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cleaned_drugbank_data.csv
| # | ['237057'] | Lepirudin | For the treatment of heparin-induced thrombocytopenia |
|---|---|---|---|
| 1 | ['318341'] | Cetuximab | Cetuximab, used in combination with irinotecan, is indicated for the treatment of EGFR-expressing, metastatic colorectal carcinoma in patients who are refractory to irinotecan-based chemotherapy. Cetuximab administered as a single agent is indicated for the treatment of EGFR-expressing, metastatic colorectal carcinoma in patients who are intolerant to irinotecan-based chemotherapy. |
| 2 | ['337623'] | Dornase alfa | Used as adjunct therapy in the treatment of cystic fibrosis. |
| 3 | ['214470'] | Denileukin diftitox | For treatment of cutaneous T-cell lymphoma |
| 4 | ['214555'] | Etanercept | Etanercept is indicated for the treatment of moderately to severely active rheumatoid arthritis in adults and chronic moderate to severe plaque psoriasis in adults. It is also used to manage signs and symptoms of polyarticular idiopathic arthritis in those aged 4 to 17 after insufficient response to one or more disease-modifying anti-rheumatic drugs. Etanercept is also used to improve psoriatic arthritis and ankylosing spondylitis. |
| 5 | ['60819'] | Bivalirudin | For treatment of heparin-induced thrombocytopenia and for the prevention of thrombosis. Bivalirudin is indicated for use in patients undergoing percutaneous coronary intervention (PCI), in patients at moderate to high risk acute coronary syndromes due to unstable angina or non-ST segment elevation in whom a PCI is planned. |
| 6 | ['42375'] | Leuprolide | For treatment of prostate cancer, endometriosis, uterine fibroids and premature puberty |
| 7 | ['120608'] | Peginterferon alfa-2a | Peginterferon alfa-2a is indicated for the treatment of HCV in combination with other antiviral drugs in patients over 5 years of age with compensated liver disease [FDA Label]. May be used as a monotherapy in patients with contraindications to or significant intolerance to other anti-viral therapies. Peginterferon alfa-2a is also indicated as a monotherapy for adult patients with HBeAg positive and HBeAg negative chronic hepatitis B infection who have compensated liver disease and evidence of viral replication and liver inflammation [FDA Label]. |
| 8 | ['8410'] | Alteplase | For management of acute myocardial infarction, acute ischemic strok and for lysis of acute pulmonary emboli |
| 9 | ['56188'] | Sermorelin | For the treatment of dwarfism, prevention of HIV-induced weight loss |
| 10 | ['202912'] | Interferon alfa-n1 | For treatment of venereal or genital warts caused by the Human Papiloma Virus |
| 11 | ['283838'] | Darbepoetin alfa | For the treatment of anemia (from renal transplants or certain HIV treatment) |
| 12 | ['11055'] | Urokinase | Urokinase can be used for the treatment of pulminary embolism, coronary artery thrombosis, IV catheter clearance, and venous and arterial blood clots. |
| 13 | ['50610'] | Goserelin | Used to treat hormone-sensitive cancers of the breast (in pre- and peri- menopausal women) and prostate, and some benign gynaecological disorders (endometriosis, uterine fibroids and endometrial thinning). In addition, goserelin is used in assisted reproduction and in the treatment of precocious puberty. |
| 14 | ['76895'] | Reteplase | For lysis of acute pulmonary emboli, intracoronary emboli and management of myocardial infarction |
| 15 | ['105694', '105695'] | Erythropoietin | For use in the treatment of symptomatic anaemia associated with chronic renal failure (CRF) in adult and paediatric patients. Also for use in the treatment of anaemia and reduction of transfusion requirements in adult patients receiving chemotherapy for solid tumours, malignant lymphoma or multiple myeloma, and at risk of transfusion as assessed by the patient's general status (e.g. cardiovascular status, pre-existing anaemia at the start of chemotherapy). Also for used to increase the yield of autologous blood from patients in a predonation program. When administered subcutaneously, Epoetin Zeta is equivalent to Epoetin Alfa in terms of clinical effectiveness. |
