1 |
2 |
unable |
2 |
unwilling to discontinue use of prohibited |
4 |
|
3 |
2 |
1 |
subject is unable |
1 |
unwilling to discontinue predefined prohibited |
2 |
listed in the protocol for 4 weeks of a drug whichever is longer prior to visit 1 and for the duration of the study |
2 |
3 |
3 |
patient is unable |
1 |
nonprescription |
1 |
for at least 7 days prior to the first dose of study drug and for the duration of the study |
1 |
4 |
4 |
expansion cohort only patient is unable |
1 |
|
NA |
for at least 28 days prior to the first dose of topotecan / pazopanib and for the duration of the study |
1 |
5 |
5 |
|
1 |
|
NA |
|
NA |
6 |
7 |
subjects who are unable |
1 |
|
NA |
|
NA |