatinine clearance at least ml/min within days prior to registration Serum creatinine within normal institutional limits OR creatinine clearance >= mL/min/for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min for patients with creatinine levels above institutional normal REGISTRATION INCLUSION CRITERIA: Creatinine =< . institutional upper limits of normal OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine =< . x institutional upper limits of normal OR creatinine clearance of >= ml/min/. m^ for patients with creatinine levels above institutional normal by hour urine Creatinine within normal institutional limits OR creatinine clearance >= mL/min for patients with creatinine levels above institutional normal Creatinine within normal institutional limits or creatinine clearance >= mL/min/. m^ for subjects with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine =< . x normal institutional limits or creatinine clearance > mL/min Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with serum creatinine < mg/mL Creatinine below or within the upper institutional limits of normal or creatinine clearance >= mL/min/. m^ for subjects with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine =< . X normal institutional limits or creatinine clearance >= mL/min/. m^ for patients with creatinine levels above normal institutional limit (a calculated one may be used) Creatinine OR creatinine clearance within normal institutional limits OR > Ml/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits or creatinine clearance >= mL/min/. m^ for subject with creatinine levels above institutional normal Creatinine:\r\n* Creatinine levels within normal institutional limits (< . x ULN); or,\r\n* Creatinine clearance >= mL/min/. m^ for participants with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine =< . x institutional upper limits of normal OR creatinine clearance > mL/min/. m^ for patients with creatinine levels above . x institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Serum creatinine within normal institutional limits OR creatinine clearance >= mL/min for patients with creatinine levels above institutional normal, as determined by a measured -hour creatinine clearance Creatinine within normal institutional limits or creatinine clearance >= mL/min/. m^ for subjects with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal (unless due to lymphoma) Creatinine within normal institutional limits OR creatinine clearance > mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within institutional limits of normal or creatinine clearance >= ml/min/m^ if elevated creatinine Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance or calculated >= mL/min/. m^ for patients with creatinine clearance or estimated creatinine levels above institutional glomerular filtration rate (eGFR) normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Serum creatinine less than upper limit of normal institutional limits or creatinine clearance >= mL/min/. m^ for participants with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Serum creatinine within normal institutional limits or less than the lower limit of normal institutional limits; or creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ if serum creatinine > institutional normal Creatinine within normal institutional limits OR creatinine clearance > mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for participants with creatinine levels above institutional normal Creatinine within normal institutional limits or creatinine clearance >= mL/min/. m^ for subjects with creatinine levels about institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for participants with creatinine levels above institutional normal SURGICAL ARM: creatinine within normal institutional limits or creatinine clearance > mL/min/. m^ for subjects with creatinine levels about institutional normal limit Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for subjects with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for subjects with creatinine levels above institutional normal Creatinine within normal institutional limits or\r\n* Creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Subject must have adequate renal function with creatinine within normal institutional limits or creatinine clearance > mL/min/. m^ for subjects with creatinine levels above institutional normal Creatinine within normal institutional limits OR creatinine clearance >= mL/min/. m^ for patients with creatinine levels above institutional normal Creatinine within normal institutional limits or creatinine clearance > mL/min/. m for subjects with creatinine levels above institutional normal. Creatinine within normal institutional limits or creatinine clearance > mL/min/. m for subjects with creatinine levels above institutional normal.