| 16 | ['36118'] | Salmon Calcitonin | Used in the treatment of symptomatic Paget's disease for patients unresponsive to alternate treatments or intolerant to such treatments. In addition, it is used in emergency situations when serum calcium levels must be decreased quickly until the underlying condition is identified. It can also be added to existing therapeutic regimens for hypercalcemia such as intravenous fluids and furosemide, oral phosphate or corticosteroids, or other agents. Calcitonin can be used in patients with azotemia and cases where intravenous fluids would be contraindicated due to limited cardiac reserves. Also for the treatment of post-menopausal osteoporosis in women more than 5 years post-menopause. |
| 17 | ['612937'] | Interferon alfa-n3 | For the intralesional treatment of refractory or recurring external condylomata acuminata. |
| 18 | ['338036'] | Pegfilgrastim | Increases leukocyte production, for treatment in non-myeloid cancer, neutropenia and bone marrow transplant. |
| 19 | ['69634'] | Sargramostim | For the treatment of cancer and bone marrow transplant |
| 20 | ['9627'] | Secretin | For diagnosis of pancreatic exocrine dysfunction and gastrinoma |
| 21 | ['253453'] | Peginterferon alfa-2b | Peginterferon alfa-2b is indicated for the treatment of HCV in combination with [DB00811] and a NS3/4A protease inhibitor for genotype 1 or without a NS3/4A protease inhibitor for genotypes 2-6 [FDA Label]. May be used as a monotherapy in patients with contraindications to or significant intolerance to other anti-viral therapies. |
| 22 | ['1156'] | Asparaginase | For treatment of acute lympocytic leukemia and non-Hodgkins lymphoma |
| 23 | ['4952', '10579'] | Thyrotropin Alfa | For detection of residueal or recurrent thyroid cancer |
| 24 | ['1300486'] | Antihemophilic factor, human recombinant | For the treatment of hemophilia A, von Willebrand disease and Factor XIII deficiency. |
| 25 | ['72435'] | Anakinra | For the treatment of adult rheumatoid arthritis and treatment of Neonatal-Onset Multisystem Inflammatory Disease (NOMID). |
| 26 | ['5011'] | Gramicidin D | For treatment of skin lesions, surface wounds and eye infections. |
| 27 | ['42386', '1426680'] | Immune Globulin Human | IVIg is used in the treatment of immunodeficiencies, as well as autoimmune and inflammatory disorders. These indications includes idiopathic thrombocytopenic purpura, Kawasaki disease, hypogammaglobulinemia, B cell chronic lymphocytic leukemia, bone marrow transplant complications, Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy (CIDP), multiple sclerosis, rheumatoid arthritis, myesthenia gravis, Wiskott–Aldrich syndrome and inflammatory skin diseases. |
| 28 | ['40028'] | Anistreplase | For lysis of acute pulmonary emboli, intracoronary emboli and management of myocardial infarction |
| 29 | ['253182', '631657'] | Insulin Human | Indicated as an adjunct to diet and exercise to improve glycemic control in adults and children with type 1 and type 2 diabetes mellitus. |
| 30 | ['259280'] | Tenecteplase | For treatment of myocardial infarction and lysis of intracoronary emboli |
| 31 | ['5882'] | Interferon gamma-1b | Interferon gamma-1b is used for the treatment of Chronic granulomatous disease and Osteopetrosis. |
| 32 | ['5879'] | Interferon Alfa-2a, Recombinant | For the treatment of chronic hepatitis C, hairy cell leukemia, AIDS-related Kaposi's sarcoma, and chronic myelogenous leukemia. Also for the treatment of oral warts arising from HIV infection. |
| 33 | ['3251'] | Desmopressin | Oral formulations may be used to manage primary nocturnal enuresis in adults and vasopressin sensitive diabetes insipidus, and for control of temporary polyuria and polydipsia following head trauma or surgery in the pituitary region. Intranasal and parenteral formulations may be used to manage spontaneous or trauma-induced bleeds (e.g. hemarthrosis, intramuscular hematoma, mucosal bleeding) in patients with hemophilia A or von Willebrand's disease Type I. May also be used parenterally to prevent or treat bleeding in patients with uremia. |
| 34 | ['4256', '253149', '314620'] | Coagulation factor VIIa Recombinant Human | For treatment of hemorrhagic complications in hemophilia A and B |
| 35 | ['139994'] | Oprelvekin | Increases reduced platelet levels due to chemotherapy |
