Downloads: 1
| # | CUI | Drug | Indication | Contraindication | |
|---|---|---|---|---|---|
| 1 | 0 | insulin lispro protamine (rDNA origin)/insulin lispro (rDNA origin) | ['type 1 diabetes mellitus or for type 2 diabetes mellitus inadequately managed by diet, exercise, and oral hypoglycemics', 'formoterol; mometasone'] | ['diarrhea', 'fever', 'infection', 'surgery', 'thyroid disease', 'trauma', 'vomiting', 'hepatic disease', 'renal failure', 'renal impairment', 'coma', 'continuous subcutaneous insulin infusion (csii) administration', 'diabetic ketoacidosis', 'hyperosmolar hyperglycemic state (hhs)', 'intravenous administration', 'hypoglycemia', 'hypokalemia', 'cresol hypersensitivity', 'labor', 'obstetric delivery', 'pregnancy', 'breast-feeding', 'children', 'infants', 'tobacco smoking', 'geriatric'] | |
| 2 | 1 | ['306266', '1546027'] | entecavir | ['chronic hepatitis b infection in patients with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ast or alt) or histologically active disease', 'chronic hepatitis b in nucleoside-treatment-naive patients with compensated liver disease', 'treatment of chronic hepatitis b in patients with compensated liver disease and a history of hepatitis b viremia while receiving lamivudine or with known lamivudine or telbivudine resistance mutations (rtm204i/v with or without rtl180m, rtl80i/v, or rtv173l)', 'chronic hepatitis b in patients coinfected with hiv�', 'chronic hepatitis b in patients with decompensated liver disease'] | ['hepatitis b exacerbation', 'hepatitis b and hiv coinfection', 'human immunodeficiency virus (hiv) infection', 'organ transplant', 'females', 'hepatic disease', 'hepatotoxicity or lactic acidosis', 'obesity', 'dialysis', 'geriatric', 'renal failure', 'renal impairment', 'children', 'infants', 'neonates', 'breast-feeding', 'pregnancy'] |
| 3 | 2 | ['60212'] | atovaquone | ['acute, mild to moderately-severe pneumocystis pneumonia (pcp) infections in patients who do not tolerate trimethoprim-sulfamethoxazole', 'primary or secondary pneumocystis pneumonia (pcp) prophylaxis', 'the acute treatment of toxoplasmic encephalitis� (toxoplasmosis�) due to <em>toxoplasma gondii</em> in hiv-infected patients', 'toxoplasmosis prophylaxis�, specifically toxoplasmic encephalitis (te), in hiv-infected patients', 'primary toxoplasmosis prophylaxis� in hiv-infected patients', 'secondary toxoplasmosis prophylaxis� (i', 'babesiosis� in combination with azithromycin'] | ['gi disease', 'infection', 'respiratory insufficiency', 'pregnancy', 'breast-feeding', 'benzyl alcohol hypersensitivity', 'neonates', 'hepatic disease'] |
| 4 | 3 | ['358274'] | ambrisentan | ['improvement in exercise ability and delay in clinical worsening in patients with who group i pulmonary hypertension (pah)'] | ['hepatic disease', 'hepatitis', 'anemia', 'geriatric', 'peripheral edema', 'pulmonary edema', 'veno-occlusive disease (vod)', 'pulmonary fibrosis', 'pregnancy', 'breast-feeding', 'contraception requirements', 'infertility', 'pregnancy testing', 'reproductive risk'] |
| 5 | 4 | ['60548'] | exenatide | ['type 2 diabetes mellitus in combination with diet and exercise'] | ['diabetic ketoacidosis', 'type 1 diabetes mellitus', 'burns', 'diarrhea', 'fever', 'infection', 'surgery', 'thyroid disease', 'trauma', 'vomiting', "crohn's disease", 'gastroparesis', 'gi disease', 'inflammatory bowel disease', 'ulcerative colitis', 'hypoglycemia', 'dehydration', 'dialysis', 'kidney transplant', 'renal disease', 'renal failure', 'renal impairment', 'tobacco smoking', 'pregnancy', 'breast-feeding', 'children', 'infants', 'pancreatitis', 'medullary thyroid carcinoma (mtc)', 'multiple endocrine neoplasia syndrome type 2 (men 2)', 'thyroid cancer', 'thyroid c-cell tumors', 'geriatric'] |
| 6 | 5 | ['9639'] | selegiline | ["parkinson's disease or parkinsonism in combination with levodopa or levodopa/carbidopa", 'major depression'] | ['maoi therapy', 'alcoholism', 'ethanol ingestion', 'hypertension', 'hypertensive crisis', 'pheochromocytoma', 'children', 'suicidal ideation', 'bipolar disorder', 'mania', 'behavioral changes', 'psychosis', 'schizophrenia', 'impulse control symptoms', 'hypotension', 'orthostatic hypotension', 'hepatic disease', 'renal failure', 'renal impairment', 'melanoma', 'driving or operating machinery', 'abrupt discontinuation', 'pregnancy', 'breast-feeding', 'geriatric', 'phenylketonuria', 'ambient temperature increase', 'heating pad', 'sunlight (uv) exposure'] |
| 7 | 6 | ['3407'] | digoxin | ['ventricular rate control in patients with chronic atrial fibrillation and/or atrial flutter�; or for the treatment of narrow-complex paroxysmal supraventricular tachycardia (psvt)� or for paroxysmal supraventricular tachycardia (psvt) prophylaxis� in patients without a delta wave on ecg during sinus rhythm; or for the treatment of congestive heart failure', 'the transplacental treatment of fetal supraventricular tachyarrhythmias�'] | ['acute myocardial infarction', 'adams-stokes syndrome', 'av block', 'bradycardia', 'cardiomyopathy', 'cor pulmonale', 'hyperthyroidism', 'hypothyroidism', 'hypoxemia', 'myocarditis', 'myxedema', 'pulmonary disease', 'sick sinus syndrome', 'carotid sinus hypersensitivity', 'ventricular arrhythmias', 'ventricular fibrillation', 'ventricular tachycardia', 'wolff-parkinson-white syndrome', 'renal disease', 'renal failure', 'renal impairment', 'geriatric', 'hepatic disease', 'constrictive pericarditis', 'idiopathic hypertrophic subaortic stenosis', 'electrolyte imbalance', 'hypercalcemia', 'hyperkalemia', 'hypocalcemia', 'hypokalemia', 'hypomagnesemia', 'hypertension', 'infants', 'neonates', 'premature neonates', 'pregnancy', 'breast-feeding', 'diarrhea', 'malabsorption syndrome', 'intramuscular administration'] |
| 8 | 7 | valacyclovir hydrochloride | ['herpes simplex virus infection, including herpes labialis and herpes genitalis, and including hiv-infected patients�', 'herpes labialis (i', 'initial episode of herpes genitalis', 'recurrent herpes genitalis, including hiv-infected patients�', 'herpes zoster (shingles) infection', 'varicella (chickenpox) infection', 'acute retinal necrosis (arn)� due to varicella-zoster virus in hiv-infected patients', 'herpes genitalis prophylaxis or for secondary herpes simplex infection prophylaxis�', 'suppressive therapy of recurrent herpes genitalis in all patients or for secondary herpes simplex infection prophylaxis� in hiv-patients for frequent or severe recurrences', 'the reduction of transmission of genital herpes to an immunocompetent uninfected sex partner, in immunocompetent patients with a history of 9 or fewer recurrences per year', 'primary cytomegalovirus (cmv) disease prophylaxis�', 'primary cytomegalovirus (cmv) disease prophylaxis� in patients after kidney transplantation', 'primary cytomegalovirus (cmv) disease prophylaxis� in patients after bone marrow transplantation', 'primary cytomegalovirus (cmv) disease prophylaxis� in patients after heart transplantation', 'the treatment and prophylaxis of encephalitis� due to b virus (cercopithecine herpesvirus) infection�', "bell's palsy� in combination with steroids", 'post-exposure varicella (chickenpox) infection prophylaxis� to prevent primary infection in hiv-infected patients'] | ['acyclovir hypersensitivity', 'famciclovir hypersensitivity', 'ganciclovir hypersensitivity', 'penciclovir hypersensitivity', 'valacyclovir hypersensitivity', 'valganciclovir hypersensitivity', 'renal failure', 'renal impairment', 'geriatric', 'dehydration', 'children', 'infants', 'neonates', 'pregnancy', 'breast-feeding'] | |
| 9 | 8 | ['4083'] | drospirenone/ethinyl estradiol | ['routine contraception', 'acne vulgaris in women who also desire oral contraception', 'premenstrual dysphoric disorder (pmdd) in women who also desire oral contraception', "endometriosis� to induce endometrial involution to a 'resting' phase and reduce the size and growth of endometrial tissue in females with no contraindications to hormonal contraceptives, who have achieved menarche and desire contraception", 'the treatment or adjuvant treatment of conditions such as amenorrhea�, hirsutism�, or polycystic ovary syndrome� related to hypoestrogenic or hyperandrogenic conditions in females who desire oral contraception', 'formoterol; mometasone'] | ['acquired immunodeficiency syndrome (aids)', 'human immunodeficiency virus (hiv) infection', 'adrenal insufficiency', 'electrolyte imbalance', 'hyperkalemia', 'renal disease', 'renal failure', 'renal impairment', 'pregnancy', 'cholestasis', 'gallbladder disease', 'hepatic disease', 'hepatitis', 'hepatocellular cancer', 'jaundice', 'porphyria', 'breast-feeding', 'obstetric delivery', 'obesity', 'diabetes mellitus', 'hyperlipidemia', 'hypertriglyceridemia', 'pancreatitis', 'atrial fibrillation', 'cerebrovascular disease', 'coronary artery disease', 'coronary thrombosis', 'endocarditis', 'hypercholesterolemia', 'hypertension', 'myocardial infarction', 'protein c deficiency', 'protein s deficiency', 'stroke', 'thromboembolic disease', 'thromboembolism', 'thrombophlebitis', 'tobacco smoking', 'valvular heart disease', 'systemic lupus erythematosus (sle)', 'surgery', 'headache', 'migraine', 'depression', 'contact lenses', 'glaucoma', 'visual disturbance', 'children', 'breast cancer', 'hypercalcemia', 'cervical cancer', 'endometrial cancer', 'ovarian cancer', 'uterine cancer', 'vaginal bleeding', 'vaginal cancer', 'hypothyroidism', 'thyroid disease', 'chloasma', 'angioedema', 'hereditary angioedema'] |
| 10 | 9 | U-500) (insulin human | ['type 1 diabetes mellitus or for type 2 diabetes mellitus inadequately managed by diet, exercise, and oral hypoglycemics', 'gestational diabetes or for the treatment of patients with pre-existing diabetes mellitus (type 1 or type 2) who are now pregnant', 'pregnant patients with gestational-onset diabetes not controlled by diet-therapy alone', 'pregnant patients with preexisting diabetes prior to pregnancy', 'diabetic ketoacidosis (dka)', 'hyperosmolar hyperglycemic state (hhs) in patients with type 2 diabetes mellitus', 'neonatal diabetes mellitus�', 'nutritional supplementation� to maintain normoglycemia in very low birthweight infants with persistent glucose intolerance, including those neonates on parenteral nutrition with persistent glucose intolerance', 'hyperkalemia�', 'formoterol; mometasone'] | ['diarrhea', 'fever', 'infection', 'surgery', 'thyroid disease', 'trauma', 'vomiting', 'hepatic disease', 'renal failure', 'renal impairment', 'intramuscular administration', 'intravenous administration', 'continuous subcutaneous insulin infusion (csii) administration', 'hypoglycemia', 'hypokalemia', 'cresol hypersensitivity', 'labor', 'neonates', 'obstetric delivery', 'pregnancy', 'breast-feeding', 'children', 'infants', 'tobacco smoking', 'geriatric'] | |
| 11 | 10 | salmeterol xinafoate | ['the maintenance prevention of bronchospasm (e', 'asthma, including nocturnal asthma symptoms, in patients receiving optimum treatment with antiinflammatory asthma agents and who still require a inhaled beta-adrenergic bronchodilator on a regular schedule', 'exercise-induced bronchospasm prophylaxis', 'the maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (copd) including emphysema and chronic bronchitis', 'altitude sickness prophylaxis<strong>***formoterol***formoterol; mometasone'] | ['monotherapy treatment of asthma', 'milk protein hypersensitivity', 'acute bronchospasm', 'asthma-related death', 'status asthmaticus', 'alcoholism', 'bradycardia', 'cardiac arrhythmias', 'cardiac disease', 'coronary artery disease', 'females', 'heart failure', 'hypertension', 'hypocalcemia', 'hypokalemia', 'hypomagnesemia', 'malnutrition', 'myocardial infarction', 'qt prolongation', 'tachycardia', 'diabetes mellitus', 'hyperthyroidism', 'pheochromocytoma', 'seizure disorder', 'seizures', 'thyroid disease', 'thyrotoxicosis', 'labor', 'pregnancy', 'breast-feeding', 'children', 'infants', 'hepatic disease', 'paradoxical bronchospasm', 'maoi therapy', 'geriatric'] | |
| 12 | 11 | triamcinolone acetonide | ['bronchospasm prophylaxis or maintenance therapy in patients who require chronic treatment with corticosteroids for control of bronchial asthma', 'severe or incapacitating allergic conditions such as asthma that are intractable to adequate trials of conventional treatment', 'symptoms of seasonal and perennial allergic rhinitis', 'severe or incapacitating allergic conditions that are intractable to adequate trials of conventional treatment', 'ocular inflammation (i', 'visualization during ocular surgery (i', 'acute rheumatic carditis, berylliosis, temporal arteritis�, or systemic lupus erythematosus (sle)', 'pruritus and topical inflammation associated with moderate to severe corticosteroid-responsive dermatoses (e', 'ulcerative or inflammatory oral lesions including aphthous ulcer, desquamative gingivitis�, and oral lichen planus�', 'severe or incapacitating allergic conditions such as atopic dermatitis, contact dermatitis, drug hypersensitivity reactions, serum sickness, transfusion reactions, bullous dermatitis herpetiformis, exfoliative erythroderma, mycosis fungoides, pemphigus, severe erythema multiforme (stevens-johnson syndrome) that are intractable to adequate trials of conventional treatment and for the treatment of idiopathic eosinophilic pneumonias', 'symptomatic sarcoidosis', "primary (addison's disease) or secondary adrenocortical insufficiency", 'congenital adrenal hyperplasia', 'hypercalcemia associated with cancer', 'nonsuppurative thyroiditis', 'a critical period of regional enteritis and ulcerative colitis', 'autoimmune hemolytic anemia, diamond-blackfan anemia, pure red cell aplasia, or selected cases of secondary thrombocytopenia', 'trichinosis with neurologic or myocardial involvement', 'complicated or disseminated pulmonary tuberculosis infection (i', 'acute exacerbations of multiple sclerosis', 'cerebral edema associated with primary or metastatic brain tumor, craniotomy, or head injury', 'proteinuria or to induce diuresis in idiopathic nephrotic syndrome or lupus erythematosus', 'an acute episode or exacerbation of ankylosing spondylitis, psoriatic arthritis, and juvenile rheumatoid arthritis (jra)/juvenile idiopathic arthritis (jia) as adjunctive therapy for short-term administration', 'dermatomyositis or polymyositis', 'inflammation and for immunosuppression associated with a variety of disorders, like hodgkin lymphoma', 'the palliative treatment of leukemias and lymphomas', 'chronic immune thrombocytopenia/idiopathic thrombocytopenic purpura (itp)', 'diabetic macular edema�', 'inflammation associated with synovitis of osteoarthritis; rheumatoid arthritis; acute and subacute bursitis; gout with acute gouty arthritis; epicondylitis; acute non-specific tenosynovitis; polychondritis�; posttraumatic osteoarthritis', 'osteoarthritis pain of the knee'] | ['epidural administration', 'intramuscular administration', 'intrathecal administration', 'intravenous administration', 'subcutaneous administration', 'acute bronchospasm', 'status asthmaticus', 'abrupt discontinuation', 'adrenal insufficiency', "cushing's syndrome", 'hyperthyroidism', 'hypothalamic-pituitary-adrenal (hpa) suppression', 'hypothyroidism', 'increased intracranial pressure', 'occlusive dressing', 'skin abrasion', 'head trauma', 'growth inhibition', 'osteoporosis', 'surgery', 'fungal infection', 'infection', 'viral infection', 'tuberculosis', 'immunosuppression', 'herpes infection', 'measles', 'varicella', 'glaucoma', 'acne rosacea', 'acne vulgaris', 'peripheral vascular disease', 'nasal septal perforation', 'nasal surgery', 'nasal trauma', 'myocardial infarction', 'heart failure', 'hypertension', 'diabetes mellitus', 'skin atrophy', 'diverticulitis', 'gi disease', 'gi perforation', 'inflammatory bowel disease', 'peptic ulcer disease', 'ulcerative colitis', 'myasthenia gravis', 'psychosis', 'seizure disorder', 'coagulopathy', 'hemophilia', 'thromboembolic disease', 'cataracts', 'ocular exposure', 'ocular infection', 'ophthalmic administration', 'visual disturbance', 'pregnancy', 'vaccination', 'breast-feeding', 'tartrazine dye hypersensitivity', 'neonates', 'premature neonates', 'idiopathic thrombocytopenic purpura (itp)', 'corticosteroid hypersensitivity', 'geriatric', 'renal disease', 'renal impairment', 'hepatic disease'] | |
