Subjects with clinical symptoms or signs of gastrointestinal obstruction and/or who require drainage gastrostomy tube and/or parenteral hydration or nutrition. Patients with clinical symptoms or signs of gastrointestinal obstruction and who require parenteral hydration and/or nutrition Patients must not require total parenteral nutrition with lipids Clinical signs or symptoms of gastrointestinal obstruction or requirement for routine parenteral hydration, parenteral nutrition, or tube feeding Clinical signs or symptoms of GI obstruction or requirement of routine parenteral nutrition or tube feedings Participant has clinical symptoms or signs of partial or complete gastrointestinal obstruction or, requires parenteral hydration and/or nutrition Clinical or radiographic evidence of bowel obstruction, or need for parenteral hydration and/or nutrition Requirement for chronic parenteral hydration/nutrition Patients must not require total parenteral nutrition with lipids Patients with clinical symptoms of gastrointestinal obstruction and who require parenteral hydration/nutrition Gastrointestinal disorders that may interfere with absorption of oral agents, such as malabsorption syndromes; additionally, patients requiring drainage gastrostomy (e.g. percutaneous endoscopic gastrostomy [PEG] tube) and/or parenteral hydration and/or nutrition support are not eligible Patients with clinical symptoms or signs of gastrointestinal obstruction and who require parenteral hydration or nutrition Patients who require parenteral hydration or nutrition and have evidence of partial bowel obstruction or perforation Require parenteral nutrition Patients with clinical symptoms or signs of gastrointestinal obstruction and who require parenteral hydration and/or nutrition. Clinical signs or symptoms of gastrointestinal obstruction or requirement for routine parenteral hydration, parenteral nutrition, or tube feeding Subjects with clinical symptoms or signs of gastrointestinal obstruction and/or who require drainage gastrostomy tube and/or parenteral hydration or nutrition. Patients requiring drainage gastrostomy (e.g., drainage percutaneous endoscopic gastrostomy [PEG] tube) and/or parenteral hydration and/or nutrition Patients with clinical symptoms or signs of gastrointestinal obstruction, require parenteral hydration or nutrition, require a drainage gastrostomy tube, and/or have any other impairment that limits their ability to take oral medication Subject has clinical symptoms or signs of partial or complete gastrointestinal obstruction or who require parenteral hydration and/or nutrition (For cohort only) Patients with clinical symptoms or signs of gastrointestinal obstruction and who require parenteral hydration and/or nutrition. History of intestinal obstruction and/or clinical signs or symptoms of GI obstruction including sub-occlusive disease related to the underlying disease or a requirement for routine parenteral hydration, parenteral nutrition, or tube feeding within months prior to Day of Cycle Subject who requires parenteral nutrition, tube feeding or has evidence of partial bowel obstruction or perforation within days prior to study drug administration. Patients with signs or symptoms of gastrointestinal obstruction including those receiving total parenteral nutrition (TPN), intravenous hydration or tube feeds Clinical signs or symptoms of active GI obstruction or requirement of routine parenteral nutrition or tube feedings Requirement for enteral or parenteral nutrition at time of diagnosis Patients with clinical symptoms or signs of gastrointestinal obstruction and/ or those who require parenteral hydration and/or nutrition; patients with history or current diagnosis of inflammatory bowel disease are not eligible Requirement at baseline for parenteral or gastrointestinal tube-delivered nutrition for any reason Clinical signs or symptoms of GI obstruction or requirement for routine parenteral hydration, parenteral nutrition, or tube feeding Clinical signs or symptoms of GI obstruction or requirement of routine parenteral nutrition or tube feedings