| 36 | ['196319'] | Palifermin | For treatment of oral mucositis associated with chemotherapy and radiation therapy. |
| 37 | ['4832', '261716'] | Glucagon recombinant | For treatment of severe hypoglycemia, also used in gastrointestinal imaging |
| 38 | ['70223'] | Aldesleukin | For treatment of adults with metastatic renal cell carcinoma. |
| 39 | ['860178'] | Botulinum Toxin Type B | For the treatment of patients with cervical dystonia to reduce the severity of abnormal head position and neck pain associated with cervical dystonia. |
| 40 | ['302379'] | Omalizumab | For treatment of asthma caused by allergies |
| 41 | ['388084'] | Lutropin alfa | For treatment of infertility in women with hypothalamic or pituitary insufficiency (hypogonadotropic hypogonadism) and profound LH deficiency (LH <1.2 international units [IU]/L) |
| 42 | ['54214'] | Lyme disease vaccine (recombinant OspA) | For prophylactic treatment of Lyme Disease |
| 43 | ['86009', '314684'] | Insulin Lispro | For the treatment of Type 1 or 2 diabetes mellitus. To be used in conjunction with an intermediate or long-acting insulin except when used in a continuous insulin infusion pump. |
| 44 | ['274783'] | Insulin Glargine | For the treatment of Type 1 or 2 diabetes mellitus in patients over 17 years old who require a long-acting (basal) insulin for the control of hyperglycemia. May be used in pediatric patients with Type 1 diabetes mellitus who require a long-acting (basal) insulin for glycemic control. |
| 45 | ['58939', '898492'] | Collagenase clostridium histolyticum | Used to promote debridement of necrotic tissue in the treatment of severe burns and dermal ulcers including decubitus ulcers. |
| 46 | ['283821'] | Rasburicase | For treatment of hyperuricemia, reduces elevated plasma uric acid levels (from chemotherapy) |
| 47 | ['68147'] | Cetrorelix | For the inhibition of premature LH surges in women undergoing controlled ovarian stimulation |
| 48 | ['327361'] | Adalimumab | For treatment of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and Crohn's disease. |
| 49 | ['61148'] | Somatotropin | For treatment of dwarfism, acromegaly and prevention of HIV-induced weight loss |
| 50 | ['84959'] | Imiglucerase | For the treatment of Gaucher's disease (deficiency in glucocerebrosidase) |
| 51 | ['83929'] | Abciximab | Abciximab is indicated as an adjunct to percutaneous coronary intervention for the prevention of cardiac ischemic complications in patients undergoing percutaneous coronary intervention and in patients with unstable angina not responding to conventional medical therapy when percutaneous coronary intervention is planned within 24 hours. Abciximab is intended for use with aspirin and heparin and has been studied only in that setting. |
| 52 | ['352374'] | Drotrecogin alfa | For reduction of mortality in patients with severe sepsis. |
| 53 | ['1294580'] | Gemtuzumab ozogamicin | Indicated for the treatment of patients with CD33 positive acute myeloid leukemia in first relapse who are 60 years of age or older and who are not considered candidates for other cytotoxic chemotherapy. Indicated for the treatment of patients aged 2 years and older with CD33-positive AML who have experienced a relapse or who have not responded to initial treatment (refractory). |
| 54 | ['535', '991743'] | Alpha-1-proteinase inhibitor | For chronic augmentation and maintenance therapy in individuals with alpha1-proteinase inhibitor (A1-PI) deficiency and clinical evidence of emphysema. |
| 55 | ['34132'] | Pegaspargase | For treatment of acute lymphoblastic leukemia |
| 56 | ['75917'] | Interferon beta-1a | For treatment of relapsing/remitting multiple sclerosis, also for condyloma acuminatum |
| 57 | ['59768'] | Pegademase bovine | For treatment of adenosine deaminase deficiency |
| 58 | ['828529', '1370439'] | Human Serum Albumin | For treatment of severe blood loss, hypervolemia, and hypoproteinemia. |
| 59 | ['75635', '288688'] | Eptifibatide | For treatment of myocardial infarction and acute coronary syndrome. |