| 13 | 12 | ['3108'] | dapsone | ['dermatitis herpetiformis', "the treatment leprosy (hansen's disease)", 'multibacillary leprosy', 'paucibacillary leprosy', 'acne vulgaris', 'actinomycotic mycetoma�', 'actinomycotic mycetoma� caused by <em>actinomadura madurae</em>� or <em>streptomyces somaliensis</em>�', 'actinomycotic mycetoma� caused by <em>nocardia</em> sp', 'granuloma annulare�', 'chronic immune thrombocytopenia/idiopathic thrombocytopenic purpura (itp)�', 'polychondritis�', 'mild to moderate pneumocystis pneumonia (pcp)�', 'pneumocystis pneumonia (pcp) prophylaxis�', 'primary pcp prophylaxis� in hiv-infected patients', 'secondary pcp prophylaxis� in hiv-infected patients after pcp treatment', 'primary toxoplasmosis prophylaxis� in hiv-infected patients, specifically prevention of toxoplasmic encephalitis (te)� due to <em>toxoplasmosis gondii</em>', 'pyoderma gangrenosum�', 'subcorneal pustular dermatosis�'] | ['anemia', 'g6pd deficiency', 'methemoglobin reductase deficiency', 'hepatic disease', 'pregnancy', 'breast-feeding', 'children', 'infants', 'neonates', 'sulfonamide hypersensitivity'] |
| 14 | 13 | fluticasone propionate | ['pruritus and topical inflammation associated with moderate to severe corticosteroid-responsive dermatoses, including the treatment of alopecia areata, discoid lupus erythematosus, generalized exfoliative dermatitis, cutaneous lichen planus, lichen simplex chronicus, lichen striatus, nodular prurigo, pompholyx (dyshidrosis), pemphigus, polymorphous light eruption, psoriasis, seborrheic dermatitis, severe contact dermatitis, severe rhus dermatitis (due to plants like poison ivy), and xerosis', 'eczema, including atopic dermatitis', 'the management of symptoms associated with seasonal or perennial allergic rhinitis, including allergic conjunctivitis', 'the management of nasal symptoms associated with vasomotor rhinitis (perennial nonallergic rhinitis)', 'the maintenance treatment of asthma', 'nasal polyps', 'exercise-induced bronchospasm prophylaxis�', 'formaldehyde hypersensitivit'] | ['corticosteroid hypersensitivity', 'milk protein hypersensitivity', 'acute bronchospasm', 'status asthmaticus', "cushing's syndrome", 'hypothalamic-pituitary-adrenal (hpa) suppression', 'occlusive dressing', 'skin abrasion', 'surgery', 'diabetes mellitus', 'nasal septal perforation', 'nasal surgery', 'nasal trauma', 'fungal infection', 'herpes infection', 'infection', 'measles', 'tuberculosis', 'varicella', 'viral infection', 'malnutrition', 'osteoporosis', 'tobacco smoking', 'geriatric', 'hepatic disease', 'acne rosacea', 'acne vulgaris', 'perioral dermatitis', 'peripheral vascular disease', 'skin atrophy', 'cataracts', 'glaucoma', 'increased intraocular pressure', 'ocular exposure', 'formaldehyde hypersensitivity', 'children', 'growth inhibition', 'increased intracranial pressure', 'infants', 'pregnancy', 'breast-feeding', 'sunlight (uv) exposure'] | |
| 15 | 14 | pramlintide acetate | ['type 1 diabetes mellitus and type 2 diabetes mellitus', 'the adjunct treatment of type 1 diabetes mellitus in patients who use mealtime insulin therapy and who have failed to achieve desired glucose control despite optimal insulin therapy', 'the adjunct treatment of type 2 diabetes mellitus in patients who use mealtime insulin therapy and who have failed to achieve desired glucose control despite optimal insulin therapy'] | ['gastroparesis', 'dialysis', 'renal failure', 'driving or operating machinery', 'hypoglycemia', 'cresol hypersensitivity', 'diarrhea', 'fever', 'infection', 'surgery', 'thyroid disease', 'trauma', 'vomiting', 'osteoporosis', 'pregnancy', 'breast-feeding', 'children', 'tobacco smoking', 'geriatric'] | |
| 16 | 15 | diphtheria and tetanus toxoids and acellular pertussis adsorbed, hepatitis B (recombinant) and inactivated poliovirus vaccine | ['simultaneous diphtheria prophylaxis, tetanus prophylaxis, pertussis prophylaxis, hepatitis b prophylaxis, and poliovirus prophylaxis for primary immunization'] | ['hepatitis', 'anticoagulant therapy', 'coagulopathy', 'hemophilia', 'intraarterial administration', 'intravenous administration', 'subcutaneous administration', 'thrombocytopenia', 'vitamin k deficiency', 'children', 'geriatric', 'infants', 'neonates', 'premature neonates', 'neomycin hypersensitivity', 'polymyxin hypersensitivity', 'yeast hypersensitivity', 'latex hypersensitivity', 'fever', 'shock', 'coma', 'encephalopathy', 'neurological disease', 'seizure disorder', 'seizures', 'guillain-barre syndrome', 'chemotherapy', 'immunosuppression', 'radiation therapy', 'pregnancy', 'breast-feeding'] | |
| 17 | 16 | ['28439'] | lamotrigine | ['partial seizures with or without secondary generalization', 'monotherapy of partial seizures in patients currently receiving treatment with a single enzyme-inducing anti-epileptic drug (aed) (e', 'monotherapy of partial seizures in patients currently receiving treatment with valproate', 'adjunctive therapy to other anticonvulsants in the treatment of partial seizures', 'monotherapy of partial seizures in patients currently receiving treatment with a single anti-epileptic drug (aed) other than carbamazepine, phenytoin, phenobarbital, primidone, or valproate', 'adjunctive therapy to other anticonvulsants in the treatment of primary generalized tonic-clonic seizures', 'adjunctive therapy to other anticonvulsants in the treatment of generalized seizures of lennox-gastaut syndrome', 'the long-term maintenance treatment of bipolar disorder (bipolar i disorder) to delay the occurrence of mood episodes (i', 'absence seizures�', 'long-term prophylaxis of short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (sunct)�'] | ['serious rash', 'depression', 'suicidal ideation', 'abrupt discontinuation', 'driving or operating machinery', 'hepatic disease', 'dialysis', 'renal disease', 'renal failure', 'renal impairment', 'cardiac disease', 'heart failure', 'black patients', 'geriatric', 'children', 'infants', 'neonates', 'folate deficiency', 'pregnancy', 'breast-feeding'] |
| 18 | 17 | ['318341'] | cetuximab | ['kras wild-type metastatic colorectal cancer', 'kras wild-type, egfr-expressing, metastatic colorectal cancer (mcrc) as a single agent after failure of both irinotecan- and oxaliplatin-based regimens or in patients who are intolerant to irinotecan-based chemotherapy', 'kras wild-type, egfr-expressing, metastatic colorectal cancer (mcrc) in combination with irinotecan in patients who are refractory to irinotecan-based chemotherapy', 'the first-line treatment of kras wild-type, egfr-expressing, metastatic colorectal cancer (mcrc) in combination with folfiri (irinotecan, 5-fluorouracil, leucovorin)', 'the first-line treatment of kras wild-type metastatic colorectal cancer (mcrc), in combination with mfolfox6 (leucovorin, oxaliplatin, 5-fluorouracil)�', 'braf mutation-positive, ras wild-type, metastatic colorectal cancer, in combination with irinotecan and vemurafenib�', 'head and neck cancer', 'recurrent or metastatic squamous cell carcinoma of the head and neck in combination with cisplatin�', 'the first-line treatment of recurrent locoregional disease or metastatic squamous cell carcinoma of the head and neck in combination with platinum-based therapy and fluorouracil', 'the first-line treatment of advanced non-small cell lung cancer (nsclc)� in combination with cisplatin and vinorelbine'] | ['acute bronchospasm', 'hypotension', 'infusion-related reactions', 'murine protein hypersensitivity', 'urticaria', 'pulmonary disease', 'pulmonary edema', 'pulmonary fibrosis', 'infection', 'sunlight (uv) exposure', 'cardiac arrest', 'cardiac arrhythmias', 'cardiac disease', 'coronary artery disease', 'electrolyte imbalance', 'heart failure', 'hypocalcemia', 'hypokalemia', 'hypomagnesemia', 'radiation therapy', 'respiratory arrest', 'male-mediated teratogenicity', 'pregnancy', 'breast-feeding', 'children', 'kras mutations'] |
| 19 | 18 | fluticasone furoate | ['pruritus and topical inflammation associated with moderate to severe corticosteroid-responsive dermatoses, including the treatment of alopecia areata, discoid lupus erythematosus, generalized exfoliative dermatitis, cutaneous lichen planus, lichen simplex chronicus, lichen striatus, nodular prurigo, pompholyx (dyshidrosis), pemphigus, polymorphous light eruption, psoriasis, seborrheic dermatitis, severe contact dermatitis, severe rhus dermatitis (due to plants like poison ivy), and xerosis', 'eczema, including atopic dermatitis', 'the management of symptoms associated with seasonal or perennial allergic rhinitis, including allergic conjunctivitis', 'the management of nasal symptoms associated with vasomotor rhinitis (perennial nonallergic rhinitis)', 'the maintenance treatment of asthma', 'nasal polyps', 'exercise-induced bronchospasm prophylaxis�', 'formaldehyde hypersensitivit'] | ['corticosteroid hypersensitivity', 'milk protein hypersensitivity', 'acute bronchospasm', 'status asthmaticus', "cushing's syndrome", 'hypothalamic-pituitary-adrenal (hpa) suppression', 'occlusive dressing', 'skin abrasion', 'surgery', 'diabetes mellitus', 'nasal septal perforation', 'nasal surgery', 'nasal trauma', 'fungal infection', 'herpes infection', 'infection', 'measles', 'tuberculosis', 'varicella', 'viral infection', 'malnutrition', 'osteoporosis', 'tobacco smoking', 'geriatric', 'hepatic disease', 'acne rosacea', 'acne vulgaris', 'perioral dermatitis', 'peripheral vascular disease', 'skin atrophy', 'cataracts', 'glaucoma', 'increased intraocular pressure', 'ocular exposure', 'formaldehyde hypersensitivity', 'children', 'growth inhibition', 'increased intracranial pressure', 'infants', 'pregnancy', 'breast-feeding', 'sunlight (uv) exposure'] | |
| 20 | 19 | tenofovir disoproxil fumarate | ['human immunodeficiency virus (hiv) infection in combination with other anti-retroviral agents', 'treatment of chronic hepatitis b infection', 'human immunodeficiency virus (hiv) prophylaxis�', 'human immunodeficiency virus (hiv) prophylaxis� after occupational exposure', 'human immunodeficiency virus (hiv) prophylaxis� after nonoccupational exposure, including sexual assault', 'pre-exposure hiv prophylaxis� of uninfected individuals to reduce the risk of sexually acquired hiv in heterosexual adults at high risk and to reduce the acquisition risk of hiv in adult injection drug users'] | ['bone fractures', 'hypophosphatemia', 'renal failure', 'renal impairment', 'osteomalacia', 'osteoporosis', 'geriatric', 'children', 'infants', 'neonates', 'alcoholism', 'females', 'hepatic disease', 'hepatotoxicity or lactic acidosis', 'obesity', 'pregnancy', 'breast-feeding', 'hepatitis b and hiv coinfection', 'hepatitis b exacerbation', 'human immunodeficiency virus (hiv) infection resistance', 'autoimmune disease', "graves' disease", 'guillain-barre syndrome', 'immune reconstitution syndrome', 'hiv serum status', 'hepatitis c and hiv coinfection'] | |
| 21 | 20 | sodium chloride | ['dehydration or hypovolemia, including during diabetic ketoacidosis, cardiopulmonary resuscitation, and shock (e', 'hyponatremia', 'mucolysis and sputum induction in patients with cystic fibrosis', 'nasal congestion and dryness', 'nutritional supplementation', 'temporary relief of corneal edema (i', 'increased intracranial pressure�', 'the inpatient management of viral bronchiolitis�', 'formoterol; mometasone'] | ['cardiac disease', 'diabetic ketoacidosis', 'edema', 'heart failure', 'hyperaldosteronism', 'hyperchloremia', 'hypernatremia', 'hypertension', 'hypervolemia', 'metabolic acidosis', 'renal artery stenosis', 'renal disease', 'renal failure', 'renal impairment', 'alcoholism', 'females', 'hyponatremia', 'hypoxemia', 'malnutrition', 'hepatic disease', 'hemolysis', 'pregnancy', 'breast-feeding', 'neonates', 'premature neonates', 'requires an experienced clinician', 'visual impairment', 'geriatric'] | |
| 22 | 21 | warfarin sodium | ['general dosing information in patients requiring warfarin anticoagulation', 'treatment of deep venous thrombosis (dvt) or pulmonary embolism and deep vein thrombosis (dvt) prophylaxis or pulmonary embolism prophylaxis', 'the treatment and further prevention of dvt or pulmonary embolism (pe) after the initial, acute phase of treatment', 'dvt prophylaxis in patients undergoing total hip or knee replacement surgery or hip fracture surgery�', 'dvt prophylaxis in patients with long-term indwelling central venous catheters to prevent axillary-subclavian venous thrombosis�', 'thrombosis prophylaxis (i', 'coronary artery thrombosis prophylaxis in high or very high-risk patients with stable angina� or chronic coronary artery disease�', 'thrombosis prophylaxis in patients with atrial fibrillation', 'thrombosis prophylaxis in patients with atrial fibrillation or atrial flutter who are undergoing cardioversion', 'thrombosis prophylaxis in patients with prosthetic heart valves', 'thrombosis prophylaxis in patients with mechanical prosthetic heart valves and a history of bleeding while receiving warfarin therapy', 'stroke prophylaxis in patients with cerebral venous sinus thrombosis (cvst) after primary treatment with heparin or lmwh', 'thrombosis prophylaxis in patients with valvular heart disease', 'stroke prophylaxis in patients with dilated cardiomyopathy (dcm), particularly in the subgroup of patients with concomitant atrial fibrillation or with a prior history of systemic embolization', 'secondary myocardial infarction prophylaxis (i', 'the coronary artery thrombosis prophylaxis in patients with unstable angina�', 'prophylaxis of arterial and/or venous thromboembolism in patients with antiphospholipid antibody syndrome', 'thromboprophylaxis� in patients with heart failure� who are in sinus rhythm'] | ['coumarin anticoagulants hypersensitivity', 'anemia', 'aneurysm', 'aortic dissection', 'atrial fibrillation', 'bleeding', 'cardiac disease', 'cerebrovascular disease', 'eclampsia', 'endocarditis', 'epidural anesthesia', 'gi bleeding', 'head trauma', 'hematological disease', 'hemophilia', 'hypertension', 'intracranial bleeding', 'leukemia', 'lumbar puncture', 'neoplastic disease', 'peptic ulcer disease', 'pericardial effusion', 'pericarditis', 'polycythemia vera', 'preeclampsia', 'renal disease', 'renal failure', 'renal impairment', 'retinal bleeding', 'spinal anesthesia', 'stroke', 'surgery', 'vasculitis', 'asian patients', 'dental work', 'diabetes mellitus', 'heparin-induced thrombocytopenia (hit)', 'idiopathic thrombocytopenic purpura (itp)', 'heart failure', 'cholestasis', 'hepatic disease', 'hepatitis', 'jaundice', 'intramuscular injections', 'protein c deficiency', 'protein s deficiency', 'vitamin c deficiency', 'anorexia nervosa', 'bulimia nervosa', 'vitamin k deficiency', 'alcoholism', 'dementia', 'psychosis', 'fever', 'hyperthyroidism', 'infection', 'diarrhea', 'hyperlipidemia', 'hypothyroidism', 'peripheral edema', 'tobacco smoking', 'geriatric', 'labor', 'obstetric delivery', 'pregnancy', 'children', 'infants', 'neonates', 'breast-feeding', 'contraception requirements', 'pregnancy testing', 'reproductive risk'] | |
| 23 | 22 | bupropion hydrochloride | ['major depression', 'the prevention of seasonal major depressive disorder episodes associated with seasonal affective disorder (sad)', 'use as an adjunct to psychosocial interventions in the management of tobacco cessation (smoking cessation)', 'use alone to aide in tobacco cessation', 'aide with tobacco cessation using bupropion in combination with a nicotine transdermal system (nts)', 'attention-deficit hyperactivity disorder (adhd)�', 'use as monotherapy of attention-deficit hyperactivity disorder (adhd)� in adults', 'the symptomatic treatment of neuropathic pain� due to various causes, including pain associated with peripheral diabetic neuropathy� or postherpetic neuralgia�', 'formoterol; mometasone'] | ['alcoholism', 'anorexia nervosa', 'benzodiazepine withdrawal', 'brain tumor', 'bulimia nervosa', 'diabetes mellitus', 'head trauma', 'hypoglycemia', 'hyponatremia', 'hypoxemia', 'intracranial mass', 'obesity treatment', 'seizure disorder', 'seizures', 'stroke', 'substance abuse', 'children', 'suicidal ideation', 'tics', "tourette's syndrome", 'behavioral changes', 'bipolar disorder', 'depression', 'mania', 'psychiatric event', 'schizophrenia', 'maoi therapy', 'neonates', 'pregnancy', 'breast-feeding', 'hepatic disease', 'renal disease', 'renal failure', 'renal impairment', 'acute myocardial infarction', 'cardiac disease', 'heart failure', 'hypertension', 'tobacco smoking', 'geriatric', 'driving or operating machinery', 'ethanol intoxication', 'closed-angle glaucoma', 'increased intraocular pressure', 'abrupt discontinuation'] | |
| 24 | 23 | ['613391'] | prasugrel | ['arterial thromboembolism prophylaxis (thrombotic cardiovascular events including stent thrombosis) in patients with acute coronary syndrome (i'] | ['anticoagulant therapy', 'bleeding', 'body weight less than 60 kg', 'coronary artery bypass graft surgery (cabg)', 'gi bleeding', 'intracranial bleeding', 'peptic ulcer disease', 'surgery', 'trauma', 'stroke', 'hepatic disease', 'thrombotic thrombocytopenic purpura (ttp)', 'abrupt discontinuation', 'asian patients', 'children', 'pregnancy', 'breast-feeding', 'renal impairment', 'thienopyridine hypersensitivity', 'geriatric'] |
| 25 | 24 | ['4083'] | drospirenone/ethinyl estradiol | ['routine contraception', 'acne vulgaris in women who also desire oral contraception', 'premenstrual dysphoric disorder (pmdd) in women who also desire oral contraception', "endometriosis� to induce endometrial involution to a 'resting' phase and reduce the size and growth of endometrial tissue in females with no contraindications to hormonal contraceptives, who have achieved menarche and desire contraception", 'the treatment or adjuvant treatment of conditions such as amenorrhea�, hirsutism�, or polycystic ovary syndrome� related to hypoestrogenic or hyperandrogenic conditions in females who desire oral contraception', 'formoterol; mometasone'] | ['acquired immunodeficiency syndrome (aids)', 'human immunodeficiency virus (hiv) infection', 'adrenal insufficiency', 'electrolyte imbalance', 'hyperkalemia', 'renal disease', 'renal failure', 'renal impairment', 'pregnancy', 'cholestasis', 'gallbladder disease', 'hepatic disease', 'hepatitis', 'hepatocellular cancer', 'jaundice', 'porphyria', 'breast-feeding', 'obstetric delivery', 'obesity', 'diabetes mellitus', 'hyperlipidemia', 'hypertriglyceridemia', 'pancreatitis', 'atrial fibrillation', 'cerebrovascular disease', 'coronary artery disease', 'coronary thrombosis', 'endocarditis', 'hypercholesterolemia', 'hypertension', 'myocardial infarction', 'protein c deficiency', 'protein s deficiency', 'stroke', 'thromboembolic disease', 'thromboembolism', 'thrombophlebitis', 'tobacco smoking', 'valvular heart disease', 'systemic lupus erythematosus (sle)', 'surgery', 'headache', 'migraine', 'depression', 'contact lenses', 'glaucoma', 'visual disturbance', 'children', 'breast cancer', 'hypercalcemia', 'cervical cancer', 'endometrial cancer', 'ovarian cancer', 'uterine cancer', 'vaginal bleeding', 'vaginal cancer', 'hypothyroidism', 'thyroid disease', 'chloasma', 'angioedema', 'hereditary angioedema'] |
| 26 | 25 | ['197'] | acetylcysteine | ['the prevention of hepatotoxicity after an acute acetaminophen overdose or repeated ingestion of supratherapeutic doses'] | ['initiate treatment within 8 hours of suspected apap ingestion for maximal protection against hepatic injury. give activated charcoal as soon as possible after ingestion to prevent apap absorption. for regular-release apap overdoses'] |
| 27 | 26 | ['2105', '343027'] | carmustine | ['brain tumors including malignant glioma and glioblastoma multiforme', 'brain tumors including malignant glioma, glioblastoma, medulloblastoma, astrocytoma, ependymoma, and brain metastases', 'newly-diagnosed high grade malignant glioma as an adjunct to surgery and radiation and as an adjunct to surgery in patients with recurrent glioblastoma multiforme', 'multiple myeloma in combination with prednisone', "relapsed or refractory hodgkin lymphoma or non-hodgkin's lymphoma (nhl), in combination with other approved drugs", 'the first-line treatment of metastatic malignant melanoma in combination with dacarbazine, cisplatin, and tamoxifen�', 'cutaneous t-cell lymphoma (ctcl)� (aka mycosis fungoides�)', 'stem cell transplant preparation, in combination with other chemotherapy agents�', 'formoterol; mometasone'] | ['anemia', 'aseptic meningitis', 'bleeding', 'bone marrow suppression', 'infection', 'leukopenia', 'neutropenia', 'thrombocytopenia', 'pulmonary fibrosis', 'pulmonary toxicity', 'new primary malignancy', 'extravasation', 'intraarterial administration', 'seizures', 'wound dehiscence', 'increased intracranial pressure', 'renal disease', 'renal failure', 'renal impairment', 'hepatic disease', 'hepatotoxicity', 'children', 'pregnancy', 'contraception requirements', 'infertility', 'male-mediated teratogenicity', 'reproductive risk', 'breast-feeding'] |
| 28 | 27 | influenza vaccine | ['annual seasonal influenza prophylaxis'] | ['intravenous administration', 'subcutaneous administration', 'fever', 'respiratory infection', 'egg hypersensitivity', 'kanamycin hypersensitivity', 'latex hypersensitivity', 'neomycin hypersensitivity', 'guillain-barre syndrome', 'geriatric', 'children', 'infants', 'pregnancy', 'breast-feeding', 'anticoagulant therapy', 'coagulopathy', 'hemophilia', 'thrombocytopenia', 'vitamin k deficiency', 'acquired immunodeficiency syndrome (aids)', 'agammaglobulinemia', 'human immunodeficiency virus (hiv) infection', 'hypogammaglobulinemia', 'immunosuppression', 'neoplastic disease', 'radiation therapy', 'severe combined immunodeficiency (scid)', 'syncope'] | |
| 29 | 28 | ['475342', '1546019'] | dasatinib | ['philadelphia chromosome-positive (ph+) chronic myelogenous leukemia (cml)', 'myeloid or lymphoid blast-phase ph+ cml with resistance or intolerance to prior therapy, including imatinib', 'chronic-phase ph+ cml with resistance or intolerance to prior therapy, including imatinib', 'newly diagnosed chronic-phase ph+ cml', 'accelerated-phase ph+ cml with resistance or intolerance to prior therapy, including imatinib', 'chronic-phase ph+ cml', 'philadelphia chromosome-positive (ph+) acute lymphocytic leukemia (all)', 'for the treatment of ph+ all with resistance or intolerance to prior therapy', 'formoterol***formoterol; mometasone'] | ['anemia', 'bone marrow suppression', 'neutropenia', 'thrombocytopenia', 'anticoagulant therapy', 'bleeding', 'gi bleeding', 'intracranial bleeding', 'edema', 'pericardial effusion', 'pleural effusion', 'alcoholism', 'cardiac arrhythmias', 'cardiac disease', 'diabetes mellitus', 'females', 'heart failure', 'hypokalemia', 'hypomagnesemia', 'long qt syndrome', 'malnutrition', 'qt prolongation', 'thyroid disease', 'lactase deficiency', 'tumor lysis syndrome (tls)', 'pulmonary hypertension', 'geriatric', 'children', 'growth inhibition', 'infants', 'neonates', 'pregnancy', 'contraception requirements', 'infertility', 'reproductive risk', 'breast-feeding'] |
| 30 | 29 | ['35636'] | risperidone | ['schizophrenia', 'bipolar disorder (bipolar i disorder), including acute mania or mixed episodes and maintenance therapy', 'acute mania or mixed episodes associated with bipolar i disorder', 'the maintenance treatment of bipolar i disorder as monotherapy or adjunct therapy to lithium or valproate', 'irritability associated with autistic disorder', "moderate to severe tics associated with tourette's syndrome�", 'moderate to severe disruptive behaviors� (e', 'delirium� in the pediatric intensive care unit (picu)', 'severe behavioral or psychological symptoms of dementia�', 'formoterol***formoterol; mometasone'] | ['cns depression', 'coadministration with other cns depressants', 'driving or operating machinery', 'ethanol ingestion', 'agranulocytosis', 'hematological disease', 'leukopenia', 'neutropenia', 'thrombotic thrombocytopenic purpura (ttp)', 'phenylketonuria', 'suicidal ideation', 'abrupt discontinuation', 'tardive dyskinesia', 'cardiac disease', 'cerebrovascular disease', 'heart failure', 'hypovolemia', 'myocardial infarction', 'orthostatic hypotension', 'syncope', 'alcoholism', 'bradycardia', 'cardiac arrhythmias', 'coronary artery disease', 'females', 'hypertension', 'hypocalcemia', 'hypokalemia', 'hypomagnesemia', 'long qt syndrome', 'malnutrition', 'qt prolongation', 'thyroid disease', 'torsade de pointes', 'hyponatremia', 'seizure disorder', 'seizures', 'renal failure', 'renal impairment', 'hepatic disease', 'neurological disease', "parkinson's disease", 'dementia', 'geriatric', 'stroke', 'dysphagia', 'ambient temperature increase', 'dehydration', 'hyperthermia', 'hypothermia', 'strenuous exercise', 'diabetes mellitus', 'diabetic ketoacidosis', 'hypercholesterolemia', 'hyperglycemia', 'hyperlipidemia', 'hyperosmolar hyperglycemic state (hhs)', 'hypertriglyceridemia', 'obesity', 'breast cancer', 'hyperprolactinemia', 'infertility', 'intravenous administration', 'subcutaneous administration', 'priapism', 'neonates', 'pregnancy', 'pregnancy testing', 'breast-feeding', 'children'] |
| 31 | 30 | ['3407'] | digoxin | ['ventricular rate control in patients with chronic atrial fibrillation and/or atrial flutter�; or for the treatment of narrow-complex paroxysmal supraventricular tachycardia (psvt)� or for paroxysmal supraventricular tachycardia (psvt) prophylaxis� in patients without a delta wave on ecg during sinus rhythm; or for the treatment of congestive heart failure', 'the transplacental treatment of fetal supraventricular tachyarrhythmias�'] | ['acute myocardial infarction', 'adams-stokes syndrome', 'av block', 'bradycardia', 'cardiomyopathy', 'cor pulmonale', 'hyperthyroidism', 'hypothyroidism', 'hypoxemia', 'myocarditis', 'myxedema', 'pulmonary disease', 'sick sinus syndrome', 'carotid sinus hypersensitivity', 'ventricular arrhythmias', 'ventricular fibrillation', 'ventricular tachycardia', 'wolff-parkinson-white syndrome', 'renal disease', 'renal failure', 'renal impairment', 'geriatric', 'hepatic disease', 'constrictive pericarditis', 'idiopathic hypertrophic subaortic stenosis', 'electrolyte imbalance', 'hypercalcemia', 'hyperkalemia', 'hypocalcemia', 'hypokalemia', 'hypomagnesemia', 'hypertension', 'infants', 'neonates', 'premature neonates', 'pregnancy', 'breast-feeding', 'diarrhea', 'malabsorption syndrome', 'intramuscular administration'] |
| 32 | 31 | sumatriptan succinate | ['the acute treatment of migraine attacks with or without aura', 'the acute treatment of cluster headache'] | ['sumatriptan hypersensitivity', 'acute myocardial infarction', 'angina', 'arteriosclerosis', 'cardiac arrhythmias', 'cardiac disease', 'coronary artery disease', 'diabetes mellitus', 'hypercholesterolemia', 'obesity', 'tobacco smoking', 'vasospastic angina', 'wolff-parkinson-white syndrome', 'hypertension', 'cerebrovascular disease', 'intracranial bleeding', 'stroke', 'basilar/hemiplegic migraine', 'intravenous administration', 'pregnancy', 'breast-feeding', 'hepatic disease', 'renal disease', 'renal failure', 'renal impairment', 'children', 'geriatric', 'driving or operating machinery', 'colitis', 'peripheral vascular disease', "raynaud's phenomenon", 'seizure disorder', 'seizures', 'visual disturbance', 'maoi therapy', 'magnetic resonance imaging (mri)'] | |