| 60 | ['191831', '1790539', '1927283'] | Infliximab | * Indicated for reducing signs and symptoms and inducing and maintaining clinical remission in adult or pediatric (≥ 6 years of age) patients with moderately to severely active **Crohn’s disease** who have had an inadequate response to conventional therapy * Indicated for reducing the number of draining enterocutaneous and rectovaginal fistulas and maintaining fistula closure in adult patients with fistulizing **Crohn’s disease**. * Indicated for reducing signs and symptoms, inducing and maintaining clinical remission and mucosal healing, and eliminating corticosteroid use in adult or pediatric (≥ 6 years of age) patients with moderately to severely active **ulcerative colitis** who have had an inadequate response to conventional therapy. * Indicated for, in combination with methotrexate, reducing signs and symptoms, inhibiting the progression of structural damage, and improving physical function in patients with moderately to severely active **rheumatoid arthritis**. * Indicated for reducing signs and symptoms in patients with active **ankylosing spondylitis**. * Indicated for reducing signs and symptoms of active arthritis, inhibiting the progression of structural damage, and improving physical function in patients with **psoriatic arthritis**. * Indicated for the treatment of adult patients with chronic severe (i.e., extensive and/or disabling) **plaque psoriasis** who are candidates for systemic therapy and when other systemic therapies are medically less appropriate. |
| 61 | ['25357', '227518', '386938'] | Follitropin | In women having been diagnosed with primary ovarian failure, it is used in combination with human chorionic gonadotropin (hCG) to assist in ovulation and fertility. In men with hypogonadotrophic hypogonadism, it is used to induce spermatogenesis. Follitropin may also be used to cause the ovary to produce several follicles, which can then be harvested for use in gamete intrafallopian transfer (GIFT) or in vitro fertilization (IVF). |
| 62 | ['11149'] | Vasopressin | For the treatment of enuresis, polyuria, diabetes insipidus, polydipsia and oesophageal varices with bleeding |
| 63 | ['72257', '72258'] | Interferon beta-1b | Interferon beta-1b is a drug used for the treatment of relapsing/remitting multiple sclerosis. It has been shown to slow the advance of the disease as well as to decrease the frequency of attacks. |
| 64 | ['59744'] | Interferon alfacon-1 | For the treatment of hairy cell leukemia, malignant melanoma, and AIDS-related Kaposi's sarcoma |
| 65 | ['5464', '486164'] | Hyaluronidase | For increase of absorption and distribution of other injected drugs and for rehydration. |
| 66 | ['221109', '1309342'] | Insulin Pork | For the treatment of type I and II diabetes mellitus. |
| 67 | ['224905'] | Trastuzumab | For treatment of early stage HER2-positive breast cancer, or metastatic breast cancer that substantially overexpress HER2. |
| 68 | ['121191'] | Rituximab | For treatment of CD20-positive non-Hodgkins lymphoma, chronic lymphocytic leukemia, and rheumatoid arthritis. |
| 69 | ['196102'] | Basiliximab | For prophylactic treatment of kidney transplant rejection |
| 70 | ['42405'] | Muromonab | For treatment of organ transplant recipients, prevention of organ rejection |
| 71 | ['1745257'] | Digoxin Immune Fab (Ovine) | For treatment of digitoxin overdose or digitalis glycoside toxicity. |
| 72 | ['262323'] | Ibritumomab tiuxetan | For treatment of non-Hodgkin's lymphoma |
| 73 | ['22299'] | Daptomycin | For the treatment of complicated skin and skin structure infections caused by susceptible strains of Gram-positive microorganisms. |
| 74 | ['263010'] | Tositumomab | For treatment of non-Hodgkin's lymphoma (CD20 positive, follicular) |
| 75 | ['278739'] | Pegvisomant | Pegvisomant is a growth hormone receptor antagonist used for the treatment of acromegaly. |
| 76 | ['1712', '860168', '860189', '1000104'] | Botulinum Toxin Type A | For the treatment of cervical dystonia in adults to decrease the severity of abnormal head position and neck pain associated with cervical dystonia. Also for the treatment of severe primary axillary hyperhidrosis that is inadequately managed with topical agents and for the treatment of strabismus and blepharospasm associated with dystonia, including benign essential blepharospasm or VII nerve disorders in patients 12 years of age and above. Also used cosmetically to temporarily improve the appearance of moderate-to-severe frown lines between the eyebrows (glabellar lines) as well as for the treatment of excessive underarm sweating. |