| 33 | 32 | ['4083']['6373'] | estradiol/levonorgestrel | ['treatment of moderate to severe vasomotor symptoms (hot flashes) of menopause and/or related genitourinary symptoms including atrophic vaginitis, vulvar atrophy (kraurosis vulvae) in women with an intact uterus', 'osteoporosis prophylaxis due to menopause (either natural or surgical) in women with an intact uterus', 'formoterol; mometasone'] | ['angioedema', 'hereditary angioedema', 'breast cancer', 'hypercalcemia', 'new primary malignancy', 'ovarian cancer', 'endometrial cancer', 'endometrial hyperplasia', 'vaginal bleeding', 'cervical cancer', 'endometriosis', 'uterine cancer', 'uterine leiomyomata', 'vaginal cancer', 'cardiac disease', 'cerebrovascular disease', 'coronary artery disease', 'hypercholesterolemia', 'hypertension', 'myocardial infarction', 'obesity', 'protein c deficiency', 'protein s deficiency', 'stroke', 'thromboembolic disease', 'thromboembolism', 'thrombophlebitis', 'tobacco smoking', 'surgery', 'pregnancy', 'breast-feeding', 'gallbladder disease', 'hepatic disease', 'hepatocellular cancer', 'jaundice', 'porphyria', 'systemic lupus erythematosus (sle)', 'hypertriglyceridemia', 'pancreatitis', 'contact lenses', 'migraine', 'visual disturbance', 'diabetes mellitus', 'hypothyroidism', 'thyroid disease', 'asthma', 'renal disease', 'seizure disorder', 'depression', 'hypocalcemia', 'hypoparathyroidism', 'dementia', 'geriatric', 'children', 'infants'] |
| 34 | 33 | ['1895'] | drospirenone/ethinyl estradiol/levomefolate calcium | ['routine contraception and to increase folate levels in women who desire to use oral contraception', 'premenstrual dysphoric disorder (pmdd) in women who desire to use an oral contraceptive', 'moderate acne vulgaris in women who also desire to use an oral contraceptive', "endometriosis� to induce endometrial involution to a 'resting' phase and reduce the size and growth of endometrial tissue in females with no contraindications to hormonal contraceptives, who have achieved menarche and desire contraception", 'formoterol; mometasone'] | ['adrenal insufficiency', 'electrolyte imbalance', 'hyperkalemia', 'renal failure', 'renal impairment', 'pregnancy', 'cholestasis', 'gallbladder disease', 'hepatic disease', 'hepatitis', 'hepatocellular cancer', 'jaundice', 'porphyria', 'breast-feeding', 'obstetric delivery', 'atrial fibrillation', 'cerebrovascular disease', 'coronary artery disease', 'coronary thrombosis', 'endocarditis', 'hypercholesterolemia', 'hypertension', 'myocardial infarction', 'protein c deficiency', 'protein s deficiency', 'stroke', 'thromboembolic disease', 'thromboembolism', 'thrombophlebitis', 'tobacco smoking', 'valvular heart disease', 'breast cancer', 'cervical cancer', 'endometrial cancer', 'ovarian cancer', 'uterine cancer', 'vaginal bleeding', 'vaginal cancer', 'surgery', 'diabetes mellitus', 'hyperlipidemia', 'hypertriglyceridemia', 'headache', 'migraine', 'depression', 'hypothyroidism', 'thyroid disease', 'pernicious anemia', 'vitamin b12 deficiency', 'contact lenses', 'glaucoma', 'visual disturbance', 'acquired immunodeficiency syndrome (aids)', 'human immunodeficiency virus (hiv) infection', 'obesity', 'systemic lupus erythematosus (sle)', 'children', 'infants', 'neonates', 'angioedema', 'hereditary angioedema', 'chloasma'] |
| 35 | 34 | aminosalicylic acid | ['tuberculosis infection in combination with other agents as second line therapy', 'aminosalicylic acid desensitization'] | ['renal disease', 'renal failure', 'hepatitis', 'jaundice', 'hepatic disease', 'vitamin b12 deficiency', 'malabsorption syndrome', 'pregnancy', 'breast-feeding'] | |
| 36 | 35 | collagenase | ['severe partial- or full-thickness burns', 'decubitus ulcer, diabetic foot ulcer, or varicose ulcer that requires debridement', "dupuytren's contracture with a palpable cord", "peyronie's disease with a palpable plaque and curvature deformity of at least 30 degrees at the start of therapy"] | ['bone marrow suppression', 'hyperglycemia', 'immunosuppression', 'infection', 'malnutrition', 'arteriosclerosis', 'diabetes mellitus', 'peripheral vascular disease', 'anticoagulant therapy', 'coagulopathy', 'hemophilia', 'thrombocytopenia', 'vitamin k deficiency', 'children', 'pregnancy', 'breast-feeding', 'corporal rupture', 'requires an experienced clinician'] | |
| 37 | 36 | ['8703'] | fenofibrate | ['use as an adjunct to diet for the treatment of adult patients with severe hypertriglyceridemia', 'use as an adjunct to diet to reduce elevated ldl-cholesterol (ldl-c), total cholesterol (total-c), triglycerides (tg), and apolipoprotein b (apo b), and to increase hdl-cholesterol (hdl-c) in adult patients with primary hypercholesterolemia or mixed dyslipidemia'] | ['cardiac disease', 'biliary cirrhosis', 'cholelithiasis', 'gallbladder disease', 'hepatic disease', 'dialysis', 'renal disease', 'renal failure', 'renal impairment', 'anticoagulant therapy', 'thromboembolic disease', 'geriatric', 'children', 'infants', 'neonates', 'pregnancy', 'breast-feeding', 'diabetes mellitus', 'hypothyroidism'] |
| 38 | 37 | sodium oxybate | ['cataplexy and excessive daytime sleepiness in patients with narcolepsy'] | ['succinic semialdehyde dehydrogenase deficiency', 'alcoholism', 'behavioral changes', 'cns depression', 'coadministration with other cns depressants', 'coma', 'depression', 'driving or operating machinery', 'ethanol ingestion', 'respiratory depression', 'substance abuse', 'suicidal ideation', 'surgery', 'hypoxemia', 'respiratory insufficiency', 'sleep apnea', 'seizure disorder', 'seizures', 'hepatic disease', 'cardiac arrhythmias', 'cardiac disease', 'heart failure', 'hypertension', 'renal disease', 'urinary incontinence', 'electrolyte imbalance', 'hypernatremia', 'hyperprolactinemia', 'hypokalemia', 'abrupt discontinuation', 'geriatric', 'eclampsia', 'labor', 'neonates', 'obstetric delivery', 'pregnancy', 'breast-feeding', 'children', 'infants'] | |
| 39 | 38 | ['276237'] | emtricitabine/tenofovir disoproxil fumarate | ['human immunodeficiency virus (hiv) infection in combination with other antiretroviral agents', 'human immunodeficiency virus (hiv) prophylaxis', 'hiv prophylaxis� after occupational exposure to hiv', 'pre-exposure hiv prophylaxis of uninfected individuals to reduce the risk of sexually acquired hiv-1 in adults at high risk', 'hiv prophylaxis� after nonoccupational exposure to hiv, including sexual assault', 'pre-exposure hiv prophylaxis of uninfected individuals at high risk of acquiring hiv infection through injection drug use�'] | ['human immunodeficiency virus (hiv) infection resistance', 'hepatitis b and hiv coinfection', 'hepatitis b exacerbation', 'alcoholism', 'females', 'hepatic disease', 'hepatotoxicity or lactic acidosis', 'obesity', 'bone fractures', 'hypophosphatemia', 'renal failure', 'renal impairment', 'osteomalacia', 'osteoporosis', 'autoimmune disease', "graves' disease", 'guillain-barre syndrome', 'immune reconstitution syndrome', 'children', 'pregnancy', 'breast-feeding', 'hiv serum status', 'hepatitis c and hiv coinfection'] |
| 40 | 39 | naratriptan hydrochloride | ['the acute treatment of migraine with or without aura', 'menstrual migraine prophylaxis�'] | ['acute myocardial infarction', 'angina', 'arteriosclerosis', 'cardiac arrhythmias', 'cardiac disease', 'coronary artery disease', 'diabetes mellitus', 'hypercholesterolemia', 'myocardial infarction', 'obesity', 'tobacco smoking', 'vasospastic angina', 'wolff-parkinson-white syndrome', 'hypertension', 'colitis', 'peripheral vascular disease', 'cerebrovascular disease', 'intracranial bleeding', 'stroke', 'basilar/hemiplegic migraine', 'renal failure', 'renal impairment', 'hepatic disease', 'pregnancy', 'breast-feeding', 'geriatric', 'driving or operating machinery'] | |
| 41 | 40 | ['1272'] | aztreonam | ['the management of pulmonary infections in patients with cystic fibrosis', 'the improvement of respiratory symptoms in cystic fibrosis patients with <em>pseudomonas aeruginosa</em> and an fev1 between 25% to 75% predicted', 'pulmonary exacerbation in patients with cystic fibrosis', 'gram-negative infections including intraabdominal infections (peritonitis), gynecologic infections (endometritis, pelvic cellulitis), skin and skin structure infections (diabetic foot ulcer, postoperative wounds, burn wound infection), and bacteremia', 'peritonitis in patients receiving peritoneal dialysis', 'complicated and uncomplicated urinary tract infection (uti) including cystitis and pyelonephritis', 'lower respiratory tract infections, including bronchitis and pneumonia (community-acquired pneumonia and nosocomial pneumonia)', 'community-acquired pneumonia (cap)', 'nosocomial pneumonia, including hospital-acquired pneumonia (hap) and ventilator-associated pneumonia (vap)', 'bronchitis', 'surgical infection prophylaxis�', 'the empiric treatment of febrile neutropenia�', 'febrile neutropenia in adults', 'febrile neutropenia in pediatric patients'] | ['viral infection', 'carbapenem hypersensitivity', 'cephalosporin hypersensitivity', 'penicillin hypersensitivity', 'renal disease', 'renal failure', 'renal impairment', 'colitis', 'diarrhea', 'gi disease', 'inflammatory bowel disease', 'pseudomembranous colitis', 'ulcerative colitis', 'acute bronchospasm', 'children', 'infants', 'neonates', 'pregnancy', 'breast-feeding', 'geriatric'] |
| 42 | 41 | ['283810'] | bimatoprost | ['the reduction of elevated or increased intraocular pressure (iop) in patients with open-angle glaucoma or ocular hypertension', 'treatment of hypotrichosis of the eyelashes'] | ['closed-angle glaucoma', 'aphakia', 'corneal abrasion', 'iritis', 'keratitis', 'ocular infection', 'ocular surgery', 'ocular trauma', 'uveitis', 'contact lenses', 'sunlight (uv) exposure', 'children', 'infants', 'neonates', 'pregnancy', 'breast-feeding'] |
| 43 | 42 | ['73710'] | paricalcitol | ['the prevention and treatment of secondary hyperparathyroidism and resultant metabolic bone disease (renal osteodystrophy�)', 'initial dosing and dosage titration in pre-dialysis patients with stage 3 or 4 chronic kidney disease', 'initial dosing and dosage titration in patients with stage 5 chronic kidney disease on dialysis', 'initial dosing and dosage titration in patients with stage 5 chronic kidney disease on dialysis (national kidney foundation guidelines)'] | ['hypercalcemia', 'hypervitaminosis d', 'pregnancy', 'breast-feeding', 'children', 'infants', 'neonates', 'geriatric'] |
| 44 | 43 | hepatitis B vaccine (recombinant) | ['hepatitis b prophylaxis', 'prophylaxis of hepatitis b using recombivax hb', 'prophylaxis of hepatitis b using engerix-b', 'booster vaccination using engerix-b', 'prophylaxis of hepatitis b using heplisav-b'] | ['yeast hypersensitivity', 'neonates', 'premature neonates', 'anticoagulant therapy', 'coagulopathy', 'hemophilia', 'intravenous administration', 'subcutaneous administration', 'thrombocytopenia', 'vitamin k deficiency', 'cardiac disease', 'fever', 'infection', 'chemotherapy', 'human immunodeficiency virus (hiv) infection', 'immunosuppression', 'dialysis', 'renal disease', 'renal failure', 'pregnancy', 'breast-feeding', 'latex hypersensitivity'] | |
| 45 | 44 | leuprolide acetate | ['the palliative treatment of advanced prostate cancer, particularly when orchiectomy or estrogen therapy are not indicated or are unacceptable', 'the management of endometriosis including pain relief and reduction of endometriotic lesions', 'central precocious puberty (idiopathic or neurogenic) in children', 'the preoperative treatment of anemia due to uterine leiomyomata (fibroids) in combination with iron supplementation when iron therapy alone fails to correct the anemia', 'benign prostatic hyperplasia (bph)�', 'the adjuvant treatment of premenopausal women with hormone receptor-positive breast cancer�', 'nonspecific symptoms associated with premenstrual syndrome (pms)�', 'inhibiting premature leuteinizing hormone (lh) surges in women undergoing controlled ovarian hyperstimulation and subsequent in vitro fertilization (ivf) or other assisted reproductive technology (art) for the treatment of infertility�', 'prevention of stuttering priapism� (i', 'formoterol***formoterol; mometasone'] | ['benzyl alcohol hypersensitivity', 'gonadotropin-releasing hormone (gnrh) analogs hypersensitivity', 'renal impairment', 'spinal cord compression', 'urinary tract obstruction', 'pituitary insufficiency', 'dysfunctional uterine bleeding', 'menstruation', 'vaginal bleeding', 'children', 'geriatric', 'osteoporosis', 'females', 'pregnancy', 'breast-feeding', 'cardiac disease', 'hypercholesterolemia', 'hypertension', 'myocardial infarction', 'obesity', 'stroke', 'tobacco smoking', 'diabetes mellitus', 'hyperglycemia', 'alcoholism', 'cardiac arrhythmias', 'coronary artery disease', 'heart failure', 'hepatic disease', 'hypocalcemia', 'hypokalemia', 'hypomagnesemia', 'long qt syndrome', 'malnutrition', 'qt prolongation', 'thyroid disease', 'brain tumor', 'cerebrovascular disease', 'seizure disorder', 'depression', 'suicidal ideation'] | |
| 46 | 45 | ['228790']['77492'] | dutasteride/tamsulosin hydrochloride | ['the signs and symptoms of benign prostatic hyperplasia (bph) in men with an enlarged prostate'] | ['females', 'pregnancy', 'breast-feeding', 'children', 'infants', 'neonates', 'geriatric', 'orthostatic hypotension', 'renal disease', 'renal failure', 'renal impairment', 'syncope', 'prostate cancer', 'urinary tract obstruction', 'blood donation', 'ocular surgery', 'sulfonamide hypersensitivity', 'hepatic disease', 'priapism', 'infertility'] |
| 47 | 46 | loteprednol etabonate/tobramycin | ['corticosteroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where a superficial bacterial ophthalmic infection or a risk of bacterial infection exists, including bacterial conjunctivitis, allergic conjunctivitis, acne rosacea, superficial punctate keratitis, herpes zoster ocular infection (keratitis), iritis, cyclitis, and chronic anterior uveitis or corneal injury resulting from chemical, radiation, or thermal ocular burns or from the penetration of foreign bodies'] | ['aminoglycoside hypersensitivity', 'corticosteroid hypersensitivity', 'glycerin hypersensitivity', 'fungal infection', 'herpes infection', 'herpes simplex keratitis (dendritic keratitis)', 'mycobacterial infection', 'ocular infection', 'varicella', 'viral infection', 'glaucoma', 'increased intraocular pressure', 'open-angle glaucoma', 'cataracts', 'diabetes mellitus', 'corneal abrasion', 'contact lenses', 'pregnancy', 'breast-feeding', 'children', 'infants', 'neonates', 'geriatric'] | |
| 48 | 47 | ['38454']['11170'] | trandolapril/verapamil hydrochloride | ['hypertension in patients who do not respond to monotherapy'] | ['ace-inhibitor induced angioedema', 'angioedema', 'angiotensin-converting enzyme inhibitors (ace inhibitors) hypersensitivity', 'black patients', 'hereditary angioedema', 'acute myocardial infarction', 'bradycardia', 'cardiogenic shock', 'heart failure', 'ventricular dysfunction', 'av block', 'sick sinus syndrome', 'atrial fibrillation', 'atrial flutter', 'lown-ganong-levine syndrome', 'ventricular tachycardia', 'wolff-parkinson-white syndrome', 'myasthenia gravis', 'neuromuscular disease', 'constipation', 'fecal impaction', 'gi obstruction', 'ileus', 'diabetes mellitus', 'hyperkalemia', 'autoimmune disease', 'bone marrow suppression', 'collagen-vascular disease', 'immunosuppression', 'renal artery stenosis', 'renal disease', 'renal failure', 'renal impairment', 'scleroderma', 'systemic lupus erythematosus (sle)', 'aortic stenosis', 'cardiomyopathy', 'cerebrovascular disease', 'coronary artery disease', 'dialysis', 'hyponatremia', 'hypotension', 'hypovolemia', 'hymenoptera venom (insect sting) allergy desensitization', 'low-density lipoprotein apheresis', 'geriatric', 'hepatic disease', 'surgery', 'pregnancy', 'breast-feeding', 'children'] |
| 49 | 48 | ['614391'] | abatacept | ['moderate to severe rheumatoid arthritis to reduce signs and symptoms of the disease, to induce a major clinical response, to inhibit the progression of structural damage, and to improve physical function', 'moderate to severe polyarticular juvenile idiopathic arthritis as monotherapy or with methotrexate to reduce signs and symptoms of the disease', 'the treatment active psoriatic arthritis in adult patients'] | ['maltose hypersensitivity', 'agranulocytosis', 'asthma', 'bone marrow suppression', 'chronic obstructive pulmonary disease (copd)', 'corticosteroid therapy', 'cystic fibrosis', 'diabetes mellitus', 'emphysema', 'hepatitis', 'immunosuppression', 'infection', 'respiratory infection', 'sepsis', 'tobacco smoking', 'tuberculosis', 'neoplastic disease', 'geriatric', 'children', 'infants', 'pregnancy', 'breast-feeding', 'hyperglycemia', 'vaccination'] |
| 50 | 49 | ['31555'] | nebivolol | ['hypertension either alone or in combination with other agents', 'heart failure�', 'migraine prophylaxis�'] | ['abrupt discontinuation', 'coronary artery disease', 'acute heart failure', 'av block', 'bradycardia', 'cardiogenic shock', 'sick sinus syndrome', 'hepatic disease', 'acute bronchospasm', 'hyperthyroidism', 'thyrotoxicosis', 'diabetes mellitus', 'surgery', 'peripheral vascular disease', 'pheochromocytoma', 'renal impairment', 'geriatric', 'children', 'infants', 'neonates', 'pregnancy', 'breast-feeding'] |
| 51 | 50 | acetylcholine chloride | ['miosis induction in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment ocular surgery where rapid miosis may be required'] | ['iritis', 'children', 'infants', 'neonates', 'pregnancy', 'breast-feeding'] | |
| 52 | 51 | eprosartan mesylate/hydrochlorothiazide | ['hypertension in patients who do not respond to monotherapy', 'formoterol***formoterol; mometasone'] | ['asthma', 'penicillin hypersensitivity', 'sulfonamide hypersensitivity', 'thiazide diuretic hypersensitivity', 'anuria', 'heart failure', 'renal artery stenosis', 'renal disease', 'renal failure', 'renal impairment', 'hepatic disease', 'hypotension', 'hypovolemia', 'orthostatic hypotension', 'sympathectomy', 'syncope', 'ace-inhibitor induced angioedema', 'angioedema', 'surgery', 'pregnancy', 'breast-feeding', 'children', 'electrolyte imbalance', 'hypercalcemia', 'hyperkalemia', 'hypokalemia', 'hypomagnesemia', 'hyponatremia', 'diabetes mellitus', 'hyperglycemia', 'pancreatitis', 'gout', 'hyperuricemia', 'systemic lupus erythematosus (sle)', 'sunlight (uv) exposure', 'geriatric'] | |
| 53 | 52 | olopatadine hydrochloride | ['the signs and symptoms of allergic conjunctivitis, including ocular pruritus', 'symptoms associated with seasonal allergic rhinitis such as rhinorrhea, sneezing, and nasal pruritus'] | ['contact lenses', 'geriatric', 'driving or operating machinery', 'children', 'infants', 'neonates', 'nasal septal perforation', 'nasal trauma', 'depression', 'pregnancy', 'breast-feeding'] | |
| 54 | 53 | ['1092437'] | belimumab | ['active, autoantibody-positive, systemic lupus erythematosus (sle) in combination with standard therapy'] | ['infusion-related reactions', 'requires an experienced clinician', 'risk of serious hypersensitivity reactions or anaphylaxis', 'immunosuppression', 'infection', 'progressive multifocal leukoencephalopathy', 'depression', 'psychiatric event', 'suicidal ideation', 'vaccination', 'new primary malignancy', 'black patients', 'infants', 'neonates', 'pregnancy', 'contraception requirements', 'reproductive risk', 'breast-feeding', 'geriatric', 'children'] |
| 55 | 54 | ['6373'] | levonorgestrel | ['routine contraception', 'use as postcoital contraception within 72 hours of unprotected intercourse or known or suspected contraceptive failure - for use in females who have no known contraindications to use, have achieved menarche, and are not known or suspected to be pregnant', 'menorrhagia (heavy menstrual bleeding)', 'endometriosis� in females with no contraindications to hormonal contraceptives, who have achieved menarche and desire contraception'] | ['ectopic pregnancy', 'intrauterine fetal death', 'pregnancy', 'pregnancy testing', 'breast-feeding', 'cervical cancer', 'incomplete abortion', 'uterine cancer', 'vaginal bleeding', 'breast cancer', 'menstrual irregularity', 'ovarian cyst', 'diabetes mellitus', 'children', 'hepatic disease', 'hepatocellular cancer', 'jaundice', 'asian patients', 'obstetric delivery', 'requires an experienced clinician', 'uterine leiomyomata', 'acquired immunodeficiency syndrome (aids)', 'cervicitis', 'endometritis', 'infection', 'leukemia', 'vaginal discharge', 'vaginitis', 'human immunodeficiency virus (hiv) infection', 'sexually transmitted disease', 'bradycardia', 'seizure disorder', 'syncope', 'obesity', 'anticoagulant therapy', 'coagulopathy', 'cerebrovascular disease', 'hypertension', 'myocardial infarction', 'stroke', 'thromboembolic disease', 'thrombophlebitis', 'tobacco smoking', 'valvular heart disease', 'headache', 'migraine', 'visual disturbance', 'renal disease', 'magnetic resonance imaging (mri)'] |
| 56 | 55 | rabeprazole sodium | ['the symptomatic treatment of non-erosive gastroesophageal reflux disease (gerd)', 'the healing of duodenal ulcer', 'erosive esophagitis (erosive gerd)', 'pathological hypersecretory conditions including zollinger-ellison syndrome', 'the short-term treatment of frequent dyspepsia� or pyrosis (heartburn)� that occurs >= 2 times per week', 'the healing of gastric ulcer�', 'proton-pump inhibitor-responsive esophageal eosinophilia (ppi-ree) in the differential diagnosis of eosinophilic esophagitis (eoe)�'] | ['proton pump inhibitors (ppis) hypersensitivity', 'hepatic disease', 'diarrhea', 'pseudomembranous colitis', 'gastric cancer', 'vitamin b12 deficiency', 'bone fractures', 'geriatric', 'osteoporosis', 'hypomagnesemia', 'long qt syndrome', 'rebound acid hypersecretion', 'pregnancy', 'breast-feeding', 'infants', 'neonates', 'systemic lupus erythematosus (sle)', 'laboratory test interference'] | |
| 57 | 56 | onabotulinumtoxinA | ['blepharospasm associated with dystonia, including benign essential blepharospasm or vii nerve disorders', 'cervical dystonia in adults to decrease the severity of abnormal head position and neck pain associated with cervical dystonia', 'strabismus', 'vertical muscles, and for horizontal strabismus of less than 20 prism diopters', 'horizontal strabismus of 20 prism diopters to 50 prism diopters', 'persistent vi nerve palsy of 1 month or longer duration', 'subsequent dosing for residual or recurrent strabismus', 'temporary improvement in the appearance of facial wrinkles', 'temporary improvement in the appearance of moderate to severe glabellar lines associated with corrugators and/or procerus muscle activity', 'temporary improvement in the appearance of other wrinkles such as melolabial folds� and other hyperkinetic facial lines�', "temporary improvement in the appearance of moderate to severe lateral canthal lines associated with orbicularis oculi activity (crow's feet)", 'moderate to severe forehead lines associated with frontalis muscle activity', 'spasticity', 'the chronic management of focal spasticity� in pediatric patients with cerebral palsy with concurrent equinus gait (tiptoeing)', 'severe primary axillary hyperhidrosis (excessive underarm sweating)', 'migraine prophylaxis in adult patients with chronic migraine', 'urinary incontinence due to detrusor overactivity associated with a neurologic condition (e', 'second line treatment of neurogenic bladder� in children', 'overactive bladder (oab) with symptoms of urge urinary incontinence, urgency, and frequency in adults intolerant to or with inadequate response from anticholinergic medications', 'achalasia�', 'sialorrhea� (excessive drooling)', "sialorrhea� associated with parkinson's disease�", 'sialorrhea� associated with amyotrophic lateral sclerosis (als)�', 'sialorrhea� associated with cerebral palsy�'] | ['intravenous administration', 'requires an experienced clinician', 'cerebral palsy', 'children', 'distant spread of toxin effects', 'infants', 'neonates', 'infection', 'urinary tract infection (uti)', 'hyperthyroidism', 'thyroid disease', 'albumin hypersensitivity', 'viral infection', 'dysphagia', 'pregnancy', 'breast-feeding', 'geriatric', 'ocular disease', 'visual disturbance', 'amyotrophic lateral sclerosis (als)', 'autonomic neuropathy', 'myasthenia gravis', 'myopathy', 'neuromuscular disease', 'cardiac disease', 'respiratory insufficiency', 'driving or operating machinery', 'surgery', 'anticoagulant therapy', 'urinary retention'] | |
| 58 | 57 | methylphenidate hydrochloride | ['attention-deficit hyperactivity disorder (adhd)', 'once-daily product dosing', 'narcolepsy', 'major depression� or post-stroke depression refractory to other therapies'] | ['hereditary fructose intolerance', 'anxiety', 'bipolar disorder', 'depression', 'mania', 'psychosis', 'schizophrenia', 'suicidal ideation', 'tics', "tourette's syndrome", 'glaucoma', 'visual disturbance', 'abrupt discontinuation', 'alcoholism', 'substance abuse', 'hypertension', 'acute myocardial infarction', 'aortic stenosis', 'arteriosclerosis', 'cardiac arrhythmias', 'cardiac disease', 'cardiomyopathy', 'congenital heart disease', 'coronary artery disease', 'heart failure', 'myocardial infarction', 'prosthetic heart valves', 'valvular heart disease', 'ventricular arrhythmias', 'ventricular dysfunction', 'cerebrovascular disease', 'stroke', 'children', 'growth inhibition', 'hyperthyroidism', 'seizure disorder', 'seizures', 'neonates', 'pregnancy', 'breast-feeding', 'driving or operating machinery', 'surgery', 'radiographic contrast administration', 'dysphagia', 'esophageal stricture', 'gi obstruction', 'ileus', 'hepatic disease', 'geriatric', 'maoi therapy', 'peripheral vascular disease', "raynaud's phenomenon", 'chemical leukoderma', 'skin hypopigmentation', 'vitiligo', 'phenylketonuria'] | |
| 59 | 58 | ['228790'] | dutasteride | ['benign prostatic hyperplasia (bph) in men with an enlarged prostate to improve urinary symptoms, reduce risk of acute urinary retention, and reduce the risk of the need for bph-related surgery', 'use in combination with tamsulosin', 'male pattern hair loss� (i'] | ['females', 'pregnancy', 'breast-feeding', 'hepatic disease', 'children', 'infants', 'neonates', 'prostate cancer', 'urinary tract obstruction', 'blood donation', 'infertility'] |
| 60 | 59 | ['57308'] | topotecan | ['patients with metastatic ovarian cancer with disease progression on or after initial or subsequent chemotherapy', 'small cell lung cancer (sclc)', 'platinum-sensitive small cell lung cancer (sclc) who progressed at least 60 days after initiation of first-line chemotherapy', 'relapsed small cell lung cancer (sclc) in patients with a prior complete or partial response and who are at least 45 days from the end of first-line chemotherapy', 'chemotherapy-naive, extensive-stage sclc in combination with paclitaxel�', 'chemotherapy-naive, extensive-stage sclc sequentially after treatment with cisplatin and etoposide�', 'stage iv-b recurrent or persistent cervical cancer that is not amendable to curative treatment with surgery and/or radiation therapy', 'metastatic rhabdomyosarcoma� in combination with cyclophosphamide and vincristine alternating with vac', 'non-small cell lung cancer (nsclc)�', 'previously untreated advanced non-small cell lung cancer (nsclc) in combination with gemcitabine�', 'the second-line treatment of advanced non-small cell lung cancer in combination with gemcitabine�'] | ['gelatin hypersensitivity', 'mannitol hypersensitivity', 'anemia', 'bone marrow suppression', 'herpes infection', 'infection', 'neutropenia', 'radiation therapy', 'thrombocytopenia', 'varicella', 'viral infection', 'dehydration', 'diarrhea', 'lung cancer', 'pulmonary fibrosis', 'extravasation', 'children', 'infants', 'neonates', 'pregnancy', 'contraception requirements', 'infertility', 'male-mediated teratogenicity', 'reproductive risk', 'breast-feeding'] |