| 77 | ['7880', '235379'] | Pancrelipase | For treatment of exocrine pancreatic insufficiency in cystic fibrosis (Ultresa™), chronic pancreatitis (Viokace™ in combination with a proton pump inhibitor), and pancreatectomy (Viokace™ in combination with a proton pump inhibitor). |
| 78 | ['10106'] | Streptokinase | For the treatment of acute evolving transmural myocardial infarction, pulmonary embolism, deep vein thrombosis, arterial thrombosis or emolism and occlusion of arteriovenous cannulae |
| 79 | ['117055'] | Alemtuzumab | Alemtuzumab (Campath) is a monoclonal antibody therapy used for treatment of B-cell chronic lymphocytic leukemia. |
| 80 | ['46049'] | Alglucerase | For the treatment of Gaucher's disease (deficiency in glucocerebrosidase) |
| 81 | ['136300'] | Capromab pendetide | For diagnosis of prostate cancer and detection of intra-pelvic metastases. |
| 82 | ['392509'] | Laronidase | For the treatment of mucopolysaccharidosis |
| 83 | ['3008'] | Cyclosporine | For treatment of transplant (kidney, liver, and heart) rejection, rheumatoid arthritis, severe psoriasis. |
| 84 | ['299635'] | Alefacept | As an immunosuppressive drug, Alefacept can be used for treatment of moderate to severe chronic plaque psoriasis |
| 85 | ['4319'] | Felypressin | For use as an alternative to adrenaline as a localising agent, provided that local ischaemia is not essential. |
| 86 | ['134404'] | Urofollitropin | For treatment of female infertility |
| 87 | ['356988'] | Efalizumab | For the treatment of adult patients with moderate to severe chronic plaque psoriasis, who are candidates for phototherapy or systemic therapy. |
| 88 | ['283550'] | Choriogonadotropin alfa | For the treatment of female infertility |
| 89 | ['107044', '225741'] | Antithymocyte immunoglobulin (rabbit) | For prevention of renal transplant rejection |
| 90 | ['68442', '1433764', '1605064'] | Filgrastim | Filgrastim is used in patients with acute myeloid leukemia receiving induction or consolidation chemotherapy. It is also used in cancer patients receiving bone marrow transplant. In general, filgrastim increases neutrophil counts in order to decrease the risk of infection or duration of neutropenia in the aforementioned patient populations. Infection and neutropenia are adverse events associated with chemotherapy. Furthermore, filgrastim is also indicated for patients with severe chronic neutropenia. It mobilizes hematopoietic progenitor cells into the peripheral blood for collection by leukapheresis to allow for a more rapid engraftment. Tbo-filgrastim has a narrower indication profile than Neupogen - it is a leukocyte growth factor indicated for the reduction in the duration of severe neutropenia in patients with non-myeloid malignancies. |
| 91 | ['1300488'] | Coagulation Factor IX (Recombinant) | For treatment of hemophilia (Christmas disease). |
| 92 | ['115238'] | Becaplermin | For topical treatment of skin ulcers (from diabetes) |
| 93 | ['259351', '338817'] | Agalsidase beta | For treatment of Fabry's disease (alpha-galactosidase A deficiency) |
| 94 | ['7617'] | Octreotide | For treatment of acromegaly and reduction of side effects from cancer chemotherapy |
| 95 | ['5880'] | Interferon Alfa-2b, Recombinant | For the treatment of hairy cell leukemia, malignant melanoma, and AIDS-related Kaposi's sarcoma. |
| 96 | ['301739'] | Abarelix | For palliative treatment of advanced prostate cancer. |
| 97 | ['7824'] | Oxytocin | Used for labor induction, augmentation of labor, postpartum abbreviation of third stage of labor, postpartum control of uterine bleeding, termination of pregnancy and for the evaluation of fetal respiratory capability. Oxytocin cannot be used for elective induction of labor, there must be a clear medical requirement. |
| 98 | ['354770'] | Natalizumab | For treatment of multiple sclerosis. |
| 99 | ['139896'] | Enfuvirtide | Enfuvirtide is an antiretroviral drug used in combination therapy for the treatment of HIV-1/AIDS. |
| 100 | ['194279'] | Palivizumab | For prophylaxis of respiratory diseases casued by respiratory syncytial virus. |