| 61 | 60 | ['4678'] | ganciclovir | ['induction treatment of cytomegalovirus (cmv) retinitis in immunocompromised patients, including hiv-infected patients', 'cytomegalovirus (cmv) disease prophylaxis in patients at risk for cmv disease', 'prophylaxis in allogeneic hematopoietic cell transplant (hct) recipients', 'solid organ transplant recipients who are cmv-seropositive or cmv-seronegative receiving an organ from a cmv-seropositive donor', 'solid organ transplant recipients who are cmv-seropositive and receiving immunosuppressive induction therapy (i', 'preemptive therapy in hematopoietic cell transplant (hct) recipients who are less than 100 days post hct�', 'preemptive therapy in hematopoietic cell transplant (hct) recipients who are more than 100 days post hct�', 'acute herpes simplex keratitis (dendritic keratitis)', 'chronic suppressive therapy of cytomegalovirus (cmv) disease, including cmv retinitis (i', 'viral encephalitis�', 'varicella-zoster (herpes zoster) encephalitis� as an alternative to acyclovir', 'cytomegalovirus (cmv) encephalitis� and for the treatment of cytomegalovirus (cmv) neurological disease� (including encephalitis�) in hiv-infected patients', 'encephalitis� due to b virus (cercopithecine herpesvirus) infection� as an alternative to valacyclovir', 'cytomegalovirus (cmv)-associated gastrointestinal disease� (e', 'cytomegalovirus (cmv) pneumonitis�', 'symptomatic congenital cytomegalovirus (cmv) disease�', 'acute retinal necrosis (arn)� due to varicella-zoster virus in hiv-infected patients', 'progressive outer retinal necrosis (porn)� due to varicella zoster virus (vzv)� in hiv-infected patients', 'severe human herpesvirus 8 (hhv-8) infection� and associated diseases in hiv-infected patients, including multicentric castleman disease� (mcd) and primary effusion lymphoma� (pel)', 'multicentric castleman disease (mcd)�', 'herpes simplex virus infection� or varicella (chickenpox) infection� due to varicella-zoster virus in hospitalized immunocompromised patients unable to take oral therapy', 'neonatal herpes simplex virus infection�', 'encephalitis caused by human herpesvirus 6 (hhv-6) infection� in immunocompromised patients'] | ['acyclovir hypersensitivity', 'famciclovir hypersensitivity', 'ganciclovir hypersensitivity', 'penciclovir hypersensitivity', 'valacyclovir hypersensitivity', 'valganciclovir hypersensitivity', 'anemia', 'bone marrow suppression', 'chemotherapy', 'leukopenia', 'neutropenia', 'radiation therapy', 'thrombocytopenia', 'intramuscular administration', 'subcutaneous administration', 'dehydration', 'geriatric', 'renal failure', 'renal impairment', 'accidental exposure', 'neoplastic disease', 'ocular exposure', 'children', 'infants', 'neonates', 'infertility', 'reproductive risk', 'antimicrobial resistance', 'contraception requirements', 'male-mediated teratogenicity', 'pregnancy', 'pregnancy testing', 'breast-feeding', 'contact lenses'] |
| 62 | 61 | glucagon (rDNA origin) | ['severe hypoglycemia', 'severe hypoglycemia in neonates', 'use in radiographic examination of the gi tract', 'congenital hyperinsulinemia� (e', 'beta-blocker toxicity�, or for adjunctive treatment of calcium channel blocker toxicity (e', 'the emergency treatment of choking due to esophageal foreign body impaction�'] | ['insulinoma', 'pheochromocytoma', 'adrenal insufficiency', 'malnutrition', 'cardiac disease', 'coronary artery disease', 'children', 'pregnancy', 'breast-feeding'] | |
| 63 | 62 | acyclovir | ['neonatal herpes simplex virus infection', 'viral encephalitis', 'herpes simplex encephalitis', 'varicella-zoster encephalitis�', 'encephalitis due to b virus (cercopithecine herpesvirus) infection� as an alternative to valacyclovir', 'herpes labialis (i', 'recurrent herpes labialis in immunocompetent adults', 'varicella (chickenpox) infection', 'varicella (chickenpox) infection in immunocompetent patients', 'for varicella (chickenpox) infection in immunocompromised patients', 'herpes zoster (shingles) infection', 'herpes zoster (shingles) infection in bone marrow and organ transplant patients, patients receiving chemotherapy, and other immunocompromised patients', 'herpes zoster (shingles) infection in immunocompetent patients', 'herpes genitalis caused by herpes simplex virus', 'initial herpes genitalis infection', 'recurrent herpes genitalis', 'chronic suppression therapy of recurrent herpes genitalis (i', 'complicated herpes simplex virus infection (e', 'neonatal herpes simplex virus infection prophylaxis� (i', 'chronic suppression of recurrent herpes labialis� (i', 'herpes simplex infection prophylaxis� in immunocompromised hosts', 'primary herpes simplex infection prophylaxis in hsv-seropositive recipients of a bone marrow transplant�', 'primary herpes simplex infection prophylaxis in immunocompromised hosts who are hsv-seropositive patients�', 'primary varicella (chickenpox) infection prophylaxis� in hiv-infected patients with significant exposure to chickenpox or shingles for patients who have no history of either condition or, if available, negative antibody to varicella-zoster virus (vzv)', 'cytomegalovirus (cmv) disease prophylaxis�', 'prevention of cmv disease� in immunocompromised patients', 'prevention of cmv disease� in cmv-seropositive patients receiving bone marrow transplantation', 'cmv disease prophylaxis� in adults receiving renal transplantation', 'hairy leukoplakia� in hiv-positive adults', "bell's palsy�in combination with steroids", 'secondary herpes simplex ocular infection prophylaxis�', 'acute herpes zoster ocular infection� (herpes zoster ophthalmicus�) in immunocompetent patients', 'acute retinal necrosis (arn)� due to varicella-zoster virus in hiv-infected patients'] | ['acyclovir hypersensitivity', 'famciclovir hypersensitivity', 'ganciclovir hypersensitivity', 'milk protein hypersensitivity', 'penciclovir hypersensitivity', 'valacyclovir hypersensitivity', 'valganciclovir hypersensitivity', 'dehydration', 'renal failure', 'renal impairment', 'neurological disease', 'seizure disorder', 'geriatric', 'pregnancy', 'breast-feeding', 'children', 'infants', 'neonates', 'ophthalmic administration', 'extravasation', 'intramuscular administration', 'subcutaneous administration', 'obesity'] | |
| 64 | 63 | ['5487']['10763'] | hydrochlorothiazide/triamterene | ['peripheral edema or hypertension', 'formoterol***formoterol; mometasone'] | ['asthma', 'penicillin hypersensitivity', 'sulfonamide hypersensitivity', 'thiazide diuretic hypersensitivity', 'anuria', 'diabetes mellitus', 'electrolyte imbalance', 'geriatric', 'hyperglycemia', 'hyperkalemia', 'hypovolemia', 'renal disease', 'renal failure', 'renal impairment', 'hypotension', 'orthostatic hypotension', 'sympathectomy', 'syncope', 'hypercalcemia', 'hyponatremia', 'acid/base imbalance', 'metabolic acidosis', 'respiratory acidosis', 'pancreatitis', 'preeclampsia', 'pregnancy', 'breast-feeding', 'children', 'infants', 'neonates', 'hepatic disease', 'jaundice', 'gout', 'hyperuricemia', 'nephrolithiasis', 'systemic lupus erythematosus (sle)', 'sunlight (uv) exposure'] |
| 65 | 64 | ['195088']['85762'] | lopinavir/ritonavir | ['human immunodeficiency virus (hiv) infection in combination with other antiretroviral agents', 'human immunodeficiency virus (hiv) prophylaxis�', 'human immunodeficiency virus (hiv) prophylaxis� after occupational exposure', 'human immunodeficiency virus (hiv) prophylaxis� after nonoccupational exposure, including sexual assault', 'formoterol***formoterol; mometasone'] | ['hepatitis', 'hepatitis b and hiv coinfection', 'alcoholism', 'hepatic disease', 'jaundice', 'hypercholesterolemia', 'hyperlipidemia', 'hypertriglyceridemia', 'pancreatitis', 'diabetes mellitus', 'diabetic ketoacidosis', 'hyperglycemia', 'hemophilia', 'human immunodeficiency virus (hiv) infection resistance', 'children', 'infants', 'neonates', 'breast-feeding', 'pregnancy', 'av block', 'cardiac disease', 'cardiomyopathy', 'bradycardia', 'cardiac arrhythmias', 'coronary artery disease', 'females', 'geriatric', 'heart failure', 'hypertension', 'hypocalcemia', 'hypokalemia', 'hypomagnesemia', 'long qt syndrome', 'malnutrition', 'myocardial infarction', 'qt prolongation', 'thyroid disease', 'autoimmune disease', "graves' disease", 'guillain-barre syndrome', 'immune reconstitution syndrome', 'hepatitis c and hiv coinfection'] |
| 66 | 65 | penicillin G benzathine | ['yaws (<em>treponema pallidum</em> subsp', 'upper respiratory tract infections such as pharyngitis, including group a beta-hemolytic streptococcal (gas) pharyngitis (rheumatic fever prophylaxis), and for bacterial colonization eradication� in chronic carriers of group a beta-hemolytic <em>streptococci</em> (gas)�', 'secondary prevention of rheumatic fever (prevention of recurrent rheumatic fever attacks) or poststreptococcal glomerulonephritis', 'chronic carriers of group a beta-hemolytic <em>streptococci</em> (gas)� (bacterial colonization eradication)', 'diphtheria prophylaxis�', 'syphilis (<em>treponema pallidum</em>), including neurosyphilis�', 'primary, secondary, or early latent (less than 1 year duration) syphilis', 'late latent (greater than 1 year duration) syphilis or latent syphilis of unknown duration', 'late or tertiary syphilis (patients with gumma and cardiovascular syphilis)', 'the follow up treatment of neurosyphilis�', 'congenital syphilis (<em>treponema pallidum</em>)'] | ['viral infection', 'asthma', 'carbapenem hypersensitivity', 'cephalosporin hypersensitivity', 'penicillin hypersensitivity', 'intravenous administration', 'colitis', 'diarrhea', 'gi disease', 'inflammatory bowel disease', 'pseudomembranous colitis', 'ulcerative colitis', 'renal failure', 'renal impairment', 'pregnancy', 'breast-feeding', 'geriatric', 'infants', 'neonates'] | |
| 67 | 66 | ['714438'] | pazopanib | ['advanced renal cell cancer', 'advanced soft-tissue sarcoma in patients who have received prior chemotherapy', 'unresectable, locally advanced, or metastatic gastrointestinal stromal tumors (gist), after progression on or intolerance to both imatinib and sunitinib�'] | ['geriatric', 'hepatic disease', 'hepatotoxicity', 'angina', 'myocardial infarction', 'stroke', 'heart failure', 'hypertension', 'alcoholism', 'bradycardia', 'cardiac arrhythmias', 'cardiac disease', 'coronary artery disease', 'diabetes mellitus', 'females', 'hypocalcemia', 'hypokalemia', 'hypomagnesemia', 'long qt syndrome', 'malnutrition', 'qt prolongation', 'thyroid disease', 'bleeding', 'gi bleeding', 'intracranial bleeding', 'hemolytic-uremic syndrome', 'thrombotic thrombocytopenic purpura (ttp)', 'surgery', 'wound dehiscence', 'hypothyroidism', 'proteinuria', 'children', 'infants', 'neonates', 'asian patients', 'neutropenia', 'serious rash', 'thrombocytopenia', 'pregnancy', 'pneumonitis', 'contraception requirements', 'infertility', 'male-mediated teratogenicity', 'pregnancy testing', 'reproductive risk', 'breast-feeding'] |
| 68 | 67 | ['22968']['4083'] | dienogest/estradiol valerate | ['routine contraception', 'menorrhagia (heavy and/or prolonged menstrual bleeding) in females who also desire contraception', "endometriosis� to induce endometrial involution to a 'resting' phase and reduce the size and growth of endometrial tissue in females with no contraindications to hormonal contraceptives, who have achieved menarche and desire contraception", 'formoterol; mometasone'] | ['acquired immunodeficiency syndrome (aids)', 'human immunodeficiency virus (hiv) infection', 'pregnancy', 'breast-feeding', 'obstetric delivery', 'cholestasis', 'gallbladder disease', 'hepatic disease', 'hepatitis', 'hepatocellular cancer', 'jaundice', 'porphyria', 'obesity', 'diabetes mellitus', 'hyperlipidemia', 'hypertriglyceridemia', 'pancreatitis', 'atrial fibrillation', 'cerebrovascular disease', 'coronary artery disease', 'coronary thrombosis', 'endocarditis', 'hypercholesterolemia', 'hypertension', 'myocardial infarction', 'protein c deficiency', 'protein s deficiency', 'renal disease', 'stroke', 'thromboembolic disease', 'thromboembolism', 'thrombophlebitis', 'tobacco smoking', 'valvular heart disease', 'surgery', 'headache', 'migraine', 'depression', 'children', 'infants', 'neonates', 'breast cancer', 'cervical cancer', 'endometrial cancer', 'ovarian cancer', 'uterine cancer', 'vaginal bleeding', 'vaginal cancer', 'hypothyroidism', 'thyroid disease', 'geriatric', 'angioedema', 'hereditary angioedema', 'systemic lupus erythematosus (sle)', 'chloasma', 'contact lenses', 'glaucoma', 'visual disturbance'] |
| 69 | 68 | ['337523'] | ixabepilone | ['breast cancer', 'metastatic or locally advanced breast cancer that is resistant to an anthracycline and a taxane, or that is taxane resistant and for patients whom further anthracycline therapy is contraindicated, in combination with capecitabine', 'metastatic or locally advanced breast cancer that is resistant or refractory to anthracyclines, taxanes, and capecitabine'] | ['polyoxyethylated castor oil hypersensitivity', 'bone marrow suppression', 'neutropenia', 'thrombocytopenia', 'hepatic disease', 'jaundice', 'diabetes mellitus', 'peripheral neuropathy', 'cardiac arrhythmias', 'cardiac disease', 'ventricular dysfunction', 'children', 'alcoholism', 'driving or operating machinery', 'substance abuse', 'geriatric', 'pregnancy', 'breast-feeding', 'radiation therapy'] |
| 70 | 69 | sipuleucel-T | ['asymptomatic or minimally symptomatic metastatic, castrate resistant (hormone refractory), prostate cancer'] | ['cardiac disease', 'infusion-related reactions', 'pulmonary disease', 'chemotherapy', 'immunosuppression', 'children', 'infants', 'neonates', 'pregnancy', 'breast-feeding'] | |
| 71 | 70 | ['274771'] | nelarabine | ['t-cell leukemia/lymphoma', 't-cell leukemia/lymphoma in patients at first relapse or with refractory disease�', 't-cell leukemia/lymphoma in patients who have not responded to or have relapsed following treatment with at least 2 chemotherapy regimens', 'relapsed or refractory chronic lymphocytic leukemia (cll)�', 'formoterol; mometasone'] | ['chemotherapy', 'driving or operating machinery', 'geriatric', 'neurological disease', 'neurotoxicity', 'peripheral neuropathy', 'radiation therapy', 'seizures', 'bone marrow suppression', 'fungal infection', 'herpes infection', 'infection', 'varicella', 'viral infection', 'dental disease', 'dental work', 'intramuscular injections', 'hyperkalemia', 'hyperphosphatemia', 'hyperuricemia', 'hypocalcemia', 'hepatic disease', 'renal failure', 'renal impairment', 'pregnancy', 'breast-feeding', 'accidental exposure', 'ocular exposure', 'vaccination'] |
| 72 | 71 | ['6218'] | lactulose | ['hepatic encephalopathy (portal-systemic encephalopathy, pse)', 'constipation, including constipation related to barium retention'] | ['galactose-free diet', 'surgery', 'diabetes mellitus', 'geriatric', 'pregnancy', 'breast-feeding'] |
| 73 | 72 | ['10379'] | testosterone | ['delayed puberty in males', 'palliative treatment of breast cancer that is inoperable in women', 'postpubertal cryptorchidism�', 'microphallus�', 'anemia� in patients with chronic renal failure', 'female-to-male gender change (trans-sexualism�)', 'lichen sclerosus�', 'aids-associated wasting syndrome�'] | ['benzoic acid hypersensitivity', 'benzyl alcohol hypersensitivity', 'polyoxyethylated castor oil hypersensitivity', 'risk of serious hypersensitivity reactions or anaphylaxis', 'soya lecithin hypersensitivity', 'magnetic resonance imaging (mri)', 'intramuscular administration', 'intravenous administration', 'breast cancer', 'geriatric', 'prostate cancer', 'prostatic hypertrophy', 'cardiac disease', 'coronary artery disease', 'heart failure', 'hepatic disease', 'myocardial infarction', 'renal disease', 'stroke', 'obesity', 'pulmonary disease', 'polycythemia', 'accidental exposure', 'females', 'contraception requirements', 'labor', 'obstetric delivery', 'pregnancy', 'reproductive risk', 'breast-feeding', 'diabetes mellitus', 'hypercalcemia', 'pulmonary oil microembolism', 'nasal polyps', 'nasal septal perforation', 'nasal surgery', 'nasal trauma', 'rhinorrhea', "sjogren's syndrome", 'children', 'infants', 'neonates', 'substance abuse', 'infertility'] |
| 74 | 73 | levothyroxine sodium | ['primary hypothyroidism with or without goiter due to diminished or absent thyroid function caused by functional deficiency, primary atrophy, partial or complete absence of the thyroid gland, or from the effects of surgery, radiation, or an antithyroid agent, and for the treatment of secondary (pituitary) or tertiary (hypothalamic) hypothyroidism', 'myxedema coma', 'thyroid stimulating hormone (tsh) suppression in thyroid nodules, euthyroid goiters, and well-differentiated thyroid cancer', 'formoterol; mometasone'] | ['adrenal insufficiency', 'hypopituitarism', 'acute myocardial infarction', 'angina', 'cardiac arrhythmias', 'cardiac disease', 'coronary artery disease', 'hypertension', 'myocardial infarction', 'diabetes mellitus', 'obesity treatment', 'infertility', 'osteoporosis', 'pregnancy', 'breast-feeding', 'dysphagia', 'geriatric'] | |
| 75 | 74 | diphtheria and tetanus toxoids and acellular pertussis vaccine adsorbed | ['simultaneous diphtheria prophylaxis, tetanus prophylaxis, and pertussis prophylaxis', 'prophylaxis against diphtheria and tetanus for patients with large, contaminated wounds who also need the pertussis component'] | ['children', 'infants', 'neonates', 'premature neonates', 'intraarterial administration', 'intravenous administration', 'subcutaneous administration', 'guillain-barre syndrome', 'latex hypersensitivity', 'coma', 'encephalopathy', 'neurological disease', 'seizure disorder', 'seizures', 'fever', 'shock', 'anticoagulant therapy', 'bleeding', 'coagulopathy', 'hemophilia', 'thrombocytopenia', 'vitamin k deficiency', 'infection', 'immunosuppression', 'pregnancy', 'breast-feeding', 'syncope'] | |
| 76 | 75 | ['21212'] | clarithromycin | ['acute exacerbations of chronic bronchitis', 'community-acquired pneumonia (cap)', 'sinusitis', 'uncomplicated skin and skin structure infections', 'acute otitis media', 'disseminated mycobacterium avium complex infection (mac) <em> </em>in hiv-positive patients', '<em>mycobacterium avium </em>complex (mac) prophylaxis in hiv-infected patients', 'primary <em>mycobacterium avium</em> complex (mac) prophylaxis', 'secondary <em>mycobacterium avium</em> complex (mac) prophylaxis in patients with disseminated disease, after treatment of the acute illness', 'helicobacter pylori (h', 'bacterial endocarditis prophylaxis�', 'pertussis (whooping cough)� caused by <em>bordetella pertussis</em>', 'postexposure pertussis prophylaxis�', 'bartonellosis� (<em>bartonella bacilliformis)</em> and other <em>bartonella sp', 'angiomatosis infections�, peliosis hepatis�, bacteremia�, and osteomyelitis� caused by <em>bartonella sp', 'long term suppression� of infections caused by <em>bartonella sp', 'pharyngitis (primary rheumatic fever prophylaxis�) or tonsillitis caused by susceptible strains of <em>streptococcus pyogenes</em> (group a beta-hemolytic streptococci)', 'formoterol; mometasone'] | ['viral infection', 'macrolide hypersensitivity', 'pregnancy', 'breast-feeding', 'hepatic disease', 'hepatitis', 'jaundice', 'renal failure', 'renal impairment', 'colitis', 'diarrhea', 'gi disease', 'inflammatory bowel disease', 'pseudomembranous colitis', 'ulcerative colitis', 'colostomy', 'ileostomy', 'children', 'infants', 'neonates', 'alcoholism', 'bradycardia', 'cardiac arrhythmias', 'cardiac disease', 'coronary artery disease', 'diabetes mellitus', 'females', 'heart failure', 'hypertension', 'hypocalcemia', 'hypokalemia', 'hypomagnesemia', 'long qt syndrome', 'malnutrition', 'mortality', 'myocardial infarction', 'qt prolongation', 'thyroid disease', 'torsade de pointes', 'ventricular arrhythmias', 'myasthenia gravis', 'geriatric'] |
| 77 | 76 | donepezil hydrochloride | ["alzheimer's disease", "mild to moderate alzheimer's disease", "moderate to severe alzheimer's disease", 'vascular dementia�', 'the short-term treatment (up to 90 days) of acute cognitive deficits following ischemic stroke�', 'dementia with lewy bodies�', 'formoterol***formoterol; mometasone'] | ['abrupt discontinuation', 'alcoholism', 'av block', 'bradycardia', 'cardiac arrhythmias', 'cardiac disease', 'coronary artery disease', 'diabetes mellitus', 'females', 'heart failure', 'hypertension', 'hypocalcemia', 'hypokalemia', 'hypomagnesemia', 'hypotension', 'long qt syndrome', 'malnutrition', 'myocardial infarction', 'qt prolongation', 'sick sinus syndrome', 'syncope', 'thyroid disease', 'diarrhea', 'gi bleeding', 'gi disease', 'peptic ulcer disease', 'vomiting', 'hepatic disease', 'asthma', 'chronic obstructive pulmonary disease (copd)', 'pulmonary disease', 'bladder obstruction', 'seizure disorder', 'seizures', 'pregnancy', 'breast-feeding', 'children', 'infants', 'neonates', 'surgery', 'geriatric'] | |
| 78 | 77 | ['72302'] | ropinirole | ["parkinson's disease", 'conversion from immediate-release to extended-release tablets', 'restless legs syndrome (rls)'] | ['pregnancy', 'breast-feeding', 'children', 'cardiac disease', 'hypertension', 'hypotension', 'orthostatic hypotension', 'syncope', 'geriatric', 'psychosis', 'dialysis', 'renal failure', 'renal impairment', 'hepatic disease', 'tobacco smoking', 'coadministration with other cns depressants', 'driving or operating machinery', 'ethanol ingestion', 'narcolepsy', 'sleep apnea', 'abrupt discontinuation', 'melanoma', 'impulse control symptoms'] |
| 79 | 78 | ['38400'] | atomoxetine | ['attention-deficit hyperactivity disorder (adhd)'] | ['pheochromocytoma', 'maoi therapy', 'hepatic disease', 'hepatitis', 'jaundice', 'closed-angle glaucoma', 'constipation', 'gi obstruction', 'ileus', 'prostatic hypertrophy', 'urinary retention', 'seizure disorder', 'seizures', 'driving or operating machinery', 'ethanol intoxication', 'bipolar disorder', 'depression', 'mania', 'psychosis', 'alcoholism', 'arteriosclerosis', 'bradycardia', 'cardiac arrhythmias', 'cardiac disease', 'cardiomyopathy', 'cerebrovascular disease', 'congenital heart disease', 'coronary artery disease', 'diabetes mellitus', 'females', 'heart failure', 'hypertension', 'hypocalcemia', 'hypokalemia', 'hypomagnesemia', 'long qt syndrome', 'malnutrition', 'myocardial infarction', 'qt prolongation', 'stroke', 'tachycardia', 'thyroid disease', 'ventricular arrhythmias', 'ventricular dysfunction', 'children', 'growth inhibition', 'suicidal ideation', 'dehydration', 'hypovolemia', 'orthostatic hypotension', 'syncope', 'pregnancy', 'breast-feeding', 'geriatric'] |
| 80 | 79 | ['14851'] | vigabatrin | ['use as monotherapy in the treatment of infantile spasms in pediatric patients for whom the potential benefits outweigh the potential risk of vision loss', 'refractory complex partial seizures', 'formoterol; mometasone'] | ['requires an experienced clinician', 'visual impairment', 'depression', 'suicidal ideation', 'abrupt discontinuation', 'driving or operating machinery', 'hepatic decompensation', 'hepatic disease', 'renal impairment', 'geriatric', 'children', 'infants', 'neonates', 'substance abuse', 'pregnancy', 'breast-feeding'] |
| 81 | 80 | diphtheria and tetanus toxoids and acellular pertussis adsorbed and inactivated poliovirus vaccine | ['simultaneous diphtheria prophylaxis, tetanus prophylaxis, pertussis prophylaxis, and poliovirus prophylaxis as the fifth dose in the diphtheria, tetanus, and acellular pertussis (dtap) vaccine series and the fourth dose in the inactivated poliovirus vaccine (ipv) series in children whose previous dtap vaccine doses have been with infanrix and/or pediarix for the first three doses and infanrix for the fourth dose'] | ['intraarterial administration', 'intravenous administration', 'subcutaneous administration', 'guillain-barre syndrome', 'neomycin hypersensitivity', 'polymyxin hypersensitivity', 'polysorbate 80 hypersensitivity', 'latex hypersensitivity', 'coma', 'encephalopathy', 'fever', 'neurological disease', 'seizure disorder', 'seizures', 'shock', 'anticoagulant therapy', 'coagulopathy', 'hemophilia', 'thrombocytopenia', 'vitamin k deficiency', 'immunosuppression', 'infection', 'children', 'infants', 'neonates', 'pregnancy', 'breast-feeding'] | |
| 82 | 81 | interferon gamma-1b | ['chronic granulomatous disease to reduce the frequency and severity of serious infections', 'severe, malignant osteopetrosis to delay the time to disease progression'] | ['pulmonary fibrosis', 'bone marrow suppression', 'immunosuppression', 'infants', 'neonates', 'angina', 'cardiac arrhythmias', 'cardiac disease', 'heart failure', 'myocardial infarction', 'driving or operating machinery', 'seizure disorder', 'e. coli protein hypersensitivity', 'latex hypersensitivity', 'mannitol hypersensitivity', 'hepatic disease', 'renal failure', 'renal impairment', 'pregnancy', 'breast-feeding', 'infertility', 'reproductive risk'] | |
| 83 | 82 | ['73710'] | paricalcitol | ['the prevention and treatment of secondary hyperparathyroidism and resultant metabolic bone disease (renal osteodystrophy�)', 'initial dosing and dosage titration in pre-dialysis patients with stage 3 or 4 chronic kidney disease', 'initial dosing and dosage titration in patients with stage 5 chronic kidney disease on dialysis', 'initial dosing and dosage titration in patients with stage 5 chronic kidney disease on dialysis (national kidney foundation guidelines)'] | ['hypercalcemia', 'hypervitaminosis d', 'pregnancy', 'breast-feeding', 'children', 'infants', 'neonates', 'geriatric'] |
| 84 | 83 | ['819300'] | golimumab | ['moderately to severely active rheumatoid arthritis (ra) in combination with methotrexate', 'active ankylosing spondylitis (as)', 'active psoriatic arthritis (psa)', 'moderately to severely active ulcerative colitis to induce and maintain clinical response, to improve endoscopic appearance of the mucosa during induction, to induce clinical remission, and to achieve and sustain clinical remission in induction responders in adults who have demonstrated corticosteroid dependence or who have had an inadequate response to or failed to tolerate oral aminosalicylates, oral corticosteroids, azathioprine, or 6-mercaptopurine'] | ['hepatitis', 'hepatitis b exacerbation', 'bone marrow suppression', 'corticosteroid therapy', 'diabetes mellitus', 'fungal infection', 'immunosuppression', 'infection', 'influenza', 'mycobacterial infection', 'sepsis', 'surgery', 'tuberculosis', 'viral infection', 'cholangitis', 'chronic obstructive pulmonary disease (copd)', 'inflammatory bowel disease', 'leukemia', 'lymphoma', 'new primary malignancy', 'skin cancer', 'ulcerative colitis', 'heart failure', 'guillain-barre syndrome', 'multiple sclerosis', 'optic neuritis', 'agranulocytosis', 'leukopenia', 'neutropenia', 'thrombocytopenia', 'latex hypersensitivity', 'vaccination', 'infants', 'neonates', 'pregnancy', 'breast-feeding', 'geriatric', 'children'] |
| 85 | 84 | ['3008'] | cyclosporine | ['kidney transplant rejection prophylaxis', 'kidney transplant rejection prophylaxis in combination with sirolimus and corticosteroids in patients who are considered low to moderate immunologic risk', 'kidney transplant rejection prophylaxis in combination with sirolimus and corticosteroids in patients who are considered high immunologic risk', 'severe, plaque-type psoriasis in immunocompetent patients who failed to respond to at least one systemic therapy (e', 'severe rheumatoid arthritis (ra) in patients unresponsive to conventional therapy, alone or in combination with methotrexate when the disease has not adequately responded to methotrexate', 'early rheumatoid arthritis (ra)', 'xerophthalmia by increasing tear production in patients whose tear production is presumed to be suppressed due to ocular inflammation associated with keratoconjunctivitis sicca', 'heart transplant rejection prophylaxis, liver transplant rejection prophylaxis, and the treatment of acute and chronic graft-versus-host disease (gvhd)� and graft-versus-host disease (gvhd) prophylaxis�', 'severe atopic dermatitis�', 'severe aplastic anemia�', 'chronic immune thrombocytopenia/idiopathic thrombocytopenic purpura (itp)�', 'myasthenia gravis� in patients who are poorly controlled with cholinesterase inhibitor therapy', 'psoriatic arthritis�', 'lupus nephritis� in patients with systemic lupus erythematosus (sle) unresponsive to conventional therapy, or for the treatment of children with idiopathic nephrotic syndrome�'] | ['fungal infection', 'herpes infection', 'immunosuppression', 'infection', 'requires a specialized care setting', 'requires an experienced clinician', 'varicella', 'viral infection', 'herpes simplex keratitis (dendritic keratitis)', 'ocular infection', 'lymphoma', 'new primary malignancy', 'radiation therapy', 'skin cancer', 'sunlight (uv) exposure', 'nephrotoxicity', 'renal disease', 'renal failure', 'renal impairment', 'hyperkalemia', 'hypertension', 'electrolyte imbalance', 'polyoxyethylated castor oil hypersensitivity', 'children', 'infants', 'pregnancy', 'breast-feeding', 'geriatric', 'alcoholism', 'biliary tract disease', 'hepatic disease', 'jaundice', 'gout', 'hyperuricemia', 'encephalopathy', 'hypomagnesemia', 'vaccination', 'contact lenses'] |
| 86 | 85 | ['68244'] | lamivudine | ['human immunodeficiency virus (hiv) infection in combination with other antiretroviral agents', 'chronic hepatitis b infection', 'chronic hepatitis b infection in hiv-negative patients', 'chronic hepatitis b infection in hiv-positive patients', 'human immunodeficiency virus (hiv) prophylaxis�', 'hiv prophylaxis after occupational exposure to hiv', 'hiv prophylaxis after non-occupational hiv exposure, including sexual assault', 'perinatal human immunodeficiency virus (hiv) prophylaxis� in neonates at high risk for hiv acquisition'] | ['hepatitis b and hiv coinfection', 'hepatitis b exacerbation', 'hiv serum status', 'alcoholism', 'females', 'hepatic disease', 'hepatotoxicity or lactic acidosis', 'obesity', 'organ transplant', 'geriatric', 'peripheral neuropathy', 'renal failure', 'renal impairment', 'children', 'infants', 'neonates', 'pancreatitis', 'pregnancy', 'breast-feeding', 'human immunodeficiency virus (hiv) infection resistance', 'diabetes mellitus', 'autoimmune disease', "graves' disease", 'guillain-barre syndrome', 'immune reconstitution syndrome', 'hepatitis c and hiv coinfection'] |
| 87 | 86 | ['861634'] | pitavastatin | ['hypercholesterolemia, hyperlipoproteinemia, and/or hypertriglyceridemia as an adjunct to dietary control', 'reduction of elevated total cholesterol, ldl-cholesterol, apolipoprotein b, and triglyceride concentrations, and to increase hdl-cholesterol in patients with primary hypercholesterolemia or mixed dyslipidemia', 'the regression of coronary atherosclerosis in patients with acute coronary syndrome (acs)'] | ['alcoholism', 'cholestasis', 'hepatic disease', 'hepatic encephalopathy', 'hepatitis', 'jaundice', 'dialysis', 'electrolyte imbalance', 'endocrine disease', 'females', 'hypotension', 'hypothyroidism', 'infection', 'myopathy', 'organ transplant', 'renal disease', 'renal failure', 'renal impairment', 'rhabdomyolysis', 'seizure disorder', 'surgery', 'trauma', 'diabetes mellitus', 'contraception requirements', 'pregnancy', 'breast-feeding', 'children', 'infants', 'geriatric'] |
| 88 | 87 | ketotifen fumarate | ['the temporary prevention of ocular pruritus due to allergic conjunctivitis', 'allergic conditions including allergic rhinitis�, atopic dermatitis�, and acute or chronic urticaria�'] | ['children', 'infants', 'neonates', 'contact lenses', 'pregnancy', 'breast-feeding'] | |
| 89 | 88 | moxifloxacin hydrochloride | ['acute bacterial exacerbation of chronic bronchitis', 'acute bacterial sinusitis', 'mild to moderate community-acquired pneumonia (cap)', 'skin and skin structure infections', 'uncomplicated skin and skin structure infections due to <em>staphylococcus aureus</em> (mssa) and <em>streptococcus pyogenes</em>', 'complicated skin and skin structure infections due to <em>enterobacter cloacae</em>, <em>escherichia coli</em>, <em>klebsiella pneumoniae</em>, or <em>staphylococcus aureus</em> (mssa)', 'complicated intraabdominal infections including polymicrobial infections such as abscesses', 'bacterial conjunctivitis (including chlamydial conjunctivitis) due to susceptible organisms', 'plague, including pneumonic and septicemic plague, and plague prophylaxis due to susceptible isolates', 'tuberculosis infection� caused by <em>mycobacterium tuberculosis�</em> in combination with other antituberculosis agents as a second line agent', 'mycobacterium avium complex infection� (mac) in hiv-infected patients', 'anthrax�', 'systemic anthrax infection', 'cutaneous anthrax infection', 'bacterial gastroenteritis� and infectious diarrhea�', 'salmonellosis� in hiv-infected patients', 'shigellosis� in hiv-infected patients', 'campylobacteriosis� in hiv-infected patients', 'surgical infection prophylaxis�', 'ophthalmic surgical prophylaxis�', 'recurrent or persistent non-gonococcal urethritis (ngu)�', 'pelvic inflammatory disease (pid)�', 'anthrax prophylaxis� after exposure to <em>bacillus anthracis</em> (postexposure prophylaxis, pep)', 'formoterol***formoterol; mometasone'] | ['viral infection', 'quinolone hypersensitivity', 'corticosteroid therapy', 'organ transplant', 'tendinitis', 'tendinopathy', 'tendon pain', 'tendon rupture', 'alcoholism', 'atrial fibrillation', 'bradycardia', 'cardiac arrhythmias', 'cardiac disease', 'coronary artery disease', 'females', 'heart failure', 'hypertension', 'hypocalcemia', 'hypokalemia', 'hypomagnesemia', 'long qt syndrome', 'malnutrition', 'myocardial infarction', 'qt prolongation', 'thyroid disease', 'torsade de pointes', 'cerebrovascular disease', 'neurotoxicity', 'peripheral neuropathy', 'seizure disorder', 'myasthenia gravis', 'hepatic disease', 'hepatitis', 'hepatotoxicity', 'jaundice', 'diabetes mellitus', 'sunlight (uv) exposure', 'colitis', 'diarrhea', 'gi disease', 'inflammatory bowel disease', 'pseudomembranous colitis', 'ulcerative colitis', 'geriatric', 'pregnancy', 'breast-feeding', 'sexually transmitted disease', 'children', 'infants', 'neonates', 'sodium restriction', 'contact lenses', 'driving or operating machinery'] | |
| 90 | 89 | formoterol fumarate | ['the maintenance prevention of bronchospasm associated with chronic obstructive pulmonary disease (copd), including chronic bronchitis and emphysema'] | ['monotherapy treatment of asthma', 'paradoxical bronchospasm', 'acute bronchospasm', 'asthma-related death', 'alcoholism', 'bradycardia', 'cardiac arrhythmias', 'cardiac disease', 'coronary artery disease', 'females', 'heart failure', 'hepatic disease', 'hypertension', 'hypocalcemia', 'hypokalemia', 'hypomagnesemia', 'long qt syndrome', 'malnutrition', 'myocardial infarction', 'qt prolongation', 'tachycardia', 'diabetes mellitus', 'diabetic ketoacidosis', 'hyperglycemia', 'hyperthyroidism', 'pheochromocytoma', 'seizure disorder', 'seizures', 'thyroid disease', 'thyrotoxicosis', 'labor', 'pregnancy', 'breast-feeding', 'maoi therapy', 'geriatric', 'children', 'infants', 'milk protein hypersensitivity'] | |
| 91 | 90 | azelaic acid | ['mild-to-moderate inflammatory acne vulgaris', 'inflammatory pustules and papules of mild-to-moderate acne rosacea', 'melasma�', 'lentigo maligna� in which surgery is contraindicated', 'cutaneous malignant melanoma�'] | ['occlusive dressing', 'ocular exposure', 'pregnancy', 'breast-feeding', 'children', 'infants', 'neonates', 'herpes infection', 'asthma', 'deterioration of asthma'] | |
| 92 | 91 | ['37418', '67158'] | sumatriptan | ['the acute treatment of migraine attacks with or without aura', 'the acute treatment of cluster headache'] | ['sumatriptan hypersensitivity', 'acute myocardial infarction', 'angina', 'arteriosclerosis', 'cardiac arrhythmias', 'cardiac disease', 'coronary artery disease', 'diabetes mellitus', 'hypercholesterolemia', 'obesity', 'tobacco smoking', 'vasospastic angina', 'wolff-parkinson-white syndrome', 'hypertension', 'cerebrovascular disease', 'intracranial bleeding', 'stroke', 'basilar/hemiplegic migraine', 'intravenous administration', 'pregnancy', 'breast-feeding', 'hepatic disease', 'renal disease', 'renal failure', 'renal impairment', 'children', 'geriatric', 'driving or operating machinery', 'colitis', 'peripheral vascular disease', "raynaud's phenomenon", 'seizure disorder', 'seizures', 'visual disturbance', 'maoi therapy', 'magnetic resonance imaging (mri)'] |
| 93 | 92 | ondansetron); (ondansetron hydrochloride | ['chemotherapy-induced nausea/vomiting prophylaxis (cinv prophylaxis) and radiation-induced nausea/vomiting prophylaxis (rinv prophylaxis)', 'post-operative nausea/vomiting (ponv) prophylaxis', 'post-operative nausea/vomiting (ponv)�', 'hyperemesis gravidarum� (severe pregnancy-induced nausea/vomiting) unresponsive to other antiemetics', 'the short-term treatment of nausea/vomiting associated with acute gastroenteritis�', 'pruritus� secondary to cholestasis', 'the maintenance treatment of alcohol dependence�', 'cyclic vomiting syndrome�', 'formoterol***formoterol; mometasone'] | ['hepatic disease', 'hepatitis', 'dolasetron hypersensitivity', 'granisetron hypersensitivity', 'ondansetron hypersensitivity', 'palonosetron hypersensitivity', 'phenylketonuria', 'gi obstruction', 'ileus', 'alcoholism', 'bradycardia', 'cardiac arrhythmias', 'cardiac disease', 'coronary artery disease', 'diabetes mellitus', 'females', 'heart failure', 'hypertension', 'hypocalcemia', 'hypokalemia', 'hypomagnesemia', 'long qt syndrome', 'malnutrition', 'myocardial infarction', 'qt prolongation', 'thyroid disease', 'children', 'infants', 'neonates', 'pregnancy', 'breast-feeding', 'geriatric'] | |
| 94 | 93 | ['1116632'] | ticagrelor | ['arterial thromboembolism prophylaxis in patients with acute coronary syndrome (acs) (unstable angina, acute myocardial infarction), including in patients undergoing percutaneous coronary intervention (pci)'] | ['bleeding', 'coronary artery bypass graft surgery (cabg)', 'gi bleeding', 'intracranial bleeding', 'surgery', 'hepatic disease', 'labor', 'obstetric delivery', 'pregnancy', 'breast-feeding', 'abrupt discontinuation', 'children', 'infants', 'neonates', 'av block', 'bradycardia', 'sick sinus syndrome', 'syncope', 'aspirin coadministration', 'geriatric'] |
| 95 | 94 | tiotropium bromide | ['the long-term maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (copd), including chronic bronchitis and emphysema, and to reduce exacerbations of copd', 'the long-term maintenance treatment of asthma'] | ['milk protein hypersensitivity', 'acute bronchospasm', 'closed-angle glaucoma', 'contact lenses', 'ocular exposure', 'ophthalmic administration', 'anticholinergic medications', 'bladder obstruction', 'prostatic hypertrophy', 'urinary retention', 'urinary tract obstruction', 'cardiac arrhythmias', 'renal impairment', 'driving or operating machinery', 'geriatric', 'pregnancy', 'breast-feeding', 'children', 'infants'] | |
| 96 | 95 | ['28439'] | lamotrigine | ['partial seizures with or without secondary generalization', 'monotherapy of partial seizures in patients currently receiving treatment with a single enzyme-inducing anti-epileptic drug (aed) (e', 'monotherapy of partial seizures in patients currently receiving treatment with valproate', 'adjunctive therapy to other anticonvulsants in the treatment of partial seizures', 'monotherapy of partial seizures in patients currently receiving treatment with a single anti-epileptic drug (aed) other than carbamazepine, phenytoin, phenobarbital, primidone, or valproate', 'adjunctive therapy to other anticonvulsants in the treatment of primary generalized tonic-clonic seizures', 'adjunctive therapy to other anticonvulsants in the treatment of generalized seizures of lennox-gastaut syndrome', 'the long-term maintenance treatment of bipolar disorder (bipolar i disorder) to delay the occurrence of mood episodes (i', 'absence seizures�', 'long-term prophylaxis of short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (sunct)�'] | ['serious rash', 'depression', 'suicidal ideation', 'abrupt discontinuation', 'driving or operating machinery', 'hepatic disease', 'dialysis', 'renal disease', 'renal failure', 'renal impairment', 'cardiac disease', 'heart failure', 'black patients', 'geriatric', 'children', 'infants', 'neonates', 'folate deficiency', 'pregnancy', 'breast-feeding'] |
| 97 | 96 | bupropion hydrochloride | ['major depression', 'the prevention of seasonal major depressive disorder episodes associated with seasonal affective disorder (sad)', 'use as an adjunct to psychosocial interventions in the management of tobacco cessation (smoking cessation)', 'use alone to aide in tobacco cessation', 'aide with tobacco cessation using bupropion in combination with a nicotine transdermal system (nts)', 'attention-deficit hyperactivity disorder (adhd)�', 'use as monotherapy of attention-deficit hyperactivity disorder (adhd)� in adults', 'the symptomatic treatment of neuropathic pain� due to various causes, including pain associated with peripheral diabetic neuropathy� or postherpetic neuralgia�', 'formoterol; mometasone'] | ['alcoholism', 'anorexia nervosa', 'benzodiazepine withdrawal', 'brain tumor', 'bulimia nervosa', 'diabetes mellitus', 'head trauma', 'hypoglycemia', 'hyponatremia', 'hypoxemia', 'intracranial mass', 'obesity treatment', 'seizure disorder', 'seizures', 'stroke', 'substance abuse', 'children', 'suicidal ideation', 'tics', "tourette's syndrome", 'behavioral changes', 'bipolar disorder', 'depression', 'mania', 'psychiatric event', 'schizophrenia', 'maoi therapy', 'neonates', 'pregnancy', 'breast-feeding', 'hepatic disease', 'renal disease', 'renal failure', 'renal impairment', 'acute myocardial infarction', 'cardiac disease', 'heart failure', 'hypertension', 'tobacco smoking', 'geriatric', 'driving or operating machinery', 'ethanol intoxication', 'closed-angle glaucoma', 'increased intraocular pressure', 'abrupt discontinuation'] | |
| 98 | 97 | ['480167'] | lapatinib | ['breast cancer', 'patients with advanced or metastatic breast cancer, in combination with capecitabine, whose tumor overexpresses the her2 protein and who have received prior therapy including an anthracycline, a taxane, and trastuzumab', 'postmenopausal women with hormone receptor positive metastatic breast cancer that overexpresses the her2 receptor and for whom hormonal therapy is indicated, in combination with letrozole', 'her2-positive, trastuzumab-refractory metastatic breast cancer� in combination with trastuzumab'] | ['serious rash', 'cardiac disease', 'heart failure', 'hypertension', 'hepatic disease', 'hepatotoxicity', 'alcoholism', 'bradycardia', 'cardiac arrhythmias', 'coronary artery disease', 'diabetes mellitus', 'females', 'geriatric', 'hypocalcemia', 'hypokalemia', 'hypomagnesemia', 'long qt syndrome', 'malnutrition', 'myocardial infarction', 'qt prolongation', 'thyroid disease', 'torsade de pointes', 'pneumonitis', 'pulmonary disease', 'asian patients', 'black patients', 'caucasian patients', 'hispanic patients', 'pregnancy', 'breast-feeding', 'children', 'infants', 'neonates'] |
| 99 | 98 | ['1100699', '1100703'] | linagliptin | ['type 2 diabetes mellitus in combination with diet and exercise', 'formoterol; mometasone'] | ['exfoliative dermatitis', 'history of angioedema', 'serious rash', 'diabetic ketoacidosis', 'type 1 diabetes mellitus', 'burns', 'fever', 'infection', 'surgery', 'trauma', 'adrenal insufficiency', 'hypoglycemia', 'hypothyroidism', 'malnutrition', 'pituitary insufficiency', 'renal impairment', 'diarrhea', 'gastroparesis', 'gi obstruction', 'ileus', 'vomiting', 'hypercortisolism', 'hyperglycemia', 'hyperthyroidism', 'pancreatitis', 'arthralgia', 'heart failure', 'pregnancy', 'breast-feeding', 'children', 'geriatric'] |
| 100 | 99 | ['857974', '1546030'] | saxagliptin | ['type 2 diabetes mellitus in combination with diet and exercise', 'formoterol; mometasone'] | ['exfoliative dermatitis', 'history of angioedema', 'serious rash', 'diabetic ketoacidosis', 'type 1 diabetes mellitus', 'burns', 'fever', 'infection', 'surgery', 'trauma', 'diarrhea', 'gastroparesis', 'gi obstruction', 'ileus', 'vomiting', 'pancreatitis', 'hypercortisolism', 'hyperglycemia', 'hyperthyroidism', 'adrenal insufficiency', 'hypoglycemia', 'hypothyroidism', 'malnutrition', 'pituitary insufficiency', 'cardiac disease', 'heart failure', 'renal disease', 'renal failure', 'renal impairment', 'arthralgia', 'geriatric', 'pregnancy', 'breast-feeding', 'children'] |